Refine your search:     
Report No.
 - 
Search Results: Records 1-9 displayed on this page of 9
  • 1

Presentation/Publication Type

Initialising ...

Refine

Journal/Book Title

Initialising ...

Meeting title

Initialising ...

First Author

Initialising ...

Keyword

Initialising ...

Language

Initialising ...

Publication Year

Initialising ...

Held year of conference

Initialising ...

Save select records

Journal Articles

Preparation and evaluation of $$^{186/188}$$Re-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate site

Ogawa, Kazuma*; Kawashima, Hidekazu*; Kinuya, Seigo*; Shiba, Kazuhiro*; Onoguchi, Masahisa*; Kimura, Hiroyuki*; Hashimoto, Kazuyuki; Odani, Akira*; Saji, Hideo*

Annals of Nuclear Medicine, 23(10), p.843 - 848, 2009/12

 Times Cited Count:9 Percentile:33.73(Radiology, Nuclear Medicine & Medical Imaging)

Rhenium is one of the most valuable elements for internal radiotherapy because $$^{186/188}$$Re have favorable physical characteristics. However, there are problems when proteins such as antibodies are used as carriers of $$^{186/188}$$Re. Labeling methods require the complicated processes. Therefore, we planned the preparation by a simple method and evaluation of a stable $$^{186/188}$$Re-labeled antibody. For this purpose, we selected $$^{186/188}$$Re(I) tricarbonyl complex as a chelating site. A7 was used as a model protein. $$^{186/188}$$Re-labeled A7 was prepared by directly reacting a $$^{186/188}$$Re(I) tricarbonyl precursor with A7. $$^{186/188}$$Re-(CO)$$_{3}$$-A7 were prepared with radiochemical yields of 23-28%. After purification, $$^{186/188}$$Re-(CO)$$_{3}$$-A7 showed a radiochemical purity of over 95%. In biodistribution experiments, $$^{186/188}$$Re-labeled A7 showed high uptakes in the tumor.

Journal Articles

Neutrino-nucleus reaction cross sections for light element synthesis in supernova explosions

Yoshida, Takashi*; Suzuki, Toshio*; Chiba, Satoshi; Kajino, Toshitaka*; Yokomakura, Hidekazu*; Kimura, Keiichi*; Takamura, Akira*; Hartmann, D.*

Astrophysical Journal, 686(1), p.448 - 466, 2008/10

The neutrino-nucleus reaction cross sections of $$^4$$He and $$^{12}$$C are evaluated using new shell model Hamiltonians. Branching ratios of various decay channels are calculated to evaluate the yields of Li, Be, and B produced through the $$nu$$-process in supernova explosions. The new cross sections enhance the yields of $$^{7}$$Li and $$^{11}$$B produced during the supernova explosion of a 16.2 M$$_odot$$ star model compared to our previous study by factors of 1.3 and 1.2, respectively. On the other hand, the yield of $$^{10}$$B decreases by a factor of three. The yields of $$^{6}$$Li, $$^{9}$$Be, and the radioactive nucleus $$^{10}$$Be are found at a level of 10 to 11 M$$_odot$$. The temperature of $$nu mu, tau$$- and $$bar{nu} mu, tau$$-neutrinos inferred from the supernova contribution of $$^{11}$$B in Galactic chemical evolution models is constrained to be in the range 4.5 MeV to 6.4 MeV. The increase in the $$^{7}$$Li and $$^{11}$$B yields due to neutrino oscillations is demonstrated with the new cross sections.

Journal Articles

Neutrino-nucleus reaction cross sections for light element synthesis in supernova explosions

Yoshida, Takashi*; Suzuki, Toshio*; Chiba, Satoshi; Kajino, Toshitaka*; Yokomakura, Hidekazu*; Kimura, Keiichi*; Takamura, Akira*; Hartmann, D. H.*

Astrophysical Journal, 686(1), p.448 - 466, 2008/10

 Times Cited Count:85 Percentile:90.15(Astronomy & Astrophysics)

The neutrino-nucleus reaction cross sections of $$^4$$He and $$^{12}$$C are evaluated using new shell model Hamiltonians. The new cross sections enhance the yields of $$^7$$Li and $$^{11}$$B produced during the supernova explosion of a 16.2 $$M_odot$$ star model compared to the case using the conventional cross sections by about 10%. On the other hand, the yield of $$^{10}$$B decreases by a factor of two. The yields of $$^6$$Li, $$^9$$Be, and the radioactive nucleus $$^{10}$$Be are found at a level of $$sim 10^{-11} M_odot$$. The temperature of $$nu_{mu,tau}$$- and $$bar{nu}_{mu,tau}$$-neutrinos inferred from the supernova contribution of $$^{11}$$B in Galactic chemical evolution models is constrained to be in the range 4.3 MeV to 6.5 MeV. The increase in the $$^7$$Li and $$^{11}$$B yields due to neutrino oscillations is demonstrated with the new cross sections.

