A Fluorometric skin-interfaced microfluidic device and smartphone imaging module for quantitative analysis of sweat chemistry

Sekine, Yurina; Kim, S. B.*; Zhang, Y.*; Bandodkar, A. J.*; Xu, S.*; Choi, J.*; Irie, Masahiro*; Ray, T. R.*; Kohli, P.*; Kozai, Naofumi; et al.

Lab on a Chip, 18(15), p.2178 - 2186, 2018/08

http://doi.org/10.1039/c8lc00530c

The rich composition of solutes and metabolites in sweat and its relative ease of collection upon excretion from skin pores make this class of biofluid an attractive candidate for point of care analysis. Here, we present a complementary approach that exploits fluorometric sensing modalities integrated into a soft, skin-interfaced microfluidic system which, when paired with a simple smartphone-based imaging module, allows for in-situ measurement of important biomarkers in sweat. A network array of microchannels and a collection of microreservoirs pre-filled with fluorescent probes that selectively react with target analytes in sweat (e.g. probes), enable quantitative, rapid analysis. Field studies on human subjects demonstrate the ability to measure the concentrations of chloride, sodium and zinc in sweat, with accuracy that matches that of conventional laboratory techniques.

Development of ceramic liner for FBR building

Himeno, Yoshiaki; Morikawa, Satoshi; Kawada, Koji; Yorita, E.*; Fujiwara, T.*; Kaneshige, T.*; Irie, S.*

PNC TN9410 91-092, 11 Pages, 1991/01

PNC-TN9410-91-092.pdf:1.53MB

To develop a ceramic liner, a selection test of materials, an improvement test of selected material, and a feasibility test of the liner have been conducted.in the selection test, fifty commercially available high temperature cement and ceramics were subjected to thermal shock test (tst), sodium exposure test(set), and sodium flame exposure test (sfet). From test results, alumina/silicon-carbide (AlO-sic)mixture base castable refractory was selected in consideration of material cost, and material availability for a simpler liner construction in the buildings. The selected material was subjected to the improvement test. from the test, proper weight fractions of additives such as alumina cement and silica were determined. Drying conditions were also determined. Finally, a sodium burning pan made of concrete whose inner surfaces were covered with the improved AlO-sic base castable refractory was fabricated and was used for a sodium burning test.