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Journal Articles

Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells

Shimada, Mikio*; Tokumiya, Takumi*; Miyake, Tomoko*; Tsukada, Kaima*; Kanzaki, Norie; Yanagihara, Hiromi*; Kobayashi, Junya*; Matsumoto, Yoshihisa*

Journal of Radiation Research (Internet), 64(2), p.345 - 351, 2023/03

 Times Cited Count:0 Percentile:0.01(Biology)

Journal Articles

Changes in sulfur metabolism in mouse brains following radon inhalation

Kanzaki, Norie; Sakoda, Akihiro; Kataoka, Takahiro*; Sun, L.*; Tanaka, Hiroshi; Otsu, Iwao*; Yamaoka, Kiyonori*

International Journal of Environmental Research and Public Health, 19(17), p.10750_1 - 10750_14, 2022/09

 Times Cited Count:0 Percentile:0(Environmental Sciences)

Reactive sulfur species (RSS) involve oxidative stress deeply and contribute anti-inflammatory effect, but no studied have focused on RSS changes after irradiation. In this study, we comprehensively analyzed the metabolites, focusing on RSS in mouse brain following radon inhalation. The ratio of oxidized glutathione to reduced glutathione and proportion of RSS in GSH or cysteine increased by radon inhalation. The sulfur ion might bind to GSH or cysteine chemically under conditions of oxidative stress, even at very low-dose exposure. We performed the overall assessment of high-dimensional data by applying machine learning and showed the specific characteristics of the effects by the exposure conditions. Our results suggested that RSS could produce a biological defense against oxidative stress following radon inhalation.

Journal Articles

Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice

Kataoka, Takahiro*; Ishida, Tsuyoshi*; Naoe, Shota*; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Journal of Radiation Research (Internet), 63(5), p.719 - 729, 2022/09

 Times Cited Count:2 Percentile:57.93(Biology)

Journal Articles

Radon solubility and diffusion in the skin surface layer

Sakoda, Akihiro; Ishida, Tsuyoshi*; Kanzaki, Norie; Tanaka, Hiroshi; Kataoka, Takahiro*; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

International Journal of Environmental Research and Public Health, 19(13), p.7761_1 - 7761_12, 2022/07

 Times Cited Count:0 Percentile:0(Environmental Sciences)

In specific situations such as bathing in a radon spa, where the radon activity concentration in thermal water is far higher than that in air, it has been revealed that radon uptake via skin can occur and should be considered for more precise dose evaluation. The primary aim of the present study was to numerically demonstrate the distribution as well as the degree of diffusion of radon in the skin, with a focus on its surface layers (i.e., stratum corneum). We made a biokinetic model that included diffusion theory at the stratum corneum, and measured radon solubility in the stratum corneum to get a crucial parameter. The implementation of the model suggested that the diffusion coefficient in the stratum corneum was as low as general radon-proof sheets. The depth profile of radon in the skin was found to be that after a 20-minute immersion in water, the radon activity concentration at the top surface skin layer was approximately 1000 times higher than that at the viable skin layer. The information on the position of radon as a radiation source would contribute to special dose evaluation where specific target cell layers are assumed for the skin.

Journal Articles

Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model

Kataoka, Takahiro*; Naoe, Shota*; Murakami, Kaito*; Yukimine, Ryohei*; Fujimoto, Yuki*; Kanzaki, Norie; Sakoda, Akihiro; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Journal of Clinical Biochemistry and Nutrition, 70(2), p.154 - 159, 2022/03

 Times Cited Count:1 Percentile:43.63(Nutrition & Dietetics)

Journal Articles

Usefulness of data visualization in radiation biology; Analysis of radiation-induced biological response using self-organizing maps

Kanzaki, Norie

Hoshasen Seibutsu Kenkyu, 56(3), p.295 - 307, 2021/09

The biological effects of low-dose radiation are confusing due to the various intertwined factors. The vital body responses are complex. In this review, we visualized the results of animal experiments using Self-organizing maps (SOM) and reported the results of the low-dose radiation biological effect assessment from a different viewpoint. For example, although the classification of these data which were the biological effects by low-dose radiation were impossible, SOM got the overall assessment and the intuitive understanding. We reported the results and the usefulness of data visualization of radiation biological effects using machine learning.

