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Journal Articles

Production of $$^{64}$$Cu and $$^{67}$$Cu with accelerator neutrons by deuterons and their separation from zinc

Nagai, Yasuki*; Kawabata, Masako*; Saeki, Hideya*; Motoishi, Shoji*; Hashimoto, Kazuyuki; Tsukada, Kazuaki; Motomura, Arata*; Ota, Akio*; Takashima, Naoki*; Hashimoto, Shintaro; et al.

Frontiers in Nuclear Medicine (Internet), 5, p.1657125_1 - 1657125_11, 2025/10

https://doi.org/10.3389/fnume.2025.1657125

In recent years, the radionuclide pair of $$^{64}$$Cu and $$^{67}$$Cu has attracted attention as an ideal theranostic agent. We proposed a novel production method utilizing a neutron source generated by deuteron beams at an accelerator facility. By irradiating enriched $$^{68}$$Zn samples with this neutron source, we measured the absolute activity and radionuclidic purity of the produced $$^{67}$$Cu. The results were consistent with calculations performed using PHITS and JENDL-5 developed by the Japan Atomic Energy Agency, confirming the reliability of the calculation method and demonstrating its capability to estimate the yields of trace radionuclides that are difficult to measure experimentally. Furthermore, we successfully separated $$^{67}$$Cu from the irradiated Zn sample using our developed sublimation and column separation techniques. These findings suggest that the production of $$^{64}$$Cu and $$^{67}$$Cu can be achieved in an economically sustainable manner at multiple sites.

Journal Articles

Estimated isotopic compositions of Yb in enriched $$^{176}$$Yb for producing $$^{177}$$Lu with high radionuclide purity by $$^{176}$$Yb($$d,x$$)$$^{177}$$Lu

Nagai, Yasuki*; Kawabata, Masako*; Hashimoto, Shintaro; Tsukada, Kazuaki; Hashimoto, Kazuyuki*; Motoishi, Shoji*; Saeki, Hideya*; Motomura, Arata*; Minato, Futoshi; Ito, Masatoshi*

Journal of the Physical Society of Japan, 91(4), p.044201_1 - 044201_10, 2022/04

https://doi.org/10.7566/JPSJ.91.044201
 Times Cited Count：6 Percentile：50.35(Physics, Multidisciplinary)

Recently, $$^{177}$$Lu is considered as one of the most important medical RIs for treating neuroendocrine tumors. A plan to produce $$^{177}$$Lu with high purity by using enriched $$^{176}$$Yb samples with irradiation of deuteron beams in accelerators has been discussed. However, since the other Yb isotopes contained in the Yb sample interacts with deuterons, Lu isotopes other than $$^{177}$$Lu are produced as impurities. Since the purity of $$^{177}$$Lu is important for medical use, a method to evaluate the impurity of Lu has been required. In this study, we proposed a new method to estimate production yields of each Lu isotopes in Yb samples with arbitrary isotopic compositions by using excitation functions of Yb($$d,x$$)Lu reactions and the particle transport calculation code PHITS. The method plays an important role in discussing the isotopic composition of enriched samples to produce high-purity $$^{177}$$Lu using accelerators.

Journal Articles

Large scale production of $$^{64}$$Cu and $$^{67}$$Cu via the $$^{64}$$Zn(n, p)$$^{64}$$Cu and $$^{68}$$Zn(n, np/d)$$^{67}$$Cu reactions using accelerator neutrons

Kawabata, Masako*; Motoishi, Shoji*; Ota, Akio*; Motomura, Arata*; Saeki, Hideya*; Tsukada, Kazuaki; Hashimoto, Shintaro; Iwamoto, Nobuyuki; Nagai, Yasuki*; Hashimoto, Kazuyuki*

Journal of Radioanalytical and Nuclear Chemistry, 330(3), p.913 - 922, 2021/12

https://doi.org/10.1007/s10967-021-07987-3
 Times Cited Count：13 Percentile：75.41(Chemistry, Analytical)

Both $$^{64}$$Cu and $$^{67}$$Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable $$^{64}$$Cu and $$^{67}$$Cu yields were estimated by experimental based numerical simulations using 100 g of enriched $$^{64}$$Zn and $$^{68}$$Zn, respectively, and elevated neutron fluxes from 40 MeV, 2 mA deuterons. A combined thermal- and resin-separation method was developed to isolate $$^{64}$$Cu and $$^{67}$$Cu from zinc, resulting in 73% separation efficiency and 97% zinc recovery. Such methods can provide large scale production of $$^{64}$$Cu and $$^{67}$$Cu for clinical applications.

