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Journal Articles

Magnetically navigated protein transduction in vivo using iron oxide-nanogel chaperone hybrid

Kawasaki, Riku*; Sasaki, Yoshihiro*; Nishimura, Tomoki*; Katagiri, Kiyofumi*; Morita, Keiichi*; Sekine, Yurina; Sawada, Shinichi*; Mukai, Sadaatsu*; Akiyoshi, Kazunari*

Advanced Healthcare Materials, 10(9), p.2001988_1 - 2001988_8, 2021/05

 Times Cited Count:6 Percentile:62.81(Engineering, Biomedical)

Systems for "protein transduction", the intracellular delivery of functional proteins, are needed to address the deliverability challenges of protein therapy, but protein transfer in vivo remains difficult. In this study, we have developed a magnetically induced in vivo protein transfection system using a magnetic nanogel chaperone (MC) composed of iron oxide nanoparticles and polysaccharide nanogels. Experiments using an oral cancer model have shown that this MC system is useful for cancer treatment.

Journal Articles

Calcium-deficient hydroxyapatite as a potential sorbent for strontium

Sekine, Yurina; Motokawa, Ryuhei; Kozai, Naofumi; Onuki, Toshihiko; Matsumura, Daiju; Tsuji, Takuya; Kawasaki, Riku*; Akiyoshi, Kazunari*

Scientific Reports (Internet), 7(1), p.2064_1 - 2064_8, 2017/05

 Times Cited Count:34 Percentile:75.84(Multidisciplinary Sciences)

A calcium (Ca)-deficient hydroxyapatite was investigated for its potential to remove Sr$$^{2+}$$ from environmentally relevant water. We conducted sorption tests on solutions having Mg$$^{2+}$$ and Ca$$^{2+}$$ as competing cations at the Sr$$^{2+}$$ concentration of 0.05 mmol/L. The Ca-deficient hydroxyapatite maintained its high Sr$$^{2+}$$ sorption ratio: the sorption ratio was above 80% in the presence of Mg$$^{2+}$$ and Ca$$^{2+}$$ in the concentrations between 0.1 to 1.0 mmol/L, whereas stoichiometric hydroxyapatite showed a lower ratio even in the presence of small amounts of Mg$$^{2+}$$ and Ca$$^{2+}$$. The bonding states of Sr$$^{2+}$$ onto the Ca-deficient hydroxyapatite were evaluated by extended X-ray absorption fine structure measurements. The results indicated that there are specific sorption sites in Ca-deficient hydroxyapatite where Sr$$^{2+}$$ could be stably and preferentially immobilized.

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