Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Pt-labeled platinum complex and evaluation of its biodistribution in healthy miceOmokawa, Marina*; Kimura, Hiroyuki*; Hatsukawa, Yuichi*; Kawashima, Hidekazu*; Tsukada, Kazuaki; Yagi, Yusuke*; Naito, Yuki*; Yasui, Hiroyuki*
Bioorganic & Medicinal Chemistry, 97, p.117557_1 - 117557_6, 2024/01
Times Cited Count：0 Percentile：0.01(Biochemistry & Molecular Biology)
Re-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate siteOgawa, Kazuma*; Kawashima, Hidekazu*; Kinuya, Seigo*; Shiba, Kazuhiro*; Onoguchi, Masahisa*; Kimura, Hiroyuki*; Hashimoto, Kazuyuki; Odani, Akira*; Saji, Hideo*
Annals of Nuclear Medicine, 23(10), p.843 - 848, 2009/12
Times Cited Count：9 Percentile：31.42(Radiology, Nuclear Medicine & Medical Imaging)Rhenium is one of the most valuable elements for internal radiotherapy because Re have favorable physical characteristics. However, there are problems when proteins such as antibodies are used as carriers of Re. Labeling methods require the complicated processes. Therefore, we planned the preparation by a simple method and evaluation of a stable Re-labeled antibody. For this purpose, we selected Re(I) tricarbonyl complex as a chelating site. A7 was used as a model protein. Re-labeled A7 was prepared by directly reacting a Re(I) tricarbonyl precursor with A7. Re-(CO)
-A7 were prepared with radiochemical yields of 23-28%. After purification, Re-(CO)-A7 showed a radiochemical purity of over 95%. In biodistribution experiments, Re-labeled A7 showed high uptakes in the tumor.
Yoshida, Takashi*; Suzuki, Toshio*; Chiba, Satoshi; Kajino, Toshitaka*; Yokomakura, Hidekazu*; Kimura, Keiichi*; Takamura, Akira*; Hartmann, D.*
Astrophysical Journal, 686(1), p.448 - 466, 2008/10
The neutrino-nucleus reaction cross sections of 
He and 
C are evaluated using new shell model Hamiltonians. Branching ratios of various decay channels are calculated to evaluate the yields of Li, Be, and B produced through the 
-process in supernova explosions. The new cross sections enhance the yields of 
Li and 
B produced during the supernova explosion of a 16.2 M
star model compared to our previous study by factors of 1.3 and 1.2, respectively. On the other hand, the yield of 
B decreases by a factor of three. The yields of 
Li, 
Be, and the radioactive nucleus Be are found at a level of 10 to 11 M. The temperature of 
- and 
-neutrinos inferred from the supernova contribution of B in Galactic chemical evolution models is constrained to be in the range 4.5 MeV to 6.4 MeV. The increase in the Li and B yields due to neutrino oscillations is demonstrated with the new cross sections.
Yoshida, Takashi*; Suzuki, Toshio*; Chiba, Satoshi; Kajino, Toshitaka*; Yokomakura, Hidekazu*; Kimura, Keiichi*; Takamura, Akira*; Hartmann, D. H.*
Astrophysical Journal, 686(1), p.448 - 466, 2008/10
Times Cited Count：92 Percentile：89.6(Astronomy & Astrophysics)The neutrino-nucleus reaction cross sections of He and C are evaluated using new shell model Hamiltonians. The new cross sections enhance the yields of 
Li and B produced during the supernova explosion of a 16.2 
star model compared to the case using the conventional cross sections by about 10%. On the other hand, the yield of B decreases by a factor of two. The yields of 
Li, 
Be, and the radioactive nucleus Be are found at a level of 
. The temperature of 
- and 
-neutrinos inferred from the supernova contribution of B in Galactic chemical evolution models is constrained to be in the range 4.3 MeV to 6.5 MeV. The increase in the Li and B yields due to neutrino oscillations is demonstrated with the new cross sections.
Mizuki, Junichiro; Kimura, Hidekazu*
Oyo Butsuri, 68(11), p.1271 - 1274, 1999/11
no abstracts in English
Uruga, Tomoya*; Tanida, Hajime*; Yoneda, Yasuhiro; Takeshita, Kunikazu*; Emura, Shuichi*; Takahashi, Masao*; Harada, Makoto*; Nishihata, Yasuo; Kubozono, Yoshihiro*; Tanaka, Tsunehiro*; et al.
Journal of Synchrotron Radiation, 6(Part3), p.143 - 145, 1999/05
An x-ray absorption fine-structure (XAFS) spectroscopy beamline, BL01B1, was installed at a bending magnet source at SPring-8 and has been open to users since October 1997. It was designed for XAFS experiments covering a wide energy range. Position tables and automatical control programs were established to adjust the x-ray optics and achieve the designed performance of the beamline under each experimental condition. This has enabled conventional XAFS measurements to be made with a good data quality from 4.5 to 110 keV.
-XAFS of europium dioxymonocyanamide with the convension He
ion yield methodTakahashi, Masao*; Harada, Makoto*; Watanabe, Iwao*; Uruga, Tomoya*; Tanida, Hajime*; Yoneda, Yasuhiro; Emura, Shuichi*; Tanaka, Tsunehiro*; Kimura, Hidekazu*; Kubozono, Yoshihiro*; et al.
Journal of Synchrotron Radiation, 6(3), p.222 - 224, 1999/05
Times Cited Count：11 Percentile：61.16(Instruments & Instrumentation)no abstracts in English
Re-labeled antibody (A7) by a simple method using rhenium(I) tricarbonyl complexOgawa, Kazuma*; Kawashima, Hidekazu*; Kinuya, Seigo*; Yoshimoto, Mitsuyoshi*; Shiba, Kazuhiro*; Kimura, Hiroyuki*; Hashimoto, Kazuyuki; Mori, Hirofumi*; Saji, Hideo*
no journal, ,
Re is one of the most useful radionuclides for internal radiotherapy. However, there is a problem when protein such as antibody is used as a carrier of Re. The labeling method using bifunctional chelating agents require the conjugation of Re-complex to protein after radiolabeling with the bifunctional chelating agent. Then, we planned the preparation of a stable Re-labeled protein by a simple method. A7 monoclonal antibody was labeled by reacting Re(I) tricarbonyl precursor with A7 directly. Re labeled A7 was prepared with radiochemical yield of 23%. After purification, Re labeled A7 showed radiochemical purity over 98%. After 24 hours of incubation, about 93% of Re-A7 remained intact, which indicates Re-A7 is stable in vitro. In biodistribution experiment, 11.2% of the injected dose/g of Re-A7 accumulated in the tumor at 24 hours postinjection, and tumor to blood ratio was over 1.0 at the same time.
Re-labeled biotin as a labeling agent for antibodiesHirasawa, Makoto*; Kawashima, Hidekazu*; Ogawa, Kazuma*; Kimura, Hiroyuki*; Ono, Masahiro*; Hashimoto, Kazuyuki; Saji, Hideo*
no journal, ,
no abstracts in English
Kawashima, Hidekazu*; Hirasawa, Makoto*; Kimura, Hiroyuki*; Ono, Masahiro*; Hashimoto, Kazuyuki; Saji, Hideo*
no journal, ,
no abstracts in English
