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Sasaki, Michiya*; Furukawa, Kyoji*; Satoh, Daiki; Shimada, Kazumasa; Kudo, Shinichi*; Takagi, Shunji*; Takahara, Shogo; Kai, Michiaki*
Journal of Radiation Protection and Research, 48(2), p.90 - 99, 2023/06
This paper reports on the calculation code that is the result of the activities of the "Task Group for Development of Cancer Risk Estimation Codes Associated with Radiation Exposure (FY2020-2021)" established by the Japan Health Physics Society. In order to promote research on the estimation of cancer risk associated with radiation exposure, the Task Group decided to disclose the source code, including the algorithm and parameters used in the calculations, and to release the code under a license that permits modification and redistribution of the code. The computational code was named SUMRAY and coded in two computer languages, that is R and Python. The code is capable of calculating the accumulated excess risk using Monte Carlo methods with a 95% confidence interval. The results of SUMRAY were compared with the results of the existing codes whose source code is not publicly available, under the same calculation conditions. From the results, it was found that they were in reasonable agreement within the confidence interval. It is expected that SUMRAY, an open-source software, will be used as a common basis for cancer risk estimation studies associated with radiation exposure.
Shimada, Kazumasa; Kai, Michiaki*
Journal of Radiation Protection and Research, 46(3), p.83 - 97, 2021/09
[Background] The lifetime risk of lung cancer incidence owing to radiation for non-smokers is overestimated because the average cancer baseline among a population including smokers is used. In recent years, the generalized multiplicative (GM) excess relative risk (ERR) model has been developed in the life span study of atomic bomb survivors to consider the joint effect of radiation and smoking. Based on this background, the issues of radiation risk assessment considering smoking will be discussed in this paper in 2 parts. [Materials and Methods] Part 1: We proposed a simple method of estimating the baseline risk for non-smokers using current smoking data. We performed sensitivity analysis on baseline risk estimation to discuss the birth cohort effects of birth year effect and smoking history. Part 2: We applied the GM ERR model for Japanese smokers to calculate lifetime attributable risk (LAR). We also performed a sensitivity analysis with other ERR models (e.g., simple additive (SA) ERR model). [Results] Part 1: The lifetime baseline risk (LBR) for non-smokers were 54% (44% - 60%) or males and 24% (18% - 29%) for females, which were lower than the LBRs for all adults including smokers. Part 2: When comparing the LAR between the SA ERR model and the GM ERR model, if the radiation dose was 
200 mGy or less, the difference between these ERR models was within the standard deviation of the LAR owing to the uncertainty of the smoking information.
Ishikawa, Tetsuo*; Matsumoto, Masaki*; Sato, Tatsuhiko; Yamaguchi, Ichiro*; Kai, Michiaki*
Journal of Radiological Protection, 38(4), p.1253 - 1268, 2018/12
Times Cited Count：7 Percentile：58.07(Environmental Sciences)The current knowledge on internal dose estimation and its health effect were reviewed in this paper. The goals were to discuss the uncertainty of current dose coefficients, to compare the effects of external and internal exposures, and to review recent epidemiological studies. Radionuclides focused on in this study were caesium-137 (
Cs), caesium-134 (
Cs), and iodine-131 (
I), which primarily contributed to internal effective thyroid doses after the Fukushima Dai-ichi Nuclear Power Station accident. Current knowledge suggests that the risk of internal exposure could be generally the same as or less than that of external exposure, when they are compared at the same effective dose.
Shimada, Kazumasa; Kai, Michiaki*
Journal of Radiological Protection, 35(4), p.763 - 775, 2015/12
Times Cited Count：16 Percentile：79.46(Environmental Sciences)This paper has proposed that disability-adjusted life year (DALY) can be used as a measure of radiation health risk. DALY is calculated as the sum of years of life lost (YLL) and years lived with disability (YLD). This multidimensional concept can be expressed as a risk index without a probability measure to avoid the misuse of the current radiation detriment at low doses. In this study, we calculated YLL and YLD using Japanese population data by gender. DALY for all cancers in Japan per 1 Gy per person was 0.84 year in men and 1.34 year in women. When we calculated the ICRP detriment from the same data, DALYs for the cancer sites were similar to the radiation detriment in the cancer sites, excluding leukemia, breast and thyroid cancer. A big advantage over the ICRP detriment is that DALY can calculate the risk components for non-fatal diseases without the data of lethality. This study showed that DALY is a practical tool that can compare many types of diseases encountered in public health.
