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Journal Articles

Comparison of the therapeutic effects of [$$^{211}$$At]NaAt and [$$^{131}$$I]NaI in an NIS-expressing thyroid cancer mouse model

Watabe, Tadashi*; Liu, Y.*; Kaneda, Kazuko*; Sato, Tatsuhiko; Shirakami, Yoshifumi*; Oe, Kazuhiro*; Toyoshima, Atsushi*; Shimosegawa, Eku*; Wang, Y.*; Haba, Hiromitsu*; et al.

International Journal of Molecular Sciences (Internet), 23(16), p.9434_1 - 9434_11, 2022/08

https://doi.org/10.3390/ijms23169434
 Times Cited Count：7 Percentile：78.48(Biochemistry & Molecular Biology)

In this study, we compare the therapeutic effect between [$$^{211}$$At]NaAt and [$$^{131}$$I]NaI. In vitro analysis of double-stranded DNA break (DSB) and colony formation assay were performed using K1-NIS cells. [$$^{211}$$At]NaAt induced higher numbers of DSBs and had a reduced colony formation than [$$^{131}$$I]NaI. In K1-NIS mice, dose-dependent therapeutic effects were observed in both [$$^{211}$$At]NaAt and [$$^{131}$$I]NaI. The superior therapeutic effect of [$$^{211}$$At]NaAt suggests the promising clinical applicability of targeted alpha therapy using [$$^{211}$$At]NaAt in patients with differentiated thyroid cancer refractory to standard [$$^{131}$$I]NaI treatment.

Journal Articles

Three-layer GSO depth-of-interaction detector for high-energy gamma camera

Yamamoto, Seiichi*; Watabe, Hiroshi*; Kawachi, Naoki; Fujimaki, Shu; Kato, Katsuhiko*; Hatazawa, Jun*

Nuclear Instruments and Methods in Physics Research A, 743, p.124 - 129, 2014/04

https://doi.org/10.1016/j.nima.2014.01.011
 Times Cited Count：10 Percentile：57.19(Instruments & Instrumentation)

Oral presentation

Three layer GSO depth-of-interaction detector for high energy $$gamma$$ camera

Yamamoto, Seiichi*; Watabe, Hiroshi*; Kawachi, Naoki; Fujimaki, Shu; Kato, Katsuhiko*; Hatazawa, Jun*

no journal, , 

Oral presentation

Development of measuring technique for radiocesium; Simple method for analysis of agricultural products, imaging of the dynamics of radiocesium into plant from the soil

Yin, Y.-G.; Suzui, Nobuo; Kawachi, Naoki; Yamaguchi, Mitsutaka; Tanoi, Keitaro*; Nakanishi, Tomoko*; Chino, Mitsuo*; Nakamura, Shinichi*; Watabe, Hiroshi*; Yamamoto, Seiichi*; et al.

no journal, , 

no abstracts in English

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