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particle impinging on Al at 230 MeV/uFuruta, Toshimasa*; Uozumi, Yusuke*; Yamaguchi, Yuji; Iwamoto, Yosuke; Koba, Yusuke*; Velicheva, E.*; Kalinnikov, V.*; Tsamalaidze, Z.*; Evtoukhovitch, P.*
Journal of Nuclear Science and Technology, 61(2), p.230 - 236, 2024/02
Times Cited Count：0 Percentile：0.01(Nuclear Science & Technology)Charged particle production from particle fragmentation reactions was investigated experimentally by measurement of 230-MeV/u particles bombarding an aluminum target. Double differential cross sections were measured for each ejectile of p, d, t, 
He, and 
He at laboratory angles between 15 and 60 deg. The results of analyzed data found the following common characteristics: (1) spectra of proton- and neutron-emission are similar in high energy region at forward angle, (2) triton-to-He ratio of -breakup yield is 1:2, which is similar to lower incident energy experiment, and (3) the shape of broad peak formed by He and particles could be explained by the process with collision between induced particle and target nucleus.
Furuta, Takuya; Koba, Yusuke*; Hashimoto, Shintaro; Chang, W.*; Yonai, Shunsuke*; Matsumoto, Shinnosuke*; Ishikawa, Akihisa*; Sato, Tatsuhiko
Physics in Medicine & Biology, 67(14), p.145002_1 - 145002_15, 2022/07
Times Cited Count：2 Percentile：47.19(Engineering, Biomedical)Carbon ion radiotherapy has an advantage over conventional radiotherapy such that its superior dose concentration on the tumor helps to reduce unwanted dose to surrounding normal tissues. Nevertheless, a little dose to normal tissues, which is a potential risk of secondary cancer, is still unavoidable. The Monte Carlo simulation is a good candidate for the tool to assess secondary cancer risk, including the contributions of secondary particles produced by nuclear reactions. We therefore developed a new dose reconstruction system implementing PHITS as the engine. In this system, the PHITS input is automatically created from the DICOM data sets recorded in the treatment planning. The developed system was validated by comparing to experimental dose distribution in water and treatment plan on an anthropomorphic phantom. This system will be used for retrospective studies using the patient data in National Institute for Quantum and Science and Technology.
Chang, W.*; Koba, Yusuke*; Furuta, Takuya; Yonai, Shunsuke*; Hashimoto, Shintaro; Matsumoto, Shinnosuke*; Sato, Tatsuhiko
Journal of Radiation Research (Internet), 62(5), p.846 - 855, 2021/09
Times Cited Count：2 Percentile：26.61(Biology)With the aim of developing a revaluation tool of treatment plan in carbon-ion radiotherapy using Monte Carlo (MC) simulation, we propose two methods; one is dedicated to identify realistic-tissue materials from a CT image with satisfying the well-calibrated relationship between CT numbers and stopping power ratio (SPR) provided by TPS, and the other is to estimate dose to water considering the particle- and energy-dependent SPR between realistic tissue materials and water. We validated these proposed methods by computing depth dose distribution in homogeneous and heterogeneous phantoms composed of human tissue materials and water irradiated by a 400 MeV/u carbon beam with 8 cm SOBP using a MC simulation code PHITS and comparing with results of conventional treatment planning system (TPS). Our result suggested that use of water as a surrogate of real tissue materials, which is adopted in conventional TPS, is inadequate for dose estimation from secondary particles because their production rates cannot be scaled by SPR of the primary particle in water. We therefore concluded that the proposed methods can play important roles in the reevaluation of the treatment plans in carbon-ion radiotherapy.
