Longitudinal analysis of male fertility using an Acr-Luc knock-in mouse model; A Preclinical platform for reproductive toxicity testing

Fukunaga, Hisanori*; Seino, Ryosuke*; Matsuya, Yusuke; Takashima, Hiroyuki*; Ishikawa, Masayori*; Onodera, Yasuhito*; Shirato, Hiroki*; Miyata, Haruhiko*; Prise, K. M.*

Medcomm (Internet), 7(1), p.e70568_1 - e70568_11, 2026/01

https://doi.org/10.1002/mco2.70568

The main purpose of reproductive toxicity testing is to evaluate whether the administration of xenobiotics, such as pharmaceuticals, food additives, and environmental chemicals, exerts adverse effects on reproductive function in living organisms. The outcomes can be applied as a scientific basis to evaluate potential risks to human reproductive health. In this study, we developed a novel luciferase reporter mouse model for assessing reproductive toxicity, enabling longitudinal and quantitative evaluations of male fertility through in vivo imaging of acrosin without the need for euthanasia. This approach promises to advance our understanding of the mechanisms underlying the onset and recovery of reproductive toxicity. Additionally, reducing the number of animals needed for evaluation aligns with the principle of Reduction, which is one of the core components of the 3Rs in animal studies.

Development of a compact He neutron spin filter at J-PARC

Takahashi, Shingo; Kiyanagi, Ryoji; Okudaira, Takuya*; Takada, Shusuke*; Kobayashi, Ryuju; Okuizumi, Mao; Ino, Takashi*; Asai, Kanta*; Tsuchikawa, Yusuke; Oikawa, Kenichi; et al.

Nuclear Instruments and Methods in Physics Research A, 1075, p.170410_1 - 170410_8, 2025/06

https://doi.org/10.1016/j.nima.2025.170410

Feasibility of individual dosimetry using RT-PHITS for patients with SPECT/CT imaging after Lu-DOTATATE peptide receptor radionuclide therapy

Miwa, Kenta*; Kakino, Ryo*; Sato, Tatsuhiko; Furuta, Takuya; Miyaji, Noriaki*; Yamao, Tensho*; Yamashita, Kosuke*; Terauchi, Takashi*

Physical and Engineering Sciences in Medicine, 9 Pages, 2025/00

https://doi.org/10.1007/s13246-025-01551-z

Radiotherapy package based on Particle and Heavy Ion Transport code System (RT-PHITS) enables to calculate the 3-dimensional dose distribution inside patients using their individual SPECT/CT images coupled with the Monte Carlo radiation transport simulation. The objective of this study is to evaluate the feasibility of individual dosimetry based on RT-PHITS for patients after Lu-DOTATATE peptide receptor radionuclide therapy.

A Cause and the measures that the expansion joint of the steam plumbing for Reprocessing Plants damaged

Nishino, Shohei; Nishida, Tetsuro; Kawasaki, Ichio; Motohashi, Masahiro; Kambara, Takashi*; Suzuki, Takaichi*; Kinoshita, Masato*

Nihon Hozen Gakkai Dai-20-Kai Gakujutsu Koenkai Yoshishu, p.14 - 21, 2024/08

Steam is used to a process and air conditioning in Nuclear fuel Cycle engineering Laboratories (NCL). The steam is used mainly in Reprocessing Plant, and it is supplied by two steam plumbing. A leak occurred from the steam plumbing in November, 2022. As a result of cause investigation, I estimated that it had leaked by a water hammer caused for the trouble of the steam trap.

Spin dependence in the -wave resonance of +

Okudaira, Takuya*; Nakabe, Rintaro*; Auton, C. J.*; Endo, Shunsuke; Fujioka, Hiroyuki*; Gudkov, V.*; Ide, Ikuo*; Ino, Takashi*; Ishikado, Motoyuki*; Kambara, Wataru*; et al.

Physical Review C, 109(4), p.044606_1 - 044606_9, 2024/04

https://doi.org/10.1103/PhysRevC.109.044606

Residual stress relaxation by bending fatigue in induction-hardened gear studied by neutron Bragg edge transmission imaging and X-ray diffraction

Su, Y. H.; Oikawa, Kenichi; Shinohara, Takenao; Kai, Tetsuya; Horino, Takashi*; Idohara, Osamu*; Misaka, Yoshitaka*; Tomota, Yo*

International Journal of Fatigue, 174, p.107729_1 - 107729_12, 2023/09

https://doi.org/10.1016/j.ijfatigue.2023.107729

Sodium-cooled Fast Reactors

Ohshima, Hiroyuki; Morishita, Masaki*; Aizawa, Kosuke; Ando, Masanori; Ashida, Takashi; Chikazawa, Yoshitaka; Doda, Norihiro; Enuma, Yasuhiro; Ezure, Toshiki; Fukano, Yoshitaka; et al.