Takahashi, Fumiaki; Sato, Kaoru; Endo, Akira; Ono, Koji*; Ban, Nobuhiko*; Hasegawa, Takayuki*; Katsunuma, Yasushi*; Yoshitake, Takayasu*; Kai, Michiaki*
Health Physics, 109(2), p.104 - 112, 2015/08
Times Cited Count：8 Percentile：56.13(Environmental Sciences)A dosimetry system, named WAZA-ARI, is developed to assess accurately radiation doses to persons from Computed Tomography (CT) examination patients in Japan. Organ doses were prepared to application to dose calculations in WAZA-ARI by numerical analyses using average adult Japanese human models with the Particle and Heavy Ion Transport code System (PHITS). Experimental studies clarified the radiation configuration on the table for some multi-detector row CT (MDCT) devices. Then, a source model in PHITS could specifically take into account for emissions of X-ray in each MDCT device based on the experiment results. Numerical analyses with PHITS revealed a concordance of organ doses with human body size. The organ doses by the JM phantoms were compared with data obtained using previously developed systems. In addition, the dose calculation in WAZA-ARI were verified with previously reported results by realistic NUBAS phantoms and radiation dose measurement using a physical Japanese model. The results implied that analyses using the Japanese phantoms and PHITS including source models can appropriately give organ dose data with consideration of the MDCT device and physiques of typical Japanese adults.
Sato, Kaoru; Takahashi, Fumiaki; Endo, Akira; Ono, Koji*; Hasegawa, Takayuki*; Katsunuma, Yasushi*; Yoshitake, Takayasu*; Ban, Nobuhiko*; Kai, Michiaki*
RIST News, (58), p.25 - 32, 2015/01
The Japan Atomic Energy Agency (JAEA) are now developing WAZA-ARI for improvement of management of exposure doses due to CT examination under the joint research with the Oita University of Nursing and Health Sciences. The trial version of WAZA-ARI has been released on 21 December 2012. In trial version, users can perform dose assessment by using organ dose database based on the average adult Japanese male (JM-103) and female (JF-103) voxel phantoms and a 4 years old female voxel phantom (UFF4). The homepage of WAZA-ARI has been accessed over 1000 times per month and 28421 times by the end of September 2014. We are developing WAZA-ARI version 2 as the extension version of dose calculation functions of WAZA-ARI. WAZA-ARI version 2 will be released by the end of March 2015. In WAZA-ARI version 2. Users can upload dose calculation results to WAZA-ARI version 2 server, and utilize improvement of the dose management of patients and the optimization of CT scan conditions.
Kiriyama, Hiromitsu; Mori, Michiaki; Okada, Hajime; Shimomura, Takuya; Nakai, Yoshiki*; Tanoue, Manabu; Kondo, Shuji; Kanazawa, Shuhei; Yogo, Akifumi; Sagisaka, Akito; et al.
JPS Conference Proceedings (Internet), 1, p.015095_1 - 015095_5, 2014/03
We present the design and characterization of a high-contrast, petawatt-class Ti:sapphire chirped-pulse amplification (CPA) laser system. Two saturable absorbers and low-gain optical parametric chirped-pulse amplification (OPCPA) preamplifier in the double CPA laser chain have improved the temporal contrast to 1.4
10
on the subnanosecond time scale at 70 terawatt level. Final uncompressed broadband pulse energy is 28 J, indicating the potential for reaching peak power near 600 terawatt. We also discuss our upgrade to over petawatt level at a 0.1 Hz repetition rate briefly.
Sagisaka, Akito; Pirozhkov, A. S.; Nishiuchi, Mamiko; Ogura, Koichi; Sakaki, Hironao; Yogo, Akifumi; Mori, Michiaki; Kiriyama, Hiromitsu; Okada, Hajime; Kanazawa, Shuhei; et al.
Reza Kenkyu, 42(2), p.160 - 162, 2014/02
High-intensity laser and thin-foil interactions produce high-energy particles, hard X-ray, high-order harmonics, and terahertz radiation. A proton beam driven by a high-intensity laser has received attention as a compact ion source for medical and other applications. We have measured the proton yield from thin-foil targets irradiated with a high-intensity Ti:sapphire laser (J-KAREN) at JAEA. The longitudinal extent of the preformed plasma protruding from the front surface of the target is reduced by decreasing the duration of the amplified spontaneous emission (ASE) before the main pulse. The maximum proton energy in the target normal direction increases when the size of the preformed plasma is controlled.
