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Journal Articles

The Analysis of boron micro-distribution in 9L gliosarmoma cells and HUVEC cells using PIXE and PIGE

Endo, Kiyoshi*; Shibata, Yasushi*; Yamamoto, Tetsuya*; Nakai, Kei*; Matsumura, Akira*; Sato, Takahiro; Yokoyama, Akihito; Koka, Masashi; Okubo, Takeru; Yamazaki, Akiyoshi; et al.

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 86, 2012/01

Journal Articles

Elemental mapping and estimation of elemental abundances of lichen by TIARA micro beam PIXE

Iwata, Yoshihiro*; Ishii, Keizo*; Kamiya, Tomihiro; Sato, Takahiro

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 90, 2012/01

Journal Articles

The Effects of essence of chicken on the trace metal distribution in stressful mice brain slices by in-air micro-PIXE

Sakurai, Eiko*; Yanai, Kazuhiko*; Ishii, Keizo*; Fujiki, Kota*; Hiraishi, Shingo*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Okamura, Nobuyuki*; Yokoyama, Akihito; Kada, Wataru; et al.

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 84, 2012/01

Journal Articles

Increased antitumor effect of chemotherapy, using radiosensitive microcapsules containing anti-RLIP076

Harada, Satoshi*; Ehara, Shigeru*; Ishii, Keizo*; Sato, Takahiro; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 89, 2012/01

JAEA Reports

Application of micro-PIXE and imaging technology to life science (Joint research)

Sato, Takahiro; Ishii, Keizo*

JAEA-Review 2010-078, 45 Pages, 2011/03

JAEA-Review-2010-078.pdf:3.92MB

The joint research on "Application of micro-PIXE and imaging technology to life science" supported by the Inter-organizational Atomic Energy Research Program, had been performed for three years, from 2006FY to 2009FY. Aiming to apply in-air micro-PIXE analytical system to life science, the research was consisting of 7 collaborative themes related to beam engineering for micro-PIXE and applied technology of element mapping in biological/medical fields. The system, so-called micro-PIXE camera, to acquire spatial element mapping in living cells was originally developed by collaborative research between the JAEA and the department of engineering of Tohoku University. This review covers these research results.

Journal Articles

Analysis of intracellular distribution of boron and gadolinium in 9L sarcoma cells using a single-ended accelerator (Micro PIXE)

Endo, Kiyoshi*; Shibata, Yasushi*; Yoshida, Fumiyo*; Nakai, Kei*; Yamamoto, Tetsuya*; Matsumura, Akira*; Ishii, Keizo*; Sakai, Takuro; Sato, Takahiro; Oikawa, Masakazu*; et al.

Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 2 Pages, 2004/10

Micro PIXE, which is installed in a single end accelerator in JAERI, was used for quantitative analysis of boron and gadolinium distribution in a cell level. The micro beam of 1 $$mu$$m diameter is possible to observe the distribution. In the adjustment procedure of the sample, first is a fix of mylar film by using a glass ring and a bite ring of 2cm diameter. Next the 9L cells were scattered on the washed film, and is cultivated on 37$$^{circ}$$C in medium until they form the mono-layer. After the Gd-BOPTA was added, it incubates for the 24-72 hour on 37$$^{circ}$$C. The film is washed in the THAM liquid, and is directly put on liquid nitrogen. A vacuum drying for 24 hours is conducted in order to fix a film on holder. It is important to uniformly fix the cell in distribution analysis in the cell using Micro PIXE. In recent result, it became possible that the distribution of P, S, Gd, etc. was analyzed. But we could not distinguish whether K and Gd exist in the cell or whether it exists around the cell. It was indicated that these elements was leaked by the reason of cell breaking or other on the cytoplasm.

