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Yoshitomi, Hiroshi; Tatebe, Yosuke; Kawai, Keiichi; Kowatari, Munehiko
Progress in Nuclear Science and Technology (Internet), 4, p.81 - 84, 2014/04
The Facility of Radiation Standards of the Japan Atomic Energy Agency provides various radiation fields for calibration and testing. It is located about 120 km away from Fukushima Dai-ichi Nuclear Power Plant, and radioactive materials discharged by the Fukushima nuclear accident contaminated around the FRS, even inside the building including radiation controlled areas. One month after the accident, the maximum contamination level in the controlled areas was 3.8 Bq/cm.
Cs,
Cs,
I,
Te and
I were detected by
spectrometry using an HPGe detector. However, contamination in controlled areas under widely contaminated environment have not been discussed in detail. As for FRS, practices for reducing contamination in the controlled areas were necessary to avoid the influence of the contamination to the calibration works. These practices described that the following two approaches were effective: (1) decontamination of the controlled areas by wiping out with wet cloth or steam cleaners, and (2) to prevent the dust with radioactive materials from letting in the controlled areas. As a result, surface contaminates inside the controlled areas were reduced to be dozens of times lower as compared with outside.
Ogawa, Kazuma*; Mukai, Takahiro*; Kawai, Keiichi*; Takamura, Norito*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Shiba, Kazuhiro*; Mori, Hirofumi*; Saji, Hideo*
European Journal of Nuclear Medicine and Molecular Imaging, 36(1), p.115 - 121, 2009/01
Times Cited Count:25 Percentile:59.41(Radiology, Nuclear Medicine & Medical Imaging)We have developed a Re-MAG3 complex-conjugated bisphosphonate (
Re-MAG3-HBP) for the treatment of painful bone metastases. We assumed competitive inhibitors of protein binding to be useful for procuring a favorable biodistribution of
Re-MAG3-HBP because it has been reported that the concurrent administration of
Tc-MAG3 and drugs with high affinity for serum protein enhanced total clearance and tissue distribution. The protein binding of
Re-MAG3-HBP in a human serum albumin solution was significantly decreased by the addition of ceftriaxone. In the biodistribution experiments, pretreatment with ceftriaxone enhanced the clearance of the radioactivity of
Re-MAG3-HBP in blood and nontarget tissues but had no effect on accumulation in bone. The findings suggested that the use of protein-binding competitive inhibitors would be effective in improving the pharmacokinetics of radiopharmaceuticals with high affinity for serum protein.
Sanada, Yukihisa; Nemoto, Makoto*; Suzuki, Kei*; Kawai, Keiichi*; Momose, Takumaro
Proceedings of 12th International Congress of the International Radiation Protection Association (IRPA-12) (CD-ROM), 7 Pages, 2008/10
The purpose of this study is to show the design principle and the determination procedures for the adequate relocation of the CADs in TRP. When the alarm trip point was 2.0 mGy/h, it is possible to detect a criticality accident even under conservative conditions (i.e. : 10 m distances from the equipment to the CAD and 140 cm concrete shield between them; neutron: 15 m distances and both 60 cm concrete shield and 60 cm steel shield). Consequently, it was found the seven CADs at these locations could monitor PCDF adequately. This study was reflected in the determination of the new CAD location.
Sanada, Yukihisa; Kobayashi, Hirohide; Furuta, Sadaaki; Nemoto, Kazuhiko*; Kawai, Keiichi*; Hashimoto, Tetsuo*
Radioisotopes, 55(12), p.727 - 734, 2006/12
The purpose of this study is to develop new measurement methods of radon progenies that discharged alpha-ray focused on pulse time interval. It is calculated that a delayed coincidence method, time-interval-analysis (TIA), has been applied to decay events on the microsecond time-scale (164microsecond). The measurement system with silicon detectors was produced and examined a basic performance of the system by using Th electrodeposited sources. This system was designed that it have shorter dead times. The results were as follows. (1) The theory of measurement
Po using TIA methods was established. (2) Development of the system that measured
Po. (3) Suggested that methods to examine a basic performance by using
Th electrodeposited sources. It is scheduled to examine the method of subtracting the progenies of the thorium series, and to reflect this system in an actual work of radiation control in the future.