Itashiki, Yutaro*; Imabayashi, Yoichi*; Shigyo, Nobuhiro*; Uozumi, Yusuke*; Satoh, Daiki; Kajimoto, Tsuyoshi*; Sanami, Toshiya*; Koba, Yusuke*; Matsufuji, Naruhiro*
Journal of Radiation Protection and Research, 41(4), p.344 - 349, 2016/12
Carbon ion therapy has achieved satisfactory results because of high curability and minimally invasiveness. However, patients have a risk to get a secondary cancer. In order to estimate the risk, it is essential to understand particle transportation and nuclear reactions in the patient's body. The particle transport Monte Carlo simulation code is a useful tool to understand them. Since the code validation for heavy ion incident reactions is not enough, the experimental data of the elementary reaction processes is needed. We measured neutron production double-differential cross-sections (DDXs) on a carbon bombarded with 430 MeV/nucleon carbon beam which is a possible candidate of future therapy beam. The experiment was performed at PH2 beam line of the HIMAC of National Institute of Radiological Sciences. The 430 MeV/nucleon carbon beam was irradiated on a 5 cm 
5 cm 1 cm graphite target rotated 45
to the beam axis. The beam intensity was set to 10
particles / spill. A 0.5 mm thick NE102A plastic scintillator was placed to monitor the beam intensity. Neutrons produced in the target were measured with two sizes of NE213 liquid organic scintillators located at six angles of 15, 30, 45, 60, 75, and 90. The 5.08 cm long one was used to obtain the neutron spectra from 1 MeV to 10 MeV and the 12.7 cm long one was used above 5 MeV. The 2 mm thick NE102A plastic scintillators to discriminate charged particles were set in front of the neutron detectors. The kinetic energies of neutrons were determined by the time-of-flight (TOF) method. Background neutrons were estimated by a measurement with iron shadow bars between the target and each neutron detector. An electronic circuit for data acquisition consisted of NIM and CAMAC modules. The experimental data was compared with calculated results obtained by Monte Carlo simulation codes as PHITS. The PHITS code reproduced the experimental data well.
Satoh, Daiki; Kajimoto, Tsuyoshi*; Shigyo, Nobuhiro*; Itashiki, Yutaro*; Imabayashi, Yoichi*; Koba, Yusuke*; Matsufuji, Naruhiro*; Sanami, Toshiya*; Nakao, Noriaki*; Uozumi, Yusuke*
Nuclear Instruments and Methods in Physics Research B, 387, p.10 - 19, 2016/11
Times Cited Count：3 Percentile：28.28(Instruments & Instrumentation)Double-differential neutron yields from a water phantom bombarded with 290-MeV/nucleon and 430-MeV/nucleon carbon ions were measured at emission angles of 15, 30, 45, 60, 75, and 90 using the neutron-detection system constituting of liquid organic scintillators. The angular distributions of neutron yields and effective doses around the phantom were obtained by integrating the double-differential neutron yields and applying the fluence-to-effective dose conversion coefficients. The experimental data were compared with results of the Monte-Carlo simulation code PHITS. The PHITS results showed good agreement with the measured data. From the results, we concluded that the PHITS simulation is applicable to the dose estimation at carbon-therapy facilities.
Shigyo, Nobuhiro*; Uozumi, Yusuke*; Imabayashi, Yoichi*; Itashiki, Yutaro*; Satoh, Daiki; Kajimoto, Tsuyoshi*; Sanami, Toshiya*; Koba, Yusuke*; Takada, Masashi*; Matsufuji, Naruhiro*; et al.
JAEA-Conf 2014-002, p.81 - 87, 2015/02
Cancer therapy using heavy ion beam has been adopted as highly advanced medical treatment by reason of its clinical advantages. It has become more important to estimate the risk of secondary cancer from recent survey. During treatment, secondary particles such as neutrons and -rays are producedby heavy ion induced nuclear reactions in a patient body as well as beam delivery apparatuses. For the risk assessment of secondary cancer, it is essential to know contribution of secondary neutrons by extra dose to organs in the vicinity of the irradiated tumor because the secondary neutron has a long flight path length and gives undesired dose to normal tissues in a wide volume. The experimental data of neutron energy spectra are required for dose estimations with high accuracy. Especially, precise data around neutron energy of 1 MeV is required because neutron of the energy region has a large relative biological eectiveness. Estimation of the secondary neutron yield data is important for estimation of radiation safety on both of workers and public in treatment facilities.
Kajimoto, Tsuyoshi*; Hashiguchi, Taro*; Shigyo, Nobuhiro*; Satoh, Daiki; Uozumi, Yusuke*; Song, T. Y.*; Lee, C. W.*; Kim, J. W.*; Yang, S. C.*; Koba, Yusuke*; et al.
JAEA-Conf 2014-002, p.127 - 132, 2015/02
Particle transport Monte Carlo codes such as PHITS, FLUKA and so on are used for radiation safety design of high energy accelerators. The validity of code is confirmed by comparison with many experimental data. In this study, we report proton, deuteron, and triton production double differential cross sections (DDXs) from a graphite target by 290 MeV/nucleon Ar ions. The measured spectra are compared with those calculated by PHITS and FLUKA codes.