Journal Articles

Anomalous radioisotope production for $$^{68}$$ZnO using polyethylene by accelerator neutrons

Tsukada, Kazuaki; Nagai, Yasuki*; Hashimoto, Shintaro; Minato, Futoshi; Kawabata, Masako*; Hatsukawa, Yuichi*; Hashimoto, Kazuyuki*; Watanabe, Satoshi*; Saeki, Hideya*; Motoishi, Shoji*

Journal of the Physical Society of Japan, 89(3), p.034201_1 - 034201_7, 2020/03

https://doi.org/10.7566/JPSJ.89.034201
 Times Cited Count：3 Percentile：22.41(Physics, Multidisciplinary)

We found anomalously large yields of $$^{67}$$Ga, $$^{66}$$Ga, $$^{rm 69m}$$Zn and $$^{64}$$Cu by neutron irradiation on a $$^{68}$$ZnO sample in a polyethylene shield. Neutron beams are generated from the $$^{9}$$Be($$d,n$$) reaction for 50 MeV deuterons. The yields obtained were more than 20 times larger than those in the unshielded sample. On the other hand, the yields of $$^{67}$$Ga, $$^{66}$$Ga, $$^{rm 69m}$$Zn and $$^{64}$$Cu from a metallic $$^{68}$$Zn sample and the yields of $$^{67}$$Cu, $$^{65}$$Ni and $$^{65}$$Zn from the $$^{68}$$ZnO and $$^{68}$$Zn samples were almost insensitive to the shield conditions. This finding would provide us a unique capability of accelerator neutrons to simultaneously produce a large amount of several radioisotopes, including proton induced reaction products, by using a single sample. The experimental data were compared with the yields estimated by using the Particle and Heavy Ion Transport code System and the result was discussed.

Journal Articles

$$^{99}$$Mo yield using large sample mass of MoO$$_{3}$$ for sustainable production of $$^{99}$$Mo

Tsukada, Kazuaki; Nagai, Yasuki*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Minato, Futoshi; Saeki, Hideya*; Motoishi, Shoji*; Ito, Masatoshi*

Journal of the Physical Society of Japan, 87(4), p.043201_1 - 043201_5, 2018/04

https://doi.org/10.7566/JPSJ.87.043201
 Times Cited Count：10 Percentile：53.73(Physics, Multidisciplinary)

Journal Articles

SPECT imaging of mice with $$^{99m}$$Tc-radiopharmaceuticals obtained from $$^{99}$$Mo produced by $$^{100}$$Mo(n,2n)$$^{99}$$Mo and fission of $$^{235}$$U

Hashimoto, Kazuyuki; Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji*; Ota, Masayuki; Konno, Chikara; Ochiai, Kentaro; et al.

Journal of the Physical Society of Japan, 84(4), p.043202_1 - 043202_4, 2015/04

https://doi.org/10.7566/JPSJ.84.043202
 Times Cited Count：8 Percentile：49.27(Physics, Multidisciplinary)

Journal Articles

New phenomenon observed in thermal release of $$^{99m}$$Tc from molten $$^{100}$$MoO$$_{3}$$

Kawabata, Masako; Nagai, Yasuki; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*

Journal of the Physical Society of Japan, 84(2), p.023201_1 - 023201_4, 2015/02

https://doi.org/10.7566/JPSJ.84.023201
 Times Cited Count：6 Percentile：41.75(Physics, Multidisciplinary)

$$^{99m}$$Tc for medical use can be separated by thermochromatography from a molten $$^{99}$$MoO$$_{3}$$ sample. Effect of moist oxygen gas on the $$^{99m}$$Tc release from molten $$^{99}$$MoO$$_{3}$$ samples was investigated using a $$^{99}$$Mo/$$^{99m}$$Tc generator. $$^{99}$$Mo was produced with $$^{100}$$Mo(n,2n)$$^{99}$$Mo. A new phenomenon has been observed: release rate, separation- and recovery-efficiencies of $$^{99m}$$Tc were higher in the moist oxygen gas than those in the dry oxygen gas. The present result is a significant progress towards the stable production of a high quality $$^{99m}$$Tc from a molten MoO$$_{3}$$ sample with high separation efficiency. The result would also give us a new insight into the interaction between the moist oxygen gas and the molten MoO$$_{3}$$.

