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Journal Articles

Modeling for predicting survival fraction of cells after ultra-high dose rate irradiation

Shiraishi, Yuta*; Matsuya, Yusuke; Kusumoto, Tamon*; Fukunaga, Hisanori*

Physics in Medicine & Biology, 69(1), p.015017_1 - 015017_14, 2024/01

FLASH radiotherapy (FLASH-RT) using ultra-high dose rate ($$>$$ 40 Gy/sec) is known as a new treatment which is expected to enable preserving normal tissue functions, compared to the conventional radiotherapy (CONV-RT) with high dose rate ($$leqq$$ 6 Gy/min). To date, it is believed that the modulation of chemical processes caused by interactions between radiation tracks under FLASH-RT is a key factor in the functional preservation of normal tissues; however, the relationship between changes in chemical processes and cellular responses remains uncertain. In this study, we developed a prediction model (integrated microdosimetric-kinetic (IMK) model for FLASH-RT) taking into account of the relationship between the chemical process and the DNA damage yields (which is the initial response) under ultra-high dose rate irradiation, to investigate the cellular mechanisms. As a result, the developed model considering the chemical-processes dependent change in DNA damage yields successfully reproduced the measured cell-killing effects of both CONV-RT and FLASH-RT for various cell line types. This model development would contribute on not only precisely understanding of cellular mechanisms after FLASH-RT irradiation but also enabling the prediction of therapeutic effects with high precision.

Journal Articles

A Step-by-step simulation code for estimating yields of water radiolysis species based on electron track-structure mode in the PHITS code

Matsuya, Yusuke; Yoshii, Yuji*; Kusumoto, Tamon*; Akamatsu, Ken*; Hirata, Yuho; Sato, Tatsuhiko; Kai, Takeshi

Physics in Medicine & Biology, 19 Pages, 2023/00

Time-dependent yields of chemical products resulted in water radiolysis play a great role in evaluating DNA damage response after exposure to ionizing radiation. Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo simulation code for radiation transport, which allows to determine several atomic interactions such as ionizations and electronic excitations as physical stage. However, a chemical code for simulating products of water radiolysis does not exist in the PHITS package. Here, we developed a chemical simulation code dedicated for the PHITS code, hereafter called PHITS-Chem code, which enables calculating G values of water radiolysis species (OH radical, e$$_{aq}$$$$^{-}$$, H$$_{2}$$, H$$_{2}$$O$$_{2}$$ etc) by electron beams. The estimated G values during 1 $$mu$$s are in agreement with the experimental ones and other simulations. This PHITS-Chem code enables simulating the dynamics in the presence of OH radical scavenger, and is useful for evaluating contributions of direct and indirect effects on DNA damage induction. This code will be included and be available in the future version of PHITS.

Journal Articles

Features of accelerator-based neutron source for boron neutron capture therapy calculated by Particle and Heavy Ion Transport code System (PHITS)

Matsuya, Yusuke; Kusumoto, Tamon*; Yachi, Yoshie*; Hirata, Yuho; Miwa, Misako*; Ishikawa, Masayori*; Date, Hiroyuki*; Iwamoto, Yosuke; Matsuyama, Shigeo*; Fukunaga, Hisanori*

AIP Advances (Internet), 12(2), p.025013_1 - 025013_9, 2022/02

 Times Cited Count:2 Percentile:51.2(Nanoscience & Nanotechnology)

Boron Neutron Capture Therapy (BNCT) is a radiation therapy, which can selectively eradicate solid tumors by $$alpha$$-particles and Li ions generated through the nuclear reaction between thermal neutron and $$^{10}$$B in tumor cells. With the development of accelerator-based neutron sources that can be installed in medical institutions, accelerator-based boron neutron capture therapy is expected to become available at several medical institutes around the world in the near future. Lithium is one of the targets that can produce thermal neutrons from the $$^{7}$$Li(p,n)$$^{7}$$Be near-threshold reaction. Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo code, which can simulate a variety of diverse particle types and nuclear reactions. The latest PHITS code enables simulating the generation of neutrons from the $$^{7}$$Li(p,n)$$^{7}$$Be reactions by using Japanese Evaluated Nuclear Data Library (JENDL-4.0/HE). In this study, we evaluated the neutron fluence using the PHITS code by comparing it to reference data. The subsequent neutron transport simulations were also performed to evaluate the boron trifluoride (BF$$_{3}$$) detector responses and the recoiled proton fluence detected by a CR-39 plastic detector. As a result, these comparative studies confirmed that the PHITS code can accurately simulate neutrons generated from an accelerator using a Li target. The PHITS code has a significant potential for contributing to more precise evaluating accelerator-based neutron fields and understandings of therapeutic effects of BNCT.

Journal Articles

Verification of dose estimation of Auger electrons emitted from Cu-64 using a combination of FNTD measurements and Monte Carlo simulations

Kusumoto, Tamon*; Matsuya, Yusuke; Baba, Kentaro*; Ogawara, Ryo*; Akselrod, M. S.*; Harrison, J.*; Fomenko, V.*; Kai, Takeshi; Ishikawa, Masayori*; Hasegawa, Sumitaka*; et al.