Journal Articles

Structure study of thin films by employing anomalous dispersion of synchrotron X-rays

Mizuki, Junichiro; Kimura, Hidekazu*

Oyo Butsuri, 68(11), p.1271 - 1274, 1999/11

no abstracts in English

Journal Articles

The XAFS beamline BL01B1 at SPring-8

Uruga, Tomoya*; Tanida, Hajime*; Yoneda, Yasuhiro; Takeshita, Kunikazu*; Emura, Shuichi*; Takahashi, Masao*; Harada, Makoto*; Nishihata, Yasuo; Kubozono, Yoshihiro*; Tanaka, Tsunehiro*; et al.

Journal of Synchrotron Radiation, 6(Part3), p.143 - 145, 1999/05

An x-ray absorption fine-structure (XAFS) spectroscopy beamline, BL01B1, was installed at a bending magnet source at SPring-8 and has been open to users since October 1997. It was designed for XAFS experiments covering a wide energy range. Position tables and automatical control programs were established to adjust the x-ray optics and achieve the designed performance of the beamline under each experimental condition. This has enabled conventional XAFS measurements to be made with a good data quality from 4.5 to 110 keV.

Journal Articles

Eu ${it K}$-XAFS of europium dioxymonocyanamide with the convension He$$^+$$ ion yield method

Takahashi, Masao*; Harada, Makoto*; Watanabe, Iwao*; Uruga, Tomoya*; Tanida, Hajime*; Yoneda, Yasuhiro; Emura, Shuichi*; Tanaka, Tsunehiro*; Kimura, Hidekazu*; Kubozono, Yoshihiro*; et al.

Journal of Synchrotron Radiation, 6(3), p.222 - 224, 1999/05

 Times Cited Count:10 Percentile:59.73(Instruments & Instrumentation)

no abstracts in English

Oral presentation

Preparation of $$^{188}$$Re-labeled antibody (A7) by a simple method using rhenium(I) tricarbonyl complex

Ogawa, Kazuma*; Kawashima, Hidekazu*; Kinuya, Seigo*; Yoshimoto, Mitsuyoshi*; Shiba, Kazuhiro*; Kimura, Hiroyuki*; Hashimoto, Kazuyuki; Mori, Hirofumi*; Saji, Hideo*

no journal, , 

$$^{188}$$Re is one of the most useful radionuclides for internal radiotherapy. However, there is a problem when protein such as antibody is used as a carrier of $$^{188}$$Re. The labeling method using bifunctional chelating agents require the conjugation of $$^{188}$$Re-complex to protein after radiolabeling with the bifunctional chelating agent. Then, we planned the preparation of a stable $$^{188}$$Re-labeled protein by a simple method. A7 monoclonal antibody was labeled by reacting $$^{188}$$Re(I) tricarbonyl precursor with A7 directly. $$^{188}$$Re labeled A7 was prepared with radiochemical yield of 23%. After purification, $$^{188}$$Re labeled A7 showed radiochemical purity over 98%. After 24 hours of incubation, about 93% of $$^{188}$$Re-A7 remained intact, which indicates $$^{188}$$Re-A7 is stable in vitro. In biodistribution experiment, 11.2% of the injected dose/g of $$^{188}$$Re-A7 accumulated in the tumor at 24 hours postinjection, and tumor to blood ratio was over 1.0 at the same time.

Oral presentation

Synthesis and evaluation of $$^{186}$$Re-labeled biotin as a labeling agent for antibodies

Hirasawa, Makoto*; Kawashima, Hidekazu*; Ogawa, Kazuma*; Kimura, Hiroyuki*; Ono, Masahiro*; Hashimoto, Kazuyuki; Saji, Hideo*

no journal, , 

no abstracts in English

Oral presentation

Pretargeted radioimmunotherapy of tumor using a novel radiorhenium-labeled biotin derivative and streptavidin conjugated anti-cytokeratin 19 monoclonal antibody

Kawashima, Hidekazu*; Hirasawa, Makoto*; Kimura, Hiroyuki*; Ono, Masahiro*; Hashimoto, Kazuyuki; Saji, Hideo*

no journal, , 

no abstracts in English

9 (Records 1-9 displayed on this page)
  • 1