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Matsuya, Yusuke; Sato, Tatsuhiko; Kusumoto, Tamon*; Yachi, Yoshie*; Seino, Ryosuke*; Miwa, Misako*; Ishikawa, Masayori*; Matsuyama, Shigeo*; Fukunaga, Hisanori*
Scientific Reports (Internet), 14, p.16696_1 - 16696_14, 2024/07
Boron neutron capture therapy (BNCT) is a unique radiotherapy to selectively eradicate tumor cells using boron compounds (e.g., 4-borono-L-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. However, the impacts of tempo-spatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector, cell cycle analysis, and biophysical simulations, we demonstrated the cell cycle-dependent heterogenicity of BPA uptake and following biological impacts of 
B(n, 
)
Li reactions in HeLa cells expressing Fluorescent Ubiquitination-based Cell Cycle Indicators (FUCCI), as well as its modification effects of polyvinyl alcohol (PVA). As a result, we revealed that the intracellular BPA concentration in the S/G2/M phase was higher than that in the G1/S phase and that PVA modified the cell cycle dependence. Further, these findings lead to the development of the first BPA-PVA-based model for predicting BNCT treatment effects. These outcomes may contribute to more precision of therapeutic efficacy, when BNCT is combined with PVA and/or cell cycle-specific anticancer agents.
Matsuya, Yusuke; Kusumoto, Tamon*; Yachi, Yoshie*; Hirata, Yuho; Miwa, Misako*; Ishikawa, Masayori*; Date, Hiroyuki*; Iwamoto, Yosuke; Matsuyama, Shigeo*; Fukunaga, Hisanori*
AIP Advances (Internet), 12(2), p.025013_1 - 025013_9, 2022/02
Times Cited Count：6 Percentile：56.00(Nanoscience & Nanotechnology)Boron Neutron Capture Therapy (BNCT) is a radiation therapy, which can selectively eradicate solid tumors by -particles and Li ions generated through the nuclear reaction between thermal neutron and B in tumor cells. With the development of accelerator-based neutron sources that can be installed in medical institutions, accelerator-based boron neutron capture therapy is expected to become available at several medical institutes around the world in the near future. Lithium is one of the targets that can produce thermal neutrons from the Li(p,n)Be near-threshold reaction. Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo code, which can simulate a variety of diverse particle types and nuclear reactions. The latest PHITS code enables simulating the generation of neutrons from the Li(p,n)Be reactions by using Japanese Evaluated Nuclear Data Library (JENDL-4.0/HE). In this study, we evaluated the neutron fluence using the PHITS code by comparing it to reference data. The subsequent neutron transport simulations were also performed to evaluate the boron trifluoride (BF
) detector responses and the recoiled proton fluence detected by a CR-39 plastic detector. As a result, these comparative studies confirmed that the PHITS code can accurately simulate neutrons generated from an accelerator using a Li target. The PHITS code has a significant potential for contributing to more precise evaluating accelerator-based neutron fields and understandings of therapeutic effects of BNCT.
Sakurai, Eiko*; Yanai, Kazuhiko*; Ishii, Keizo*; Fujiki, Kota*; Hiraishi, Shingo*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Okamura, Nobuyuki*; Yokoyama, Akihito; Kada, Wataru; et al.
JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 84, 2012/01
Harada, Satoshi*; Ehara, Shigeru*; Ishii, Keizo*; Sato, Takahiro; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro
JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 89, 2012/01
Sato, Takahiro; Ishii, Keizo*; Kamiya, Tomihiro; Sakai, Takuro; Oikawa, Masakazu*; Arakawa, Kazuo; Matsuyama, Shigeo*; Yamazaki, Hiromichi*
Nuclear Instruments and Methods in Physics Research B, 210, p.113 - 116, 2003/09
Times Cited Count：1 Percentile：12.37(Instruments & Instrumentation)A new detection apparatus for both low energy X-rays and back-scattered protons of MeV energy and its measurement system were developed. The detection apparatus consists of a multi-element detector, pre-amplifiers with active reset system and so on. The detector elements are arranged in the shape of a pentagonal pyramid and fully cover the sample. On each one detection side, 9 detector elements are arranged. The entire detection system consists thus of 45 detector elements. The micro-beam irradiates the sample through the center of the pentagonal pyramid and X-rays emitted from the sample are detected in close to 
geometry. This novel detection setup has about 10 times the sensitivity of a conventional Micro-PIXE camera. The counting rate of back-scattered protons per detection element is small despite lack of a passive absorber. It appears possible that X-rays from the very small quantity of elements could also be detected. The advantage over a conventional Micro-PIXE camera includes simultaneous detection of back-scattered protons from N, C and O.
Harada, Satoshi*; Tamakawa, Yoshiharu*; Ishii, Keizo*; Tanaka, Akira*; Sato, Takahiro; Matsuyama, Shigeo*; Yamazaki, Hiromichi*; Kamiya, Tomihiro; Sakai, Takuro; Arakawa, Kazuo; et al.
Nuclear Instruments and Methods in Physics Research B, 189(1-4), p.437 - 442, 2002/04
Times Cited Count：1 Percentile：12.42(Instruments & Instrumentation)To study the interactions between the induction of radiation-induced apoptosis and trace elements kinetics, human leukemia cells were irradiated in vitro by 
Co 
rays, after which the cells were evaluated for the detection of apoptosis and trace element imaging was carried out. The frequency of apoptosis was obtained by microscopic assay using TUNEL staining. The trace element distribution in the cell was determined by micro-PIXE. In the early phase of apoptosis, the maximum level of Fe accumulation was observed in the cell stroma. In the mid to end phase, Fe accumulation was diminished, and instead, Ca accumulation increased and Zn decreased in the nucleus. There appear to be two steps for the development of apoptosis: (1) the signaling from cell stroma to nucleus by Fe or an Fe-containing enzyme; and (2) the degeneration of the nucleus by Ca-dependent enzyme, and release of Zn from digested nucleus. Those strong accumulations may be new markers for apoptosis.