Journal Articles

Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions

Kataoka, Takahiro*; Shuto, Hina*; Naoe, Shota*; Yano, Junki*; Kanzaki, Norie; Sakoda, Akihiro; Tanaka, Hiroshi; Hanamoto, Katsumi*; Mitsunobu, Fumihiro*; Terato, Hiroaki*; et al.

Journal of Radiation Research (Internet), 62(5), p.861 - 867, 2021/09

 Times Cited Count:5 Percentile:60.89(Biology)

Journal Articles

Dosimetry of radon progeny deposited on skin in air and thermal water

Sakoda, Akihiro; Ishimori, Yuu; Kanzaki, Norie; Tanaka, Hiroshi; Kataoka, Takahiro*; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Journal of Radiation Research (Internet), 62(4), p.634 - 644, 2021/07

 Times Cited Count:3 Percentile:42.88(Biology)

It is held that the skin dose from radon progeny is not negligibly small and that introducing cancer is a possible consequence under normal circumstances, while there are a number of uncertainties in terms of related parameters such as activity concentrations in air, target cells in skin, skin covering materials, and deposition velocities. Meanwhile, an interesting proposal emerged in that skin exposure to natural radon-rich thermal water as part of balneotherapy can produce an immune response to induce beneficial health effects. The goal of the present study was to obtain generic dose coefficients with a focus on the radon progeny deposited on the skin in air or water in relation to risk or therapeutic assessments. We thus first estimated the skin deposition velocities of radon progeny in the two media based on data from the latest human studies. Using the optimized velocities, skin dosimetry was then performed under different assumptions regarding alpha-emitting source position and target cell (i.e., basal cells or Langerhans cells). Furthermore, the impact of the radon progeny deposition on effective doses from all exposure pathways relating to "radon exposure" was assessed using various possible scenarios. It was found that in both exposure media, effective doses from radon progeny inhalation are one to four orders of magnitude higher than those from the other pathways. In addition, absorbed doses on the skin can be the highest among all pathways when the radon activity concentrations in water are two or more orders of magnitude higher than those in air.

Journal Articles

Evaluation of the redox state in mouse organs following radon inhalation

Kataoka, Takahiro*; Kanzaki, Norie; Sakoda, Akihiro; Shuto, Hina*; Yano, Junki*; Naoe, Shota*; Tanaka, Hiroshi; Hanamoto, Katsumi*; Terato, Hiroaki*; Mitsunobu, Fumihiro*; et al.

Journal of Radiation Research (Internet), 62(2), p.206 - 216, 2021/03


 Times Cited Count:6 Percentile:67.16(Biology)

Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation. Mice inhaled radon at concentrations of 2 or 20 kBq/m$$^{3}$$ for 1, 3, or 10 days. The relationship between antioxidative function and oxidative stress was evaluated by principal component analysis (PCA) and correlation coefficient compared with control mice subjected to sham inhalation. These findings suggested that radon inhalation altered the redox state in organs, but that the characteristics varied depending on the redox state in organs.

Journal Articles

Methodology for simple spot measurement of equilibrium equivalent radon concentration

Sakoda, Akihiro; Ishimori, Yuu; Kanzaki, Norie; Tanaka, Hiroshi

Radiation Protection Dosimetry, 191(4), p.383 - 390, 2020/10

 Times Cited Count:1 Percentile:13.39(Environmental Sciences)

Estimation of the effective inhalation dose of short half-life radon progeny requires the quantification of radon equilibrium equivalent activity concentrations (EEC). The aim of the present study is to develop new methodology that focuses on spot measurements to determine EEC from single gross alpha counts and determine an optimized protocol. The core of the approach is to measure alpha particles over time when the radon progeny attached to the sampling filter are significantly disintegrated. The calibration curve of single counts to EEC is theoretically deduced and validated by a comparison test. The advantage of the present method is its minimal requirements, including the use of common instruments and simple sampling, alpha counting, and analysis procedures. This approach offers an option for radon practitioners working in a variety of fields, as well as the possibility for non-experts to easily measure EEC.