Kiriyama, Hiromitsu; Shimomura, Takuya; Mori, Michiaki; Nakai, Yoshiki*; Tanoue, Manabu; Kondo, Shuji; Kanazawa, Shuhei; Pirozhkov, A. S.; Esirkepov, T. Z.; Hayashi, Yukio; et al.
Applied Sciences (Internet), 3(1), p.214 - 250, 2013/03
Times Cited Count：15 Percentile：50(Chemistry, Multidisciplinary)This paper reviews techniques for improving the temporal contrast and spatial beam quality in an ultra-intense laser system that is based on chirped-pulse amplification (CPA). We describe the design, performance, and characterization of our laser system, which has the potential for achieving a peak power of 600 TW. We also describe applications of the laser system in the relativistically dominant regime of laser-matter interactions and discuss a compact, high efficiency diode-pumped laser system.
Mizuta, Yoshio*; Hosokai, Tomonao*; Masuda, Shinichi*; Zhidkov, A.*; Makito, Keigo*; Nakanii, Nobuhiko*; Kajino, Shohei*; Nishida, Akinori*; Kando, Masaki; Mori, Michiaki; et al.
Physical Review Special Topics; Accelerators and Beams, 15(12), p.121301_1 - 121301_10, 2012/12
Times Cited Count：21 Percentile：72.39(Physics, Nuclear)Kiriyama, Hiromitsu; Shimomura, Takuya; Sasao, Hajime; Nakai, Yoshiki*; Tanoue, Manabu; Kondo, Shuji; Kanazawa, Shuhei; Pirozhkov, A. S.; Mori, Michiaki; Fukuda, Yuji; et al.
Optics Letters, 37(16), p.3363 - 3365, 2012/08
Times Cited Count：39 Percentile：85.86(Optics)We demonstrate the temporal contrast enhancement in a petawatt-class Ti:sapphire chirped-pulse amplification (CPA) laser system. An extra saturable absorber, introduced downstream a low gain optical parametric chirped-pulse amplification (OPCPA) preamplifier, has improved the temporal contrast in the system to 1.410 on the sub-nanosecond time scale at 70 TW power level. We have achieved 28 J of uncompressed broadband output energy with this system, indicating the potential for reaching peak powers near 600 TW.
Ogura, Koichi; Shizuma, Toshiyuki; Hayakawa, Takehito; Yogo, Akifumi; Nishiuchi, Mamiko; Orimo, Satoshi; Sagisaka, Akito; Pirozhkov, A. S.; Mori, Michiaki; Kiriyama, Hiromitsu; et al.
Japanese Journal of Applied Physics, 51(4), p.048003_1 - 048003_2, 2012/04
Times Cited Count：2 Percentile：8.93(Physics, Applied)A proton beam driven by a repetitive high-intensity-laser is utilized to induce a 
Li(p,n)Be nuclear reaction. The total activity of Be are evaluated by two different methods. The activity obtained measuring the decay 
-rays after 1912 shots at 1 Hz is 1.7
0.2 Bq. This is in good agreement with 1.60.3 Bq evaluated from the proton energy distribution measured using a time-of-flight detector and the nuclear reaction cross-sections. We conclude that the production of activity can be monitored in real time using the time-of-flight-detector placed inside a diverging proton beam coupled with a high-speed signal processing system.