Shigyo, Nobuhiro*; Uozumi, Yusuke*; Uehara, Haruhiko*; Nishizawa, Tomoya*; Mizuno, Takafumi*; Takamiya, Masanori*; Hashiguchi, Taro*; Satoh, Daiki; Sanami, Toshiya*; Koba, Yusuke*; et al.
Nuclear Data Sheets, 119, p.303 - 306, 2014/05
Times Cited Count：0 Percentile：0.02(Physics, Nuclear)Heavy ion cancer therapy has been increased by reason of its clinical advantages. During the treatment, the secondary particles such as neutron and 
-ray are produced by nuclear reactions of a heavy ion incidence on a nucleus in a patient body. Estimation of the secondary neutrons yields data is essential for assessment of radiation safety on both of workers and public in treatment facilities. We have measured the neutron yields from carbon ion incidence on carbon, nitrogen and oxygen targets in wide angular range from 15 to 90 with 100- and 290-MeV/u.
Shigyo, Nobuhiro*; Uozumi, Yusuke*; Uehara, Haruhiko*; Nishizawa, Tomoya*; Hirabayashi, Keiichi*; Satoh, Daiki; Sanami, Toshiya*; Koba, Yusuke*; Takada, Masashi*; Matsufuji, Naruhiro*
Progress in Nuclear Science and Technology (Internet), 4, p.709 - 712, 2014/04
Heavy ion cancer therapy has been increased by reason of its clinical advantages. During the treatment, the secondary particles such as neutron and -ray are produced by nuclear reactions of a heavy ion incidence on a nucleus in a patient body. Estimation of the secondary neutrons yields data is essential for assessment of radiation safety on both of workers and public in treatment facilities. Neutron energy spectra from a water phantom simulating the patient body were obtained at GSI only for forward directions. We measured the neutron yields from carbon ion incident on a water phantom in wide angular range from 15 to 90 with the therapeutic ion energy.
Shigyo, Nobuhiro*; Uozumi, Yusuke*; Uehara, Haruhiko*; Nishizawa, Tomoya*; Mizuno, Takafumi*; Satoh, Daiki; Sanami, Toshiya*; Koba, Yusuke*; Takada, Masashi*; Matsufuji, Naruhiro*
JAEA-Conf 2013-002, p.137 - 142, 2013/10
Heavy ion cancer therapy has been increased by reason of its clinical advantages. During the treatment, the secondary particles such as neutron and -ray are produced by nuclear reactions of a heavy ion incidence on a nucleus in a patient body. Estimation of double differential cross sections of secondary neutron is important to risk assessment of extra dose to organs in the vicinity of the irradiated tumor. Accurate data in neutron energy around 1 MeV is required because neutron in the energy region has large relative biological effectiveness. Neutron double differential cross sections by inducing 290 MeV/u carbon ion to bio-elements have been obtained experimentally. In order to have knowledge of neutron production by deceleration carbon in a human body, we measured the neutron yields from carbon ion incidence on a carbon target of neutron energy below 1 MeV in wide angular range from 15 to 90 with 100 MeV/u.
Uozumi, Yusuke*; Shigyo, Nobuhiro*; Uehara, Haruhiko*; Nishizawa, Tomoya*; Mizuno, Takafumi*; Satoh, Daiki; Sanami, Toshiya*; Koba, Yusuke*; Takada, Masashi*; Matsufuji, Naruhiro*; et al.
HIMAC-140, p.234 - 235, 2013/08
In the heavy-ion radiotherapy, considerable discussion has been attracted regarding the potential for second cancer induction by secondary neutrons produced from the primary heavy-ion fragmentation. We have started new measurements at 100 MeV/u to investigate the neutron production by heavy ions decelerating in a patient body.
Uozumi, Yusuke*; Shigyo, Nobuhiro*; Kajimoto, Tsuyoshi*; Hirabayashi, Keiichi*; Uehara, Haruhiko*; Nishizawa, Tomoya*; Satoh, Daiki; Sanami, Toshiya*; Koba, Yusuke*; Takada, Masashi*; et al.