Sanada, Yukihisa; Nohara, Naofumi*; Adachi, Yasuyuki*; Nemoto, Kazuhiko*; Kawai, Keiichi*; Kobayashi, Hirohide; Hashimoto, Tetsuo*
JAEA-Technology 2005-009, 33 Pages, 2006/01
An -ray measurement methods based on analyzing the time interval of pulses was newly developed. This method was developed aiming to suppress the background counts originated in progeny of uranium series. A delayed coincidence and time interval analysis (TIA) methods have been applied to measure a-b decay successive events (correlated events) on microsecond time-scale (164
s). The measurement system have such functions with silicon detectors was developed intending to shorten the dead time. The basic performance of the system was examined by using
Th electrodeposited sources. Follows were obtained in this work : The theory of measurement
Po using TIA methods was established. Measurement system of
Po was developed. Conformation methods of correlated events by using
Th electrodeposited sources was suggested. The efficiency of correlated events in aerosol samples was estimated. The methods to measure correlated events was indicated by addition of
Th. The method of subtracting the progenies of the thorium series are to examine.
Oblozinsk, P.*; Herman, M.*; Mughabghab, S. F.*; Sirakov, I.*; Chang, J.*; Nakagawa, Tsuneo; Shibata, Keiichi; Kawai, Masayoshi*; Ignatyuk, A. V.*; Pronyaev, V. G.*; et al.
AIP Conference Proceedings 769, p.438 - 441, 2005/05
Review of neutron cross-section evaluations for fission products included in 5 major evaluated nuclear-data libralies was performed. The aim of the project, conducted under the WPEC Subgroup 21 during 2001-2004, was to prepare recommendations for best evaluations of nuclei in the range Z=1-68. Altogether, existing evaluations for 211 materials were reviewd, 7 new materials were added, and recommendations were prepared for 218 materials.
Kawano, Toshihiko*; Matsunobu, Hiroyuki*; Murata, Toru*; Zukeran, Atsushi*; Nakajima, Yutaka*; Kawai, Masayoshi*; Iwamoto, Osamu; Shibata, Keiichi; Nakagawa, Tsuneo; Osawa, Takaaki*; et al.
JAERI-Research 2003-026, 53 Pages, 2003/12
New evaluations of neutron nuclear data for Uranium, Plutonium, and Thorium isotopes which are essential for applications to nuclear technology were carried out for the Japanese Evaluated Nuclear Data Library, JENDL-3.3. The objectives of the current release of JENDL were to fix several problems which have been reported for the previous version, to improve the accuracy of the data, and to evaluate covariances for the important nuclides. Quantities in JENDL-3.2 were extensively re-evaluated or replaced by more reliable values. The heavy nuclide data in JENDL-3.3 were validated with several benchmark tests, and it was reported that the current release gave a good prediction of criticalities.
Shibata, Keiichi; Kawano, Toshihiko*; Nakagawa, Tsuneo; Iwamoto, Osamu; Katakura, Junichi; Fukahori, Tokio; Chiba, Satoshi; Hasegawa, Akira; Murata, Toru*; Matsunobu, Hiroyuki*; et al.
Journal of Nuclear Science and Technology, 39(11), p.1125 - 1136, 2002/11
Times Cited Count:674 Percentile:93.94(Nuclear Science & Technology)Evaluation for JENDL-3.3 has been performed by considering the accumulated feedback information and various benchmark tests of the previous library JENDL-3.2. The major problems of the JENDL-3.2 data were solved by the new library: overestimation of criticality values for thermal fission reactors was improved by the modifications of fission cross sections and fission neutron spectra for U; incorrect energy distributions of secondary neutrons from important heavy nuclides were replaced with statistical model calculations; the inconsistency between elemental and isotopic evaluations was removed for medium-heavy nuclides. Moreover, covariance data were provided for 20 nuclides. The reliability of JENDL-3.3 was investigated by the benchmark analyses on reactor and shielding performances. The results of the analyses indicate that JENDL-3.3 predicts various reactor and shielding characteristics better than JENDL-3.2.
Fukahori, Tokio; Chiba, Satoshi; Shibata, Keiichi; Ikeda, Yujiro; Aruga, Takeo; Watanabe, Yukinobu*; Murata, Toru*; Yamano, Naoki*; Kawai, Masayoshi*
Reactor Dosimetry: Radiation Metrology and Assessment (ASTM STP 1398), p.591 - 598, 2001/00
no abstracts in English
Kawano, Toshihiko*; Matsunobu, Hiroyuki*; Murata, Toru*; Zukeran, Atsushi*; Nakajima, Yutaka*; Kawai, Masayoshi*; Iwamoto, Osamu; Shibata, Keiichi; Nakagawa, Tsuneo; Osawa, Takaaki*; et al.
