Comparison of the therapeutic effects of [At]NaAt and [I]NaI in an NIS-expressing thyroid cancer mouse model

Watabe, Tadashi*; Liu, Y.*; Kaneda, Kazuko*; Sato, Tatsuhiko; Shirakami, Yoshifumi*; Oe, Kazuhiro*; Toyoshima, Atsushi*; Shimosegawa, Eku*; Wang, Y.*; Haba, Hiromitsu*; et al.

International Journal of Molecular Sciences (Internet), 23(16), p.9434_1 - 9434_11, 2022/08

https://doi.org/10.3390/ijms23169434

In this study, we compare the therapeutic effect between [At]NaAt and [I]NaI. In vitro analysis of double-stranded DNA break (DSB) and colony formation assay were performed using K1-NIS cells. [At]NaAt induced higher numbers of DSBs and had a reduced colony formation than [I]NaI. In K1-NIS mice, dose-dependent therapeutic effects were observed in both [At]NaAt and [I]NaI. The superior therapeutic effect of [At]NaAt suggests the promising clinical applicability of targeted alpha therapy using [At]NaAt in patients with differentiated thyroid cancer refractory to standard [I]NaI treatment.

Structural & chemical study of molecular crystals based on precise positions of hydrogen atoms by single-crystal neutron diffraction

Ohara, Takashi

Nihon Kessho Gakkai-Shi, 64(2), p.132 - 139, 2022/05

https://doi.org/10.5940/jcrsj.64.132

no abstracts in English

Improvement of nano-polycrystalline diamond anvil cells with Zr-based bulk metallic glass cylinder for higher pressures; Application to Laue-TOF diffractometer

Yamashita, Keishiro*; Komatsu, Kazuki*; Ohara, Takashi; Munakata, Koji*; Irifune, Tetsuo*; Shimmei, Toru*; Sugiyama, Kazumasa*; Kawamata, Toru*; Kagi, Hiroyuki*

High Pressure Research, 42(1), p.121 - 135, 2022/03

https://doi.org/10.1080/08957959.2022.2045982

Two-dimensional scintillation neutron detectors for the extension of SENJU diffractometer

Nakamura, Tatsuya; To, Kentaro; Koizumi, Tomokatsu; Kiyanagi, Ryoji; Ohara, Takashi; Ebine, Masumi; Sakasai, Kaoru

Proceedings of 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2020), Vol.1, p.483 - 484, 2021/09

https://doi.org/10.1109/NSS/MIC42677.2020.9507813

Two-dimensional neutron detectors were developed for the extension of SENJU time-of-flight Laue single crystal neutron diffractometer in J-PARC MLF. The detectors are to be installed at the additional detector bank for the SENJU instrument. The detector module is made based on ZnS scintillator and wavelength-shifting fiber technology, where each detector module maintains a neutron-sensitive area of 256256 mm with a pixel size of 44 mm. To meet the tight space limitation in the instrument, the detector was designed as compact as possible. The detector has a depth of 170 mm, which is about 40% smaller than that of the original SENJU detector. All four produced detectors exhibited similar detector performances: detection efficiency 50-60% for 2- neutron, Co gamma-ray sensitivity 110, count uniformity 3-6%.

Quantum proton entanglement on a nanocrystalline silicon surface

Matsumoto, Takahiro*; Sugimoto, Hidehiko*; Ohara, Takashi; Tokumitsu, Akio*; Tomita, Makoto*; Ikeda, Susumu*

Physical Review B, 103(24), p.245401_1 - 245401_9, 2021/06

https://doi.org/10.1103/PhysRevB.103.245401

Programmable synthesis of silver wheels

Kwon, H.*; Pietrasiak, E.*; Ohara, Takashi; Nakao, Akiko*; Chae, B.*; Hwang, C.-C.*; Jung, D.*; Hwang, I.-C.*; Ko, Y. H.*; Kim, K.*; et al.

Inorganic Chemistry, 60(9), p.6403 - 6409, 2021/05

https://doi.org/10.1021/acs.inorgchem.1c00106

Development of spin-contrast-variation neutron powder diffractometry for extracting the structure factor of hydrogen atoms

Miura, Daisuke*; Kumada, Takayuki; Sekine, Yurina; Motokawa, Ryuhei; Nakagawa, Hiroshi; Oba, Yojiro; Ohara, Takashi; Takata, Shinichi; Hiroi, Kosuke; Morikawa, Toshiaki*; et al.

Journal of Applied Crystallography, 54(2), p.454 - 460, 2021/04

https://doi.org/10.1107/S1600576721000303

We developed a spin-contrast-variation neutron powder diffractometry technique that extracts the structure factor of hydrogen atoms, namely, the contribution of hydrogen atoms to a crystal structure factor. Crystals of L-glutamic acid were dispersed in a dpolystyrene matrix containing 4-methacryloyloxy-2,2,6,6,-tetramethyl-1-piperidinyloxy (TEMPO methacrylate) to polarize their proton spins dynamically. The intensities of the diffraction peaks of the sample changed according to the proton polarization, and the structure factor of the hydrogen atoms was extracted from the proton-polarization dependent intensities. This technique is expected to enable analyses of the structures of hydrogen-containing materials that are difficult to determine with conventional powder diffractometry.

Neutron Bragg-edge transmission imaging for microstructure and residual strain in induction hardened gears

Su, Y. H.; Oikawa, Kenichi; Shinohara, Takenao; Kai, Tetsuya; Horino, Takashi*; Idohara, Osamu*; Misaka, Yoshitaka*; Tomota, Yo*

Scientific Reports (Internet), 11, p.4155_1 - 4155_14, 2021/02

https://doi.org/10.1038/s41598-021-83555-9

Development of three-dimensional distribution visualization technology for boron using energy resolved neutron-imaging system (RADEN)

Abe, Yuta; Tsuchikawa, Yusuke; Kai, Tetsuya; Matsumoto, Yoshihiro*; Parker, J. D.*; Shinohara, Takenao; Oishi, Yuji*; Kamiyama, Takashi*; Nagae, Yuji; Sato, Ikken

Proceedings of 2020 International Conference on Nuclear Engineering (ICONE 2020) (Internet), 6 Pages, 2020/08

https://doi.org/10.1115/ICONE2020-16723

The Energy-resolved neutron imaging system, RADEN

Shinohara, Takenao; Kai, Tetsuya; Oikawa, Kenichi; Nakatani, Takeshi; Segawa, Mariko; Hiroi, Kosuke; Su, Y. H.; Oi, Motoki; Harada, Masahide; Iikura, Hiroshi; et al.

Review of Scientific Instruments, 91(4), p.043302_1 - 043302_20, 2020/04

https://doi.org/10.1063/1.5136034