HIMAC-138, p.237 - 238, 2012/08
In the heavy-ion radiotherapy, considerable discussion has been attracted regarding the potential for second cancer induction by secondary neutrons produced from the primary heavy-ion fragmentation. It is important to measure energy-angle double-differential cross sections (DDXs) of neutron- and photon-productions in heavy-ion nuclear reactions. Since it is notoriously hard to measure the spectral cross sections of neutrons in an energy range of around 1 MeV where the RBE value reaches at its maximum. In the project by last year, experiments were carried out at the synchrotron HIMAC of NIRS, Japan. The beams were 
C and 
O of 290 MeV/u and bombarded a carbon target. In measurements of neutrons and photons were used liquid scintillator detectors of 5" and 2". We have succeeded to lower the neutron energy threshold down to 0.6 MeV. The present results for neutron productions are in reasonable agreements with PHITS. Since our goal in technical aspects has been fulfilled, measurements will be continued for other reactions.
Uozumi, Yusuke*; Shigyo, Nobuhiro*; Kajimoto, Tsuyoshi*; Moriguchi, Daisuke*; Ueyama, Masahiko*; Yoshioka, Masakatsu*; Satoh, Daiki; Sanami, Toshiya*; Koba, Yusuke*; Takada, Masashi*; et al.
HIMAC-136, p.248 - 249, 2011/11
no abstracts in English
Satoh, Daiki; Moriguchi, Daisuke*; Kajimoto, Tsuyoshi*; Koba, Yusuke*; Nakamura, Yasuhiro*; Shigyo, Nobuhiro*; Ueyama, Masahiko*; Uozumi, Yusuke*; Yoshioka, Masakatsu*; Matsufuji, Naruhiro*; et al.
Journal of the Korean Physical Society, 59(2), p.1741 - 1744, 2011/08
Times Cited Count：3 Percentile：27.54(Physics, Multidisciplinary)The data of neutron production from heavy-ion interactions are of great importance for the dose assessment in heavy-ion therapy. We have already evaluated the data of neutron production for thick targets, in which the incident heavy ions completely stop, by the measurements and the reevaluation of the existing data reported by Kurosawa et al. As a next step of the research, we plan to evaluate the neutron-production cross-section data for thin targets. These data are useful to understand the mechanism of heavy-ion interaction, and improve the reaction model in particle transport codes. The previously reported cross-section data by Iwata et al. were revised by using a new set of neutron-detection efficiency values calculated with SCINFUL-QMD code. While the original data gave the larger values than the predictions of particle transport codes above 200 MeV due to the underestimation of the efficiencies, it was improved by this revision. In addition, we have started the new cross-section measurements at HIMAC. All the data of neutron-production cross sections were compared with the predictions of particle transport codes.
Satoh, Daiki; Moriguchi, Daisuke*; Kajimoto, Tsuyoshi*; Uehara, Haruhiko*; Shigyo, Nobuhiro*; Ueyama, Masahiko*; Yoshioka, Masakatsu*; Uozumi, Yusuke*; Sanami, Toshiya*; Koba, Yusuke*; et al.
Nuclear Instruments and Methods in Physics Research A, 644(1), p.59 - 67, 2011/07
Times Cited Count：18 Percentile：77.43(Instruments & Instrumentation)Neutron-production double-differential cross sections on carbon-carbon and oxygen-carbon reactions with incident heavy-ion energy of 290 MeV/nucleon were measured by time-of-flight method using liquid organic scintillators. By use of a detection system specialized for low-energy neutrons, the cross sections were obtained in a wide energy region from several hundred MeV down to 0.6 MeV for the oxygen-ion incidences. The experimental data were compared with the calculation results using the Monte-Carlo simulation code, PHITS. The PHITS results gave an overall agreement with the measured data within a factor of two.
Uozumi, Yusuke*; Iwamoto, Hiroki*; Koba, Yusuke*; Matsufuji, Naruhiro*; Sanami, Toshiya*; Satoh, Daiki; Shigyo, Nobuhiro*; Takada, Masashi*; Ueyama, Masahiko*; Yoshioka, Masakatsu*; et al.
Progress in Nuclear Science and Technology (Internet), 1, p.114 - 117, 2011/02
It is important to assess and suppress the potential for second cancer induction by secondary neutrons produced in primary heavy-ion fragmentation in patient body. Since it is very difficult to measure high-energy neutron doses in mixed radiation fields, a Monte-Carlo simulation approach has attracted much attention as an alternative for neutron dose estimation. It is notoriously hard to reproduce the spectral cross sections of neutrons from high-energy heavy-ion collisions. We, therefore, have planned experiments to measure energy-angle double-differential cross sections of nuclear reactions.
