Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

余語 覚文; 前田 拓也; 堀 利彦; 榊 泰直; 小倉 浩一; 西内 満美子; 匂坂 明人; 桐山 博光; 岡田 大; 金沢 修平; et al.

Applied Physics Letters, 98(5), p.053701_1 - 053701_3, 2011/02

https://doi.org/10.1063/1.3551623

Human cancer cells are irradiated by laser-driven quasi-monoenergetic protons. Laser pulse intensities at the W/cm level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in-vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels up to 8 Gy, for which the single bunch does rate is Gy/s and the effective dose rate is 0.2 Gy/s for 1-Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be using protons with a linear energy transfer of 17.1 keV/m.