Role of DNA repair and effect of herbal extract on LOH induced by ion beam radiations in

Nunoshiba, Tatsuo*; Yamauchi, Ayako*; Iwata, Rika*; Sato, Katsuya; Ono, Yutaka; Narumi, Issey*

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 124, 2015/03

https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2014-050.pdf#page=156

Effects of ion beam radiation on genome integrity in

Nunoshiba, Tatsuo*; Hirasawa, Yukei*; Yamauchi, Ayako*; Sato, Katsuya; Tejima, Kohei*; Onodera, Takefumi; Narumi, Issei

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 111, 2013/01

https://jopss.jaea.go.jp/pdfdata/JAEA-Review-2012-046.pdf

Role of DNA repair and effect of herbal extract on LOH induced by ion beam radiations in

Nunoshiba, Tatsuo*; Sakata, Yayoi*; Yamauchi, Ayako*; Reed, R.*; Sato, Katsuya; Onodera, Takefumi*; Narumi, Issey*

no journal, , 

The LOH (loss of heterozygosity) induction by various ion beam radiations was investigated in diploid . The ion beams C, C, He and Ar at the lowest dose (75, 75, 200 and 150 Gy, respectively), which had 3050% lethality, induced LOH with 10-fold higher frequency. The LOH induction was predominantly (90%) resulted from homologous recombination. Pol may be involved in the induction of LOH by ion beam radiations, because in the strain lacking Rev3, only slight induction of LOH was observed. In addition, the effects of 14 herbal extracts were examined on iron-beam radiation induced LOH, and ethanol extract of possessed inhibitory effect on LOH induced by C ion-beam radiation with the manner dependent on doses of extract.