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Takai, Toshihide; Furukawa, Tomohiro; Watanabe, Shigeki*; Ishioka, Noriko*
Mechanical Engineering Journal (Internet), 9(4), p.21-00397_1 - 21-00397_11, 2022/08
For the mass production of astatine-211, a promising radiopharmaceutical for cancer treatment, the National Institute for Quantum and Radiological Science and Technology has proposed the innovative "Liquid Bismuth Target System." The target window in this system must be made from a material that resists the highly corrosive liquid bismuth environment. To meet this requirement, a promising target window material was selected in corrosion experiments performed in stagnant liquid bismuth. Based on knowledge of corrosion in liquid lead-bismuth eutectic gained during the development of fast reactors and accelerator-driven subcritical systems, experiments were carried out under saturated dissolved oxygen and low oxygen conditions, and the corrosion behaviors of the specimens were evaluated. The FeCrAl-alloy exhibited the most excellent corrosion resistance, followed by FeCrMo-alloy. Both materials are suitable candidates for the target window.
Shinohara, Ayaka*; Hanaoka, Hirofumi*; Sakashita, Tetsuya*; Sato, Tatsuhiko; Yamaguchi, Aiko*; Ishioka, Noriko*; Tsushima, Yoshito*
Annals of Nuclear Medicine, 32(2), p.114 - 122, 2018/02
Times Cited Count:6 Percentile:40.36(Radiology, Nuclear Medicine & Medical Imaging)Radionuclide therapy with low-energy auger electron emitters could potentially provide high anti-tumor efficacy while keeping normal organs toxicity low. In this study, we evaluated the usefulness of auger electron emitter I and compared it with beta-emitter
I for tumor treatment in 2D and 3D cell culture models. The computer simulation model for 2D and 3D cell culture were constructed, and the absorbed radiation dose of
I or
I in each model were calculated by using a Monte Carlo simulation code (PHITS). The therapeutic effect of
I was comparable to that of
I in 2D model, but the efficacy was inferior to that of
I-MIBG in 3D model, since crossfire effect is negligible and the homogeneous distribution of radionuclide was insufficient.
Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Sugo, Yumi; Yamada, Keiichi*; Hanaoka, Hirofumi*; Ishioka, Noriko
Peptide Science 2015, p.243 - 246, 2016/03
Mori, Masanobu*; Sagara, Katsuya*; Arai, Kaori*; Nakatani, Nobutake*; Ohira, Shinichi*; Toda, Kei*; Itabashi, Hideyuki*; Kozaki, Daisuke*; Sugo, Yumi; Watanabe, Shigeki; et al.
Journal of Chromatography A, 1431, p.131 - 137, 2016/01
Times Cited Count:10 Percentile:45.46(Biochemical Research Methods)Nishinaka, Ichiro; Yokoyama, Akihiko*; Washiyama, Koshin*; Maeda, Eita*; Watanabe, Shigeki; Hashimoto, Kazuyuki; Ishioka, Noriko; Makii, Hiroyuki; Toyoshima, Atsushi; Yamada, Norihiro*; et al.
Journal of Radioanalytical and Nuclear Chemistry, 304(3), p.1077 - 1083, 2015/06
Times Cited Count:9 Percentile:64.1(Chemistry, Analytical)Production cross sections of astatine isotopes At in the 29-57 MeV
Li induced reaction with
Pb target have been measured by
- and
-ray spectrometry. Excitation functions of production cross sections have been compared with a statistical model calculation to study the reaction mechanism of
Li +
Pb. Considerably small experimental cross sections of
At and
At compared with the calculation were clearly observed at incident energies higher than 44 MeV, indicating that the effects of breakup reaction play a role. A chemical separation of astatine from an irradiated lead target has been studied with a dry-distillation method. A complementary way to produce astatine isotopes has been developed.
Hanaoka, Hirofumi*; Ohshima, Yasuhiro; Suzuki, Yurika*; Yamaguchi, Aiko*; Watanabe, Shigeki; Uehara, Tomoya*; Nagamori, Shushi*; Kanai, Yoshikatsu*; Ishioka, Noriko; Tsushima, Yoshito*; et al.
