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Journal Articles

Practice for reducing contamination of controlled area under the influence of Fukushima nuclear accident

Yoshitomi, Hiroshi; Tatebe, Yosuke; Kawai, Keiichi; Kowatari, Munehiko

Progress in Nuclear Science and Technology (Internet), 4, p.81 - 84, 2014/04

The Facility of Radiation Standards of the Japan Atomic Energy Agency provides various radiation fields for calibration and testing. It is located about 120 km away from Fukushima Dai-ichi Nuclear Power Plant, and radioactive materials discharged by the Fukushima nuclear accident contaminated around the FRS, even inside the building including radiation controlled areas. One month after the accident, the maximum contamination level in the controlled areas was 3.8 Bq/cm$$^2$$. $$^{134}$$Cs, $$^{137}$$Cs, $$^{131}$$I, $$^{132}$$Te and $$^{132}$$I were detected by $$gamma$$ spectrometry using an HPGe detector. However, contamination in controlled areas under widely contaminated environment have not been discussed in detail. As for FRS, practices for reducing contamination in the controlled areas were necessary to avoid the influence of the contamination to the calibration works. These practices described that the following two approaches were effective: (1) decontamination of the controlled areas by wiping out with wet cloth or steam cleaners, and (2) to prevent the dust with radioactive materials from letting in the controlled areas. As a result, surface contaminates inside the controlled areas were reduced to be dozens of times lower as compared with outside.

Journal Articles

Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of $$^{186}$$Re-MAG3-conjugated bisphosphonate ($$^{186}$$Re-MAG3-HBP), an agent for treatment of painful bone metastases

Ogawa, Kazuma*; Mukai, Takahiro*; Kawai, Keiichi*; Takamura, Norito*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Shiba, Kazuhiro*; Mori, Hirofumi*; Saji, Hideo*

European Journal of Nuclear Medicine and Molecular Imaging, 36(1), p.115 - 121, 2009/01

 Times Cited Count:22 Percentile:57.96(Radiology, Nuclear Medicine & Medical Imaging)

We have developed a $$^{186}$$Re-MAG3 complex-conjugated bisphosphonate ($$^{186}$$Re-MAG3-HBP) for the treatment of painful bone metastases. We assumed competitive inhibitors of protein binding to be useful for procuring a favorable biodistribution of $$^{186}$$Re-MAG3-HBP because it has been reported that the concurrent administration of $$^{rm 99m}$$Tc-MAG3 and drugs with high affinity for serum protein enhanced total clearance and tissue distribution. The protein binding of $$^{186}$$Re-MAG3-HBP in a human serum albumin solution was significantly decreased by the addition of ceftriaxone. In the biodistribution experiments, pretreatment with ceftriaxone enhanced the clearance of the radioactivity of $$^{186}$$Re-MAG3-HBP in blood and nontarget tissues but had no effect on accumulation in bone. The findings suggested that the use of protein-binding competitive inhibitors would be effective in improving the pharmacokinetics of radiopharmaceuticals with high affinity for serum protein.

Journal Articles

Replacement of the criticality accident alarm system in the Tokai reprocessing plant

Sanada, Yukihisa; Nemoto, Makoto*; Suzuki, Kei*; Kawai, Keiichi*; Momose, Takumaro

Proceedings of 12th International Congress of the International Radiation Protection Association (IRPA-12) (CD-ROM), 7 Pages, 2008/10

The purpose of this study is to show the design principle and the determination procedures for the adequate relocation of the CADs in TRP. When the alarm trip point was 2.0 mGy/h, it is possible to detect a criticality accident even under conservative conditions (i.e. $$gamma$$: 10 m distances from the equipment to the CAD and 140 cm concrete shield between them; neutron: 15 m distances and both 60 cm concrete shield and 60 cm steel shield). Consequently, it was found the seven CADs at these locations could monitor PCDF adequately. This study was reflected in the determination of the new CAD location.

