Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Kawasaki, Riku*; Sasaki, Yoshihiro*; Nishimura, Tomoki*; Katagiri, Kiyofumi*; Morita, Keiichi*; Sekine, Yurina; Sawada, Shinichi*; Mukai, Sadaatsu*; Akiyoshi, Kazunari*
Advanced Healthcare Materials, 10(9), p.2001988_1 - 2001988_8, 2021/05
Times Cited Count：11 Percentile：57.42(Engineering, Biomedical)Systems for "protein transduction", the intracellular delivery of functional proteins, are needed to address the deliverability challenges of protein therapy, but protein transfer in vivo remains difficult. In this study, we have developed a magnetically induced in vivo protein transfection system using a magnetic nanogel chaperone (MC) composed of iron oxide nanoparticles and polysaccharide nanogels. Experiments using an oral cancer model have shown that this MC system is useful for cancer treatment.
Nishimura, Tomoki*; Akiyoshi, Kazunari*; Sekine, Yurina
Hamon, 30(2), p.102 - 105, 2020/05
The development of drug delivery systems (DDS) that enable encapsulation of drugs, selective delivery to target tissues or organs has improved therapeutic effect and reduced side effects. DDS carriers are mainly based on the self-assembled nanoparticles, and their size and shape have significant influences on the therapeutic effect and side effects. However, their small sizes preclude from obtaining structural data with high accuracy by using conventional structural analysis techniques. We thus have analyzed the structures of supramolecular assemblies under the same conditions in actual use by neutron and synchrotron radiation small-angle X-ray scattering. Here, we review our recent studies on the structural analysis of supramolecular assemblies, including nanogels and polymer vesicles using contrast-variation neutron scattering and X-ray small-angle scattering measurements.
Nishimura, Katsuhiko*; Matsuda, Kenji*; Lee, S.*; Nunomura, Norio*; Shimano, Tomoki*; Bendo, A.*; Watanabe, Katsumi*; Tsuchiya, Taiki*; Namiki, Takahiro*; Toda, Hiroyuki*; et al.
Journal of Alloys and Compounds, 774, p.405 - 409, 2019/02
Times Cited Count：3 Percentile：14.87(Chemistry, Physical)