Refine your search:     
Report No.
 - 
Search Results: Records 1-2 displayed on this page of 2
  • 1

Presentation/Publication Type

Initialising ...

Refine

Journal/Book Title

Initialising ...

Meeting title

Initialising ...

First Author

Initialising ...

Keyword

Initialising ...

Language

Initialising ...

Publication Year

Initialising ...

Held year of conference

Initialising ...

Save select records

Oral presentation

3D analysis by whole body serial sections of the systemic responses induced by local carbon-ion irradiation in medaka (${it Oryzias latipes}$)

Asaka, Tomomi*; Hashimoto, Chika*; Ito, Kazusa*; Yasuda, Takako*; Nagata, Kento*; Nishimaki, Toshiyuki*; Katsumura, Takafumi*; Ota, Hiroki*; Suzuki, Michiyo; Funayama, Tomoo; et al.

no journal, , 

It is thought that the irradiation to the particular area of the individual could induce the irradiation impact to the outside of the irradiated area in addition to the irradiated region. In this study, we established the procedures to conduct carbon ion irradiation on adult Medaka, which can irradiate only either dorsal or ventral side of the fish, using the broad-beam irradiation system of JAEA-Takasaki. The irradiated fish were examined heart rate before the fixation. Thereafter, the systemic alteration was evaluated by serial cross sections of the whole body of the fish. Tissues at the irradiated side were seriously injured that corresponded to the range of the beam. However, secondary gill lamella showed the characteristic edema in either the ventral or dorsal irradiated fish unless the gill located at ventral, suggesting the systemic irradiation effect. There was no alteration in the heart rate after the irradiation suggesting no severe effects in blood flow in this condition.

Oral presentation

Availability of medaka as systemic effect model of local irradiation by histological analysis

Asaka, Tomomi*; Ito, Kazusa*; Hashimoto, Chika*; Yasuda, Takako*; Nagata, Kento*; Nishimaki, Toshiyuki*; Katsumura, Takafumi*; Ota, Hiroki*; Suzuki, Michiyo; Funayama, Tomoo; et al.

no journal, , 

Radiotherapy has been widely used in cancer target. It is thought that the irradiation to the particular area of the individual could induce the irradiation impact to the nearby and distant tissues of the irradiated area in addition to the irradiated region. However, it is still difficult to analyze influences to the whole body using mice because of its big body size. Medaka, ${it Oryzias latipes}$, is small enough to examine the acute somatic effects induced in all tissues at the cellular levels. In this study, we developed a method to conduct local irradiation on adult medaka using low energy carbon-ion beam in TIARA, JAEA-Takasaki. The irradiated fish were measured the heart rate to evaluate the impact to the heart, chemically fixed, serially sectioned and Hematoxylin/eosin stained. The results suggested that there would be the systemic effects by local irradiation in addition to the effects in the irradiated region, which is probably caused by immune system though blood.

2 (Records 1-2 displayed on this page)
  • 1