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Journal Articles

Impressions of the 3rd Joint Meeting of Japanese Society of Radiation Safety Management and Japan Health Physics Society

Watanabe, Yuki; Tsuji, Tomoya; Hirota, Seiko*; Hokama, Tomonori; Nakajima, Junya; Tsujiguchi, Takakiyo*; Kimura, Tatsuki*; Koike, Hiromi*; Nakamura, Kaori*; Kuwata, Haruka*; et al.

Hoken Butsuri (Internet), 57(1), p.54 - 64, 2022/03

no abstracts in English

Journal Articles

Report on social communication activities of Young Researchers Association and Students Association of JHPS; Chiba-shi Science Festa

Yamada, Ryohei; Kono, Takahiko; Nakajima, Junya; Hirouchi, Jun; Tsuji, Tomoya; Umeda, Masayuki; Igarashi, Yu*; Koike, Hiromi*

Hoken Butsuri (Internet), 56(1), p.32 - 38, 2021/03

no abstracts in English

Journal Articles

Impressions of the 53rd Annual Meeting of Japan Health Physics Society

Hirouchi, Jun; Tani, Kotaro*; Tamakuma, Yuki*; Nakasone, Shunya*; Koike, Hiromi*

Hoken Butsuri (Internet), 55(4), p.185 - 190, 2020/12

no abstracts in English

Journal Articles

"J-KAREN"; High intensity, high contrast laser

Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya*; Tanoue, Manabu*; Okada, Hajime; Sasao, Hajime; Wakai, Daisuke*; Kondo, Shuji; Kanazawa, Shuhei; et al.

JAEA-Conf 2009-007, p.97 - 100, 2010/03

no abstracts in English

Journal Articles

Generation of above 10$$^{10}$$ temporal contrast, above 10$$^{20}$$W/cm$$^2$$ peak intensity pulses at a 10 Hz repetition rate using an OPCPA preamplifier in a double CPA, Ti:sapphire laser system

Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.

AIP Conference Proceedings 1153, p.3 - 6, 2009/07

We demonstrate a high-contrast, high-intensity double chirped-pulse amplification (CPA) Ti:sapphire laser system using an optical parametric chirped-pulse amplifier (OPCPA) as a preamplifier. By injecting cleaned microjoule seed pulses into the OPCPA, a temporal contrast greater than 10$$^{10}$$ within picosecond times before the main femtosecond pulse is demonstrated with the output pulse energy of 1.7 J and pulse duration of 30 fs, corresponding to a peak power of 60 TW at a 10 Hz repetition rate. This system uses a cryogenically-cooled Ti:sapphire final amplifier and generates focused peak intensities in excess of 10$$^{20}$$ W/cm$$^2$$.

Journal Articles

Design, synthesis, and evaluation of [$$^{188}$$Re]Organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels

Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Hashimoto, Kazuyuki; Akizawa, Hiromichi*; Endo, Keigo*; Arano, Yasushi*

Bioconjugate Chemistry, 18(1), p.190 - 198, 2007/01

 Times Cited Count:15 Percentile:50.52(Biochemical Research Methods)

Renal localization of radiolabeled antibody fragments constitutes a problem in targeted imaging and radiotherapy. To estimate the applicability of the molecular design to metallic radionuclides, [$$^{188}$$Re]tricarbonyl(cyclopentadienylcarbonate)rhenium ([$$^{188}$$Re]CpTR-COOH) was conjugated with maleoyl-glycyl-lysine to prepare [$$^{188}$$Re]CpTR-GK. The cleavage of the glycyl-lysine linkage of the compound generates a glycine conjugate of [$$^{188}$$Re]CpTR-Gly. [$$^{188}$$Re]CpTR-GK was conjugated to thiolated Fab fragments to prepare [$$^{188}$$Re]CpTR-GK-Fab. The biodistribution of radioactivity after injection of [$$^{188}$$Re]CpTR-GK-Fab was compared with that of [$$^{188}$$Re]CpTR-Fab. [$$^{188}$$Re]CpTR-GK-Fab exhibited significantly lower renal radioactivity levels than did [$$^{188}$$Re]CpTR-Fab. The analysis of urine samples collected for 6 h postinjection of [$$^{188}$$Re]CpTR-GK-Fab showed that [$$^{188}$$Re]CpTR-Gly was the major radiometabolite. In tumor-bearing mice, [$$^{188}$$Re]CpTR-GK-Fab significantly reduced renal radioactivity levels without impairing the radioactivity levels in tumor. These findings indicate that the molecular design of radioparmaceuticals labeled with metallic radionuclides can be useful by using a radiometal chelate of high inertness and by designing a radiometabolite of high urinary excretion when released from antibody fragments following cleavage of a glycyl-lysine linkage. This study also indicates that a change in chemical structure of a radiolabel attached to a glycyl-lysine linkage significantly affected enzymes involved in the hydrolysis reaction.

