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Journal Articles

Downward terrestrial gamma-ray flash observed in a winter thunderstorm

Wada, Yuki*; Enoto, Teruaki*; Nakazawa, Kazuhiro*; Furuta, Yoshihiro; Yuasa, Takayuki*; Nakamura, Yoshitaka*; Morimoto, Takeshi*; Matsumoto, Takahiro*; Makishima, Kazuo*; Tsuchiya, Harufumi

Physical Review Letters, 123(6), p.061103_1 - 061103_6, 2019/08

AA2018-0706.pdf:0.79MB

 Times Cited Count:14 Percentile:82.27(Physics, Multidisciplinary)

Journal Articles

Gamma-ray glow preceding downward terrestrial gamma-ray flash

Wada, Yuki*; Enoto, Teruaki*; Nakamura, Yoshitaka*; Furuta, Yoshihiro; Yuasa, Takayuki*; Nakazawa, Kazuhiro*; Morimoto, Takeshi*; Sato, Mitsuteru*; Matsumoto, Takahiro*; Yonetoku, Daisuke*; et al.

Communications Physics (Internet), 2(1), p.67_1 - 67_9, 2019/06

 Times Cited Count:18 Percentile:89.5(Physics, Multidisciplinary)

Journal Articles

Evaluation of SCCVII tumor cell survival in clamped and non-clamped solid tumors exposed to carbon-ion beams in comparison to X-rays

Hirayama, Ryoichi*; Uzawa, Akiko*; Takase, Nobuhiro*; Matsumoto, Yoshitaka*; Noguchi, Miho; Koda, Kana*; Ozaki, Masakuni*; Yamashita, Kei*; Li, H.*; Kase, Yuki*; et al.

Mutation Research; Genetic Toxicology And Environmental Mutagenesis, 756(1-2), p.146 - 151, 2013/08

 Times Cited Count:19 Percentile:60.07(Biotechnology & Applied Microbiology)

Journal Articles

Induction of DNA DSB and its rejoining in clamped and non-clamped tumours after exposure to carbon ion beams in comparison to X-rays

Hirayama, Ryoichi*; Uzawa, Akiko*; Matsumoto, Yoshitaka*; Noguchi, Miho; Kase, Yuki*; Takase, Nobuhiro*; Ito, Atsushi*; Koike, Sachiko*; Ando, Koichi*; Okayasu, Ryuichi*; et al.

Radiation Protection Dosimetry, 143(2-4), p.508 - 512, 2011/02

 Times Cited Count:10 Percentile:65.84(Environmental Sciences)

We studied double-strand breaks (DSB) induction and rejoining in clamped and non-clamped transplanted tumours in mice leg after exposure to 80 keV/$$mu$$m carbon ions and X-rays. The yields of DSB in the tumours were analysed by a static-field gel electrophoresis. The OER of DSB after X-rays was 1.68, and this value was not changed after 1 h rejoining time (1.40). These damages in oxygenated conditions were rejoined 60-70% within 1 h in situ. No difference was found between the exposure to X-rays and carbon ions for the induction and rejoining of DSB. Thus, the values of OER and rejoined fraction after exposure to carbon ions were similar to those after X-rays, and the calculated relative biological effectivenesses of carbon ion were around 1 under both oxygen conditions. The yields of DSB in vivo depend on exposure doses, oxygen conditions and rejoining time, but not on the types of radiation quality.

Journal Articles

Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams

Hirayama, Ryoichi*; Matsumoto, Yoshitaka*; Kase, Yuki*; Noguchi, Miho; Ando, Koichi*; Ito, Atsushi*; Okayasu, Ryuichi*; Furusawa, Yoshiya*

Radiation Physics and Chemistry, 78(12), p.1175 - 1178, 2009/12

 Times Cited Count:10 Percentile:60.19(Chemistry, Physical)

The contribution of OH radical-mediated indirect action by particle beams under hypoxic irradiation condition was investigated by using a radical scavenger. V79 cells were irradiated with 150 MeV/nucleon helium ions at an LET of 2.2 keV/mm in the presence or absence of DMSO, and their colony survivals were determined. The contribution of indirect action to cell killing under hypoxic condition was estimated to be 52 %. We conclude that OH radical mediated indirect action still has a half in total contribution on cell killing under hypoxic condition.

