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Journal Articles

A Laser-plasma-produced soft X-ray laser at 89 eV generates DNA double-strand breaks in human cancer cells

Sato, Katsutoshi*; Nishikino, Masaharu; Kawachi, Tetsuya; Shimokawa, Takashi*; Imai, Takashi*; Teshima, Teruki*; Nishimura, Hiroaki*; Kando, Masaki

Journal of Radiation Research, 56(4), p.633 - 638, 2015/07

 Times Cited Count:1 Percentile:7.15(Biology)

While X-ray laser is expected to be widely applied to biomedical studies, this has not been achieved to date and its biological effects such as DNA damage have not been evaluated. As a first step for its biological application, we developed a culture cell irradiation system using laser-plasma soft X-ray laser and investigated whether the soft X-ray laser is able to induce the DNA double strand breaks (DSBs) in living cells or not. The human adenocarcimona cell line A549 was irradiated with the soft X-ray laser at a photon energy of 89 eV and then the repair focus formation of the DSBs was assessed by immunofluorescence staining with anti-phosphorylated DNA-PKcs antibody. As a result, the phosphorylated DNA-PKcs foci were clearly identified even with just a single shot of the soft X-ray laser. In this study, we successfully demonstrated for the first time that soft X-ray laser at 89 eV induced the DNA double strand breaks in living cells.

Journal Articles

Study on simulation code for dilute bubbly flow

Ito, Kei; Takata, Takashi*; Ohno, Shuji; Kogawa, Hiroyuki; Kamide, Hideki; Imai, Yasutomo*; Kawamura, Takumi*

Nihon Kikai Gakkai Rombunshu, B, 79(808), p.2630 - 2634, 2013/12

In a sodium-cooled fast reactor, inert gas exists in the primary coolant system as bubbles or dissolved gas. Similarly, small bubbles exist also in the mercury target loop in J-PARC to suppress cavitation erosion. To simulate these inert gas behaviors in liquid metal flows, the Japan Atomic Energy Agency (JAEA) has developed a plant dynamics code VIBUL. In this study, new models, i.e. the bubble release and bubble carry under models, are introduced to simulate the bubble behaviors in the fast reactor and mercury target system. Then, the small bubble behavior in the mercury target system is simulated to check the validity of the new models.

Journal Articles

Development of multi-purpose MW gyrotrons for fusion devices

Minami, Ryutaro*; Kariya, Tsuyoshi*; Imai, Tsuyoshi*; Numakura, Tomoharu*; Endo, Yoichi*; Nakabayashi, Hidetaka*; Eguchi, Taku*; Shimozuma, Takashi*; Kubo, Shin*; Yoshimura, Yasuo*; et al.

Nuclear Fusion, 53(6), p.063003_1 - 063003_7, 2013/06

Journal Articles

Development of multi-purpose MW gyrotrons for fusion devices

Minami, Ryutaro*; Kariya, Tsuyoshi*; Imai, Tsuyoshi*; Numakura, Tomoharu*; Endo, Yoichi*; Nakabayashi, Hidetaka*; Eguchi, Taku*; Shimozuma, Takashi*; Kubo, Shin*; Yoshimura, Yasuo*; et al.

Nuclear Fusion, 53(6), p.063003_1 - 063003_7, 2013/06

 Times Cited Count:12 Percentile:48.49(Physics, Fluids & Plasmas)

Journal Articles

Tilted-foil technique for producing a spin-polarized radioactive isotope beam

Hirayama, Yoshikazu*; Mihara, Mototsugu*; Watanabe, Yutaka*; Jeong, S. C.*; Miyatake, Hiroari*; Momota, Sadao*; Hashimoto, Takashi*; Imai, Nobuaki*; Matsuta, Kensaku*; Ishiyama, Hironobu*; et al.

