Wada, Yuki*; Enoto, Teruaki*; Nakamura, Yoshitaka*; Furuta, Yoshihiro; Yuasa, Takayuki*; Nakazawa, Kazuhiro*; Morimoto, Takeshi*; Sato, Mitsuteru*; Matsumoto, Takahiro*; Yonetoku, Daisuke*; et al.
Communications Physics (Internet), 2(1), p.67_1 - 67_9, 2019/06
Iguchi, Masahide; Saito, Toru; Kawano, Katsumi; Chida, Yutaka; Nakajima, Hideo; Ogawa, Tsuyoshi*; Katayama, Yoshinori*; Ogata, Hiroshige*; Minemura, Toshiyuki*; Tokai, Daisuke*; et al.
Fusion Engineering and Design, 88(9-10), p.2520 - 2524, 2013/10
ITER TFC structures are large welding structures made of heavy thick stainless steels. JAEA plans to apply narrow gap TIG welding with FMYJJ1 which is full austenitic stainless filler material to manufacture TFC structure. FMYJJ1 is specified in "Codes for Fusion Facilities -Rules on Superconducting Magnet Structure (2008)". In order to evaluate effect of base material combinations and thickness of welded joint on tensile properties at 4 K, tensile tests were conducted at 4 K by using tensile specimens taken from 40 mm thickness weld joints of four combinations and 200 mm thickness ones of two combinations of base materials. These weld joints were manufactured by one side narrow gap TIG welding with FMYJJ1. As the results, it was confirmed that yield and tensile strengths of welded joint at 4K were decreased with decreasing of nitrogen of base material, and there were no large distribution of strengths at 4 K along the thickness of welded joints of 200 mm thickness.
Sato, Takahiro*; Iwasaki, Atsushi*; Owada, Shigeki*; Yamanouchi, Kaoru*; Takahashi, Eiji*; Midorikawa, Katsumi*; Aoyama, Makoto; Yamakawa, Koichi; Togashi, Tadashi*; Fukami, Kenji*; et al.
Journal of Physics B; Atomic, Molecular and Optical Physics, 46(16), p.164006_1 - 164006_6, 2013/08
By introducing 13th- (61.7 nm) and 15th-order harmonics (53.4 nm) of femtosecond laser pulses at 800 nm into an undulator of SCSS (SPring-8 Compact SASE Source) test accelerator at RIKEN, these harmonic pulses were amplified by a factor of more than 10 with a high contrast ratio through the interaction between accelerated electron bunches and the harmonic pulses. From numerical simulations of the amplification processes of high-order harmonic pulses in the undulator, optimum conditions of the electron bunch duration interacting with the high-order harmonic pulses were investigated for generating full-coherent and intense pulses in the extreme ultraviolet wavelength region.
Iguchi, Masahide; Chida, Yutaka; Takano, Katsutoshi; Kawano, Katsumi; Saito, Toru; Nakajima, Hideo; Koizumi, Norikiyo; Minemura, Toshiyuki*; Ogata, Hiroshige*; Ogawa, Tsuyoshi*; et al.
IEEE Transactions on Applied Superconductivity, 22(3), p.4203305_1 - 4203305_5, 2012/06
Japan Atomic Energy Agency (JAEA) has responsibility to procure 19 structures for ITER toroidal field (TF) coils as in-kind components. JAEA plans to use materials specified in the material section of "Codes for Fusion Facilities; Rules on Superconducting Magnet Structure (2008)" issued by the Japan Society of Mechanical Engineers (JSME) in 2008. Large forged products were produced and their mechanical properties at 4K were evaluated. In addition, the following activities have been performed; (1) to optimize the design of each weld type identified in the manufacturing sequence, (2) to qualify typical welding procedure including repair, (3) to establish welding techniques other than narrow gap TIG welding with FMYJJ1, (4) to demonstrate the manufacturing procedures through manufacture of 1-m mockups and full-scale segments of TFC structure. This paper describes the results of material qualification and industrialization activities of manufacturing processes of ITER TFC structure.