Iwamoto, Hiroki; Imamura, Minoru*; Koba, Yusuke*; Fukui, Yoshinori*; Wakabayashi, Genichiro*; Uozumi, Yusuke*; Kin, Tadahiro; Iwamoto, Yosuke; Hohara, Shinya*; Nakano, Masahiro*
Physical Review C, 82(3), p.034604_1 - 034604_8, 2010/09
Times Cited Count：13 Percentile：63.2(Physics, Nuclear)We investigate proton-production double-differential cross sections (DDXs) for 300- and 392-MeV proton-induced reactions on O, V, Tb, Ta, Au, Pb, and Bi. Emitted proton energies are measured with stacked scintillator spectrometers by the 
- technique. Experimental results are compared with the intranuclear cascade (INC) and quantum molecular dynamics models. Although both models can reproduce spectral DDXs, there is a difference at the most forward and backward angles. The cause of these differences is discussed in terms of the refraction caused by the nuclear potential. Angular distributions of the present data are well accounted for by the Kalbach systematics plus INC one-step calculations. The quasi-free-scattering contribution increases with decreasing target mass and increasing emission energy.
Satoh, Daiki; Moriguchi, Daisuke*; Nakamura, Yasuhiro*; Kajimoto, Tsuyoshi*; Ueyama, Masahiko*; Yoshioka, Masakatsu*; Koba, Yusuke*; Shigyo, Nobuhiro*; Uozumi, Yusuke*; Matsufuji, Naruhiro*; et al.
no journal, ,
Neutron production double differential cross sections have been measured at HIMAC in National Institute of Radiological Sciences. The cross sections were obtained in the energy region from a few MeV to several hundred MeV. In addition, we got the systematic cross section data by revising the detection efficiencies in the existing data. All the data were compared with the predictions of Monte Carlo simulation codes. While the codes show a good agreement in the backward angular region, they can not reproduce the peak structure observed in the forward angular region. This indicates that the nucleus-nucleus reaction model in the simulation codes must be revised.
Satoh, Daiki; Shigyo, Nobuhiro*; Uozumi, Yusuke*; Moriguchi, Daisuke*; Kajimoto, Tsuyoshi*; Yoshioka, Masakatsu*; Ueyama, Masahiko*; Sanami, Toshiya*; Koba, Yusuke*; Matsufuji, Naruhiro*; et al.
no journal, ,
Neutron-production double-differential cross sections from heavy-ion interactions have been measured at Heavy-Ion Medical Accelerator in Chiba (HIMAC) of National Institute of Radiological Sciences (NIRS), Japan. 290-MeV/u O ions were bombarded upon a carbon target. The outgoing neutrons from the target were measured by a detection system that consist of two sizes of liquid organic scintillators with Time-of-Flight (TOF) technique in order to obtain a wide range of neutron spectrum from sub MeV to several hundred MeV. We have successfully measured the cross sections with a good precision.
Shigyo, Nobuhiro*; Uozumi, Yusuke*; Kajimoto, Tsuyoshi*; Moriguchi, Daisuke*; Ueyama, Masahiko*; Yoshioka, Masakatsu*; Koba, Yusuke*; Nakamura, Yasuhiro*; Satoh, Daiki; Sanami, Toshiya*; et al.
no journal, ,
Radiation dose by neutrons produced by proton and heavy ion induced nuclear reactions around tumor is essential for dose assessment in proton and heavy ion radiotherapies. Double differential cross section (DDX) of neutron production is one of important physical quantities for dose estimation by radiation transport codes. Some experimental data of neutron production DDXs have been reported above 5 MeV of neutron energy for heavy ion incident reactions. Neutron production DDX for carbon ion incidence on carbon target was measured at the Heavy Ion Medical Accelerator in Chiba (HIMAC) including low neutron energy region for validation of radiation transport codes. Incident carbon energy was 290 MeV/u. NE213 liquid organic scintillators were deployed as neutron detectors and placed at 15, 30 45, 60, 75 and 90. Neutron energies were determined by the time-of-flight methods. Neutron detection efficiency was calculated by the SCINFUL-QMD code. The obtained minimum neutron energy was about 2.8 MeV. The experimental data of neutron production DDX was compared with that by one of radiation transport codes, PHITS.