European Physical Journal A, 48(5), p.54_1 - 54_10, 2012/05

 Times Cited Count:2 Percentile:17.01(Physics, Nuclear)

Journal Articles

Manufacturing of JT-60SA equilibrium field coils

Hasegawa, Mitsuru*; Horii, Hiroyuki*; Nomoto, Kazuhiro*; Imai, Yoshio*; Murai, Takashi*; Minato, Tsuneaki*; Kuno, Kazuo*; Tsuchiya, Katsuhiko; Murakami, Haruyuki; Kizu, Kaname; et al.

Proceedings of 24th International Cryogenic Engineering Conference (ICEC 24) and International Cryogenic Materials Conference 2012 (ICMC 2012) (CD-ROM), p.571 - 574, 2012/05

JT-60U magnet system will be upgraded to the superconducting coils (JT-60SA) in the Broader Approach project. JT-60SA magnet system has 18 Toroidal Field coils, a Central Solenoid with 4 modules and 6 Equilibrium Field (EF) coils. This paper describes the manufacturing procedure of EF4 coil, that is the first manufactured EF coil of JT-60SA. The winding pack of EF4 coil was successfully manufactured within geometrical tolerance requirements.

Journal Articles

GEM-MSTPC; An Active-target type detector in low-pressure He/CO$$_{2}$$ mixed gas

Ishiyama, Hironobu*; Yamaguchi, Kanako*; Mizoi, Yutaka*; Watanabe, Yutaka*; Das, S. K.*; Hashimoto, Takashi*; Miyatake, Hiroari*; Hirayama, Yoshikazu*; Imai, Nobuaki*; Oyaizu, Mitsuhiro*; et al.

Journal of Instrumentation (Internet), 7(3), p.C03036_1 - C03036_14, 2012/03

 Times Cited Count:7 Percentile:38.25(Instruments & Instrumentation)

We developed an active-target type gas counter operating with low He/CO$$_{2}$$ (10%) detector gas for application in studying low-energy nuclear reactions using radioactive beams. A 400-$$mu$$m-thick gas electron multiplier (THGEM) was used as the proportional counter for high injection rate capability. We examined the gas gain stability and the influence of ion feedback on particle tracks at high beam injection rates of up to 10$$^{5}$$ particles per second (pps) using a low-energy $$^{12}$$C beam. From the result of this examination, we found that the THGEM was found to be applicable for our active target at high injection rates of up to 10$$^{5}$$ pps.

Journal Articles

Identified charged hadron production in $$p + p$$ collisions at $$sqrt{s}$$ = 200 and 62.4 GeV

Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Armendariz, R.*; et al.

Physical Review C, 83(6), p.064903_1 - 064903_29, 2011/06

 Times Cited Count:176 Percentile:99.42(Physics, Nuclear)

Transverse momentum distributions and yields for $$pi^{pm}, K^{pm}, p$$, and $$bar{p}$$ in $$p + p$$ collisions at $$sqrt{s}$$ = 200 and 62.4 GeV at midrapidity are measured by the PHENIX experiment at the RHIC. We present the inverse slope parameter, mean transverse momentum, and yield per unit rapidity at each energy, and compare them to other measurements at different $$sqrt{s}$$ collisions. We also present the scaling properties such as $$m_T$$ and $$x_T$$ scaling and discuss the mechanism of the particle production in $$p + p$$ collisions. The measured spectra are compared to next-to-leading order perturbative QCD calculations.

Journal Articles

Azimuthal correlations of electrons from heavy-flavor decay with hadrons in $$p+p$$ and Au+Au collisions at $$sqrt{s_{NN}}$$ = 200 GeV

Adare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Aramaki, Y.*; et al.

