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Hashimoto, Kazuyuki; Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji*; Ota, Masayuki; Konno, Chikara; Ochiai, Kentaro; et al.
Journal of the Physical Society of Japan, 84(4), p.043202_1 - 043202_4, 2015/04
Times Cited Count:8 Percentile:50.90(Physics, Multidisciplinary)Kawabata, Masako; Nagai, Yasuki; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*
Journal of the Physical Society of Japan, 84(2), p.023201_1 - 023201_4, 2015/02
Times Cited Count:6 Percentile:43.32(Physics, Multidisciplinary)Tc for medical use can be separated by thermochromatography from a molten
MoO
sample. Effect of moist oxygen gas on the
Tc release from molten
MoO
samples was investigated using a
Mo/
Tc generator.
Mo was produced with
Mo(n,2n)
Mo. A new phenomenon has been observed: release rate, separation- and recovery-efficiencies of
Tc were higher in the moist oxygen gas than those in the dry oxygen gas. The present result is a significant progress towards the stable production of a high quality
Tc from a molten MoO
sample with high separation efficiency. The result would also give us a new insight into the interaction between the moist oxygen gas and the molten MoO
.
Kimura, Akihiro; Awaludin, R.*; Shiina, Takayuki*; Tanase, Masakazu*; Kawauchi, Yukimasa*; Gunawan, A. H.*; Lubis, H.*; Sriyono*; Ota, Akio*; Genka, Tsuguo; et al.
Proceedings of 3rd Asian Symposium on Material Testing Reactors (ASMTR 2013), p.109 - 115, 2013/11
Tc is generated by decay of
Mo. Production of
Mo is carried out by (n,f) method with high enriched uranium targets, and the production are currently producing to meet about 95% of global supply. Recently, it is difficult to carry out a stable supply for some problems such as aging of reactors etc. Furthermore, the production has difficulties in nuclear proliferation resistance etc. Thus, (n,
) method has lately attracted considerable attention. The (n,
) method has several advantages, but the extremely low specific activity makes its uses less convenient than (n,f) method. We proposed a method based on the solvent extraction, followed by adsorption of
Tc with alumina column. In this paper, a practical production of
Tc was tried by the method with 1Ci of
Mo produced in MPR-30. The recovery yields were approximately 70%. Impurity of
Mo was less than 4.0
10
% and the radiochemical purity was over 99.2%.
Kimura, Akihiro; Awaludin, R.*; Shiina, Takayuki*; Tanase, Masakazu*; Kawauchi, Yukimasa*; Gunawan, A. H.*; Lubis, H.*; Sriyono*; Ota, Akio*; Genka, Tsuguo; et al.
Proceedings of 6th International Symposium on Material Testing Reactors (ISMTR-6) (Internet), 7 Pages, 2013/10
JP, 2011-173260This research is development of Tc production.
Tc is generated by decay of
Mo. The supply of
Mo in Japan depends entirely on the import from foreign countries. Thus, it is needed to supply
Mo stably by the domestic manufacturing. A practical production of
Tc was tried by the method with 1 Ci of
Mo produced in MPR-30. The results showed that the recovery yields were approximately 70%. The concentration of the product obtained was estimated to be corresponding to about 30 GBq (800 mCi)/ml when 150g of MoO
was irradiated for 5 days in MPR-30. Impurity of
Mo was less than 4.4
10
%, which was lower than that of Japanese tentative regulation criteria. The radiochemical purity was higher than 99.8% that cleared the tentative regulation (95%) of Japan.
Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji; Sonoda, Nozomi; Kawabata, Masako; Harada, Hideo; Kin, Tadahiro*; Tsukada, Kazuaki; et al.
Journal of the Physical Society of Japan, 82(6), p.064201_1 - 064201_7, 2013/06
Times Cited Count:46 Percentile:85.28(Physics, Multidisciplinary)Nishikata, Kaori; Kimura, Akihiro; Tsuchiya, Kunihiko; Suzuki, Kunihiko*; Akiyama, Hiroaki*; Nagakura, Masaaki*; Kawauchi, Yukimasa*; Tanase, Masakazu*
Proceedings of 5th International Symposium on Material Testing Reactors (ISMTR-5) (Internet), 9 Pages, 2012/10
In this study, experimental fabrication tests of the high-density MoO pellets were carried out by the Plasma Activated Sintering (PAS) method, which requires relatively lower temperature and shorter time to fabricate the pellets. From the results, the PAS method combined with oxidation process, prior to dissolution into sodium hydroxide solution, is a useful measure to fabricate high-density MoO
Pellets for the future domestic production of
Tc. The irradiation tests and characterization with these pellets will be carried out under the international cooperation.
Tanase, Masakazu*; Shiina, Takayuki*; Kimura, Akihiro; Nishikata, Kaori; Fujisaki, Saburo*; Ota, Akio*; Kobayashi, Masaaki*; Yamamoto, Asaki*; Kawauchi, Yukimasa*; Tsuchiya, Kunihiko; et al.
Proceedings of 5th International Symposium on Material Testing Reactors (ISMTR-5) (Internet), 9 Pages, 2012/10
Tc is used as a radiopharmaceutical and manufactured from the parent nuclide of
Mo. Extraction method of
Tc from (n,
)
Mo have been developed, as a part of the industrial use expansion after JMTR will re-start. In this research, the method proposed would be applicable to a practical production of
Tc obtained from (n,
)
Mo in large quantities. The method proposed would be applicable to a practical production of
Tc obtained from (n,
)
Mo in large quantities.
