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Journal Articles

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; *; Morikawa, Naotake*; ; ; ; ; Tachikawa, Enzo;

Shin Jikken Kagaku Koza 11, 507 Pages, 1976/00

no abstracts in English

Journal Articles

Improved synthesis method of biphenyl ( phenyl $$^{1}$$$$^{ }$$4C )

Tsuchihashi, Genichi; Morikawa, Naotake*; Koyama, Hiroaki

Radioisotopes, 11(1), 107 Pages, 1962/00

https://doi.org/10.3769/radioisotopes.11.107

no abstracts in English

Journal Articles

Synthesis of biphenyl-(phenyl-$$^{14}$$C )

Koyama, Hiroaki; Morikawa, Naotake*; Migita, Toshihiko*; Ito, Ryoichi*; Tsuchihashi, Genichi

Radioisotopes, 9(2), p.112 - 116, 1960/00

https://doi.org/10.3769/radioisotopes.9.112

no abstracts in English

Oral presentation

Stability of $$^{186}$$Re- and $$^{188}$$Re-DMSAs and removal of impurity in the product

Komoto, Kazuki*; Nogawa, Norio*; Sato, Jun*; Makide, Yoshihiro*; Morikawa, Naotake*; Hashimoto, Kazuyuki; Sorita, Takami

no journal, , 

Complex compound of $$^{186}$$Re and $$^{188}$$Re with meso-2,3-dimercaptosuccinic acid (DMSA) is expected to be effective against cancerous disease. This compound is synthesized with high radiochemical yield by use of SnCl$$_{2}$$ as reducing reagent. However, the product contains a large amount of SnCl$$_{2}$$ which is harmful to human body. The removal of tin impurity was tested with cation exchange resin. $$^{186}$$Re-DMSA complex was also obtained with high radiochemical yield by use of other harmless reducing agents (L-ascorbic acid, Na$$_{2}$$SO$$_{3}$$, H$$_{3}$$PO$$_{3}$$). Synthesized $$^{186}$$Re-DMSA by use of SnCl$$_{2}$$ was stable in sodium acetate buffer for 5 hours, while survival amount of $$^{186}$$Re-DMSA synthesized by other reducing agents decreased in a short time.

Oral presentation

Study of the PZC$$^{188}$$W/$$^{188}$$Re generator and of the synthesis condition of $$^{186/188}$$Re-DMSA

Nogawa, Norio*; Ikeda, Keishiro*; Morikawa, Naotake*; Motoishi, Shoji; Matsuoka, Hiromitsu; Hashimoto, Kazuyuki

no journal, , 

Rhenium-186(T$$_{1/2}$$=90h; E$$_beta$$=1.1 MeV; E$$_gamma$$=137 keV) and rhenium-188(T$$_{1/2}$$=17h; E$$_beta$$=2.1 MeV; E$$_gamma$$=153 keV) are $$beta$$$$^{-}$$ particle emitting radionuclides with excellent properties for targeted radiotherapy. Re-188 has the advantages associated with carrier-free, generator-produced radionuclides. PZC generator with many tungsten molecules is expected for as practical generator. This generator was experimented for clarifying a characteristic. Meso-2,3-dimercaptosuccinic acid (DMSA) is applied for palliative treatment of pain associated with disease. Effect of pH is studied on preparation of $$^{186/188}$$Re-DMSA.

Oral presentation

Study of the $$^{188}$$W-$$^{188}$$Re generator using PZC and synthesis of $$^{186}$$Re and $$^{188}$$Re-DMSA

Nogawa, Norio*; Hashimoto, Kazuyuki; Kurihara, Yuichi*; Koike, Yuya*; Morikawa, Naotake*; Ijiri, Kenichi*

no journal, , 

no abstracts in English

Oral presentation

Study of the $$^{188}$$W-$$^{188}$$Re generator using PZC

Kurihara, Yuichi*; Nogawa, Norio*; Hashimoto, Kazuyuki; Koike, Yuya*; Morikawa, Naotake*; Ijiri, Kenichi*

no journal, , 

no abstracts in English

Oral presentation

Synthesis of $$^{186,188}$$Re-MAG3 and $$^{186,188}$$Re-[(CO)$$_{3}$$(H$$_{2}$$O)$$_{3}$$]$$^{+}$$

Kurihara, Yuichi*; Nogawa, Norio*; Hashimoto, Kazuyuki; Koike, Yuya*; Morikawa, Naotake*; Ijiri, Kenichi*

no journal, , 

no abstracts in English

Oral presentation

Study of the $$^{188}$$W-$$^{188}$$Re generator using PZC

Kurihara, Yuichi*; Nogawa, Norio*; Hashimoto, Kazuyuki; Koike, Yuya*; Morikawa, Naotake*; Ijiri, Kenichi*

no journal, , 

no abstracts in English

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