Journal Articles

High thermo-separation efficiency of $$^{99m}$$Tc from molten $$^{100}$$MoO$$_{3}$$ samples by repeated milking tests

Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*

Journal of the Physical Society of Japan, 83(8), p.083201_1 - 083201_4, 2014/07

https://doi.org/10.7566/JPSJ.83.083201
 Times Cited Count：12 Percentile：59.23(Physics, Multidisciplinary)

Journal Articles

Generation of radioisotopes with accelerator neutrons by deuterons

Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji; Sonoda, Nozomi; Kawabata, Masako; Harada, Hideo; Kin, Tadahiro*; Tsukada, Kazuaki; et al.

Journal of the Physical Society of Japan, 82(6), p.064201_1 - 064201_7, 2013/06

https://doi.org/10.7566/JPSJ.82.064201
 Times Cited Count：47 Percentile：84.71(Physics, Multidisciplinary)

Journal Articles

Successful labeling of $$^{rm 99m}$$Tc-MDP using $$^{rm 99m}$$Tc separated from $$^{99}$$Mo produced by $$^{100}$$Mo($textit{n}$,2$textit{n}$)$$^{99}$$Mo

Nagai, Yasuki; Hatsukawa, Yuichi; Kin, Tadahiro; Hashimoto, Kazuyuki; Motoishi, Shoji; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke; Sato, Yuichi*; Kawauchi, Yukimasa*; et al.

Journal of the Physical Society of Japan, 80(8), p.083201_1 - 083201_4, 2011/08

https://doi.org/10.1143/JPSJ.80.083201
 Times Cited Count：15 Percentile：63.47(Physics, Multidisciplinary)

We have for the first time succeeded to separate $$^{rm 99m}$$Tc from a Mo oxide sample irradiated by accelerator neutrons, and to formulate $$^{rm 99m}$$Tc-methylene diphosphonate ($$^{rm 99m}$$Tc-MDP). $$^{99}$$Mo, the mother nuclide of $$^{rm 99m}$$Tc, was produced by the $$^{100}$$Mo($textit{n}$,2$textit{n}$)$$^{99}$$Mo reaction using about 14 MeV neutrons provided at the Fusion Neutronics Source of Japan Atomic Energy Agency. The $$^{rm 99m}$$Tc was separated from $$^{99}$$Mo by the sublimation method, and its radionuclide purity was confirmed to be higher than 99.99%. The labeling efficiency of $$^{rm 99m}$$Tc-MDP was shown to be higher than 99%. These values exceed the United States Pharmacopeia requirements for a fission product, $$^{99}$$Mo. Consequently, a $$^{rm 99m}$$Tc radiopharmaceutical preparation formed by using the mentioned $$^{99}$$Mo can be a promising substitute for the fission product $$^{99}$$Mo. A longstanding problem to ensure a reliable and constant supply of $$^{99}$$Mo in Japan can be partially mitigated.

Journal Articles

In vivo recognition of Cyclopentadienyltricarbonylrhenium (CpTR) derivatives

Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Miyamoto, Shigehiko*; Motoishi, Shoji; Hashimoto, Kazuyuki; Oku, Naoto*; Nakayama, Morio*; Arano, Yasushi*

Nuclear Medicine and Biology, 30(3), p.327 - 334, 2003/04

https://doi.org/10.1016/S0969-8051(02)00437-7
 Times Cited Count：20 Percentile：48.91(Radiology, Nuclear Medicine & Medical Imaging)

no abstracts in English

Journal Articles

Experimental radioimmunotherapy with $$^{186}$$Re-MAG3-A7 anti-colorectal cancer monoclonal antibody; Comparison with $$^{131}$$I-counterpart

Kinuya, Seigo*; Yokoyama, Kunihiko*; Kobayashi, Katsutoshi; Motoishi, Shoji; Onoma, Katsuyuki; Watanabe, Naoto*; Shuke, Noriyuki*; Bunko, Hisashi*; Nichigishi, Takatoshi*; Tonami, Norihisa*

Annals of Nuclear Medicine, 15(3), p.199 - 202, 2001/06

https://doi.org/10.1007/BF02987831
 Times Cited Count：10 Percentile：32.63(Radiology, Nuclear Medicine & Medical Imaging)

no abstracts in English

Journal Articles

Methylxanthine sensitization of human colon cancer cells to $$^{186}$$Re-labeled monoclonal antibody

