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Oral presentation

Synthesis of $$^{85}$$Sr@C60 by nuclear recoil using high energy neutrons

Miyashita, Yuka*; Akiyama, Kazuhiko*; Hatsukawa, Yuichi; Chiba, Kazuki*; Tadai, Tomohiro*; Sato, Yuta*; Kubuki, Shiro*

no journal, , 

Metallofullerene is one of promising material for the drug delivery system transporting useful encapsulated atoms, such as radioisotopes, with their characteristic cage-like structure. The methods to synthesize radioactive metallofullerenes are, for example, to irradiate cold metallofullerenes by thermal neutrons in a nuclear reactor and to prepare metallofullerene by an arc discharge method using radioisotopes created by an accelerator. However, the radioactive metallofullerenes synthesized these methods are including many amount of non-radioactive carriers and radioisotopes are dispersed into not only targeted fullerene species but also various kind of other species. In this study, we tried to synthesize radioactive metallofullerenes of carrier-free and single molecular species using the nuclear recoil technique by high energy neutron irradiation.

Oral presentation

Synthesis of endohedral 85-Sr metallofullerene by nuclear recoil using high energy neutron

Miyashita, Yuka*; Akiyama, Kazuhiko*; Hatsukawa, Yuichi; Tadai, Tomohiro*; Chiba, Kazuki*; Sato, Yuta*; Kubuki, Shiro*

no journal, , 

To obtain an endohedral metallofullerenes with high specific radioactivity using nuclear recoil phenomena, many experiments have been performed so far. However, production yield of metallofullerene by nuclear recoil using high LET radiation was found to be very small because radiation damages to targeted fullerene molecule were not negligible. In order to increase the yield of radioactive metallofullerenes, it is very promising to employ the recoil of nuclear reaction by fast neutron from the viewpoint of reducing the radiation damage. In this session, we will report the synthesis of $$^{85}$$Sr@C$$_{60}$$ using nuclear recoil of $$^{86}$$Sr (n,2n) $$^{85}$$Sr reaction by 14 MeV fast neutron. Mixture of C$$_{60}$$ with strontium salts such as Sr(NO$$_{3}$$)$$_{2}$$ and SrC$$_{2}$$O$$_{4}$$ were employed for the target materials. These samples were irradiated by fast neutron in Fusion Neutronics Source at Japan Atomic Energy Agency. After the irradiation, CS$$_{2}$$, aniline, and HCl$$_{aq}$$ were passed through the irradiated samples on the filter to dissolve C$$_{60}$$, Sr@C$$_{60}$$, and strontium salts, respectively. The $$gamma$$-ray from these solutions were measured by Ge detector. As a result, about 0.75% of radioactivity was observed in the aniline solution from SrC$$_{2}$$O$$_{4}$$ sample. This result strongly suggests that Sr@C$$_{60}$$ was efficiently produced by fast neutron irradiation of SrC$$_{2}$$O$$_{4}$$/C$$_{60}$$ target.

Oral presentation

Improvement in production yield of radioactive strontium endohedral fullerene using nuclear recoil

Miyashita, Yuka*; Akiyama, Kazuhiko*; Hatsukawa, Yuichi; Kubuki, Shiro*

no journal, , 

Considering about the radio pharmaceutical application of metallofullerenes, the production methods using nuclear recoil phenomena is very useful because specific radioactivity of products is higher than that obtained by other methods. Due to these advantages, this production method has been attracted and examined using various nuclear reactions so far. However, reported production yields of radioactive metallofullerenes were not enough because of the radiation damages of a targeted fullerene molecule caused by incident charged particles. One of the promising method to improve the production yield of radioactive metallofullerenes is ion implantation using the nuclear recoil induced by nuclear reaction with fast neutrons. In this study, we will report the synthesis of $$^{85}$$Sr endohedral fullerene using the nuclear recoil of $$^{86}$$Sr (n, 2n) $$^{85}$$Sr reaction with 14 MeV fast neutron produced by DT reaction. As a result, the radioactivity of $$^{85}$$Sr observed in the aniline solutions derived from $$^{85}$$Sr endohedral fullerene was estimated to be about 6.8% at the best for those before extraction. Generally, production yield of metallofullerenes by the standard arc discharge method is about 0.1% or less. Therefore, observed production yield of $$^{85}$$Sr endohedral fullerene in this study is found to be extremely efficient compared to the standard methods.

Oral presentation

Improvement in production yield of $$^{85}$$Sr@C$$_{60}$$ using nuclear recoil

Miyashita, Yuka*; Akiyama, Kazuhiko*; Hatsukawa, Yuichi; Kubuki, Shiro*

no journal, , 

To obtain an endohedral metallofullerenes with high specific radioactivity using nuclear recoil phenomena, many experiments have been performed so far. However, production yield of metallofullerene by nuclear recoil using high LET radiation was found to be very small because radiation damages to targeted fullerene molecule were not negligible. In order to increase the yield of radioactive metallofullerenes, it is very promising to employ the recoil of nuclear reaction by fast neutron from the viewpoint of reducing the radiation damage. In this session, we will report the synthesis of $$^{85}$$Sr@C$$_{60}$$ using nuclear recoil of $$^{86}$$Sr(n,2n)$$^{85}$$Sr reaction by 14 MeV fast neutron. Mixture of C$$_{60}$$ with strontium salts such as Sr(NO$$_{3}$$)$$_{2}$$ and SrC$$_{2}$$O$$_{4}$$ were employed for the target materials. These samples were irradiated by fast neutron in Fusion Neutronics Source at Japan Atomic Energy Agency. After the irradiation, CS$$_{2}$$, aniline, and HCl$$_{aq}$$ were passed through the irradiated samples on the filter to dissolve C$$_{60}$$, Sr@C$$_{60}$$, and strontium salts, respectively. The $$gamma$$-ray from these solutions were measured by Ge detector. As a result, about 0.75 % of radioactivity was observed in the aniline solution from SrC$$_{2}$$O$$_{4}$$ sample. This result strongly suggests that Sr@C$$_{60}$$ was efficiently produced by fast neutron irradiation of SrC$$_{2}$$O$$_{4}$$/C$$_{60}$$ target.

4 (Records 1-4 displayed on this page)
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