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Journal Articles

LET dependency of human normal dermal cells survival in carbon ion irradiation

Yoshida, Yukari*; Mizohata, Kensuke*; Matsumura, Akihiko*; Isono, Mayu*; Yako, Tomoko*; Nakano, Takashi*; Funayama, Tomoo; Kobayashi, Yasuhiko; Kanai, Tatsuaki*

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 81, 2015/03

In the clinical application of carbon-ion (C-ion) radiation therapy in Japan, different RBE values of carbons have been used for clinical and biological endpoints. The biological RBE (bRBE) was estimated by a method that is based on the linear-quadratic (LQ) model, and was defined ${it in vitro}$ at the 10% surviving fraction of human salivary gland (HSG) tumor cells. However, many of biological parameters, that is, type of tissues, different sort of cells, oxygenation levels, and all, could affect radiosensitivity. Thus, normal human dermal fibroblasts (NHDF) cells were exposed to C-ion beams at Gunma University (10-80 keV/micrometer) and TIARA (108 and 158 keV/micrometer). The surviving fractions were analyzed with colony formation assays. The experimental RBE (eRBE) values were estimated from the radiation dose survival curve fitted by LQ model, and defined ${it in vitro}$.

Journal Articles

Corrosion behavior of F82H exposed to high temperature pressurized water with a rotating apparatus

Kanai, Akihiko*; Kasada, Ryuta*; Nakajima, Motoki; Hirose, Takanori; Tanigawa, Hisashi; Enoeda, Mikio; Konishi, Satoshi*

Journal of Nuclear Materials, 455(1-3), p.431 - 435, 2014/12

 Times Cited Count:0 Percentile:0.01(Materials Science, Multidisciplinary)

Journal Articles

Compatibility of Ni and F82H with liquid Pb-Li under rotating flow

Kanai, Akihiko*; Park, C.*; Noborio, Kazuyuki*; Kasada, Ryuta*; Konishi, Satoshi*; Hirose, Takanori; Nozawa, Takashi; Tanigawa, Hiroyasu

Fusion Engineering and Design, 89(7-8), p.1653 - 1657, 2014/10

 Times Cited Count:4 Percentile:36.81(Nuclear Science & Technology)

Oral presentation

Compatibility of F82H in flowing high temperature and high pressure water, 1; Effect of testing environment on corrosion behaviour

Nakajima, Motoki; Kanai, Akihiko*; Hirose, Takanori; Tanigawa, Hisashi; Enoeda, Mikio

no journal, , 

no abstracts in English

Oral presentation

Compatibility of F82H in flowing high temperature and high pressure water, 2; Microstructural analysis on corroded surface

Kanai, Akihiko*; Kasada, Ryuta*; Konishi, Satoshi*; Nakajima, Motoki; Hirose, Takanori; Tanigawa, Hisashi; Enoeda, Mikio

no journal, , 

no abstracts in English

Oral presentation

LET dependency of relative biological effectiveness in normal human dermal fibroblasts irradiated with carbon ion beam

Mizohata, Kensuke*; Yoshida, Yukari*; Matsumura, Akihiko*; Isono, Mayu*; Yako, Tomoko*; Ando, Koichi*; Funayama, Tomoo; Ono, Tatsuya*; Nakano, Takashi*; Kanai, Tatsuaki*

no journal, , 

Clinical RBE (cRBE), which was used to decide a clinical dose of carbon ion radiotherapy, is calculated by multiply experimental RBE (eRBE) by scaling factor. A value of eRBE was measured by colony formation assay of HSG cells in past, and adopted to the therapy of all patients and organ. However, there are question whether it was proper to use conventional eRBE in a different organization, different cell type. Therefore, we irradiated X-rays or a carbon line to NHDF cell and performed a colony assay to determine RBE of different cell type. The value of RBE was calculated from the cell survival rate fit in LQ model. As a result, the value of RBE was increased in LET-dependent manner, and the RBE obtained from the NHDF cell exhibited higher value than that of HSG cells. Thus, we concluded that it might be necessary to change scaling factor when evaluate different organ.

Oral presentation

Risk reduction associated with prolonged decommissioning for Fukushima Daiichi Nuclear Power Plant

Nishimura, Akihiko; Kanai, Akio*; Yoshida, Minoru*

no journal, , 

no abstracts in English

Oral presentation

Risk reduction associated with prolonged decommissioning for Fukushima Daiichi Nuclear Power Plant

Nishimura, Akihiko; Kanai, Akio*; Yoshida, Minoru*

no journal, , 

no abstracts in English

Oral presentation

16S rRNA gene amplicon sequencing analysis of microorganisms derived from environmental samples near the Fukushima Daiichi Nuclear Power Station

Warashina, Tomoro*; Sato, Asako*; Shagimardanova, E.*; Maruyama, Shigenori*; Mori, Hiroshi*; Narumi, Issey*; Gusev, O.*; Saito, Motofumi*; Sanada, Yukihisa; Sasaki, Yoshito; et al.

no journal, , 

no abstracts in English

Oral presentation

Research on methods for reducing risk factors for decommissioning

Nishimura, Akihiko; Kanai, Akio*; Yoshida, Minoru*

no journal, , 

no abstracts in English

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