Kamiya, Tomihiro; Sakai, Takuro; Oikawa, Masakazu*; Sato, Takahiro*; Ishii, Keizo*; Sugimoto, Asuka*; Matsuyama, Shigeo*
International Journal of PIXE, 9(3&4), p.217 - 225, 1999/11
no abstracts in English
Li at 10 to 20 MeVChiba, Satoshi; ; ; ; Matsuyama, Shigeo*; Shibata, Keiichi; Iwamoto, Osamu; A.J.Koning*; G.M.Hale*; M.B.Chadwick*; et al.
Physical Review C, 58(4), p.2205 - 2216, 1998/10
Times Cited Count：16 Percentile：65.59(Physics, Nuclear)no abstracts in English
Li at 10 to 20MeV region; ; Matsuyama, Shigeo*; Chiba, Satoshi; ; Shibata, Keiichi; Iwamoto, Osamu; A.J.Koning*; G.M.Hale*; M.B.Chadwick*
JAERI-Research 98-032, 28 Pages, 1998/06
JAERI-Research-98-032.pdf:1.31MB
no abstracts in English
Sakai, Takuro; ; Hirao, Toshio; Kamiya, Tomihiro; ; ; Matsuyama, Shigeo*; ; Ishii, Keizo*
Nuclear Instruments and Methods in Physics Research B, 136-138, p.390 - 394, 1998/00
Times Cited Count：18 Percentile：78.73(Instruments & Instrumentation)no abstracts in English
Sakurai, Eiko*; Ishii, Keizo*; Yamanaka, Kentaro*; Okura, Satoru*; Fujiki, Kota*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro; Sato, Takahiro; Arakawa, Kazuo*; et al.
no journal, ,
Cognitive degradation and behavior disorder occur under the mental disease caused by stimulant drugs. In this study, it was continuously administered to mice. After that, neuropoiesis of dentate gyrus and trace elements in its brain were analyzed by in-air micro-PIXE. As a result, the distribution of trace elements was different from that of normal mice.
Harada, Satoshi*; Ehara, Shigeru*; Ishii, Keizo*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Sato, Takahiro; Kamiya, Tomihiro; Sera, Koichiro*; Saito, Yoshihiro*
no journal, ,
no abstracts in English
Sato, Takahiro; Koka, Masashi; Kada, Wataru; Yokoyama, Akihito; Okubo, Takeru; Yamazaki, Akiyoshi; Ishii, Yasuyuki; Kamiya, Tomihiro; Matsuyama, Shigeo*; Ishii, Keizo*
no journal, ,
In order to make elemental analysis in a minute cell, we developed in-air micro-PIXE analysis system in which light-ion microbeam of diameter 0.25
m is used, and the imaging of the trace-element distribution was successfully carried out. This system is widely applied in the fields of medicine, biology, pharmacy, and dentistry.
Sakurai, Eiko*; Yanai, Kazuhiko*; Ishii, Keizo*; Oyama, Ryohei*; Sakamaki, Manabu*; Yamanaka, Kentaro*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Kamiya, Tomihiro; Sato, Takahiro; et al.
no journal, ,
no abstracts in English
Harada, Satoshi*; Ehara, Shigeru*; Ishii, Keizo*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro
no journal, ,
no abstracts in English
Sakurai, Eiko*; Sakurai, Eiichi*; Ishii, Keizo*; Koshio, Shigeki*; Ito, Shun*; Matsuyama, Shigeo*; Koka, Masashi; Yamada, Naoto; Kitamura, Akane; Sato, Takahiro; et al.
no journal, ,
no abstracts in English
Koshio, Shigeki*; Ito, Shun*; Ishii, Keizo*; Matsuyama, Shigeo*; Terakawa, Atsuki*; Sata, Daichi*; Toyama, Sho*; Kasahara, Kazuto*; Kubo, Ryosuke*; Koka, Masashi; et al.
no journal, ,
no abstracts in English
Miyazaki, Yasunori; Sano, Yuichi; Takeuchi, Masayuki; Arai, Tsuyoshi*; Kim, S.-Y.*; Wu, H.*; Miwa, Misako*; Matsuyama, Shigeo*
no journal, ,
Separation of minor actinides (MA; Am, Cm) is social demand to reduce the volume and toxicity of radioactive waste generated by spent nuclear fuel reprocessing. We have proposed extraction chromatography that employs the TEHDGA-impregnated adsorbent in a separation column. From the previous study, MA recovery from the real radioactive waste liquid was achieved, and a flowsheet study is continued to improve the product purity (or decontamination coefficient). On the other hand, we are also investigating the decomposition and reuse of spent adsorbent. In this presentation, both of the degradability of the adsorbent by the Fenton reaction and the reusability of the re-impregnated adsorbent from the batch-wise adsorption test results are reported by the element distribution by micro-PIXE analysis.
Sakurai, Eiko*; Yanai, Kazuhiko*; Okamura, Nobuyuki*; Ishii, Keizo*; Fujiki, Kota*; Hiraishi, Shingo*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Yokoyama, Akihito; Kada, Wataru; et al.
no journal, ,
no abstracts in English
Sakurai, Eiko*; Yanai, Kazuhiko*; Okamura, Nobuyuki*; Ishii, Keizo*; Hiraishi, Shingo*; Yamauchi, Shosei*; Yamazaki, Hiromichi*; Matsuyama, Shigeo*; Yokoyama, Akihito; Kada, Wataru; et al.
no journal, ,
no abstracts in English
