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Journal Articles

Analysis of trace elements in erythrocytes obtained from dialysis patients using in-air micro PIXE

Kikuchi, Hiroki*; Nagamine, Takeaki*; Tokita, Yoshiharu*; Sato, Takahiro; Kamiya, Tomihiro

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 88, 2012/01

Journal Articles

Analysis on the co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-PIXE

Dobashi, Kunio*; Shimizu, Yasuo*; Matsuzaki, Shinichi*; Nagamine, Takeaki*; Sato, Takahiro; Okubo, Takeru; Yokoyama, Akihito; Ishii, Yasuyuki; Kamiya, Tomihiro; Arakawa, Kazuo*; et al.

JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 87, 2012/01

Journal Articles

Analysis on the Co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-PIXE

Matsuzaki, Shinichi*; Shimizu, Yasuo*; Dobashi, Kunio*; Nagamine, Takeaki*; Sato, Takahiro; Okubo, Takeru; Yokoyama, Akihito; Ishii, Yasuyuki; Kamiya, Tomihiro; Arakawa, Kazuo*; et al.

International Journal of Immunopathology and Pharmacology, 23(1), p.1 - 11, 2010/01

Journal Articles

Intracellular changes of metal elements by fucoidan extracted from brown seaweed; ${it Cladosiphon okamuranus}$

Nagamine, Takeaki*; Takada, Hisashi*; Kusakabe, Takahiko*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Kamiya, Tomihiro; Arakawa, Kazuo; Iha, Masahiko*

Biological Trace Element Research, 124(1), p.60 - 69, 2008/07

 Times Cited Count:2 Percentile:7.24(Biochemistry & Molecular Biology)

This study was undertaken to elucidate the intracellular changes of metal elements after the administration of fucoidan extracted from ${it Cladosiphon okamuranus}$. TRL1215 cells (normal rat liver cell line) were treated with 0, 0.1, or 1.0 mg/mL fucoidan. The cellular distribution of elements was analyzed using in-air micro-PIXE induced X-ray emission. In fucoidan-treated cells, the focal accumulation of Br (BrdU) was correlated spatially with phosphorous-rich region, suggesting that Br was localized within the nucleus. Al distribution provided a spatial association with Br map. These data suggest that fucoidan binding Al us postulated to be transferred into the nucleus.

Journal Articles

Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice

Nakazato, Kyomi*; Nagamine, Takeaki*; Suzuki, Keiji*; Kusakabe, Takahiko*; Moon, H. D.*; Oikawa, Masakazu*; Sakai, Takuro; Arakawa, Kazuo

Biometals, 21(1), p.83 - 91, 2008/02

 Times Cited Count:15 Percentile:32.1(Biochemistry & Molecular Biology)

To clarify the relation of essential metals to cadmium (Cd) toxicity, we evaluated metallothionein expression and analyzed the subcellular distribution of essential metals using in-air micro-PIXE. Four mice were dosed orally with 100 mg/L of Cd in drinking water for 1.5 or 2 years. Compared to the control, the Cd-exposed mice markedly accumulated zinc in the liver and renal cortex. Elemental maps showed that a large amount of Cd was spatially combined with zinc in the 1.5y-Cd mouse. The data suggest that zinc may contribute to protect against oral-administrated Cd toxicity.

Journal Articles

Interferon$$beta$$-induced changes in metallothionein expression and subcellular distribution of zinc in HepG2 cells

Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Sato, Takahiro; Arakawa, Kazuo

Cytokine, 34(5-6), p.312 - 319, 2006/06

 Times Cited Count:8 Percentile:17.62(Biochemistry & Molecular Biology)

no abstracts in English

Journal Articles

Research of disease onset mechanism by determining the distribution of intracellular trace elements using an in-air micro-PIXE analyzer system

Nakano, Takashi*; Arakawa, Kazuo; Sakurai, Hideyuki*; Hasegawa, Masatoshi*; Yuasa, Kazuhisa*; Saito, Etsuko*; Takagi, Hitoshi*; Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; et al.

International Journal of PIXE, 16(1&2), p.69 - 76, 2006/00

A new program was started out to create a new medical scientific field, which is consisting of radiation oncology and nuclear medicine, utilizing the advanced accelerator and ion beam technology. An in-air micro-PIXE analyzer system, which is among the most important technical basis of the program, was upgraded to improve accuracy of elemental mapping for samples having thickness variation in a scope of microbeam scanning. In the program, on the other hand, in order to approach important bio-medical problems on cancer, intracellular dynamics of the trace elements according to mechanism of development of diseases were studied using this system. This paper outlines this program and shows the system upgraded, and results of preliminary studied about the problems.