Journal Articles

Comparison of antioxidative effects between radon and thoron inhalation in mouse organs

Kobashi, Yusuke*; Kataoka, Takahiro*; Kanzaki, Norie; Ishida, Tsuyoshi*; Sakoda, Akihiro; Tanaka, Hiroshi; Ishimori, Yuu; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Radiation and Environmental Biophysics, 59(3), p.473 - 482, 2020/08

 Times Cited Count:5 Percentile:43.83(Biology)

Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m$$^{3}$$ or 2000 Bq/m$$^{3}$$, and thoron inhalation at a dose of 500 Bq/m$$^{3}$$ or 2000 Bq/m$$^{3}$$ were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.

Journal Articles

Report on the 65th Annual Meeting of the Radiation Research Society

Kanzaki, Norie

Hoeikyo Nyusu, (102), p.20 - 21, 2020/01

no abstracts in English

Journal Articles

Identification of potential biomarkers of radiation exposure in blood cells by capillary electrophoresis time-of-flight mass spectrometry

Sun, L.*; Inaba, Yohei*; Kanzaki, Norie; Bekal, M.*; Chida, Koichi*; Moritake, Takashi*

International Journal of Molecular Sciences (Internet), 21(3), p.812_1 - 812_12, 2020/01

 Times Cited Count:7 Percentile:39.83(Biochemistry & Molecular Biology)

Biodosimetry is a useful method to estimate the personal dose after unexpected ionizing radiation exposure. Studies have been reported that metabolites are useful markers for biodosimetry. However, these studies only focused on non-cellular biofluid (e.g., serum, plasma, urine, or saliva). Blood cell metabolites may reflect the health status or environmental stresses differently than metabolites of plasma. Here, we report changes in the metabolites of blood cells after X-ray irradiation of C57BL/6J mice. Blood cell metabolites were measured by capillary electrophoresis time-of-flight mass spectrometry. We found that 106 metabolites were changed significantly after irradiation. We identified that 2'-deoxycytidine, choline, and N6-acetyllysine as potentially useful discriminating markers of radiation exposure. These metabolites have not been reported previously. Furthermore, we established a prediction panel of the exposure dose using stepwise regression analysis. These findings suggest that blood cell metabolites may be useful biomarkers to estimate exposure doses during unexpected radiation incidents.

Journal Articles

Study of biokinetics of radon progeny with thoron progeny as the isotope tracer

Sakoda, Akihiro; Kanzaki, Norie; Tanaka, Hiroshi; Kataoka, Takahiro*; Yamaoka, Kiyonori*

Nihon Kenko Kaihatsu Zasshi, (40), p.90 - 94, 2019/06

no abstracts in English

Journal Articles

Big data analysis of radiation biological effects using machine learning

Kanzaki, Norie

Kankyo Gijutsu, 48(3), p.121 - 125, 2019/05

no abstracts in English

Journal Articles

Comparative effects of radon inhalation according to mouse strain and cisplatin dose in a cisplatin-induced renal damage model

Sasaoka, Kaori*; Kataoka, Takahiro*; Kanzaki, Norie; Kobashi, Yusuke*; Sakoda, Akihiro; Ishimori, Yuu; Yamaoka, Kiyonori*

Pakistan Journal of Zoology, 50(3), p.1157 - 1170, 2018/06

 Times Cited Count:2 Percentile:18.68(Zoology)

Cisplatin (CDDP) is widely used for treating solid cancers; however, it induces nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m$$^{3}$$ and 2000 Bq/m$$^{3}$$ for 24 h. Radon inhalation had a slight positive effect against CDDP toxicity in C57BL/6J mice with respect to improved hair condition, whereas radon inhalation exacerbated CDDP-induced toxicity in BALB/c mice. When BALB/c mice were treated with a lower dose of CDDP (15 mg/kg) after 1000 Bq/m$$^{3}$$ radon inhalation, the creatinine level was reduced and the superoxide dismutase content was increased. The supportive effect of radon inhalation shows its good potential as a candidate treatment to alleviate CDDP-induced renal damage.

