Polyelectrolyte-protein synergism; pH-responsive polyelectrolyte/insulin complexes as versatile carriers for targeted protein and drug delivery

Murmiliuk, A.*; Iwase, Hiroki*; Kang, J.-J.*; Mohanakumar, S.*; Appavou, M.-S.*; Wood, K.*; Almsy, L.*; Len, A.*; Schwrzer, K.*; Allgaier, J.*; et al.

Journal of Colloid and Interface Science, 665, p.801 - 813, 2024/07

https://doi.org/10.1016/j.jcis.2024.03.156

The complexity of protein structure limits our ability to predict and tune the properties of the formed nanoparticles. The goal of our research is to elucidate the key triggers of the morphological transition in protein/PE complexes, evaluate their encapsulation efficacy, and assess particle stability by the systematic study of complexes formed by block copolymers with proteins and ionic drugs. We demonstrated that copolymers consisting of PE and neutral hydrophilic block co-assemble with insulin at pH values close to the protein isoelectric point. The insulin arrangement within the particle is controlled by electrostatic forces between protein molecules, and the morphology of the formed particles can be tuned by varying pH and ionic strength.

Transport model comparison studies of intermediate-energy heavy-ion collisions

Walter, H.*; Colonna, M.*; Cozma, D.*; Danielewicz, P.*; Ko, C. M.*; Kumar, R.*; Ono, Akira*; Tsang, M. Y. B*; Xu, J.*; Zhang, Y.-X.*; et al.

Progress in Particle and Nuclear Physics, 125, p.103962_1 - 103962_90, 2022/07

https://doi.org/10.1016/j.ppnp.2022.103962

Transport models are the main method to obtain physics information on the nuclear equation of state and in-medium properties of particles from low to relativistic-energy heavy-ion collisions. The Transport Model Evaluation Project (TMEP) has been pursued to test the robustness of transport model predictions to reach consistent conclusions from the same type of physical model. To this end, calculations under controlled conditions of physical input and set-up were performed by the various participating codes. These included both calculations of nuclear matter in a periodic box, which test individual ingredients of a transport code, and calculations of complete collisions of heavy ions. Over the years, five studies were performed within this project. They show, on one hand, that in box calculations the differences between the codes can be well understood and a convergence of the results can be reached. These studies also highlight the systematic differences between the two families of transport codes, known under the names of Boltzmann-Uehling-Uhlenbeck (BUU) and Quantum Molecular Dynamics (QMD) type codes. On the other hand, there still exist substantial differences when these codes are applied to real heavy-ion collisions. The results of transport simulations of heavy-ion collisions will have more significance if codes demonstrate that they can verify benchmark calculations such as the ones studied in these evaluations.

Asymmetric and symmetric fission of excited nuclei of Hg and Pb formed in the reactions with Ar and Ca ions

Bogachev, A. A.*; Kozulin, E. M.*; Knyazheva, G. N.*; Itkis, I. M.*; Itkis, M. G.*; Novikov, K. V.*; Kumar, D.*; Banerjee, T.*; Diatlov, I. N.*; Cheralu, M.*; et al.

Physical Review C, 104(2), p.024623_1 - 024623_11, 2021/08

https://doi.org/10.1103/PhysRevC.104.024623

For the purpose of the study of asymmetric and symmetric fission modes of Hg and Pb nuclei, mass-energy distributions of fission fragments of Hg and Pb formed in the Ar + Sm and Ca + Sm reactions, respectively, at energies near the Coulomb barrier have been measured using the double-arm time-of-flight spectrometer CORSET and compared with previously measured Pb isotopes produced in the Ca + Sm reactions. Conclusion is the studied properties of asymmetric fission of Hg and Pb nuclei point out the existence of well deformed proton shell at Z36 and less deformed proton shell at Z46.

Probing the adsorption of nonionic micelles on different-sized nanoparticles by scattering techniques

Singh, H.*; Ray, D.*; Kumar, S.*; Takata, Shinichi; Aswal, V. K.*; Seto, Hideki

Physical Review E, 102(6), p.062601_1 - 062601_11, 2020/12

https://doi.org/10.1103/PhysRevE.102.062601

neutron diffraction study on the deformation of a TRIP-assisted multi-phase steel composed of ferrite, austenite and martensite

Lavakumar, A.*; Park, M. H.*; Gao, S.*; Shibata, Akinobu*; Okitsu, Yoshitaka*; Gong, W.; Harjo, S.; Tsuji, Nobuhiro*

IOP Conference Series; Materials Science and Engineering, 580, p.012036_1 - 012036_6, 2019/09

https://doi.org/10.1088/1757-899X/580/1/012036

-factor measurement of the 2738 keV isomer in La

Laskar, Md. S. R.*; Saha, S.*; Palit, R.*; Mishra, S. N.*; Shimizu, Noritaka*; Utsuno, Yutaka; Ideguchi, Eiji*; Naik, Z.*; Babra, F. S.*; Biswas, S.*; et al.

Physical Review C, 99(1), p.014308_1 - 014308_6, 2019/01

https://doi.org/10.1103/PhysRevC.99.014308

no abstracts in English

Fast magnetic field annihilation driven by two laser pulses in underdense plasma

Gu, Y. J.*; Klimo, O.*; Kumar, D.*; Bulanov, S. V.; Esirkepov, T. Z.; Weber, S.*; Korn, G.*

Physics of Plasmas, 22(10), p.103113_1 - 103113_9, 2015/10

AA2015-0547.pdf:4.08MB

https://doi.org/10.1063/1.4933408

identification of the metastable phase during solidification from the undercooled YFeO melt by fast X-ray diffractometry at 250 Hz

Nagashio, Kosuke*; Kuribayashi, Kazuhiko*; Vijaya Kumar, M. S.*; Niwata, Kenji*; Hibiya, Taketoshi*; Mizuno, Akitoshi*; Watanabe, Masahito*; Katayama, Yoshinori

Applied Physics Letters, 89(24), p.241923_1 - 241923_3, 2006/12

https://doi.org/10.1063/1.2408666

A time-resolved X-ray diffraction (XRD) experiment at 250 Hz using a synchrotron radiation source was carried out during the containerless solidification of ReFeO (Re=Y and Lu) in order to identify the metastable phase . The metastable phase solidified primarily from the undercooled YFeO melt finally transformed to the stable orthorhombic YFeO phase during the short period of recalescence (0.035 s). Although the metastable phase could not be detected in the as-solidified sample by the powder XRD, the successfully obtained diffraction pattern of the metastable phase in the YFeO system was consistent with that of the metastable hexagonal LuFeO phase.

Free energy landscape for interactions between DNA bases and protein side chains

Yoshida, Tomoki*; Doi, Hideo*; Aida, Misako*; Kono, Hidetoshi; Kumar, S.*; Gromiha, M. M.*; Sarai, Akinori*

no journal, , 

no abstracts in English