Journal of Nuclear Medicine, 56(5), p.791 - 797, 2015/05
Times Cited Count:16 Percentile:61.96(Radiology, Nuclear Medicine & Medical Imaging)Sugo, Yumi; Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Ishioka, Noriko
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 100, 2015/03
Watanabe, Satoshi; Hashimoto, Kazuyuki; Ishioka, Noriko
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 102, 2015/03
Sugo, Yumi; Ohshima, Yasuhiro; Sasaki, Ichiro; Ishioka, Noriko
Peptide Science 2014, p.303 - 306, 2015/03
Sasaki, Ichiro; Hanaoka, Hirofumi*; Yamada, Keiichi*; Watanabe, Shigeki; Sugo, Yumi; Ohshima, Yasuhiro; Suzuki, Hiroyuki; Ishioka, Noriko
Peptide Science 2014, p.257 - 260, 2015/03
Watanabe, Satoshi; Hashimoto, Kazuyuki; Ishioka, Noriko
Journal of Radioanalytical and Nuclear Chemistry, 303(2), p.1519 - 1521, 2015/02
Times Cited Count:8 Percentile:59.65(Chemistry, Analytical)As basic studies of bifunctional chelating agent for Lu-labeled antibodies,
Lu complexation of DOTA and DTPA was investigated by the addition of competing metals, Ca(II), Fe(II) and Zn(II). From comparison of competing metals, the inhibition by competing metals on the
Lu complexation was in the order of Ca(II)
Fe(II)
Zn(II) and Ca(II)
Zn(II)
Fe(II) as DOTA and DTPA, respectively. For comparison between DOTA and DTPA, the susceptibility to the inhibition on
Lu complexation by all the three competing metals was DTPA
DOTA. Therefore, it was found that DTPA is advantageous for
Lu complexation compared with DOTA in the presence of Ca(II), Fe(II) and Zn(II), and that the elimination of Fe from
Lu solution is especially effective because the
Lu complexation of DTPA is highly inhibited by Fe(II).
Sugo, Yumi; Sasaki, Yuji; Taguchi, Mitsumasa; Ishioka, Noriko
Journal of Radioanalytical and Nuclear Chemistry, 303(2), p.1381 - 1384, 2015/02
Times Cited Count:2 Percentile:19.22(Chemistry, Analytical)Watanabe, Satoshi; Hashimoto, Kazuyuki; Watanabe, Shigeki; Iida, Yasuhiko*; Hanaoka, Hirofumi*; Endo, Keigo*; Ishioka, Noriko
Journal of Radioanalytical and Nuclear Chemistry, 303(1), p.935 - 940, 2015/01
Times Cited Count:10 Percentile:67.69(Chemistry, Analytical)Sato, Nozomi; Tsukada, Kazuaki; Watanabe, Satoshi; Ishioka, Noriko; Kawabata, Masako; Saeki, Hideya; Nagai, Yasuki; Kin, Tadahiro*; Minato, Futoshi; Iwamoto, Nobuyuki; et al.
Journal of the Physical Society of Japan, 83(7), p.073201_1 - 073201_4, 2014/07
Times Cited Count:12 Percentile:63.85(Physics, Multidisciplinary)We have for the first time demonstrated that the therapeutic nuclide of Cu produced by
Zn(
,
)
Cu has highest radionuclide purity compared to previous ones. We measured a
-ray spectrum of the reaction product produced by bombarding an enriched
Zn sample with neutrons with a HPGe detector. The neutrons were obtained by
C(
,
) using 41 MeV deuterons provided from Takasaki Ion Accelerators for Advanced Radiation Application of Japan Atomic Energy Agency. Relative production yields of impurity radionuclides such as
Zn to
Cu are extremely low, which allow us to chemically separate
Cu from an irradiated
Zn sample with a few steps and to reuse high cost an enriched
Zn sample. The present result strongly suggest that the
Zn(
,
)
Cu reaction is the most promising route to produce high quality
Cu and could solve a longstanding problem of establishing an appropriate production method of
Cu.
Ishioka, Noriko
Hoshasen To Sangyo, (136), p.4 - 8, 2014/06
no abstracts in English
Toyoda, Minoru*; Kaira, Kyoichi*; Ohshima, Yasuhiro; Ishioka, Noriko; Shino, Masato*; Sakakura, Koichi*; Takayasu, Yukihiro*; Takahashi, Katsumasa*; Tominaga, Hideyuki*; Oriuchi, Noboru*; et al.
British Journal of Cancer, 110(10), p.2506 - 2513, 2014/05
Times Cited Count:96 Percentile:94.96(Oncology)Suzuki, Shigemasa*; Kaira, Kyoichi*; Ohshima, Yasuhiro; Ishioka, Noriko; Soda, Makoto*; Yokobori, Takehiko*; Miyazaki, Tatsuya*; Oriuchi, Noboru*; Tominaga, Hideyuki*; Kanai, Yoshikatsu*; et al.
British Journal of Cancer, 110(8), p.1985 - 1991, 2014/04
Times Cited Count:22 Percentile:60.13(Oncology)Sugo, Yumi; Sasaki, Yuji; Ishioka, Noriko
JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012, P. 17, 2014/03
Sasaki, Ichiro; Yamada, Keiichi*; Watanabe, Shigeki; Hanaoka, Hirofumi*; Sugo, Yumi; Oku, Hiroyuki*; Ishioka, Noriko
JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012, P. 96, 2014/03
Watanabe, Satoshi; Hashimoto, Kazuyuki; Ishioka, Noriko
JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012, P. 97, 2014/03