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Furuta, Takuya; Koba, Yusuke*; Hashimoto, Shintaro; Chang, W.*; Yonai, Shunsuke*; Matsumoto, Shinnosuke*; Ishikawa, Akihisa*; Sato, Tatsuhiko
Physics in Medicine & Biology, 67(14), p.145002_1 - 145002_15, 2022/07
Times Cited Count：2 Percentile：47.19(Engineering, Biomedical)Carbon ion radiotherapy has an advantage over conventional radiotherapy such that its superior dose concentration on the tumor helps to reduce unwanted dose to surrounding normal tissues. Nevertheless, a little dose to normal tissues, which is a potential risk of secondary cancer, is still unavoidable. The Monte Carlo simulation is a good candidate for the tool to assess secondary cancer risk, including the contributions of secondary particles produced by nuclear reactions. We therefore developed a new dose reconstruction system implementing PHITS as the engine. In this system, the PHITS input is automatically created from the DICOM data sets recorded in the treatment planning. The developed system was validated by comparing to experimental dose distribution in water and treatment plan on an anthropomorphic phantom. This system will be used for retrospective studies using the patient data in National Institute for Quantum and Science and Technology.
Chang, W.*; Koba, Yusuke*; Furuta, Takuya; Yonai, Shunsuke*; Hashimoto, Shintaro; Matsumoto, Shinnosuke*; Sato, Tatsuhiko
Journal of Radiation Research (Internet), 62(5), p.846 - 855, 2021/09
Times Cited Count：2 Percentile：26.61(Biology)With the aim of developing a revaluation tool of treatment plan in carbon-ion radiotherapy using Monte Carlo (MC) simulation, we propose two methods; one is dedicated to identify realistic-tissue materials from a CT image with satisfying the well-calibrated relationship between CT numbers and stopping power ratio (SPR) provided by TPS, and the other is to estimate dose to water considering the particle- and energy-dependent SPR between realistic tissue materials and water. We validated these proposed methods by computing depth dose distribution in homogeneous and heterogeneous phantoms composed of human tissue materials and water irradiated by a 400 MeV/u carbon beam with 8 cm SOBP using a MC simulation code PHITS and comparing with results of conventional treatment planning system (TPS). Our result suggested that use of water as a surrogate of real tissue materials, which is adopted in conventional TPS, is inadequate for dose estimation from secondary particles because their production rates cannot be scaled by SPR of the primary particle in water. We therefore concluded that the proposed methods can play important roles in the reevaluation of the treatment plans in carbon-ion radiotherapy.
Sakoda, Akihiro; Matsumoto, Shinnosuke*
Hoken Butsuri, 51(3), p.187 - 190, 2016/09
This article gives the report on participation in 14th International Congress of the International Radiation Protection Association (IRPA-14), which was held in Cape Town, South Africa on between May 9th and 13th, 2016.
Koba, Yusuke*; Nakada, Yoshihiro*; Matsumoto, Shinnosuke*; Akahane, Keiichi*; Ono, Koji*; Sato, Kaoru; Takahashi, Fumiaki; Endo, Akira; Shimada, Yoshiya*; Kai, Michiaki*
no journal, ,
While CT scan is useful for diagnosis, exposure dose derived from CT scan is relatively high. Therefore, it is important to manage patient doses and to prevent the excess exposures in young patients. JAEA developed the CT dose calculator, WAZA-ARIv2 under the collaboration research project with the National Institute of Radiological Sciences and the Oita University of Nursing and Health Sciences. In WAZA-ARIv2, users can accurately calculate exposure doses through the browser under consideration of patients information about sexes, ages (0y, 1y, 5y, 10y, 15y and adult) and fatness (small, large and extra-large body sizes). The functions of registration and database compilation of CT scan conditions and patient doses are newly added to a WAZA-ARIv2. Users can compare the distribution of patient doses in Japan with those in user's medical institution. Therefore, it will be expected that WAZA-ARIv2 can contribute the management and optimization of patients doses due to CT scan.
Koba, Yusuke*; Matsumoto, Shinnosuke*; Nakada, Yoshihiro*; Kasahara, Tetsuji*; Akahane, Keiichi*; Okuda, Yasuo*; Sato, Kaoru; Takahashi, Fumiaki; Yoshitake, Takayasu*; Hasegawa, Takayuki*; et al.
no journal, ,
Many of the CT devices are in Japan. It is guessed that exposure doses of Japanese derived from CT scans are higher than others. Thus, it is needed to properly manage scan conditions and exposure doses of individual patients. JAEA developed WAZA-ARI under the collaboration research project with the National Institute of Radiological Sciences (NIRS) and the Oita University of Nursing and Health Sciences. Practical use of new version WAZA-ARI named WAZA-ARIv2 began on January 30, 2015 at the web server in NIRS. In WAZA-ARIv2, users can calculate patients doses by using only standard condition (120 kV) of X-tube voltage. In recent years, CT scans at low tube voltage against pediatric patients with high radiosensitivity are increasing. In this study, spectrum of X-ray derived from CT scan at low tube voltage was examined, and was defined in "usrsors.f" file of PHITS. We reported the characteristics of X-ray and organ doses derived from CT scan at low tube voltage (80 kV).