Journal Articles

Development of a large-solid-angle and multi-device detection system for elemental analysis

Sato, Takahiro; Ishii, Keizo*; Kamiya, Tomihiro; Sakai, Takuro; Oikawa, Masakazu*; Arakawa, Kazuo; Matsuyama, Shigeo*; Yamazaki, Hiromichi*

Nuclear Instruments and Methods in Physics Research B, 210, p.113 - 116, 2003/09

 Times Cited Count:1 Percentile:12.53(Instruments & Instrumentation)

A new detection apparatus for both low energy X-rays and back-scattered protons of MeV energy and its measurement system were developed. The detection apparatus consists of a multi-element detector, pre-amplifiers with active reset system and so on. The detector elements are arranged in the shape of a pentagonal pyramid and fully cover the sample. On each one detection side, 9 detector elements are arranged. The entire detection system consists thus of 45 detector elements. The micro-beam irradiates the sample through the center of the pentagonal pyramid and X-rays emitted from the sample are detected in close to $$pi$$ geometry. This novel detection setup has about 10 times the sensitivity of a conventional Micro-PIXE camera. The counting rate of back-scattered protons per detection element is small despite lack of a passive absorber. It appears possible that X-rays from the very small quantity of elements could also be detected. The advantage over a conventional Micro-PIXE camera includes simultaneous detection of back-scattered protons from N, C and O.

Journal Articles

The Kinetics of Fe and Ca for the development of radiation-induced apoptosis by micro-PIXE imaging

Harada, Satoshi*; Tamakawa, Yoshiharu*; Ishii, Keizo*; Tanaka, Akira*; Sato, Takahiro; Matsuyama, Shigeo*; Yamazaki, Hiromichi*; Kamiya, Tomihiro; Sakai, Takuro; Arakawa, Kazuo; et al.

Nuclear Instruments and Methods in Physics Research B, 189(1-4), p.437 - 442, 2002/04

 Times Cited Count:1 Percentile:12.51(Instruments & Instrumentation)

To study the interactions between the induction of radiation-induced apoptosis and trace elements kinetics, human leukemia cells were irradiated in vitro by $$^{60}$$Co $$gamma$$ rays, after which the cells were evaluated for the detection of apoptosis and trace element imaging was carried out. The frequency of apoptosis was obtained by microscopic assay using TUNEL staining. The trace element distribution in the cell was determined by micro-PIXE. In the early phase of apoptosis, the maximum level of Fe accumulation was observed in the cell stroma. In the mid to end phase, Fe accumulation was diminished, and instead, Ca accumulation increased and Zn decreased in the nucleus. There appear to be two steps for the development of apoptosis: (1) the signaling from cell stroma to nucleus by Fe or an Fe-containing enzyme; and (2) the degeneration of the nucleus by Ca-dependent enzyme, and release of Zn from digested nucleus. Those strong accumulations may be new markers for apoptosis.

Journal Articles

JAERI Takasaki in-air micro-PIXE system for various applications

Sakai, Takuro; Kamiya, Tomihiro; Oikawa, Masakazu*; Sato, Takahiro; Tanaka, Akira*; Ishii, Keizo*

Nuclear Instruments and Methods in Physics Research B, 190(1-4), p.271 - 275, 2001/09

 Times Cited Count:64 Percentile:95.99(Instruments & Instrumentation)

no abstracts in English

Journal Articles

STIM imaging for mammalian cell samples before micro-PIXE analyses in air environment at JAERI Takasaki light ion microbeam system

Kamiya, Tomihiro; Sakai, Takuro; Oikawa, Masakazu*; Sato, Takahiro*; Ishii, Keizo*; Sugimoto, Asuka*; Matsuyama, Shigeo*

International Journal of PIXE, 9(3&4), p.217 - 225, 1999/11

no abstracts in English

Journal Articles

Development of a fast multi-parameter data acquisition system for microbeam analyses

Sakai, Takuro; *; Hirao, Toshio; Kamiya, Tomihiro; *; *; Matsuyama, Shigeo*; *; Ishii, Keizo*

Nuclear Instruments and Methods in Physics Research B, 136-138, p.390 - 394, 1998/00

 Times Cited Count:18 Percentile:79.19(Instruments & Instrumentation)

no abstracts in English

Journal Articles

Diagnosis of the profile of the heavy-ion microbeam and estimation of the aiming accuracy of the single-ion-hit with using CR-39