Iguchi, Masahide; Chida, Yutaka; Nakajima, Hideo; Ogawa, Tsuyoshi*; Katayama, Yoshinori*; Ogata, Hiroshige*; Minemura, Toshiyuki*; Miyabe, Keisuke*; Tokai, Daisuke*; Niimi, Kenichiro*
Teion Kogaku, 47(3), p.193 - 199, 2012/03
Japan Atomic Energy Agency (JAEA) has conducted qualification and rationalization activities in Japan in order to rationalize manufacturing procedure of ITER Toroidal Field (TF) coil structures. The activities included qualification of structural materials and qualification of welding procedure according to Japan Society of Mechanical Engineers (JSME) code constituted for fusion devices, demonstration of the manufacturing method and procedures through full-scale segments of TF coil structure. From results of these activities, JAEA confirmed applicability of JSME code to actual series TF coil structures as quality control method hence the quality of structural materials and weld joints of Gas Tungsten Arc Welding (GTAW) were satisfied ITER requirement. In addition, JAEA obtained knowledge of welding deformation of actual TF coil structures. This paper describes results of these qualification and development activities for TF coil structure.
Togashi, Tadashi*; Takahashi, Eiji*; Midorikawa, Katsumi*; Aoyama, Makoto; Yamakawa, Koichi; Sato, Takahiro*; Iwasaki, Atsushi*; Owada, Shigeki*; Okino, Tomoya*; Yamanouchi, Kaoru*; et al.
Optics Express (Internet), 19(1), p.317 - 324, 2011/01
The 13th harmonic of a Ti:sapphire (Ti:S) laser in the plateau region was injected as a seeding source to a 250-MeV free-electron-laser (FEL) amplifier. When the amplification conditions were fulfilled, strong enhancement of the radiation intensity by a factor of 650 was observed. The random and uncontrollable spikes, which appeared in the spectra of the Self-Amplified Spontaneous Emission (SASE) based FEL radiation without the seeding source, were found to be suppressed drastically to form to a narrow-band, single peak profile at 61.2 nm. The properties of the seeded FEL radiation were well reproduced by numerical simulations. We discuss the future precept of the seeded FEL scheme to the shorter wavelength region.
Ogawa, Kazuma*; Kawashima, Hidekazu*; Kinuya, Seigo*; Shiba, Kazuhiro*; Onoguchi, Masahisa*; Kimura, Hiroyuki*; Hashimoto, Kazuyuki; Odani, Akira*; Saji, Hideo*
Annals of Nuclear Medicine, 23(10), p.843 - 848, 2009/12
Rhenium is one of the most valuable elements for internal radiotherapy because Re have favorable physical characteristics. However, there are problems when proteins such as antibodies are used as carriers of Re. Labeling methods require the complicated processes. Therefore, we planned the preparation by a simple method and evaluation of a stable Re-labeled antibody. For this purpose, we selected Re(I) tricarbonyl complex as a chelating site. A7 was used as a model protein. Re-labeled A7 was prepared by directly reacting a Re(I) tricarbonyl precursor with A7. Re-(CO)-A7 were prepared with radiochemical yields of 23-28%. After purification, Re-(CO)-A7 showed a radiochemical purity of over 95%. In biodistribution experiments, Re-labeled A7 showed high uptakes in the tumor.
Ogawa, Kazuma*; Mukai, Takahiro*; Kawai, Keiichi*; Takamura, Norito*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Shiba, Kazuhiro*; Mori, Hirofumi*; Saji, Hideo*
European Journal of Nuclear Medicine and Molecular Imaging, 36(1), p.115 - 121, 2009/01
We have developed a Re-MAG3 complex-conjugated bisphosphonate (Re-MAG3-HBP) for the treatment of painful bone metastases. We assumed competitive inhibitors of protein binding to be useful for procuring a favorable biodistribution of Re-MAG3-HBP because it has been reported that the concurrent administration of Tc-MAG3 and drugs with high affinity for serum protein enhanced total clearance and tissue distribution. The protein binding of Re-MAG3-HBP in a human serum albumin solution was significantly decreased by the addition of ceftriaxone. In the biodistribution experiments, pretreatment with ceftriaxone enhanced the clearance of the radioactivity of Re-MAG3-HBP in blood and nontarget tissues but had no effect on accumulation in bone. The findings suggested that the use of protein-binding competitive inhibitors would be effective in improving the pharmacokinetics of radiopharmaceuticals with high affinity for serum protein.