Journal Articles

Characterization and degradation of ZEP520 resist film by TOF-PSID and NEXAFS

Ikeura, Hiromi*; Sekiguchi, Tetsuhiro; Koike, Masaki*

Journal of Electron Spectroscopy and Related Phenomena, 144-147, p.453 - 455, 2005/06

 Times Cited Count:15 Percentile:59.09(Spectroscopy)

no abstracts in English

Journal Articles

Anion-exchange behavior of Rf in HCl and HNO$$_{3}$$ solutions

Haba, Hiromitsu; Tsukada, Kazuaki; Asai, Masato; Goto, Shinichi*; Toyoshima, Atsushi; Nishinaka, Ichiro; Akiyama, Kazuhiko; Hirata, Masaru; Ichikawa, Shinichi; Nagame, Yuichiro; et al.

Journal of Nuclear and Radiochemical Sciences, 3(1), p.143 - 146, 2002/06

We have investigated the sorption behavior of element 104 rutherfordium (Rf) on an anion exchange resin from HCl and HNO$$_{3}$$ solutions. In the HCl experiments, the distribution coefficients of Rf increase with an increase of HCl concentration from 7.0 M to 11.5 M, indicating that anionic species such as [Rf(OH)Cl$$_{5}$$]$$^{2-}$$ or [RfCl$$_{6}$$]$$^{2-}$$ are formed. This sorption behavior of Rf is typical of the group-4 elements Zr and Hf, and is quite different from that of the pseudo-homologue Th. It is also noted that the distribution coefficients decrease in the order Rf, Zr, Hf at 9.0 M HCl, which is consistent with the expected order of ionic radii. On the other hand, Rf appears to behave like Zr and Hf in 8 M HNO$$_{3}$$ not like Pu and Th.

Oral presentation

Research activities in our laser R&D group; Present & future

Sugiyama, Akira; Kondo, Kiminori; Kiriyama, Hiromitsu; Ochi, Yoshihiro; Tanaka, Momoko; Nakai, Yoshiki; Sasao, Hajime; Tateno, Ryo; Okada, Hajime; Koike, Masato

no journal, , 

Our laser research and development group was newly founded in this April. The aim of our group is to build up powerful light sources promoting the high-peak optical field science such as laser particle acceleration and quantum beam generation, etc. To realize our mission, we will intend to develop the essential technology for the upgrade of J-KAREN and TOPAZ systems. These essential technologies that will be developed in two laser systems can be absolutely used for the advanced laser light source in near future.

Oral presentation

High-efficiency nonlinear optical parametric chirped-pulse amplification system

Okada, Hajime; Kiriyama, Hiromitsu; Nakai, Yoshiki; Shimomura, Takuya*; Tanoue, Manabu*; Akutsu, Atsushi; Kondo, Shuji; Kanazawa, Shuhei; Sugiyama, Akira; Daido, Hiroyuki; et al.

no journal, , 

no abstracts in English

Oral presentation

High intensity, high beam quality laser pulses with a double CPA, OPCPA/Ti:sapphire laser system for studying relativistic light-matter interactions

Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.

no journal, , 

We demonstrated laser peak intensity above 10$$^{20}$$W/cm$$^2$$ and temporal contrast exceeding 10$$^{10}$$ at a 10 Hz repetition rate with a 60 TW, 30 fs laser (J-KAREN laser). Here we report the upgrade of the J-KAREN laser to the petawatt peak power level. This is accomplished by adding a Ti:sapphire booster amplifier downstream of the final amplifier chain of the 60 TW J-KAREN laser system. Stretched pulses of energy 3 J from the previous J-KAREN laser are up-collimated and introduced into the final booster amplifier. The booster amplifier consists of a large-aperture Ti:sapphire crystal pumped by a frequency-doubled Nd:silicate glass laser with pulse energy 60 J. Diffractive optical elements are used for pump beam homogenization to maintain a uniform spatial profile and reliable, damage-free operation. The system produces an uncompressed output pulse energy exceeding 30 J with a near homogeneous flat-top spatial distribution, indicating potential peak power of 500 TW.

Oral presentation

Demonstration of high peak power, high contrast OPCPA/Ti:sapphire hybrid laser system

Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.

no journal, , 

We have demonstrated over 30 J broadband output energy based on optical parametric chirped-pulse amplification (OPCPA) and Ti:sapphire chirped-pulse amplification (CPA), indicating potential for peak power of 500 TW with extremely high temporal contrast.

12 (Records 1-12 displayed on this page)
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