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Yoshida, Yukari*; Mizohata, Kensuke*; Matsumura, Akihiko*; Isono, Mayu*; Yako, Tomoko*; Nakano, Takashi*; Funayama, Tomoo; Kobayashi, Yasuhiko; Kanai, Tatsuaki*
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 81, 2015/03
In the clinical application of carbon-ion (C-ion) radiation therapy in Japan, different RBE values of carbons have been used for clinical and biological endpoints. The biological RBE (bRBE) was estimated by a method that is based on the linear-quadratic (LQ) model, and was defined 
at the 10% surviving fraction of human salivary gland (HSG) tumor cells. However, many of biological parameters, that is, type of tissues, different sort of cells, oxygenation levels, and all, could affect radiosensitivity. Thus, normal human dermal fibroblasts (NHDF) cells were exposed to C-ion beams at Gunma University (10-80 keV/micrometer) and TIARA (108 and 158 keV/micrometer). The surviving fractions were analyzed with colony formation assays. The experimental RBE (eRBE) values were estimated from the radiation dose survival curve fitted by LQ model, and defined .
Kanai, Akihiko*; Kasada, Ryuta*; Nakajima, Motoki; Hirose, Takanori; Tanigawa, Hisashi; Enoeda, Mikio; Konishi, Satoshi*
Journal of Nuclear Materials, 455(1-3), p.431 - 435, 2014/12
Times Cited Count：0 Percentile：0.01(Materials Science, Multidisciplinary)Kanai, Akihiko*; Park, C.*; Noborio, Kazuyuki*; Kasada, Ryuta*; Konishi, Satoshi*; Hirose, Takanori; Nozawa, Takashi; Tanigawa, Hiroyasu
Fusion Engineering and Design, 89(7-8), p.1653 - 1657, 2014/10
Times Cited Count：4 Percentile：30.92(Nuclear Science & Technology)Nakajima, Motoki; Kanai, Akihiko*; Hirose, Takanori; Tanigawa, Hisashi; Enoeda, Mikio
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no abstracts in English
Kanai, Akihiko*; Kasada, Ryuta*; Konishi, Satoshi*; Nakajima, Motoki; Hirose, Takanori; Tanigawa, Hisashi; Enoeda, Mikio
no journal, ,
no abstracts in English
Mizohata, Kensuke*; Yoshida, Yukari*; Matsumura, Akihiko*; Isono, Mayu*; Yako, Tomoko*; Ando, Koichi*; Funayama, Tomoo; Ono, Tatsuya*; Nakano, Takashi*; Kanai, Tatsuaki*
no journal, ,
Clinical RBE (cRBE), which was used to decide a clinical dose of carbon ion radiotherapy, is calculated by multiply experimental RBE (eRBE) by scaling factor. A value of eRBE was measured by colony formation assay of HSG cells in past, and adopted to the therapy of all patients and organ. However, there are question whether it was proper to use conventional eRBE in a different organization, different cell type. Therefore, we irradiated X-rays or a carbon line to NHDF cell and performed a colony assay to determine RBE of different cell type. The value of RBE was calculated from the cell survival rate fit in LQ model. As a result, the value of RBE was increased in LET-dependent manner, and the RBE obtained from the NHDF cell exhibited higher value than that of HSG cells. Thus, we concluded that it might be necessary to change scaling factor when evaluate different organ.
Nishimura, Akihiko; Kanai, Akio*; Yoshida, Minoru*
no journal, ,
no abstracts in English
Nishimura, Akihiko; Kanai, Akio*; Yoshida, Minoru*
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no abstracts in English
Warashina, Tomoro*; Sato, Asako*; Shagimardanova, E.*; Maruyama, Shigenori*; Mori, Hiroshi*; Narumi, Issey*; Gusev, O.*; Saito, Motofumi*; Sanada, Yukihisa; Sasaki, Yoshito; et al.
no journal, ,
no abstracts in English
Nishimura, Akihiko; Kanai, Akio*; Yoshida, Minoru*
no journal, ,
no abstracts in English
