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Fujimoto, Hirofumi*; Higuchi, Mariko; Koike, Manabu*; Ode, Hirotaka*; Pinak, M.; Kotulic Bunta, J.*; Nemoto, Toshiyuki*; Sakudo, Takashi*; Honda, Naoko*; Maekawa, Hideaki*; et al.
Journal of Computational Chemistry, 33(3), p.239 - 246, 2012/01
Times Cited Count：37 Percentile：64.85(Chemistry, Multidisciplinary)Lysine acetylation is one of the most common protein post transcriptional modifications. The acetylation effects of lysine residues on Ku protein were examined herein applying several computer simulation techniques. Acetylation of the lysine residues did not reduce the affinity between Ku and its substrate, DNA, in spite of the fact that the substitution of lysine with glutamine (KQ mutant) reduced the affinity of Ku for DNA, or the substitution of lysine with arginine (KR mutant) did not reduce it, as previously reported in experimental studies. These results suggest that the effects of in vivo acetylation may be overestimated when the KQ mutant is employed in mimicry of the acetylated protein.
Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya*; Tanoue, Manabu*; Okada, Hajime; Sasao, Hajime; Wakai, Daisuke*; Kondo, Shuji; Kanazawa, Shuhei; et al.
JAEA-Conf 2009-007, p.97 - 100, 2010/03
no abstracts in English
temporal contrast, above 10
W/cm
peak intensity pulses at a 10 Hz repetition rate using an OPCPA preamplifier in a double CPA, Ti:sapphire laser systemKiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.
AIP Conference Proceedings 1153, p.3 - 6, 2009/07
We demonstrate a high-contrast, high-intensity double chirped-pulse amplification (CPA) Ti:sapphire laser system using an optical parametric chirped-pulse amplifier (OPCPA) as a preamplifier. By injecting cleaned microjoule seed pulses into the OPCPA, a temporal contrast greater than 10 within picosecond times before the main femtosecond pulse is demonstrated with the output pulse energy of 1.7 J and pulse duration of 30 fs, corresponding to a peak power of 60 TW at a 10 Hz repetition rate. This system uses a cryogenically-cooled Ti:sapphire final amplifier and generates focused peak intensities in excess of 10 W/cm.
Okada, Hajime; Kiriyama, Hiromitsu; Nakai, Yoshiki; Shimomura, Takuya*; Tanoue, Manabu*; Akutsu, Atsushi; Kondo, Shuji; Kanazawa, Shuhei; Sugiyama, Akira; Daido, Hiroyuki; et al.
no journal, ,
no abstracts in English
Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.
no journal, ,
We demonstrated laser peak intensity above 10W/cm and temporal contrast exceeding 10 at a 10 Hz repetition rate with a 60 TW, 30 fs laser (J-KAREN laser). Here we report the upgrade of the J-KAREN laser to the petawatt peak power level. This is accomplished by adding a Ti:sapphire booster amplifier downstream of the final amplifier chain of the 60 TW J-KAREN laser system. Stretched pulses of energy 3 J from the previous J-KAREN laser are up-collimated and introduced into the final booster amplifier. The booster amplifier consists of a large-aperture Ti:sapphire crystal pumped by a frequency-doubled Nd:silicate glass laser with pulse energy 60 J. Diffractive optical elements are used for pump beam homogenization to maintain a uniform spatial profile and reliable, damage-free operation. The system produces an uncompressed output pulse energy exceeding 30 J with a near homogeneous flat-top spatial distribution, indicating potential peak power of 500 TW.
Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.
no journal, ,
We have demonstrated over 30 J broadband output energy based on optical parametric chirped-pulse amplification (OPCPA) and Ti:sapphire chirped-pulse amplification (CPA), indicating potential for peak power of 500 TW with extremely high temporal contrast.