*; Hirao, Toshio; Nashiyama, Isamu; Sakai, Takuro; Kamiya, Tomihiro; *; Ishii, Keizo*

Radiation Physics and Chemistry, 53(5), p.461 - 467, 1998/00

 Times Cited Count:1 Percentile:15.05(Chemistry, Physical)

no abstracts in English

Oral presentation

Application of in-air micro-PIXE to biological sample

Sakurai, Eiko*; Yanai, Kazuhiko*; Ishii, Keizo*; Oyama, Ryohei*; Sakamaki, Manabu*; Yamanaka, Kentaro*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro; Sato, Takahiro; et al.

no journal, , 

no abstracts in English

Oral presentation

Measurement of sensitivity of microbeam system to zinc and platinum using standard sample made of ion exchange resin

Iwata, Yoshihiro*; Ishii, Keizo*; Yokota, Wataru; Kamiya, Tomihiro; Sato, Takahiro; Oikawa, Masakazu*

no journal, , 

no abstracts in English

Oral presentation

Elemental analysis of an ionic distribution in rat basophilic leukemia cells (RBL-2H3) by in-air micro-PIXE

Sakurai, Eiko*; Ishii, Keizo*; Sato, Takahiro; Kamiya, Tomihiro; Yanai, Kazuhiko*

no journal, , 

Oral presentation

Change of elemental distribution in sections of brain found by in-air micro-PIXE

Sakurai, Eiko*; Ishii, Keizo*; Yamanaka, Kentaro*; Okura, Satoru*; Fujiki, Kota*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro; Sato, Takahiro; Arakawa, Kazuo*; et al.

no journal, , 

Cognitive degradation and behavior disorder occur under the mental disease caused by stimulant drugs. In this study, it was continuously administered to mice. After that, neuropoiesis of dentate gyrus and trace elements in its brain were analyzed by in-air micro-PIXE. As a result, the distribution of trace elements was different from that of normal mice.

Oral presentation

Protraction of drug effectiveness using radiosensitive microcapsules in targeted therapy

Harada, Satoshi*; Ehara, Shigeru*; Ishii, Keizo*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Sato, Takahiro; Kamiya, Tomihiro; Sera, Koichiro*; Saito, Yoshihiro*

no journal, , 

no abstracts in English

Oral presentation

Influence of methamphetamine on the trace element distribution within a brain

Sakurai, Eiko*; Ishii, Keizo*; Okamura, Nobuyuki*; Sato, Takahiro; Kamiya, Tomihiro; Yanai, Kazuhiko*

no journal, , 

The brain section of the mouse which prescribed methamphetamine was analyzed using micro-PIXE. When bromine in the hippocampal dentate gyrus of a mouse which caused the behavioral change, and other amounts of elements were measured, the amount of bromine accumulation was on the decrease, but the accumulation of zinc, iron, and calcium were on the increase. It was suggested that the medicine which gives change to the amount of actions has also affected distribution of the trace element within a brain.

Oral presentation

Transition of the trace element within a brain by delivery of a controlled substance

Sakurai, Eiko*; Yanai, Kazuhiko*; Ishii, Keizo*; Sato, Takahiro; Kamiya, Tomihiro

no journal, , 

Methamphetamine was repeatedly administered to mice 1 mg/kg per day for seven days. After that, the brain sections containing a sea horse were analyzed by submilli-PIXE. As a result, iron accumulation was seen at a methamphetamine administration group.

Oral presentation

Role of histamine receptor in brain monoamine isolation

Sakurai, Eiko*; Kuramasu, Atsuro*; Sato, Takahiro; Kamiya, Tomihiro; Ishii, Keizo*; Yanai, Kazuhiko*

no journal, , 

The elemental distribution in a brain section of a histamine-receptor-deficit mouse was measured by in-air micro-PIXE. The relation of monoamine in a brain and activity of the mouse suggested that the histamine receptor is a important part in a nervous system of monoamine.

45 (Records 1-20 displayed on this page)