Kinuya, Seigo*; Yokoyama, Kunihiko*; Kudo, Miho*; Kasahara, Yoshihito*; Kobayashi, Katsutoshi; Motoishi, Shoji; Onoma, Katsuyuki; Bunko, Hisashi*; Nichigishi, Takatoshi*; Tonami, Norihisa*

Journal of Nuclear Medicine, 42(4), p.596 - 600, 2001/04

no abstracts in English

JAEA Reports

Measurement of tritium activity in the aluminum pipe of JRR-2 heavy water primary cooling system using imaging plate

Motoishi, Shoji; Kobayashi, Katsutoshi; Saeki, Hideya*

JAERI-Tech 2000-070, 34 Pages, 2000/12

JAERI-Tech-2000-070.pdf:5.19MB

no abstracts in English

Journal Articles

Production of $$^{186,188}$$Re and recovery of tungsten from spent $$^{188}$$W/$$^{188}$$Re generator

Kobayashi, Katsutoshi; Motoishi, Shoji; Terunuma, Kuzuo; Rauf, A. A.*; Hashimoto, Kazuyuki

Radiochemistry, 42(6), p.551 - 554, 2000/12

no abstracts in English

Journal Articles

Measurement of the effective neutron capture cross section of cesium-134 by triple neutron capture reaction method

Harada, Hideo; Nakamura, Shoji; Kato, Toshio; Kobayashi, Katsunori*; Motoishi, Shoji*; Tanase, Masakazu*

Journal of Nuclear Science and Technology, 36(8), p.635 - 640, 1999/08

https://doi.org/10.1080/18811248.1999.9726249
 Times Cited Count：3 Percentile：27.85(Nuclear Science & Technology)

None

Journal Articles

Thermal neutron cross section and resonance integral of the reaction of $$^{135}$$Cs(n,$$gamma$$)$$^{136}$$Cs; Fundamental data for the transmutation of nuclear waste

Hatsukawa, Yuichi*; Shinohara, Nobuo*; Hata, Kentaro*; Kobayashi, Katsunori*; Motoishi, Shoji*; Tanase, Masakazu*; Kato, Toshio; Nakamura, Shoji; Harada, Hideo

Journal of Radioanalytical and Nuclear Chemistry, 239(3), p.455 - 458, 1999/03

https://doi.org/10.1007/BF02349050
 Times Cited Count：2 Percentile：20.64(Chemistry, Analytical)

no abstracts in English

Journal Articles

Measurement of the Effective Neutron Capture Cross Section of Cesium-134 by Triple Neutron Capture Reaction Method

Harada, Hideo; Nakamura, Shoji; Kato, Toshio; Kobayashi, Katsunori*; Motoishi, Shoji*; Tanase, Masakazu*

Journal of Nuclear Science and Technology, 36(8), p.635 - 640, 1999/00

https://doi.org/10.1080/18811248.1999.9726249

None

Journal Articles

Thermal neutron cross section and resonance integral of the reaction of $$^{135}$$Cs(n,$$gamma$$)$$^{136}$$Cs; Fundamental data for the transmutation of nuclear waste

Hatsukawa, Yuichi; Shinohara, Nobuo; ; Kobayashi, Katsutoshi; Motoishi, Shoji; Tanase, Masakazu; ; ; Harada, Hideo*

Journal of Radioanalytical and Nuclear Chemistry, 239(3), p.455 - 458, 1999/00

https://doi.org/10.1007/BF02349050
 Times Cited Count：2 Percentile：75.00(Chemistry, Analytical)

no abstracts in English

Journal Articles

Measurement of thermal neutron cross section and resonance integral of the reaction $$^{135}$$Cs(n,$$gamma$$)$$^{136}$$Cs

Kato, Toshio; Nakamura, Shoji; Harada, Hideo; Hatsukawa, Yuichi*; Shinohara, Nobuo*; Hata, Kentaro*; Kobayashi, Katsunori*; Motoishi, Shoji*; Tanase, Masakazu*

Journal of Nuclear Science and Technology, 34(5), p.431 - 438, 1997/05

https://doi.org/10.1080/18811248.1997.9733686

no abstracts in English

42 (Records 1-20 displayed on this page)