Takahashi, Fumiaki; Sato, Kaoru; Endo, Akira; Ono, Koji*; Yoshitake, Takayasu*; Hasegawa, Takayuki*; Katsunuma, Yasushi*; Ban, Nobuhiko*; Kai, Michiaki*
Progress in Nuclear Science and Technology (Internet), 2, p.153 - 159, 2011/10
Computed Tomography (CT) is one of the most useful tools for medical diagnosis, and is becoming a major source of medical exposure in developed countries. Appropriate radiation protection in CT examinations is emphasized by international organizations, such as the International Atomic Energy Agency (IAEA), because the patients receive higher radiation doses than in conventional radiography. Medical staffs can acquire dose information on the conditions of some CT examinations with available dosimetry systems, which had been already developed. These systems utilize datasets of organ and tissue doses, which were derived with Monte Carlo calculations. Methods in computational analyses, however, have been improved, since these calculations had been performed. Then, our new dosimetry system for CT examination, WAZA-ARI, is being developed to estimate radiation dose based upon the state-of-art numerical analyses. Our analysis adopts Particle and Heavy Ion Transport code System (PHITS) coupled with a voxel-type phantom, JM phantom, for the organ dose calculation. PHITS has advantageous to define the model of photon emission from X-ray tube in a CT device for radiation transport calculations. The physique and mass of organs for JM phantom are similar to those for average Japanese male adults. Since the goal of WAZA-ARI is to provide dosimetric information of arbitrary patient, it is important to evaluate uncertainty due to different configurations in human bodies between JM phantom and individual patients. For this purpose, the organ doses are calculated and compared for different human models; another Japanese male adult voxel phantom and the ICRP reference voxel phantom, which is constructed on the basis of Caucasian data.
Ban, Nobuhiko*; Takahashi, Fumiaki; Sato, Kaoru; Endo, Akira; Ono, Koji*; Hasegawa, Takayuki*; Yoshitake, Takayasu*; Katsunuma, Yasushi*; Kai, Michiaki*
Radiation Protection Dosimetry, 147(1-2), p.333 - 337, 2011/09
Times Cited Count：27 Percentile：87.94(Environmental Sciences)A web-system of WAZA-ARI is being developed to assess radiation dose to a patient in a Computed Tomography (CT) examination. The databases of organ doses for WAZA-ARI were derived by the Japanese adult Male phantom (JM phantom) combined with the Particle and Heavy Ion Transport code System, PHITS. In the Monte Carlo simulation, the phantoms were irradiated with a 5 mm-thick fan-shaped photon beam, which was moved every 5 mm along the body axis from the upper leg to the top of head. The attenuation by the beam-shaping filter (bow-tie filter) was also taken into account here. The MIRD-type phantom was also applied to the calculations. The MIRD phantom sometimes showed step changes for organ doses, while smoother curves were obtained for JM phantom. The dose data by JM phantom were incorporated into the WAZA-ARI system, which has been implemented on a Linux server. With regard to the system implementation, the system has achieved a high degree of flexibility without commercial software.
Takahashi, Fumiaki; Sato, Kaoru; Endo, Akira; Ono, Koji*; Yoshitake, Takayasu*; Hasegawa, Takayuki*; Katsunuma, Yasushi*; Ban, Nobuhiko*; Kai, Michiaki*
Radiation Protection Dosimetry, 146(1-3), p.241 - 243, 2011/07
Times Cited Count：20 Percentile：81.61(Environmental Sciences)A web-system of WAZA-ARI is being developed to assess radiation dose to a patient in a Computed Tomography (CT) examination. WAZA-ARI utilizes a set of organ and tissue doses in a database for the dose assessment, according to the given resources with a consideration of the examination condition. The organ and tissue doses in the database have been derived with the Particle and Heavy Ion Transport code System, PHITS. Modeling of the patient was a significant issue in the radiation transport calculation. JM phantom, whose height (171 cm) and weight (65 kg) are near to those averaged over Japanese male adults, was incorporated to PHITS as a human model. Since JM phantom consisted of about 1 mm
size voxel, the shapes could be realistically reproduced even for small organs such as thyroid, adrenals. Masses of most organs could be also adjusted to the averaged values of Japanese male adults. In addition, our calculations introduced a new phantom without arms based upon JM phantom, because the patient usually puts arms toward the head direction in a torso examination. Some of organ doses calculated by JM phantom were compared with results, which were derived with a MIRD-type phantom. Differences could be seen in some organ doses between the phantoms, if photon attenuations in a shaping (Bow-tie) filter were taken into account to a source model in PHITS.
