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Oral presentation

Neurocytotoxic effects of microbeam irradiation of heavy carbon-ions on the developing brain measured in vivo using medaka (${it Oryzias latipes}$), a vertebrate model

Yasuda, Takako*; Oda, Shoji*; Hibi, Yusuke*; Urushihara, Yusuke*; Mitani, Hiroshi*; Funayama, Tomoo; Yokota, Yuichiro; Muto, Yasuko; Ikeda, Hiroko; Kobayashi, Yasuhiko

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Using heavy-ion microbeam system of JAEA-Takasaki, we irradiated brain of the embryos of the Medaka with carbon ion microbeam. After irradiation, inductions of apoptosis were observed using whole-mount staining of acridine orange. In targeted position of the brain, we observed the induction of radiation induced apoptosis, indicating that the system can irradiate specific region of the brain of the Medaka embryo.

Oral presentation

The Systemic effects of irradiation revealed by the local irradiation to the medaka testis using carbon-ion microbeam system in TIARA

Oda, Shoji*; Yasuda, Takako*; Hibi, Yusuke*; Asaka, Tomomi*; Ikeda, Hiroko; Muto, Yasuko*; Yokota, Yuichiro; Sakashita, Tetsuya; Suzuki, Michiyo; Funayama, Tomoo; et al.

no journal, , 

We have developed a new irradiation protocol for tissue specific irradiation to living embryo and adult medaka, ${it Oryzias latipes}$. In the study, a testis of p53 knockout fish were irradiated with multi-shots of microbeam. Less numbers of testis-ova were induced in the in p53- lacking testis 1 week after the irradiation compared to whole body irradiated testis. Specific irradiation of microbeam onto the right (or left) lobe of the optic tectum in medaka embryos of 2 days post fertilization ectopically induced apoptotic cells in the body trunk and the tail in addition to the irradiated position. The systemic effects as endocrine system, autonomic nervous system and immunity reactions occur in adult medaka and these results suggested that the systemic effects might be functional even in developing embryos.

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