Journal Articles

Selective detection using pulse time interval analysis for correlated events in Rn-progeny with a microsecond lifetime

Sanada, Yukihisa; Kobayashi, Hirohide; Furuta, Sadaaki; Nemoto, Kazuhiko*; Kawai, Keiichi*; Hashimoto, Tetsuo*

Radioisotopes, 55(12), p.727 - 734, 2006/12

The purpose of this study is to develop new measurement methods of radon progenies that discharged alpha-ray focused on pulse time interval. It is calculated that a delayed coincidence method, time-interval-analysis (TIA), has been applied to decay events on the microsecond time-scale (164microsecond). The measurement system with silicon detectors was produced and examined a basic performance of the system by using $$^{230}$$Th electrodeposited sources. This system was designed that it have shorter dead times. The results were as follows. (1) The theory of measurement $$^{214}$$Po using TIA methods was established. (2) Development of the system that measured $$^{214}$$Po. (3) Suggested that methods to examine a basic performance by using $$^{230}$$Th electrodeposited sources. It is scheduled to examine the method of subtracting the progenies of the thorium series, and to reflect this system in an actual work of radiation control in the future.

JAEA Reports

Development of new $$alpha$$-ray measurement methods with radon suppression focused on pulse time interval

Sanada, Yukihisa; Nohara, Naofumi*; Adachi, Yasuyuki*; Nemoto, Kazuhiko*; Kawai, Keiichi*; Kobayashi, Hirohide; Hashimoto, Tetsuo*

JAEA-Technology 2005-009, 33 Pages, 2006/01

JAEA-Technology-2005-009.pdf:1.42MB

An $$alpha$$-ray measurement methods based on analyzing the time interval of pulses was newly developed. This method was developed aiming to suppress the background counts originated in progeny of uranium series. A delayed coincidence and time interval analysis (TIA) methods have been applied to measure a-b decay successive events (correlated events) on microsecond time-scale (164$$mu$$s). The measurement system have such functions with silicon detectors was developed intending to shorten the dead time. The basic performance of the system was examined by using $$^{230}$$Th electrodeposited sources. Follows were obtained in this work : The theory of measurement $$^{214}$$Po using TIA methods was established. Measurement system of $$^{214}$$Po was developed. Conformation methods of correlated events by using $$^{230}$$Th electrodeposited sources was suggested. The efficiency of correlated events in aerosol samples was estimated. The methods to measure correlated events was indicated by addition of $$^{230}$$Th. The method of subtracting the progenies of the thorium series are to examine.

Journal Articles

Review of neutron cross-section evaluations for fission products

Oblozinsk$'y$, P.*; Herman, M.*; Mughabghab, S. F.*; Sirakov, I.*; Chang, J.*; Nakagawa, Tsuneo; Shibata, Keiichi; Kawai, Masayoshi*; Ignatyuk, A. V.*; Pronyaev, V. G.*; et al.

AIP Conference Proceedings 769, p.438 - 441, 2005/05

Review of neutron cross-section evaluations for fission products included in 5 major evaluated nuclear-data libralies was performed. The aim of the project, conducted under the WPEC Subgroup 21 during 2001-2004, was to prepare recommendations for best evaluations of nuclei in the range Z=1-68. Altogether, existing evaluations for 211 materials were reviewd, 7 new materials were added, and recommendations were prepared for 218 materials.

JAEA Reports

Evaluations of heavy nuclide data for JENDL-3.3

Kawano, Toshihiko*; Matsunobu, Hiroyuki*; Murata, Toru*; Zukeran, Atsushi*; Nakajima, Yutaka*; Kawai, Masayoshi*; Iwamoto, Osamu; Shibata, Keiichi; Nakagawa, Tsuneo; Osawa, Takaaki*; et al.

JAERI-Research 2003-026, 53 Pages, 2003/12

JAERI-Research-2003-026.pdf:2.48MB

New evaluations of neutron nuclear data for Uranium, Plutonium, and Thorium isotopes which are essential for applications to nuclear technology were carried out for the Japanese Evaluated Nuclear Data Library, JENDL-3.3. The objectives of the current release of JENDL were to fix several problems which have been reported for the previous version, to improve the accuracy of the data, and to evaluate covariances for the important nuclides. Quantities in JENDL-3.2 were extensively re-evaluated or replaced by more reliable values. The heavy nuclide data in JENDL-3.3 were validated with several benchmark tests, and it was reported that the current release gave a good prediction of criticalities.