Oral presentation

Analysis of heavy metal distribution in testicular lesion of cadmium using in-air micro-PIXE method

Kusakabe, Takahiko*; Nakazato, Kyomi*; Takada, Hisashi*; Hisanaga, Etsuko*; Moon, H. D.*; Nakajima, Katsuyuki*; Suzuki, Keiji*; Oikawa, Masakazu*; Sato, Takahiro; Arakawa, Kazuo; et al.

no journal, , 

no abstracts in English

Oral presentation

Zinc kinetics in HCV Replicon

Takizawa, Daichi*; Takagi, Hitoshi*; Makita, Chikako*; Nakajima, Yuka*; Saito, Etsuko*; Oyama, Tatsuya*; Ichikawa, Takeshi*; Kakizaki, Akira*; Sato, Ken*; Mori, Masatomo*; et al.

no journal, , 

no abstracts in English

Oral presentation

Interacellular change of metal elements by fucoidan

Takada, Hisashi*; Kusakabe, Takahiko*; Nakazato, Kyomi*; Oikawa, Masakazu*; Sato, Takahiro; Kamiya, Tomihiro; Arakawa, Kazuo; Nagamine, Takeaki*

no journal, , 

no abstracts in English

Oral presentation

In-air micro-PIXE analysis of asbestos and metal elements in asbestos exposed lung

Shimizu, Yasuo*; Dobashi, Kunio*; Kusakabe, Takahiko*; Nagamine, Takeaki*; Oikawa, Masakazu*; Sato, Takahiro; Haga, Junji*; Okubo, Takeru; Ishii, Yasuyuki; Kamiya, Tomihiro; et al.

no journal, , 

no abstracts in English

Oral presentation

Influence of inhaled dust upon expression of Fas protein under idiopathic interstitial pneumonia

Shimizu, Yasuo*; Matsuzaki, Shinichi*; Sato, Takahiro; Kamiya, Tomihiro; Okubo, Takeru; Ishii, Yasuyuki; Arakawa, Kazuo*; Nagamine, Takeaki*; Dobashi, Kunio*

no journal, , 

no abstracts in English

Oral presentation

Elementary analysis of erythrocyte of dialysis patients using in-air micro-PIXE

Kikuchi, Hiroki*; Tokita, Yoshiharu*; Nagamine, Takeaki*; Sato, Takahiro; Kamiya, Tomihiro

no journal, , 

no abstracts in English

Oral presentation

Analysis of anemia of liver patients using in-air micro-PIXE

Nagamine, Takeaki*; Akutsu, Taito*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro

no journal, , 

no abstracts in English

Oral presentation

Relevancy of elemental analysis by in-air micro PIXE for fine grains in a lung tissue to pathogenesis of idiopathicinterstitial pneumonia

Dobashi, Kunio*; Shimizu, Yasuo*; Matsuzaki, Shinichi*; Ishizuka, Tamotsu*; Mori, Masatomo*; Sato, Takahiro; Koka, Masashi; Yokoyama, Akihito; Okubo, Takeru; Ishii, Yasuyuki; et al.

no journal, , 

no abstracts in English

Oral presentation

Investigation on pathology of anemia using in-air micro-PIXE; Examination for treatment of chronic hepatitis c with interferon

Akutsu, Taito*; Tomioka, Satoru*; Nagamine, Takeaki*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro

no journal, , 

no abstracts in English

Oral presentation

Clinical applications of elemental analysis of erythrocyte using micro-PIXE

Tomioka, Satoru*; Nagamine, Takeaki*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro

no journal, , 

no abstracts in English

Oral presentation

Analysis of erythrocyte elements in chronic hepatitis C patients treated with interferon and ribavirin by in-air microPIXE

Nagamine, Takeaki*; Tomioka, Satoru*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro

no journal, , 

Oral presentation

Measurement of trace elements in an erythrocyte of myelodysplastic syndrome (MDS) using in-air micro-PIXE

Kasamatsu, Tetsuhiro*; Nagashima, Tomomi*; Nagai, Kiyoe*; Nagamine, Takeaki*; Murakami, Hirokazu*; Koka, Masashi; Yamada, Naoto; Kitamura, Akane; Sato, Takahiro; Yokoyama, Akihito; et al.

no journal, , 

no abstracts in English

19 (Records 1-19 displayed on this page)
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