Nagai, Yasuki; Hatsukawa, Yuichi; Kin, Tadahiro; Hashimoto, Kazuyuki; Motoishi, Shoji; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke; Sato, Yuichi*; Kawauchi, Yukimasa*; et al.
Journal of the Physical Society of Japan, 80(8), p.083201_1 - 083201_4, 2011/08
Times Cited Count:15 Percentile:64.22(Physics, Multidisciplinary)We have for the first time succeeded to separate Tc from a Mo oxide sample irradiated by accelerator neutrons, and to formulate
Tc-methylene diphosphonate (
Tc-MDP).
Mo, the mother nuclide of
Tc, was produced by the
Mo(
,2
)
Mo reaction using about 14 MeV neutrons provided at the Fusion Neutronics Source of Japan Atomic Energy Agency. The
Tc was separated from
Mo by the sublimation method, and its radionuclide purity was confirmed to be higher than 99.99%. The labeling efficiency of
Tc-MDP was shown to be higher than 99%. These values exceed the United States Pharmacopeia requirements for a fission product,
Mo. Consequently, a
Tc radiopharmaceutical preparation formed by using the mentioned
Mo can be a promising substitute for the fission product
Mo. A longstanding problem to ensure a reliable and constant supply of
Mo in Japan can be partially mitigated.
Kogure, Hiroto; Sorita, Takami; Iwamoto, Seikichi; Nagata, Yasushi*; Hiraoka, Masahiro*; Iwata, Kazuro*; Kawauchi, Yukimasa*; Suzuki, Kazutoshi*
JAERI-Tech 2003-003, 26 Pages, 2003/03
Intravascular brachytherapy is a novel therapy for preventing the restenosis of coronary artery by use of low-dose irradiation. JAERI and Kyoto University have been developing Ir radiation sources by the cooperative research project entitled as "The research on safety and effectiveness of the intravascular brachytherapy for preventing restenosis of the coronary artery disease" since 1998. The radiation source was introduced into the stenosis through a catheter (a guide-tube to insert directly into vascular) to irradiate the diseased part. Ten
Ir seed sources (
0.4 mm
2.5 mm) were positioned between nylon spacers (
0.3 mm
1.0 mm) in a flexible covering tube and the tube was plugged with a core-wire; the tube was shrunk to fix the inside materials and the size is 0.46 mm in diameter and 3 m in length. The physically optimal design was determined to insert the radiation source easily into vascular and to get the dose uniformity in the diseased part. The production method of the radiation source, which is practical to use in the clinics was also established.
Fujino, Shunsuke; Hashimoto, Kazuyuki; Saeki, Hideya*; Kawauchi, Yukimasa*; Kawabata, Masako*; Chiba, Yusuke
no journal, ,
Lutetium-177 (Lu-177)is a medical radioisotope used in approved radiopharmaceutical "Lutathera" to treat neuroendocrine tumours. And it is one of the promising radionuclides for new therapeutic radiopharmaceuticals. However, Lu-177 is dependent on imports from overseas, and there are concerns that transportation problems etc. may affect domestic distribution and development of new pharmaceuticals. In order to confirm whether JAEA can produce a portion of the Lu-177 for research, we conducted a production test of Lu-177 using JRR-3.
Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Hatsukawa, Yuichi; Ota, Akio; Shiina, Takayuki; Kawauchi, Yukimasa
no journal, ,
Tc, the daughter nuclide of
Mo, is widely used for medical diagnosis. In Japan, about 0.9 million diagnostic procedures are carried out using
Tc.
Mo has been mostly produced using
U in research reactors. Because of recent shortages of
Mo, a variety of alternative production methods of
Mo or
Tc were proposed. We proposed to produce
Mo by
Mo(n,2n) using neutrons from an accelerator. The route is characterized to produce a large quantity of high-quality
Mo with a minimum level of radioactive wastes, since the cross section of the
Mo(n,2n)
Mo reaction at 11
En
18 MeV is large, and the cross sections of the (n,He), (n,n'p), and (n,p) reactions on
Mo are quite small. Intense neutrons are available because of recent progresses of accelerator and target technologies. In the talk, we show our recent experimental results to obtain
Tc with high-quality using
Mo produced by
Mo(n,2n).
Tanase, Masakazu*; Shiina, Takayuki*; Ota, Akio*; Fujisaki, Saburo*; Kawauchi, Yukimasa*; Kimura, Akihiro; Nishikata, Kaori; Yonekawa, Minoru; Ishida, Takuya; Kato, Yoshiaki; et al.
no journal, ,
Preliminary studies for obtaining Tc from, (n,
)
Mo produced in JMTR has been carried out, as a part of the industrial use expansion after JMTR will re-start. In order to obtain high specific-volume of
Tc, a method was proposed for extracting
Tc with MEK, followed by purification and concentration with acidic and basic alumina. In this study, preliminary tests, aiming construction of production system, were carried out using Re instead of
Tc because Re and Tc are homologous elements. The average recovery yield of Re was very high to be 98%. Based on the result, an apparatus for
Tc production was assembled.
Kawabata, Masako*; Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Motoishi, Shoji*; Saeki, Hideya*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*; et al.
no journal, ,
no abstracts in English