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Dobashi, Kunio*; Shimizu, Yasuo*; Matsuzaki, Shinichi*; Nagamine, Takeaki*; Sato, Takahiro; Okubo, Takeru; Yokoyama, Akihito; Ishii, Yasuyuki; Kamiya, Tomihiro; Arakawa, Kazuo*; et al.
JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 87, 2012/01
Kikuchi, Hiroki*; Nagamine, Takeaki*; Tokita, Yoshiharu*; Sato, Takahiro; Kamiya, Tomihiro
JAEA-Review 2011-043, JAEA Takasaki Annual Report 2010, P. 88, 2012/01
Matsuzaki, Shinichi*; Shimizu, Yasuo*; Dobashi, Kunio*; Nagamine, Takeaki*; Sato, Takahiro; Okubo, Takeru; Yokoyama, Akihito; Ishii, Yasuyuki; Kamiya, Tomihiro; Arakawa, Kazuo*; et al.
International Journal of Immunopathology and Pharmacology, 23(1), p.1 - 11, 2010/01
Nagamine, Takeaki*; Takada, Hisashi*; Kusakabe, Takahiko*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Kamiya, Tomihiro; Arakawa, Kazuo; Iha, Masahiko*
Biological Trace Element Research, 124(1), p.60 - 69, 2008/07
Times Cited Count：2 Percentile：6.78(Biochemistry & Molecular Biology)This study was undertaken to elucidate the intracellular changes of metal elements after the administration of fucoidan extracted from . TRL1215 cells (normal rat liver cell line) were treated with 0, 0.1, or 1.0 mg/mL fucoidan. The cellular distribution of elements was analyzed using in-air micro-PIXE induced X-ray emission. In fucoidan-treated cells, the focal accumulation of Br (BrdU) was correlated spatially with phosphorous-rich region, suggesting that Br was localized within the nucleus. Al distribution provided a spatial association with Br map. These data suggest that fucoidan binding Al us postulated to be transferred into the nucleus.
Nakazato, Kyomi*; Nagamine, Takeaki*; Suzuki, Keiji*; Kusakabe, Takahiko*; Moon, H. D.*; Oikawa, Masakazu*; Sakai, Takuro; Arakawa, Kazuo
Biometals, 21(1), p.83 - 91, 2008/02
Times Cited Count：15 Percentile：28.75(Biochemistry & Molecular Biology)To clarify the relation of essential metals to cadmium (Cd) toxicity, we evaluated metallothionein expression and analyzed the subcellular distribution of essential metals using in-air micro-PIXE. Four mice were dosed orally with 100 mg/L of Cd in drinking water for 1.5 or 2 years. Compared to the control, the Cd-exposed mice markedly accumulated zinc in the liver and renal cortex. Elemental maps showed that a large amount of Cd was spatially combined with zinc in the 1.5y-Cd mouse. The data suggest that zinc may contribute to protect against oral-administrated Cd toxicity.
-induced changes in metallothionein expression and subcellular distribution of zinc in HepG2 cellsNagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Sato, Takahiro; Arakawa, Kazuo
Cytokine, 34(5-6), p.312 - 319, 2006/06
Times Cited Count：8 Percentile：16.31(Biochemistry & Molecular Biology)no abstracts in English
Nakano, Takashi*; Arakawa, Kazuo; Sakurai, Hideyuki*; Hasegawa, Masatoshi*; Yuasa, Kazuhisa*; Saito, Etsuko*; Takagi, Hitoshi*; Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; et al.
International Journal of PIXE, 16(1&2), p.69 - 76, 2006/00
A new program was started out to create a new medical scientific field, which is consisting of radiation oncology and nuclear medicine, utilizing the advanced accelerator and ion beam technology. An in-air micro-PIXE analyzer system, which is among the most important technical basis of the program, was upgraded to improve accuracy of elemental mapping for samples having thickness variation in a scope of microbeam scanning. In the program, on the other hand, in order to approach important bio-medical problems on cancer, intracellular dynamics of the trace elements according to mechanism of development of diseases were studied using this system. This paper outlines this program and shows the system upgraded, and results of preliminary studied about the problems.
Nagamine, Takeaki*; Akutsu, Taito*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro
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Akutsu, Taito*; Tomioka, Satoru*; Nagamine, Takeaki*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro
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Tomioka, Satoru*; Nagamine, Takeaki*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro
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Takizawa, Daichi*; Takagi, Hitoshi*; Makita, Chikako*; Nakajima, Yuka*; Saito, Etsuko*; Oyama, Tatsuya*; Ichikawa, Takeshi*; Kakizaki, Akira*; Sato, Ken*; Mori, Masatomo*; et al.
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Kusakabe, Takahiko*; Nakazato, Kyomi*; Takada, Hisashi*; Hisanaga, Etsuko*; Moon, H. D.*; Nakajima, Katsuyuki*; Suzuki, Keiji*; Oikawa, Masakazu*; Sato, Takahiro; Arakawa, Kazuo; et al.
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Nagamine, Takeaki*; Tomioka, Satoru*; Sato, Takahiro; Koka, Masashi; Kamiya, Tomihiro
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Shimizu, Yasuo*; Matsuzaki, Shinichi*; Sato, Takahiro; Kamiya, Tomihiro; Okubo, Takeru; Ishii, Yasuyuki; Arakawa, Kazuo*; Nagamine, Takeaki*; Dobashi, Kunio*
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no abstracts in English
Kikuchi, Hiroki*; Tokita, Yoshiharu*; Nagamine, Takeaki*; Sato, Takahiro; Kamiya, Tomihiro
no journal, ,
no abstracts in English
Dobashi, Kunio*; Shimizu, Yasuo*; Matsuzaki, Shinichi*; Ishizuka, Tamotsu*; Mori, Masatomo*; Sato, Takahiro; Koka, Masashi; Yokoyama, Akihito; Okubo, Takeru; Ishii, Yasuyuki; et al.
no journal, ,
no abstracts in English
Kasamatsu, Tetsuhiro*; Nagashima, Tomomi*; Nagai, Kiyoe*; Nagamine, Takeaki*; Murakami, Hirokazu*; Koka, Masashi; Yamada, Naoto; Kitamura, Akane; Sato, Takahiro; Yokoyama, Akihito; et al.
no journal, ,
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Takada, Hisashi*; Kusakabe, Takahiko*; Nakazato, Kyomi*; Oikawa, Masakazu*; Sato, Takahiro; Kamiya, Tomihiro; Arakawa, Kazuo; Nagamine, Takeaki*
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Shimizu, Yasuo*; Dobashi, Kunio*; Kusakabe, Takahiko*; Nagamine, Takeaki*; Oikawa, Masakazu*; Sato, Takahiro; Haga, Junji*; Okubo, Takeru; Ishii, Yasuyuki; Kamiya, Tomihiro; et al.
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no abstracts in English