Ban, Nobuhiko*; Takahashi, Fumiaki; Ono, Koji*; Hasegawa, Takayuki*; Yoshitake, Takayasu*; Katsunuma, Yasushi*; Sato, Kaoru; Endo, Akira; Kai, Michiaki*
Radiation Protection Dosimetry, 146(1-3), p.244 - 247, 2011/07
Times Cited Count：20 Percentile：81.61(Environmental Sciences)We are developing a web-based system, WAZA-ARI, for the dose calculation of patients undergoing X-ray CT examinations. Tissue doses were calculated in a Japanese adult male phantom (JM phantom) using a Monte Carlo code, PHITS, and the normalized dose coefficient data are stored as XML files. The system is implemented in Java on a Linux server running Apache Tomcat, which is accessed via a web browser over a network. Users are requested to choose scanning options and to input parameters in the data entry screen. The corresponding dose data are called upon input, and they are summed over the scan range specified by the user to estimate unit tissue doses. Tissue doses are computed based on the radiographic exposure (mAs), the beam pitch and air kerma at the beam center on the axis of rotation. Users can also use their own air kerma, CTDI vol and DLP values for the dose computation instead of the default setting. Although the dose coefficients are prepared for only limited CT scanner models currently, our system has achieved high usability and easy maintenance without commercial software. Possibility of further expansion for the practical application is also discussed.
Sagisaka, Akito; Pirozhkov, A. S.; Mori, Michiaki; Yogo, Akifumi; Ogura, Koichi; Orimo, Satoshi; Nishiuchi, Mamiko; Ma, J.*; Kiriyama, Hiromitsu; Kanazawa, Shuhei; et al.
NIFS-PROC-85, p.30 - 33, 2011/02
The experiment of proton generation is performed for developing the laser-driven ion source. We observe proton signals in the laser-plasma interaction by using a thin-foil target. To get higher energy protons the size of the preformed plasma is reduced by changing the laser contrast level. In the high-contrast laser pulse case the maximum energy of the protons generated at rear side of the target increases.
Takahashi, Fumiaki; Endo, Akira; Sato, Kaoru; Hasegawa, Takayuki*; Katsunuma, Yasushi*; Ono, Koji*; Yoshitake, Takayasu*; Ban, Nobuhiko*; Kai, Michiaki*
Progress in Nuclear Science and Technology (Internet), 1, p.517 - 520, 2011/02
Several dose assessment system were developed to avoid unnecessary exposure for a patient in a Computed Tomography (CT) examination. Most of these systems contain datasets of organ doses, which had been calculated with mathematical phantoms. The numerical analyses for radiation dosimetry and CT machines have progressed in recent years. Thus, a project is being carried out to develop a new dosimetry system, named WAZA-ARI. The basic data of organ doses are calculated with a male voxel phantom (JM phantom), which defines configurations of the human body more precisely than the mathematical model. The radiation transports in CT examination can be simulated with the Particle and Heavy Ion Transport code System, PHITS. A source model can be set up for emissions of photons from the X-ray tube with a subroutine, including the helical scanning. Thus, the WAZA-ARI system can assess radiation dose based upon the organ doses, which are calculated with the appropriate source and human models.
Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki*; Shimomura, Takuya; Sasao, Hajime*; Tanaka, Momoko; Ochi, Yoshihiro; Tanoue, Manabu*; Kondo, Shuji; Kanazawa, Shuhei; et al.
Reza Kenkyu, 38(9), p.669 - 675, 2010/09
This paper reviews the temporal contrast and spatial beam quality improvement techniques in a high intensity Ti:sapphire laser system that is based on chirped-pulse amplification (CPA). We describe a low gain optical parametric chirped-pulse amplification (OPCPA) preamplifier that uses high energy, clean pulse seeding and is shown to significantly improve the contrast to better than 10
-10
relative to the peak of the main femtosecond pulse. We also report the use of a diffractive optical element for beam homogenization of a 100 J level Nd:glass green pump laser, achieving a flat-topped spatial profile with a filling factor near 80 %.
Sagisaka, Akito; Pirozhkov, A. S.; Mori, Michiaki; Yogo, Akifumi; Ogura, Koichi; Orimo, Satoshi; Nishiuchi, Mamiko; Ma, J.*; Kiriyama, Hiromitsu; Kanazawa, Shuhei; et al.
Reza Kenkyu, 38(9), p.702 - 705, 2010/09
High-intensity laser and thin-foil interactions produce high-energy particles, hard X-ray, high-order harmonics, and terahertz (THz) radiation. A proton beam driven by a high-intensity laser has received attention as a compact ion source for medical applications. In this study we have tested simultaneous generation of protons and THz radiation from a thin-foil target. We use a Ti:sapphire laser system (J-KAREN) at JAEA. A laser beam is focused by an off-axis parabolic mirror at the thin-foil target. We observed the high-energy proton in the rear side of the target and THz radiation in the reflected direction. Next, high energy protons are observed by reducing the size of preformed plasma.