Ono, Koji*; Koba, Yusuke*; Matsumoto, Shinnosuke*; Nakada, Yoshihiro*; Okuda, Yasuo*; Akahane, Keiichi*; Sato, Kaoru; Takahashi, Fumiaki; Yoshitake, Takayasu*; Hasegawa, Takayuki*; et al.
no journal, ,
In medical treatment, CT scan is useful diagnostic method. On the other hand, exposure doses derived from CT scans are dependent on body sizes of patients. Therefore, consideration of body sizes is essential for accurate dose assessment of individual patients. JAEA developed the CT dose calculator, WAZA-ARIv2 under the collaboration research project with the National Institute of Radiological Sciences and the Oita University of Nursing and Health Sciences. WAZA-ARIv2 enable users to accurately calculate exposure doses of patients with sexes, ages (0y, 1y, 5y, 10y, 15y and adult) and fatness (small, large and extra-large body sizes). In the future, we will be plans to add the dose calculation functions corresponding to the scan conditions at low tube voltage and multi-detector row (more 80) CT devices to WAZA-ARIv2. We reported the system and future plans of WAZA-ARIv2 corresponding to dose calculation of patients with various body sizes.
Furuta, Takuya; Koba, Yusuke*; Chang, W.*; Hashimoto, Shintaro; Yonai, Shunsuke*; Matsumoto, Shinnosuke*; Sato, Tatsuhiko
no journal, ,
Heavy-ion (carbon-ion) therapy has advantages over conventional radiotherapy such as superior dose concentration and better relative biological effectiveness while the secondary particles produced by nuclear reactions between incident carbon ions and matters induce complexity for risk assessment of secondary cancer. For this assessment, precise transport calculation of secondary particles are required so the Monte Carlo transport calculation is desired. We therefore construct a dosimetry system including PHITS as the engine. In this system, the PHITS input is automatically created from the DICOM data sets recorded in the treatment planning. The transport calculation is simulated by PHITS and dose distribution around the tumor but also out-of-filed is computed. This system will be used as retrospective study in National Institute of Radiological Sciences.
Chang, W.*; Koba, Yusuke*; Furuta, Takuya; Yonai, Shunsuke*; Hashimoto, Shintaro; Matsumoto, Shinnosuke*; Sato, Tatsuhiko
no journal, ,
In the treatment planning system (TPS) for radiotherapy, approximate calculation by replacing all materials with water and accounting only the density variation is adopted to reduce the computational cost. On the other hand, conversion from patient CT data to elemental compositions and densities is required to conduct Monte Carlo simulation. Especially for the assessment of secondary cancer risk in carbon therapy, secondary particles produced in the nuclear reaction between incident carbons and human tissues are important so that the difference of the elemental compositions is essential. We have therefore developed a method to convert CT number to human tissues keeping the consistency with the water stopping power table embedded in TPS. We applied this conversion method to 9 different human tissues and confirmed the range of carbon beams are reproduced within 1 mm precision for all the materials.
Ishikawa, Akihisa*; Koba, Yusuke*; Furuta, Takuya; Chang, W.*; Hashimoto, Shintaro; Yonai, Shunsuke*; Matsumoto, Shinnosuke*; Sato, Tatsuhiko
no journal, ,
There found to be a relationship between the dose-averaged linear energy transfer LETd and local tumor control in carbon-ion radiotherapy (CIRT). However, only physical dose and biological dose are registered in the past treatment records of CIRT in QST hospital and LETd can not be deduced directly. There is a method to estimate LETd based on RBE-LETd-fitted function but some problems such as non-singularity at the end point of carbon ions are known. On the other hand, we propose a method to reproduce the CIRT by reconstructing the beam transport geometry based on the treatment planning data and conduct Monte Carlo simulation. The LETd can be also computed directly. We therefore compared LETd obtained by Monte Carlo simulation with estimated LETd using the treatment planning data. We found that underestimation around the end point of carbon ions but the influence was local and thus the LETd estimates are valid for the purpose computing in organ scale.