Journal Articles

Japanese evaluated nuclear data library version 3 revision-3; JENDL-3.3

Shibata, Keiichi; Kawano, Toshihiko*; Nakagawa, Tsuneo; Iwamoto, Osamu; Katakura, Junichi; Fukahori, Tokio; Chiba, Satoshi; Hasegawa, Akira; Murata, Toru*; Matsunobu, Hiroyuki*; et al.

Journal of Nuclear Science and Technology, 39(11), p.1125 - 1136, 2002/11

 Times Cited Count:658 Percentile:96.97(Nuclear Science & Technology)

Evaluation for JENDL-3.3 has been performed by considering the accumulated feedback information and various benchmark tests of the previous library JENDL-3.2. The major problems of the JENDL-3.2 data were solved by the new library: overestimation of criticality values for thermal fission reactors was improved by the modifications of fission cross sections and fission neutron spectra for $$^{235}$$U; incorrect energy distributions of secondary neutrons from important heavy nuclides were replaced with statistical model calculations; the inconsistency between elemental and isotopic evaluations was removed for medium-heavy nuclides. Moreover, covariance data were provided for 20 nuclides. The reliability of JENDL-3.3 was investigated by the benchmark analyses on reactor and shielding performances. The results of the analyses indicate that JENDL-3.3 predicts various reactor and shielding characteristics better than JENDL-3.2.

Journal Articles

JENDL PKA/KERMA file for IFMIF project

Fukahori, Tokio; Chiba, Satoshi; Shibata, Keiichi; Ikeda, Yujiro; Aruga, Takeo; Watanabe, Yukinobu*; Murata, Toru*; Yamano, Naoki*; Kawai, Masayoshi*

Reactor Dosimetry: Radiation Metrology and Assessment (ASTM STP 1398), p.591 - 598, 2001/00

no abstracts in English

Journal Articles

Simultaneous evaluation of fission cross sections of uranium and plutonium isotopes for JENDL-3.3

Kawano, Toshihiko*; Matsunobu, Hiroyuki*; Murata, Toru*; Zukeran, Atsushi*; Nakajima, Yutaka*; Kawai, Masayoshi*; Iwamoto, Osamu; Shibata, Keiichi; Nakagawa, Tsuneo; Osawa, Takaaki*; et al.

Journal of Nuclear Science and Technology, 37(4), p.327 - 334, 2000/04

no abstracts in English

JAEA Reports

Evaluation of fission cross sections and covariances for $$^{233}$$U,$$^{235}$$U,$$^{238}$$U,$$^{239}$$Pu,$$^{240}$$Pu,and $$^{241}$$Pu

Kawano, Toshihiko*; Matsunobu, Hiroyuki*; Murata, Toru*; Zukeran, Atsushi*; Nakajima, Yutaka*; Kawai, Masayoshi*; Iwamoto, Osamu; Shibata, Keiichi; Nakagawa, Tsuneo; Osawa, Takaaki*; et al.

JAERI-Research 2000-004, p.76 - 0, 2000/02

JAERI-Research-2000-004.pdf:2.39MB

no abstracts in English

Journal Articles

Japanese evaluated nuclear data library, version 3 revision-2; JENDL-3.2

Nakagawa, Tsuneo; Shibata, Keiichi; Chiba, Satoshi; Fukahori, Tokio; Nakajima, Yutaka; ; Kawano, Toshihiko*; Kanda, Yukinori*; Osawa, Takaaki*; Matsunobu, Hiroyuki*; et al.

Journal of Nuclear Science and Technology, 32(12), p.1259 - 1271, 1995/12

 Times Cited Count:493 Percentile:99.95(Nuclear Science & Technology)

no abstracts in English

Journal Articles

Japanese evaluated nuclear data library, JENDL-3

Asami, Tetsuo*; Iijima, Shungo*; ; Ihara, Hitoshi; Kawai, Masayoshi*; ; Komuro, Yuichi; Shibata, Keiichi; Takano, Hideki; *; et al.

