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浜田 信行*; 今岡 達彦*; 増永 慎一郎*; 尾方 俊至*; 岡安 隆一*; 高橋 昭久*; 加藤 宝光*; 小林 泰彦; 大西 武雄*; 小野 公二*; et al.
Journal of Radiation Research, 51(4), p.365 - 383, 2010/07
被引用回数:119 パーセンタイル:90.80(Biology)Superb biological effectiveness and dose conformity represent a rationale for heavy-ion therapy, which has thus far achieved good cancer controllability while sparing critical normal organs. Immediately after irradiation, heavy ions produce dense ionization along their trajectories, cause irreparable clustered DNA damage, and alter cellular ultrastructure. These ions, as a consequence, inactivate cells more effectively with less cell-cycle and oxygen dependence than conventional photons. The modes of heavy ion-induced cell death/inactivation include apoptosis, necrosis, autophagy, premature senescence, accelerated differentiation, delayed reproductive death of progeny cells, and bystander cell death. This paper briefly reviews the current knowledge of the biological aspects of heavy-ion therapy, with emphasis on the authors' recent findings. The topics include (1) repair mechanisms of heavy ion-induced DNA damage, (2) superior effects of heavy ions on radioresistant tumor cells (intratumor quiescent cell population, TP53-mutated and BCL2-overexpressing tumors), (3) novel capacity of heavy ions in suppressing cancer metastasis and neoangiogenesis, and (4) potential of heavy ions to induce secondary (especially breast) cancer.
山外 功太郎; 今岡 達彦*; Le Ngoc Thiem*; 松本 義久*
放射線科学, 52(10), p.21 - 25, 2009/10
平成21年9月3, 4日に経済協力開発機構原子力機関(OECD/NEA)の常設委員会である放射線防護・公衆衛生委員会が主催する「第5回放射線防護体系の進展にかかわるアジア会合」が開催された。本会合では、若手が企画するセッション「放射線防護に責任を有する若手専門家の確保と育成」が設けられた。本報告書では、若手セッションの企画から実施までの印象を、各講演者と座長の立場から述べる。