Ogawa, Kazuma*; Mukai, Takahiro*; Asano, Daigo*; Kawashima, Hidekazu*; Kinuya, Seigo*; Shiba, Kazuhiro*; Hashimoto, Kazuyuki; Mori, Hirofumi*; Saji, Hideo*
Journal of Nuclear Medicine, 48(1), p.122 - 127, 2007/01
We developed a highly stable rhenium-186 (Re)-MAG3 complex-conjugated bisphosphonate, (Re-MAG3-HBP), for the treatment of painful bone metastases. This agent showed a superior biodistribution as a bone-seeking agent in normal mice when compared with Re-HEDP. In this study, we evaluated the therapeutic effects of Re-MAG3-HBP using an animal model of bone metastasis. In the rats treated with Re-HEDP, tumor growth was comparable to that in untreated rats. In contrast, when Re-MAG3-HBP was administered, tumor growth was significantly inhibited. Allodynia induced by bone metastasis was attenuated by treatment with Re-MAG3-HBP or Re-HEDP, but Re-MAG3-HBP tended to be more effective. These results indicate that Re-MAG3-HBP could be useful as a therapeutic agent for the palliation of metastatic bone pain.
Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Otaka, Akira*; Ueda, Masashi*; Uehara, Tomoya*; Magata, Yasuhiro*; Hashimoto, Kazuyuki; Saji, Hideo*
Nuclear Medicine and Biology, 33(4), p.513 - 520, 2006/05
To develop a radiopharmaceutical for the palliation of painful bone metastases based on the concept of bifunctional radiopharmaceuticals, we synthesized a bisphosphonate derivative labeled with rhenium-186 (Re) that contains a hydroxyl group at the central carbon of its bisphosphonate structure and attached a stable Re-MAMA chelate to the amino group of a 4-amino-butylidene-bisphosphonate derivative, Re-MAMA-HBP, and investigated the effect of a hydroxyl group at the central carbon of its bisphosphonate structure on the affinity for hydroxyapatite and biodistribution by conducting a comparative study with Re-MAMA-BP. Re-MAMA-HBP was prepared by a reaction with ReO and SnCl in citrate buffer after the deprotection of trityl groups of Tr-MAMA-HBP. After reversed phase HPLC, Re-MAMA-HBP had a radiochemical purity of over 95 %. Compared with Re-MAMA-BP, Re-MAMA-HBP showed a greater affinity for hydroxyapatite beads in vitro and accumulated a significantly higher level in the femur in vivo. Thus, the introduction of a hydroxyl group into Re complex-conjugated bisphosphonates would be effective in enhancing accumulation in bone. These findings provide useful information on the design of bone-seeking therapeutic radiopharmaceuticals.
Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Ono, Masahiro*; Hanaoka, Hirofumi*; Ishino, Seigo*; Hashimoto, Kazuyuki; Nishimura, Hiroshi*; Saji, Hideo*
Bioconjugate Chemistry, 16(4), p.751 - 757, 2005/07
Rhenium-186-1-hydroxyethylidene-1,1-diphosphonate (Re-HEDP) has been used for the palliation of metastatic bone pain. Delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of Re-HEDP in vivo. In this study, on the basis of the concept of bifunctional radiopharmaceuticals, we designed a stable Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosphonate (Re-MAG3-HBP). After purification by HPLC, Re-MAG3-HBP was synthesized with a radiochemical purity of over 95%. In biodistribution experiments, the radioactivity level ofRe-MAG3-HBP in bone was significantly higher than that of Re-HEDP. Blood clearance of Re-MAG3-HBP was faster than that of Re-HEDP. In addition, the gastric accumulation of Re-MAG3-HBP radioactivity was lower than that of Re-HEDP. In conclusion, Re-MAG3-HBP is expected to be a useful radiopharmaceutical for the palliation of metastatic bone pain.