Sodium-cooled Fast Reactors; JSME Series in Thermal and Nuclear Power Generation, Vol.3, 631 Pages, 2022/07

https://shop.elsevier.com/books/sodium-cooled-fast-reactors/morishita/978-0-12-824076-2

This book is a collection of the past experience of design, construction, and operation of two reactors, the latest knowledge and technology for SFR designs, and the future prospects of SFR development in Japan. It is intended to provide the perspective and the relevant knowledge to enable readers to become more familiar with SFR technology.

Association of hydrothermal plagioclase alteration with micropores in a granite; Petrographic indicators to evaluate the extent of hydrothermal alteration

Yuguchi, Takashi*; Izumino, Yuya*; Sasao, Eiji

Journal of Mineralogical and Petrological Sciences (Internet), 117(1), p.220415_1 - 220415_12, 2022/00

https://doi.org/10.2465/jmps.220415

This study presents the use of petrographic plagioclase alteration indicators as a new method for quantitatively evaluating the extent of plagioclase alteration within granites, using the Toki granite, central Japan. Alteration indicators and areal fractions of microvoids in the plagioclases were obtained via BSE image analysis. The volume of the micropores in the altered plagioclase was characterized by the areal fraction of microvoids in the grains. The plagioclase alteration indicators were obtained as the ratio between the alteration product area and the original plagioclase area. In our previous study, we focused on biotite chloritization indicators. We found positive correlations between the plagioclase alteration and biotite chloritization indicators in the same sample, indicating that each alteration indicator can be used independently as a representative value for the sample. In the Toki granite, the plagioclase alteration was related to the biotite chloritization.

Genesis and development processes of fractures in granite; Petrographic indicators of hydrothermal alteration

Yuguchi, Takashi*; Izumino, Yuya*; Sasao, Eiji

PLOS ONE (Internet), 16(5), p.e0251198_1 - e0251198_17, 2021/05

https://doi.org/10.1371/journal.pone.0251198

This study analyzes the relationships among alteration indicators, areal microvoid fractions in chloritized biotite, and macroscopic fracture frequencies in the Toki granite, central Japan, to establish the genesis and development processes of fractures in granite. Petrographic alteration indicators using biotite chloritization as innovative methods are proposed to evaluate the extent of hydrothermal alteration and fracture frequency within granites. Samples with high macroscopic fracture frequencies correspond to a high number of areal microvoid fractions and large alteration indicators. The alteration indicators contribute to the characterization of present and future distributions of macroscopic fracture frequencies.

Study of neutron-nuclear spin correlation term with a polarized Xe target

Sakai, Kenji; Oku, Takayuki; Okudaira, Takuya; Kai, Tetsuya; Harada, Masahide; Hiroi, Kosuke; Hayashida, Hirotoshi*; Kakurai, Kazuhisa*; Shimizu, Hirohiko*; Hirota, Katsuya*; et al.

JPS Conference Proceedings (Internet), 33, p.011116_1 - 011116_6, 2021/03

https://doi.org/10.7566/JPSCP.33.011116

In neutron fundamental physics, study of correlation term of a neutron spin and a target nuclear spin is important because term interferes to parity non-conserving (PNC) and time reversal non-conserving terms. For this study, a xenon (Xe) is an interesting nucleus because it has been observed an enhancement of PNC effect around neutron resonance peaks, and polarizes up to by using a spin exchange optical pumping (SEOP) method. We would plan to develop a polarized Xe gas target with a compact in-situ SEOP system, and to study term by utilizing epithermal neutron beams supplied from a high intense pulsed spallation neutron source. As the first step, we attempted to measure neutron polarizing ability caused by term at a 9.6 eV s-wave resonance peak of Xe at BL10 in MLF, by detecting change of ratio between neutron transmissions with the polarized and unpolarized Xe target. After demonstrating that our apparatus could detect small change () of neutron transmissions caused by Doppler broadening effect, a signified value of has been obtained as preliminary results. For analyzing the obtained in detail, we are improving our nuclear magnetic resonance and electron paramagnetic resonance systems for evaluating Xe polarization independently of neutron beams.