Nihon Genshiryoku Gakkai-Shi, 31(11), p.1190 - 1217, 1989/11

no abstracts in English

Oral presentation

Rapid evaluation method of concentrations of radioactive material in air using background-compensated dust monitor

Sanada, Yukihisa; Kobayashi, Hirohide; Nemoto, Kazuhiko*; Kawai, Keiichi*; Hashimoto, Tetsuo*

no journal, , 

no abstracts in English

Oral presentation

Control of biodistribution of Rhenium-186-MAG3-conjugated bisphosphonate using a competitive inhibitor of protein binding

Ogawa, Kazuma*; Mukai, Takahiro*; Kawai, Keiichi*; Takamura, Norito*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Saji, Hideo*

no journal, , 

Previously, based on the concept of bifunctional radiopharmaceuticals, we developed a highly stable$$^{186}$$Re-MAG3 complex conjugated bisphosphonate ($$^{186}$$Re-MAG3-HBP) for treatment of the painful bone metastases. We assumed that competitive inhibitors of protein binding might be useful for$$^{186}$$Re-MAG3-HBP because it has been reported that the concurrent administration between $$^{99m}$$Tc-MAG3 and drugs with high protein binding affinity produced competitive displacement at the specific binding sites and enhanced total clearance and tissue distribution. In this study, the displacement effect between $$^{186}$$Re-MAG3-HBP and several protein binding inhibitors were investigated. Effects of each competitive protein binding inhibitor were examined in in vitro human serum. Bucolome, ceftriaxione and cefazolin as displacers of human serum albumin (HSA) binding site I, and ibuprofen as a displacer of HSA binding site II were added to each serum before addition of $$^{186}$$Re-MAG3-HBP. As a result of in vitro study, the free fraction rate of $$^{186}$$Re-MAG3-HBP was significantly increased by the addition of ceftriaxone. In biodistribution studies, the loading ceftriaxone enhanced the clearance of radioactivity of $$^{186}$$Re-MAG3-HBP in blood and non-target tissues without the reduction of the bone accumulation. These findings suggested that the use of a protein binding competitive inhibitor would be effective for lowering the side effects of $$^{186}$$Re-MAG3-HBP.

Oral presentation

Design for placements of criticality accident alarm detectors in plutonium conversion development facility

Sanada, Yukihisa; Tsujimura, Norio; Shimizu, Yoshio; Izaki, Kenji; Jin, Kazumi; Mikami, Satoshi; Kobayashi, Hirohide; Kawai, Keiichi*

no journal, , 

no abstracts in English

Oral presentation

Replacement of the criticality alarm system in the plutonium conversion development facility

Hikinuma, Yuichi; Sanada, Yukihisa; Hasegawa, Ichiro; Kanazawa, Nobuyuki; Kawai, Keiichi*; Momose, Takumaro

no journal, , 

no abstracts in English

Oral presentation

Radiation protection practices at the nuclear science research institute under the influence of Fukushima nuclear accident, 3; Implementation for reducing radioactive contamination in FRS

Yoshitomi, Hiroshi; Tatebe, Yosuke; Kawai, Keiichi; Kowatari, Munehiko; Nidaira, Atsushi; Fukami, Tomoyo; Sawahata, Katsunori

no journal, , 

no abstracts in English

Oral presentation

Influence of difference in structure of the beta calibration sources on calibration for personal dosimeters

Yoshitomi, Hiroshi; Tatebe, Yosuke; Kowatari, Munehiko; Kawai, Keiichi; Miyauchi, Hideaki; Yoshizawa, Michio

no journal, , 

no abstracts in English

Oral presentation

Development of low-dose rate photon calibration field in the range of $$mu$$Sv/h

Yoshitomi, Hiroshi; Tanimura, Yoshihiko; Tatebe, Yosuke; Kawai, Keiichi; Kowatari, Munehiko; Yoshizawa, Michio

no journal, , 

no abstracts in English

22 (Records 1-20 displayed on this page)