Radiation Measurements, 132, p.106256_1 - 106256_4, 2020/03

 Times Cited Count:5 Percentile:54.54(Nuclear Science & Technology)

Internal radiation therapy with Cu-64 concentrates energy deposition in tumor cells by virtue of released Auger electrons with low energy. In our previous study, we have attached the solutions at the surface of Fluorescent Nuclear Track Detector (FNTD) and succeeded in measuring the absorbed doses of Auger electrons registered in FNTD. However, because there are several types of radiation emitted from the source, i.e., beta rays, positron etc., the contribution degree of Auger electron to energy concentration remain uncertain. In this study, we quantitatively analyzed the spatial dose distribution in the FNTD based on Monte Carlo simulation with PHITS and GEANT4, and evaluated high dose deposited by Auger electrons. The dose distribution calculated by the PHITS code is exactly equivalent to that by Geant4. Also, the simulations are well agreement with experimental results. If the contribution of Auger electrons is ignored, the significantly high absorbed dose proximal to the source is not properly reduced. These findings demonstrate that Auger electrons work very effectively to kill cancer cells proximal to Cu-64 source while minimizing damage effects on normal cells distal to the source.

Oral presentation

Laser driven ion acceleration experiment by high contrast high intensity laser J-KAREN system

Nishiuchi, Mamiko; Sakaki, Hironao; Sagisaka, Akito; Maeda, Shota; Pirozhkov, A. S.; Pikuz, T.; Faenov, A. Ya.*; Ogura, Koichi; Fukuda, Yuji; Matsukawa, Kenya*; et al.

no journal, , 

no abstracts in English

Oral presentation

Measurement of electron spectrum generated by irradiating thin-Foil target with Ultra-intense Ultra-short pulse laser

Maeda, Shota; Nishiuchi, Mamiko; Sakaki, Hironao; Sagisaka, Akito; Pirozhkov, A. S.; Pikuz, T.; Faenov, A. Ya.*; Ogura, Koichi; Fukuda, Yuji; Matsukawa, Kenya*; et al.

no journal, , 

In JAEA, the high energy ions generated by the interaction between Ultra-intense Ultra-Short pulse laser and thin-foil target is being studied. Irradiating condition must be optimized to generate higher energy ions while suppress the becoming gigantic of laser. It is necessary to know the physical phenomenon in plasma to determine the parameter to optimize from the information on the electron and neutron, X-rays, which are generated simultaneously with ion. In this study, in order to measure electron temperature accurately, an electron spectrometer was developed which have broad range (1-200 MeV). The detector is comprised of permanent magnets and a fluorescent plate, CCD camera. In the presentation, the result of the calibration experiment carried out using 4, 9, 12, 15 MeV quasi-monoenergetic electron beam in HIBMC will be reported. Moreover, response analysis method was inspected using PHITS which is particle transporting Monte Carlo simulation code, and will also report the result.

Oral presentation

Evaluation of neutron from the laser-driven acceleration

Sakaki, Hironao; Nishiuchi, Mamiko; Maeda, Shota; Sagisaka, Akito; Pirozhkov, A. S.; Pikuz, T.; Faenov, A. Y.*; Ogura, Koichi; Fukuda, Yuji; Matsukawa, Kenya*; et al.

no journal, , 

We report that the results of simultaneous novel measurements of electron-induced photonuclear neutrons (photoneutron), which are a diagnostic of the laser-plasma interaction. The proposed method is demonstrated by the laser irradiation with the intensity of 1$$times$$10$$^{21}$$ W/cm$$^{2}$$ on the metal foil target. The photoneutrons are measured by using NE213 liquid scintillation detectors. The measured signals of the electron-induced photoneutrons are well reproduced by using the Particle and Heavy Ion Transport code System (PHITS).

Oral presentation

Current development status of simulation code for physical and chemical processes in PHITS

Matsuya, Yusuke; Kai, Takeshi; Yoshii, Yuji*; Kusumoto, Tamon*; Akamatsu, Ken*; Hirata, Yuho; Sato, Tatsuhiko

no journal, , 

To clarify the mechanisms on radiation-induced biological effects such as cell death and mutations, it is of importance to evaluate the initial processes such as atomic interactions (physical processes) and radical reactions (chemical processes). Recently, in the recent development of a general-purpose Monte Carlo code for radiation transport, PHITS, a detailed simulation codes that estimate these processes have been implemented. In this presentation, we will introduce the features and the current development status of the track-structure modes (i.e., PHITS-ETS and PHITS-KURBUC modes), that allows the calculation of the physical processes of radiation in the human body, and a chemical code (i.e., PHITS-Chem code) that enables simulating radicals dynamics after irradiation. This presentation would contribute not only to accurate understanding of radiation effects in life sciences and medical fields but also to further applications in nuclear engineering.

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