Journal Articles

Knowledge discovery of suppressive effect of disease and increased anti-oxidative function by low-dose radiation using self-organizing map

Kanzaki, Norie; Kataoka, Takahiro*; Kobashi, Yusuke*; Yunoki, Yuto*; Ishida, Tsuyoshi*; Sakoda, Akihiro; Ishimori, Yuu; Yamaoka, Kiyonori*

Radioisotopes, 67(2), p.43 - 57, 2018/02

We previously reported that low-dose radiation induces the anti-oxidative function in many organ systems of mice. This results in the suppression of several kinds of oxidative stress-induced damage. This study was conducted with the objective of revealing the health effects of low-dose radiation obtained from our previous reports and searching for a new treatment based on low-dose radiation, such as radon therapy. We extracted the characteristics of the effects of low dose radiation suppressing diseases and enhancing the anti-oxidative function using fuzzy answer by self-organizing map (SOM) based on mutual knowledge. The relationship between the suppressive effect and increased antioxidative function was shown in our result, and the concentration dependence of the effect against pain was shown on the output map. Although the effect against other organs depending on concentration was unpredictable, our results indicate that low-dose radiation may also be suitable for treatment of liver disease and brain disease.

Journal Articles

Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice

Etani, Reo*; Kataoka, Takahiro*; Kanzaki, Norie*; Sakoda, Akihiro; Tanaka, Hiroshi; Ishimori, Yuu; Mitsunobu, Fumihiro*; Taguchi, Takehito*; Yamaoka, Kiyonori*

Journal of Radiation Research, 58(5), p.614 - 625, 2017/05

 Times Cited Count:11 Percentile:52.38(Biology)

Radon therapy using radon ($$^{222}$$Rn) gas is classified into two types of treatment: inhalation of radon gas and drinking water containing radon. Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear. In the present study, we examined the protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice. Mice inhaled radon at a concentration of 2000 Be/m$$^{3}$$ for 24 h or were provided with hot spring water for 2 weeks. The activity density of $$^{222}$$Rn ranged from 663 Bq/l (start point of supplying) to 100 Bq/l (end point of supplying).Mice were then orally administered ethanol at three concentrations. The ulcer index (UI), an indicator of mucosal injury, increased in response to the administration of ethanol; however, treatment with either radon inhalation or hot spring water inhibited the elevation in the UI due to ethanol. Although no significant differences in antioxidative enzymes were observed between the radon-treated groups and the non-treated control groups, lipid peroxide levels were significantly lower in the stomachs of mice pre-treated with radon or hot spring water. These results suggest that hot spring water drinking and radon inhalation inhibit ethanol-induced gastric mucosal injury.

Journal Articles

Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice

Etani, Reo*; Kataoka, Takahiro*; Kanzaki, Norie*; Sakoda, Akihiro; Tanaka, Hiroshi; Ishimori, Yuu; Mitsunobu, Fumihiro*; Yamaoka, Kiyonori*

Journal of Radiation Research, 57(3), p.250 - 257, 2016/06

 Times Cited Count:10 Percentile:47.46(Biology)

Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. After mice inhaled radon at a concentration of 2000 Bq/m$$^{3}$$ for 24 h or were given hot spring water for 2 weeks, they were administrated PO. Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Radon inhalation activated anti-oxidative functions in the liver and kidney. These results suggest that radon inhalation inhibits PO-induced hyperuricemia by activating anti-oxidative functions, while hot spring water drinking may suppress PO-induced elevations in serum uric acid levels through the pharmacological effects of the chemical compositions dissolved in it.

Oral presentation

Comparative of suppressive effects by low-dose radiation and related-medicine using machine learning

Kanzaki, Norie; Kataoka, Takahiro*; Kobashi, Yusuke*; Ishida, Tsuyoshi*; Yunoki, Yuto*; Sakoda, Akihiro; Ishimori, Yuu; Yamaoka, Kiyonori*

no journal, , 

We have suggested that low-dose radiation increases anti-oxidative function and inhibits various oxidative stress-related diseases. On the other hand, there are some reports about the extraction of some plants which inhibit similar diseases. In this research, we collected and analyzed the reports for comprehensive comparison. For example, we found that the effects of radon 2000 Bq/m$$^{3}$$ inhalation for 24 hours (low-dose irradiation) or taraxeren-3-one (the extraction from diospyros maritima) 20 mg/kg bodyweight administration were similar with the effects of indomethacin 10 mg/kg bodyweight administration regarding carrageenan-induced paw edema. Our results have a limitation of small dataset but are useful for future research about oxidative stress.

52 (Records 1-20 displayed on this page)