Physical Review C, 83(4), p.044912_1 - 044912_16, 2011/04

 Times Cited Count:7 Percentile:46.52(Physics, Nuclear)

Measurements of electrons from the decay of open-heavy-flavor mesons have shown that the yields are suppressed in Au+Au collisions compared to expectations from binary-scaled $$p+p$$ collisions. Here we extend these studies to two particle correlations where one particle is an electron from the decay of a heavy flavor meson and the other is a charged hadron from either the decay of the heavy meson or from jet fragmentation. These measurements provide more detailed information about the interaction between heavy quarks and the quark-gluon matter. We find the away-side-jet shape and yield to be modified in Au+Au collisions compared to $$p+p$$ collisions.

Journal Articles

Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond

Tamada, Taro; Kinoshita, Takayoshi*; Kurihara, Kazuo; Adachi, Motoyasu; Ohara, Takashi; Imai, Keisuke*; Kuroki, Ryota; Tada, Toshiji*

Journal of the American Chemical Society, 131(31), p.11033 - 11040, 2009/07

 Times Cited Count:56 Percentile:78.96(Chemistry, Multidisciplinary)

To help resolve long-standing questions regarding the catalytic activity of the serine proteases the structure of porcine pancreatic elastase has been analyzed by high-resolution neutron and X-ray crystallography. In order to mimic the tetrahedral transition intermediate a peptidic inhibitor was used. A single large crystal was used to collect room-temperature neutron data to 1.65 ${AA}$ resolution and X-ray data to 1.20 ${AA}$ resolution. Another crystal provided a low-temperature X-ray data set to 0.94 ${AA}$ resolution. The neutron data are to higher resolution than previously reported for a serine protease and the X-ray data are comparable with other studies. The neutron and X-ray data show that the hydrogen bond between His57 and Asp102 (chymotrypsin numbering) is 2.60 ${AA}$ in length and that the hydrogen-bonding hydrogen is 0.80-0.96 ${AA}$ from the histidine nitrogen. This is not consistent with a low-barrier hydrogen which is predicted to have the hydrogen midway between the donor and acceptor atom. The observed interaction between His57 and Asp102 is essentially a short but conventional hydrogen bond, sometimes described as a short ionic hydrogen bond. The neutron analysis also shows that the oxygen of the oxopropyl group of the inhibitor is present as an oxygen anion rather than a hydroxyl group, supporting the role of the "oxyanion hole" in stabilizing the tetrahedral intermediate in catalysis.

Journal Articles

Distinct response of irradiated normal human fibroblasts and their bystander cells to heavy-ion radiation in confluent cultures

Hamada, Nobuyuki*; Iwakawa, Mayumi*; Imadome, Kaori*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Ni, M.*; Imai, Takashi*; Kobayashi, Yasuhiko

Journal of Radiation Research, 50(Suppl.A), P. A118, 2009/05

Journal Articles

A New measurement of the astrophysical $$^8$$Li(d,t)$$^7$$Li reaction

Hashimoto, Takashi; Ishiyama, Hironobu*; Watanabe, Yutaka*; Hirayama, Yoshikazu*; Imai, Nobuaki*; Miyatake, Hiroari; Jeong, S.-C.*; Tanaka, Masahiko*; Yoshikawa, Nobuharu*; Nomura, Toru*; et al.

Physics Letters B, 674(4-5), p.276 - 280, 2009/04

 Times Cited Count:6 Percentile:43.74(Astronomy & Astrophysics)

The excitation function of the $$^8$$Li(d,t)$$^7$$Li reaction was directly measured using $$^8$$Li beams at E$$_{mathrm{cm}}$$ = 0.3, 0.4, 0.5, 0.7, 0.8, 1.0, 1.1, and 1.2 MeV with CD$$_2$$ targets. The beam energies covered the Gamow peaks for 1$$sim$$3$$times$$10$$^9$$ K. Large cross sections were observed at around E$$_{mathrm{cm}}$$ = 0.8 MeV, implying a resonance state located at 22.4 MeV in $$^{10}$$Be. The present astrophysical reaction rate is higher in one order magnitude than the presently adopted rate at around 1$$times$$10$$^9$$ K.

