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Journal Articles

Innate immune genes including a mucin-like gene, ${it mul-1}$, induced by ionizing radiation in ${it Caenorhabditis elegans}$

Kimura, Takafumi*; Takanami, Takako*; Sakashita, Tetsuya; Wada, Seiichi*; Kobayashi, Yasuhiko; Higashitani, Atsushi*

Radiation Research, 178(4), p.313 - 320, 2012/10

 Times Cited Count:6 Percentile:39.9(Biology)

Here, we found that exposure to ionizing radiation (IR) induce certain innate immune response gene of ${it mul-1}$ in the intestine. Pre-treatment with IR before seeding on ${it Pseudomonas aeruginosa}$ lawn plate, significantly increased survival rate in the nematode. IR induction of ${it mul-1}$ gene was highly dependent on the ELT-2 transcription factor and p38 MAPK. Moreover, the insulin/IGF-1 signal pathway works as an enhancer of induction of this gene. Silencing of the ${it mul-1}$ gene led to growth retardation after IR irradiation. Finally, we describe the cross-tolerance between the responses to radiation exposure and innate immune system.

Journal Articles

Radiation biology of ${it Caenorhabditis elegans}$; Germ cell response, aging and behavior

Sakashita, Tetsuya; Takanami, Takako*; Yanase, Sumino*; Hamada, Nobuyuki*; Suzuki, Michiyo; Kimura, Takafumi*; Kobayashi, Yasuhiko; Ishii, Naoaki*; Higashitani, Atsushi*

Journal of Radiation Research, 51(2), p.107 - 121, 2010/03

 Times Cited Count:27 Percentile:61.15(Biology)

The study of radiation effect in ${it Caenorhabditis (C.) elegans}$ have been carried out over three decades and now allow for understanding at the molecular, cellular and individual levels. This review describes the current knowledge of the biological effects of ionizing irradiation with a scope of the germ line, aging and behavior. ${it C. elegans}$ may be a good ${it in vivo}$ model system in the field of radiation biology.

Journal Articles

Effects of ionizing radiation on locomotory behavior and mechanosensation in ${it Caenorhabditis elegans}$

Suzuki, Michiyo; Sakashita, Tetsuya; Yanase, Sumino*; Kikuchi, Masahiro; Oba, Hirofumi; Higashitani, Atsushi*; Hamada, Nobuyuki*; Funayama, Tomoo; Fukamoto, Kana; Tsuji, Toshio*; et al.

Journal of Radiation Research, 50(2), p.119 - 125, 2009/04

 Times Cited Count:6 Percentile:22.92(Biology)

Journal Articles

Effect of energetic heavy-ion irradiation on gene expression in ${it Caenorhabdits elegans}$

Higashitani, Atsushi*; Mori, Chihiro*; Kimura, Takafumi*; Ikenaga, Takahiko*; Takanami, Takako*; Sakashita, Tetsuya; Wada, Seiichi*; Hamada, Nobuyuki*; Kobayashi, Yasuhiko

JAEA-Review 2007-060, JAEA Takasaki Annual Report 2006, P. 112, 2008/03

We investigated the gene expression of ${it C. elegans}$ following carbon and $$gamma$$ irradiation using DNA microarray analysis. We observed the 187 and 297 upregulated genes after $$gamma$$ and carbon irradiation with 100 Gy, respectively, in which 51 genes were upregulated following both irradiations. On the other hand, the 358 and 388 genes were downregulated after $$gamma$$ and carbon irradiation, respectively.

Journal Articles

Construction of monitoring system for biological effects of local ionizing radiation using the nematode ${it C. elegans}$

Higashitani, Atsushi*; Sugimoto, Tomoko*; Mori, Chihiro*; Suzuki, Yoko*; Saito, Rumiko*; Ichishi, Eiichiro*; Sakashita, Tetsuya; Hamada, Nobuyuki*; Wada, Seiichi*; Kakizaki, Takehiko; et al.

JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 113, 2007/02

no abstracts in English

Journal Articles

Cell cycle arrest and apoptosis in ${it Caenorhabditis elegans}$ germline cells following heavy-ion microbeam irradiation

Sugimoto, Tomoko*; Dazai, Kumiko*; Sakashita, Tetsuya; Funayama, Tomoo; Wada, Seiichi; Hamada, Nobuyuki*; Kakizaki, Takehiko; Kobayashi, Yasuhiko; Higashitani, Atsushi*

International Journal of Radiation Biology, 82(1), p.31 - 38, 2006/01

 Times Cited Count:39 Percentile:92.82(Biology)

no abstracts in English

Journal Articles

Electronic structure and the Fermi surface of UBe$$_{13}$$

Maehira, Takahiro; Higashitani, Atsushi*; Higuchi, Masahiko*; Yasuhara, Hiroshi*; Hasegawa, Akira*

Physica B; Condensed Matter, 312-313(1-4), p.103 - 105, 2002/03

 Times Cited Count:12 Percentile:54.45(Physics, Condensed Matter)

UBe$$_{13}$$ is a typical heavy-fermion superconductor compound. The lowtemperature electronic specific heat coefficient has the anomalous large value, $$gamma_{exp}$$=1.1J/K$$^2$$mol, which is the largest among the heavy fermion uranium compounds. It also becomes the superconductor below T$$_C$$=0.85K. Therefore, UBe$$_{13}$$ is an important material as a strongly correlated electron system, and it is necessary to study from both sides of the theory and the experiment. The measurement suggests that the Fermi surface of UBe$$_{13}$$ may consist of small sheets. The energy band structure and the Fermi surface for UBe$$_{13}$$ are calculated by the relativistic linear APW method.

Oral presentation

Radiation effect and bystander effect of heavy ion particle irradiation on apoptosis in ${it Caenorhabditis elegans}$ germ cell development

Higashitani, Atsushi*; Sugimoto, Tomoko*; Dazai, Kumiko*; Mori, Chihiro*; Sakashita, Tetsuya; Funayama, Tomoo; Kakizaki, Takehiko; Hamada, Nobuyuki*; Wada, Seiichi*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Study of biological responses to ionizing radiation in the germline cells of ${it C. elegans}$

Mori, Chihiro*; Sugimoto, Tomoko*; Dazai, Kumiko*; Sakashita, Tetsuya; Funayama, Tomoo; Kakizaki, Takehiko; Hamada, Nobuyuki*; Wada, Seiichi*; Kobayashi, Yasuhiko; Ichishi, Eiichiro*; et al.

no journal, , 

no abstracts in English

Oral presentation

Study of biological responses to heavy-ion microbeams in the nematode ${it C. elegans}$

Higashitani, Atsushi*; Mori, Chihiro*; Sugimoto, Tomoko*; Dazai, Kumiko*; Sakashita, Tetsuya; Funayama, Tomoo; Kakizaki, Takehiko; Hamada, Nobuyuki*; Wada, Seiichi*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Approach to the radiobiological study of ${it Caenorhabditis elegans}$ using heavy-ion microbeam

Sakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Ikeda, Daisuke*; Fukamoto, Kana; Yokota, Yuichiro; Funayama, Tomoo; Yanase, Sumino*; Higashitani, Atsushi*; Ishii, Naoaki*; et al.

no journal, , 

Using ${it Caenorhabditis elegans}$ as a model multicellular organism, we push forward a heavy-ion microbeam irradiation individual-study. As for about 1.2 mm in a range of carbon ions in water, all cells and tissues of ${it C. elegans}$ are microbeam irradiation objects. Sugimoto et al. showed DNA-damage-induced cell cycle arrest and apoptosis in locally irradiated areas of ${it C. elegans}$. We focus the nervous system of ${it C. elegans}$ and study the effects of localized irradiation on salt chemotaxis learning behavior. However, the anesthetic method for fixation of animals is not usable because the whole body irradiation of $$^{60}$$Co $$gamma$$ rays affected only transition stage of the conditioning for salt chemotaxis learning. Thus, now we are constructing the heavy-ion microbeam irradiation system for living target ${it C. elegans}$.

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