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Sakai, Toshihiro; Nohara, Tsuyoshi; Ishibashi, Masayuki
JAEA-Research 2016-009, 27 Pages, 2016/07
JAEA-Research-2016-009.pdf:4.05MB
In the Phase II, the geophysical and geological surveys, and the borehole investigation of the research galleries were carried out and the results obtained were used to validate and update the geological model. Through these surveys and analysis work, we confirmed the geological properties and the distribution of model components and evaluated the accuracy of these research methods. This report presents the geological model updated based on the information of the distributions of lithofacies and geological structures at a depth 500m research galleries, and besides, the validity of the geological model of the site scale developed in the Phase I is confirmed by comparing with the updated model.
Hama, Katsuhiro; Mikake, Shinichiro; Ishibashi, Masayuki; Sasao, Eiji; Kuwabara, Kazumichi; Ueno, Tetsuro; Onuki, Kenji*; Beppu, Shinji; Onoe, Hironori; Takeuchi, Ryuji; et al.
JAEA-Review 2015-024, 122 Pages, 2015/11
JAEA-Review-2015-024.pdf:80.64MB
Japan Atomic Energy Agency (JAEA) at Tono Geoscience Center (TGC) is pursuing a geoscientific research and development project namely the Mizunami Underground Research Laboratory (MIU) Project in crystalline rock environment in order to construct scientific and technical basis for geological disposal of High-level Radioactive Waste (HLW). The MIU Project has three overlapping phases: Surface-based Investigation phase (Phase I), Construction phase (Phase II), and Operation phase (Phase III). The MIU Project has been ongoing the Phase III, as the Phase II was concluded for a moment with the completion of the excavation of horizontal tunnels at GL-500m level in February 2014. This report presents the results of the investigations, construction and collaboration studies in fiscal year 2014.
Ishibashi, Toshihiro*; Tomota, Yo*; Sugaya, Satoshi*; Toyokawa, Hiroyuki*; Hirade, Tetsuya; Horita, Zenji*; Suzuki, Hiroshi
Materials Transactions, 54(9), p.1562 - 1569, 2013/09
Bulky averaged microstructural parameters like vacancy density, texture, intergranular stress, etc. for 99.99% Cu subjected to Equal-Channel Angular Pressing (ECAP) were investigated using Accelerator-based gamma-ray-Induced Positron Annihilation Spectroscopy (AIPAS) and neutron diffraction. The Doppler-broadening parameter (S) for positron annihilation peaks of AIPAS increased by the first ECAP cycle and then decreased slightly with further ECAP cycles. Upon annealing, the S recovered at a lower temperature for the eight-cycle ECAP processed sample than for the one-cycle processed sample. The texture and intergranular stresses generated by ECAP are determined by neutron diffraction analyses. Changes in FWHM and intensity of neutron diffractions monitored in situ during annealing indicate the early onset of recrystallization in the eight-cycle ECAP sample. These bulky averaged data show good agreements qualitatively with local SEM/EBSD observations and the results of mechanical tests.
-sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for -form prion proteinKubota, Toshiya*; Hamazoe, Yuta*; Hashiguchi, Shuhei*; Ishibashi, Daisuke*; Akasaka, Kazuyuki*; Nishida, Noriyuki*; Katamine, Shigeru*; Sakaguchi, Suehiro*; Kuroki, Ryota; Nakashima, Toshihiro*; et al.
Journal of Biological Chemistry, 287(17), p.14023 - 14039, 2012/04
Times Cited Count：5 Percentile：11.64(Biochemistry & Molecular Biology)We prepared -sheet-rich recombinant full-length prion protein (-form PrP) (Jackson, G. S., Hosszu, L. L., Power, A., Hill, A. F., Kenney, J., Saibil, H., Craven, C. J., Waltho, J. P., Clarke, A. R., and Collinge, J. (1999) Science 283, 1935-1937). Using this -form PrP and a human single chain Fv-displaying phage library, we have established a human IgG1 antibody specific to -form but not 
-form PrP, PRB7 IgG. When prion-infected ScN2a cells were cultured with PRB7 IgG, they generated and accumulated PRB7-binding granules in the cytoplasm with time, consequently becoming apoptotic cells bearing very large PRB7-bound aggregates. The SAF32 antibody recognizing the N-terminal octarepeat region of full-length PrP stained distinct granules in these cells as determined by confocal laser microscopy observation. When the accumulation of proteinase K-resistant PrP was examined in prion-infected ScN2a cells cultured in the presence of PRB7 IgG or SAF32, it was strongly inhibited by SAF32 but not at all by PRB7 IgG. Thus, we demonstrated direct evidence of the generation and accumulation of -sheet-rich PrP in ScN2a cells de novo. These results suggest first that PRB7-bound PrP is not responsible for the accumulation of -form PrP aggregates, which are rather an end product resulting in the triggering of apoptotic cell death, and second that SAF32-bound PrP lacking the PRB7-recognizing -form may represent so-called PrPSc with prion propagation activity. PRB7 is the first human antibody specific to -form PrP and has become a powerful tool for the characterization of the biochemical nature of prion and its pathology.