Journal of Nuclear Science and Technology, 37(4), p.327 - 334, 2000/04
no abstracts in English
Kawano, Toshihiko*; Matsunobu, Hiroyuki*; Murata, Toru*; Zukeran, Atsushi*; Nakajima, Yutaka*; Kawai, Masayoshi*; Iwamoto, Osamu; Shibata, Keiichi; Nakagawa, Tsuneo; Osawa, Takaaki*; et al.
JAERI-Research 2000-004, p.76 - 0, 2000/02
no abstracts in English
Nakagawa, Tsuneo; Shibata, Keiichi; Chiba, Satoshi; Fukahori, Tokio; Nakajima, Yutaka; ; Kawano, Toshihiko*; Kanda, Yukinori*; Osawa, Takaaki*; Matsunobu, Hiroyuki*; et al.
Journal of Nuclear Science and Technology, 32(12), p.1259 - 1271, 1995/12
Times Cited Count:503 Percentile:99.95(Nuclear Science & Technology)no abstracts in English
Asami, Tetsuo*; Iijima, Shungo*; ; Ihara, Hitoshi; Kawai, Masayoshi*; ; Komuro, Yuichi; Shibata, Keiichi; Takano, Hideki; ; et al.
Nihon Genshiryoku Gakkai-Shi, 31(11), p.1190 - 1217, 1989/11
no abstracts in English
Sanada, Yukihisa; Tsujimura, Norio; Shimizu, Yoshio; Izaki, Kenji; Jin, Kazumi; Mikami, Satoshi; Kobayashi, Hirohide; Kawai, Keiichi*
no journal, ,
no abstracts in English
Yoshitomi, Hiroshi; Tatebe, Yosuke; Kowatari, Munehiko; Kawai, Keiichi; Miyauchi, Hideaki; Yoshizawa, Michio
no journal, ,
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Yoshitomi, Hiroshi; Tanimura, Yoshihiko; Tatebe, Yosuke; Kawai, Keiichi; Kowatari, Munehiko; Yoshizawa, Michio
no journal, ,
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Yoshitomi, Hiroshi; Tatebe, Yosuke; Kawai, Keiichi; Kowatari, Munehiko; Yoshizawa, Michio
no journal, ,
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Yoshitomi, Hiroshi; Nishino, Sho; Kawai, Keiichi; Umino, Kazushige; Kowatari, Munehiko; Tanimura, Yoshihiko; Yoshizawa, Michio
no journal, ,
no abstracts in English
Ogawa, Kazuma*; Mukai, Takahiro*; Kawai, Keiichi*; Takamura, Norito*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Saji, Hideo*
no journal, ,
Previously, based on the concept of bifunctional radiopharmaceuticals, we developed a highly stableRe-MAG3 complex conjugated bisphosphonate (
Re-MAG3-HBP) for treatment of the painful bone metastases. We assumed that competitive inhibitors of protein binding might be useful for
Re-MAG3-HBP because it has been reported that the concurrent administration between
Tc-MAG3 and drugs with high protein binding affinity produced competitive displacement at the specific binding sites and enhanced total clearance and tissue distribution. In this study, the displacement effect between
Re-MAG3-HBP and several protein binding inhibitors were investigated. Effects of each competitive protein binding inhibitor were examined in in vitro human serum. Bucolome, ceftriaxione and cefazolin as displacers of human serum albumin (HSA) binding site I, and ibuprofen as a displacer of HSA binding site II were added to each serum before addition of
Re-MAG3-HBP. As a result of in vitro study, the free fraction rate of
Re-MAG3-HBP was significantly increased by the addition of ceftriaxone. In biodistribution studies, the loading ceftriaxone enhanced the clearance of radioactivity of
Re-MAG3-HBP in blood and non-target tissues without the reduction of the bone accumulation. These findings suggested that the use of a protein binding competitive inhibitor would be effective for lowering the side effects of
Re-MAG3-HBP.
Sanada, Yukihisa; Kobayashi, Hirohide; Nemoto, Kazuhiko*; Kawai, Keiichi*; Hashimoto, Tetsuo*
no journal, ,
no abstracts in English