Journal Articles

Development of 28 GHz and 77 GHz 1 MW gyrotron for ECRH of magnetically confined plasma

Kariya, Tsuyoshi*; Minami, Ryutaro*; Imai, Tsuyoshi*; Sakamoto, Keishi; Kubo, Shin*; Shimozuma, Takashi*; Takahashi, Hiromi*; Ito, Satoshi*; Muto, Takashi*; Mitsunaka, Yoshika*; et al.

Fusion Science and Technology, 55(2T), p.91 - 94, 2009/02

 Times Cited Count:11 Percentile:60.33(Nuclear Science & Technology)

Journal Articles

Heavy ion-induced bystander effects; Intercellular signaling from irradiated cells to their non-irradiated neighbors

Hamada, Nobuyuki*; Iwakawa, Mayumi*; Imai, Takashi*; Kobayashi, Yasuhiko

Hoshasen Kagaku, 51(8), p.31 - 41, 2008/08

no abstracts in English

Journal Articles

On-line diffusion tracing in Li ionic conductors by the short-lived radioactive beam of $$^{8}$$Li

Jeong, S.-C.*; Katayama, Ichiro*; Kawakami, Hirokane*; Watanabe, Yutaka*; Ishiyama, Hironobu*; Imai, Nobuaki*; Hirayama, Yoshikazu*; Miyatake, Hiroari; Sataka, Masao; Sugai, Hiroyuki; et al.

Japanese Journal of Applied Physics, 47(8), p.6413 - 6415, 2008/08

 Times Cited Count:5 Percentile:22.97(Physics, Applied)

A non-destructive and on-line diffusion tracing in Li ionic conductors has been demonstrated. As a tracer, pulsed beam of $$^{8}$$Li was implanted into LiGa. By analyzing the time dependent yield of the $$alpha$$-particles decaying from $$^{8}$$Li, diffusion coefficients were extracted with a high accuracy. The ordering of Li vacancies in the Li-deficient $$beta$$ phase of LiGa was observed for the first time in terms of the Li diffusion.

Journal Articles

Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells

Iwakawa, Mayumi*; Hamada, Nobuyuki*; Imadome, Kaori*; Funayama, Tomoo; Sakashita, Tetsuya; Kobayashi, Yasuhiko; Imai, Takashi*

Mutation Research; Fundamental and Molecular Mechanisms of Mutagenesis, 642(1-2), p.57 - 67, 2008/07

 Times Cited Count:34 Percentile:66.9(Biotechnology & Applied Microbiology)

Journal Articles

Diffusion of $$^{8}$$Li short-lived radiotracer in Li ionic conductors of NaTl-type intermetallic compounds

Sugai, Hiroyuki; Sataka, Masao; Okayasu, Satoru; Ichikawa, Shinichi; Nishio, Katsuhisa; Mitsuoka, Shinichi; Nakanoya, Takamitsu; Osa, Akihiko; Sato, Tetsuya; Hashimoto, Takashi; et al.

Defect and Diffusion Forum, 273-276, p.667 - 672, 2008/00

Journal Articles

Crystallization of porcine pancreatic elastase and a preliminary neutron diffraction experiment

Kinoshita, Takayoshi*; Tamada, Taro; Imai, Keisuke*; Kurihara, Kazuo; Ohara, Takashi; Kuroki, Ryota

Acta Crystallographica Section F, 63(4), p.315 - 317, 2007/04

 Times Cited Count:8 Percentile:66.81(Biochemical Research Methods)

Porcine pancreatic elastase (PPE) resembles the attractive drug target leukocyte elastase, which has been implicated in a number of inflammatory disorders. In order to investigate the structural characteristics of the covalent inhibitor bound to PPE, including hydrogen and hydration of water, a single crystal of PPE for neutron diffraction study was grown in D$$_{2}$$O containing 0.2 M sodium sulfate (pD=5.0) using the sitting-drop vapor diffusion method. The crystal was grown to a size of 1.6 mm$$^{3}$$ by repeated macro-seeding. The neutron diffraction data were collected at room temperature using a BIX-3 diffractometer at the JRR-3 research reactor of the Japan Atomic Energy Agency (JAEA). The data set was integrated and scaled to 2.3${AA}$ resolution with space group P212121 and cell dimensions of a=51.2${AA}$, b=57.8${AA}$ and c=75.6${AA}$.