Saito, Toru*; Suzuki, Hiroshi; Ishibashi, Toshihiro*; Tomota, Yo*
Nihon Kikai Gakkai Rombunshu, A, 74(744), p.1118 - 1125, 2008/08
The residual stresses in a forged part made of an aluminum alloy with grain size of approximately 1.0 mm were determined by neutron diffraction where the oscillation method was employed. An optimal range of the oscillation is discussed from the relations between the gauge volume and the number of crystal grain. It is found that the stress measurement could be performed with the oscillation range of 
3 degrees if 1000 grains exist in a gauge volume. The influence of diffraction plane reveals that adoption of (311) requires smaller oscillation angle than (111), (220) or (200). The hydrostatic tensile stress of about 100 MPa was observed inside the part, which was caused by thermal misfit strains caused during cooling after the heat treatment.
Kato, Toshihiro*; ; ; ; Ishibashi, Yuzo; Takeda, Seiichiro
PNC TN8410 98-070, 31 Pages, 1998/02
None
Saito, Toru; Terakado, Katsuyoshi*; Ishibashi, Toshihiro*; Katayanagi, Kazue*; Machiya, Shutaro; Tomota, Yo*
no journal, ,
no abstracts in English
-rays and application to material studyToyokawa, Hiroyuki*; Hirade, Tetsuya; Tomota, Yo*; Ishibashi, Toshihiro*; Sugaya, Satoshi*; Suzuki, Ryoichi*
no journal, ,
The brittleness of materials might be affected by defects, dislocations and impurities. However it is not well understood. Clarifying these problems is very important to make reliable models for estimating the degradation of materials for atomic energy. Injecting high energy photons with more than 1.02 MeV to materials can produce electron/positron pairs. Collimated MeV-energy--rays with several mm diameters can produce needle shaped positron distribution. By use of the produced positrons, it is possible to make 3D views of defect distribution or cross section of electro/positron pair production at deeper region of materials. This method is expected to be applied for measurements in atmosphere or high-temperature/high-pressure environments. We succeeded to obtain CT images of the transmission view and electron/positron pair production cross section of reinforcing bars in concrete by use of 5 mm diameter 9.1 MeV -rays. We also measured S-parameters for defects in metal samples.
Nohara, Tsuyoshi; Sakai, Toshihiro; Ishibashi, Masayuki; Matsumoto, Jun*
no journal, ,
Data analysis about the distribution of the high-angle fault (Main-shaft fault) and the water permeability in the granite was performed in MIU. We recognized wide range of strike of a fault and that the spray fault and the fault crowd are observed in a shallow depth in the tunnel scale. I could think fault and altered-zone distributed successively, and formed a low permeable zone.
Nohara, Tsuyoshi; Sakai, Toshihiro; Murakami, Hiroaki; Ishibashi, Masayuki
no journal, ,
Existing data was analyzed in order to understand Hydrological and Geological Characterization of deep subsurface structures in and around the Main Shaft fault at the Mizunami Underground Research Laboratory. As a result, in response to the low permeability structure of the Main Shaft Fault, fault gouges and alteration parts are found to be continuously distributed in the wall of the Main Shaft. One of the most high-permeable structure was estimated to be constituted by low-angle fractures with a sheet-like calcite. Shear of low angle fractures showed relatively low permeability. It may be possible to understand the permeability structure of these features in a drilling survey of granitic rocks.
Nohara, Tsuyoshi; Sakai, Toshihiro; Murakami, Hiroaki; Ishibashi, Masayuki
no journal, ,
It was carried out research on influences of the faults and fractures distribution and geological environment in granitic rocks, in the Mizunami Underground Research Laboratory (MIU) Project. The geological model was updated based on the information of the distributions of lithofacies and geological structures at a depth 500m research galleries, and besides, the validity of the geological model of the site scale developed in the Phase I is confirmed by comparing with the updated model. The relationship between the permeability and fracture filling materials in granitic rocks was examined. As a result, it is confirmed that the water permeability is different by the kind of filling mineral dominant.