Isozaki, Kazunori; Ogawa, Toru; Nishino, Kazunari; Kaito, Yasuaki; Ichige, Satoshi; Sumino, Kozo; Suto, Masayoshi; Kawahara, Hirotaka; Suzuki, Toshiaki; Takamatsu, Misao; et al.
JNC TN9440 2005-003, 708 Pages, 2005/05
Periodic safety review (Review of the aging management) which consisted of Technical review on aging for the safety related structures, systems and components and Establish a long term maintenance program was carried out up to April 2005.1. Technical review on aging for the safety related structures, systems and components It was technically confirmed to prevent the loss of function of the safety related structures, systems and components due to aging phenomena, which (1) irradiation damage, (2) corrosion, (3) abrasion and erosion, (4) thermal aging, (5) creep and fatigue, (6) Stress Corrosion Cracking, (7) insulation deterioration and (8) general deterioration, under the periodic monitoring or renewal of them 2. Establish a long term maintenance program The long term maintenance program during JPY2005 to 2014 were established based on the technical review on aging for the safety related structures, systems and components. It was evaluated that the inspection or renewal based on the long term maintenance program, in addition to the spontaneous inspection long-term schedule of the long term voluntary inspection plan, could prevent the loss of function of the safety related structures, systems and components in future.
Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Nishimura, Hiroshi*; Saji, Hideo*
Journal of Labelled Compounds and Radiopharmaceuticals, 47(11), p.753 - 761, 2004/11
no abstracts in English
Munakata, Masahiro; Kimura, Hideo; Tanaka, Tadao; Mukai, Masayuki; Maeda, Toshikatsu; Ogawa, Hiromichi
Nihon Genshiryoku Gakkai Wabun Rombunshi, 2(3), p.361 - 367, 2003/09
no abstracts in English
Kitao, Hideo*; Kogawa, Noritaka*
JNC TJ6420 2003-010, 156 Pages, 2003/02
Tanaka, Tadao; Mukai, Masayuki; Maeda, Toshikatsu; Matsumoto, Junko; Ogawa, Hiromichi; Munakata, Masahiro; Kimura, Hideo; Bamba, Tsunetaka; Fujine, Sachio
Genshiryoku eye, 49(2), p.76 - 79, 2003/02
no abstracts in English
Mukai, Takahiro*; Ogawa, Kazuma*; Arano, Yasushi*; Ono, Masahiro*; Fujioka, Yasushi*; Izumo, Mishiroku; Konishi, Junji*; Saji, Hideo*
Journal of Labelled Compounds and Radiopharmaceuticals, 44(Suppl.1), p.S617 - S618, 2001/05
no abstracts in English
Ogawa, Hiromichi; Nagao, Seiya; Yamaguchi, Tetsuji; Mukai, Masayuki; Munakata, Masahiro; Sakamoto, Yoshiaki; Nakayama, Shinichi; Takeda, Seiji; Kimura, Hideo; Kumata, Masahiro; et al.
JAERI-Research 2000-052, 101 Pages, 2001/01
no abstracts in English
Ogawa, Kazuma*; Ono, Masahiro*; Fujioka, Yasushi*; Saji, Hideo*; Mukai, Takahiro*; Konishi, Junji*; Uehara, Tomoya*; Arano, Yasushi*; Onoma, Katsuyuki
Kaku Igaku, 37(5), P. 577, 2000/09
no abstracts in English
*; Miyamoto, Yoshiaki; Akino, Norio; Shiina, Yasuaki; Hishida, Makoto*; Ogawa, Masuro; Fumizawa, Motoo; Inagaki, Yoshiyuki; Takeda, Tetsuaki; Takada, Shoji; et al.
JAERI-Review 98-024, 403 Pages, 1999/01
no abstracts in English