Journal Articles

Contributions of direct and indirect actions in cell killing by high-LET radiations

Hirayama, Ryoichi*; Ito, Atsushi*; Tomita, Masanori*; Tsukada, Teruyo*; Yatagai, Fumio*; Noguchi, Miho; Matsumoto, Yoshitaka*; Kase, Yuki*; Ando, Koichi*; Okayasu, Ryuichi*; et al.

Radiation Research, 171(2), p.212 - 218, 2009/02

 Times Cited Count:100 Percentile:95.21(Biology)

The biological effects of radiation originate principally in damages to DNA. DNA damages by X-rays as well as heavy ions are induced by a combination of direct and indirect actions. The contribution of indirect action in cell killing can be estimated from the maximum degree of protection by dimethylsulfoxide (DMSO), which suppresses indirect action without affecting direct action. Exponentially growing Chinese hamster V79 cells were exposed to high-LET radiations of 20 to 2106 keV/$$mu$$m in the presence or absence of DMSO and their survival was determined using a colony formation assay. The contribution of indirect action to cell killing decreased with increasing LET. However, the contribution did not reach zero even at very high LETs and was estimated to be 32% at an LET of 2106 keV/$$mu$$m. Therefore, even though the radiochemically estimated G value of OH radicals was nearly zero at an LET of 1000 keV/$$mu$$m, indirect action by OH radicals contributed to a substantial fraction of the biological effects of high-LET radiations. The RBE determined at a survival level of 10% increased with LET, reaching a maximum value of 2.88 at 200 keV/$$mu$$m, and decreased thereafter. When the RBE was estimated separately for direct action (RBE(D)) and indirect action (RBE(I)); both exhibited an LET dependence similar to that of the RBE, peaking at 200 keV/$$mu$$m. However, the peak value was much higher for RBE(D) (5.99) than RBE(I) (1.89). Thus direct action contributes more to the high RBE of high-LET radiations than indirect action does.

Journal Articles

Particle number- and LET-dependency of bystander effect through the gap junction signalling in human normal fibroblast cells exposed to heavy-ion beams

Matsumoto, Yoshitaka*; Hamada, Nobuyuki*; Aoki, Mizuho*; Wada, Seiichi*; Funayama, Tomoo; Sakashita, Tetsuya; Kakizaki, Takehiko; Kobayashi, Yasuhiko; Furusawa, Yoshiya*

JAEA-Review 2006-042, JAEA Takasaki Annual Report 2005, P. 110, 2007/02

JAEA Reports

Study on the prediction accuracy of nuclide generation and depletion with JENDL

Okumura, Keisuke; Oki, Shigeo*; Yamamoto, Munenari*; Matsumoto, Hideki*; Ando, Yoshihira*; Tsujimoto, Kazufumi; Sasahara, Akihiro*; Katakura, Junichi; Matsumura, Tetsuo*; Aoyama, Takafumi*; et al.

JAERI-Research 2004-025, 154 Pages, 2005/01

JAERI-Research-2004-025.pdf:19.46MB

This report summarizes the activity (FY2000-2003) of Working Group (WG) on Evaluation of Nuclide Generation and Depletion under Subcommittee on Nuclear Fuel Cycle of Japanese Nuclear Data Committee. In the WG, analyses of Post Irradiation Examinations have been carried out for UO$$_{2}$$ and MOX fuels irradiated in PWRs, BWRs and FBRs, and for actinide samples irradiated in fast reactors, by using ORIGEN or more detailed calculation codes with their libraries based on JENDL-3.2, JENDL-3.3 and other foreign nuclear data files. From these results, current prediction accuracy and problems for evaluation of nuclide generation and depletion are discussed. Furthermore, this report covers other products of our activity; development of the ORIGEN libraries for PWR, BWR and FBR based on JENDL-3.3, study on introduction of neutron spectrum index to ORIGEN calculations, and results of questionnaire survey on desirable accuracy of ORIGEN calculations.

Journal Articles

Microbeams of heavy charged particles

Kobayashi, Yasuhiko; Funayama, Tomoo; Wada, Seiichi; Furusawa, Yoshiya*; Aoki, Mizuho*; Shao, C.*; Yokota, Yuichiro; Sakashita, Tetsuya; Matsumoto, Yoshitaka*; Kakizaki, Takehiko; et al.