JAEA Reports

2005 Annual report of MEXT specially promoted research, "Development of the 4D space access neutron spectrometer (4SEASONS) and elucidation of the mechanism of oxide high-$$T_c$$ superconductivity"

Arai, Masatoshi; Yokoo, Tetsuya*; Kajimoto, Ryoichi; Nakajima, Kenji; Shamoto, Shinichi; Yamada, Kazuyoshi*; Fujita, Masaki*; Ino, Takashi*; Soyama, Kazuhiko; Nakamura, Mitsutaka; et al.

JAEA-Review 2006-033, 58 Pages, 2006/11


A research project entitled "Development of the 4D Space Access Neutron Spectrometer (4SEASONS) and Elucidation of the Mechanism of Oxide High-$$T_c$$ Superconductivity" has started in 2005 (repr. by M. Arai). It is supported by MEXT, Grant-in-Aid for Specially Promoted Research and is going to last until fiscal 2009. The goal of the project is to elucidate the mechanism of oxide high-$$T_c$$ superconductivity by neutron scattering technique. For this purpose, we will develop an inelastic neutron scattering instrument 4SEASONS (4d SpacE AccesS neutrON Spectrometer) for the spallation neutron source in Japan Proton Accelerator Research Complex (J-PARC). The instrument will have 100 times higher performance than existing world-class instruments, and will enable detailed observation of anomalous magnetic excitations and phonons in a four-dimensional momentum-energy space. This report summarizes the progress in the research project in fiscal 2007.

Journal Articles

Suppression of fast electron leakage from large openings in a plasma neutralizer for N-NB systems

Kashiwagi, Mieko; Hanada, Masaya; Yamana, Takashi*; Inoue, Takashi; Imai, Tsuyoshi*; Taniguchi, Masaki; Watanabe, Kazuhiro

Fusion Engineering and Design, 81(23-24), p.2863 - 2869, 2006/11

 Times Cited Count:4 Percentile:31.05(Nuclear Science & Technology)

Plasma neutralizer is one of key components to achieve the required system efficiency ($$>$$ 50 %) for a negative-ion based neutral beam (N-NB) system in a fusion power plant. In the plasma neutralizer, highly ionized plasma is required at lower pressure, e.g., ionization degrees of $$>$$ 30 % at $$<$$ 0.08 Pa for 1 MeV negative ions. In such low pressure, mean free path of fast electron that contributes to ionizations becomes longer than the neutralizer's dimensions. Therefore, suppression of fast electron leakage from large openings that are beam entrance and exit is a crucial issue to realize plasma neutralizers. To suppress the fast electron leakage from the openings, authors propose a shield field, which is a weak transverse magnetic field of only 30 Gauss applied locally around the opening. The shield field are numerically examined and designed by using a three dimensional particle orbit code. In the experimental studies, this weak shield field is applied at the openings (diam. = 20 cm) of an arc discharge driven plasma neutralizer (length = 200 cm, diam. = 60 cm). The plasma parameters inside and outside of the opening were measured by a Langmuir probe. The electron energy distribution function (EEDF) showed that considerable fast electrons, which were leaked from the opening, were suppressed successfully by the weak shield field of 30 Gauss. Thus the leaking fast electrons were repelled into the neutralizer to deposit their energy for the plasma production. At a result, the plasma production efficiency (plasma density / arc power) was improved by a factor of 1.5 at $$<$$ 0.08 Pa.

102 (Records 1-20 displayed on this page)