Uchu Seibutsu Kagaku, 18(4), p.235 - 240, 2004/12

no abstracts in English

JAEA Reports

Burnup code for fuel assembly by Monte Carlo code; MKENO-BURN

Naito, Yoshitaka; Suyama, Kenya; Masukawa, Fumihiro; Matsumoto, Kiyoshi; Kurosawa, Masayoshi; *

JAERI-Data/Code 96-037, 70 Pages, 1996/12

JAERI-Data-Code-96-037.pdf:1.68MB

no abstracts in English

JAEA Reports

DABIE: A Data banking system of integral experiments for reactor core characteristics computer codes; Users manual

Matsumoto, Kiyoshi; Naito, Yoshitaka; ; *

JAERI-M 87-067, 132 Pages, 1987/05

JAERI-M-87-067.pdf:2.56MB

no abstracts in English

Oral presentation

Bystander effect and radiation quality with microbeams on cells

Furusawa, Yoshiya*; Matsumoto, Yoshitaka*; Hamada, Nobuyuki*; Wada, Seiichi*; Kobayashi, Yasuhiko; Funayama, Tomoo; Sakashita, Tetsuya; Kakizaki, Takehiko

no journal, , 

no abstracts in English

Oral presentation

Direct action is the key to understand the high biological effects caused by particle beams

Hirayama, Ryoichi*; Matsumoto, Yoshitaka*; Uzawa, Akiko*; Takase, Nobuhiro*; Tsuruoka, Chizuru*; Wada, Mami*; Noguchi, Miho; Kase, Yuki*; Matsufuji, Naruhiro*; Ito, Atsushi*; et al.

no journal, , 

The contribution of indirect action mediated by OH radicals in cell killing can be estimated from the maximum degree of protection by dimethylsulfoxide (DMSO), which suppresses indirect action of radiation without affecting direct action. Exponentially growing Chinese hamster ovary cells under oxic and hypoxic conditions were exposed to X-rays and iron ions having a dose-averaged LET at 200 keV/micrometer in the presence or absence of DMSO, and the cell survival was determined using the colony formation assay. The contributions of indirect action of 76% and 50% were found for X-rays under oxic and hypoxic conditions, respectively. In contrast, the contributions of indirect action for iron ions were estimated to be 42% and 32%. The RBE values were 2.8 for oxic and 5.3 for hypoxic, and the OER values were 2.8 for X-rays and 1.5 for iron ions. When the RBE and OER were estimated separately for direct action (RBE(D) and OER(D)) and indirect action (RBE(I) and OER(I)); the RBE(D) was larger than RBE(I) under both normal and low oxygen concentrations. The OER(D) values for both X-rays and iron ions were lower than that for OER(I). Thus, direct action of radiation gives a remarkably higher RBE and lower OER for cell killing than indirect action. It is possible that particle beams may be highly effective in treating cancer if the particle therapy can only use the portion of direct action out of total radiation actions; this would be exemplified by the usage of radioactive 9C-ion beams and boron neutron capture.

Oral presentation

Rejoining of DNA double-strand breaks in hypoxic cells following irradiation by X-rays and heavy ions

Hirayama, Ryoichi*; Matsumoto, Yoshitaka*; Noguchi, Miho; Uzawa, Akiko*; Koda, Kana*; Furusawa, Yoshiya*

no journal, , 

The presence or absence of molecular oxygen dramatically influences the biological effect of low LET radiations. To produce oxygen effect, molecular oxygen must be present during the radiation exposure or at least during the lifetime of the free radicals generated by the radiation. Little study has been done to actually investigate the influence of oxygen after the radiation exposure. The present study was undertaken in order to explore the rejoining activity of DNA-DSB induced by anaerobic X-ray or carbon ion ($$sim$$80 keV/$$mu$$m) irradiations under oxic and hypoxic holdings (37 $$^{circ}$$C). DNA-DSB in CHO cells were analyzed by a static-field gel electrophoresis. The kinetics of the rejoining could be described by a sum of fast and slow components. The slow component of DNA-DSB induced by X-ray under oxic incubation was faster than that under hypoxic incubation. Furthermore, the percentages of non-reparable DNA damage were 5% and 20% under oxic and hypoxic incubation conditions, respectively. However, no difference between oxic and hypoxic incubation conditions was found for carbon ion irradiation. There results indicate that molecular oxygen influences the rejoining of DNA-DSB after low LET radiation exposure.

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