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Watanabe, Yuki; Tsuji, Tomoya; Hirota, Seiko*; Hokama, Tomonori; Nakajima, Junya; Tsujiguchi, Takakiyo*; Kimura, Tatsuki*; Koike, Hiromi*; Nakamura, Kaori*; Kuwata, Haruka*; et al.
Hoken Butsuri (Internet), 57(1), p.54 - 64, 2022/03
no abstracts in English
Yamada, Ryohei; Kono, Takahiko; Nakajima, Junya; Hirouchi, Jun; Tsuji, Tomoya; Umeda, Masayuki; Igarashi, Yu*; Koike, Hiromi*
Hoken Butsuri (Internet), 56(1), p.32 - 38, 2021/03
no abstracts in English
Hirouchi, Jun; Tani, Kotaro*; Tamakuma, Yuki*; Nakasone, Shunya*; Koike, Hiromi*
Hoken Butsuri (Internet), 55(4), p.185 - 190, 2020/12
no abstracts in English
Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya*; Tanoue, Manabu*; Okada, Hajime; Sasao, Hajime; Wakai, Daisuke*; Kondo, Shuji; Kanazawa, Shuhei; et al.
JAEA-Conf 2009-007, p.97 - 100, 2010/03
no abstracts in English
temporal contrast, above 10
W/cm
peak intensity pulses at a 10 Hz repetition rate using an OPCPA preamplifier in a double CPA, Ti:sapphire laser systemKiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.
AIP Conference Proceedings 1153, p.3 - 6, 2009/07
We demonstrate a high-contrast, high-intensity double chirped-pulse amplification (CPA) Ti:sapphire laser system using an optical parametric chirped-pulse amplifier (OPCPA) as a preamplifier. By injecting cleaned microjoule seed pulses into the OPCPA, a temporal contrast greater than 10 within picosecond times before the main femtosecond pulse is demonstrated with the output pulse energy of 1.7 J and pulse duration of 30 fs, corresponding to a peak power of 60 TW at a 10 Hz repetition rate. This system uses a cryogenically-cooled Ti:sapphire final amplifier and generates focused peak intensities in excess of 10 W/cm.
Re]Organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levelsUehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Hanaoka, Hirofumi*; Iida, Yasuhiko*; Hashimoto, Kazuyuki; Akizawa, Hiromichi*; Endo, Keigo*; Arano, Yasushi*
Bioconjugate Chemistry, 18(1), p.190 - 198, 2007/01
Times Cited Count：20 Percentile：55.24(Biochemical Research Methods)Renal localization of radiolabeled antibody fragments constitutes a problem in targeted imaging and radiotherapy. To estimate the applicability of the molecular design to metallic radionuclides, [Re]tricarbonyl(cyclopentadienylcarbonate)rhenium ([Re]CpTR-COOH) was conjugated with maleoyl-glycyl-lysine to prepare [Re]CpTR-GK. The cleavage of the glycyl-lysine linkage of the compound generates a glycine conjugate of [Re]CpTR-Gly. [Re]CpTR-GK was conjugated to thiolated Fab fragments to prepare [Re]CpTR-GK-Fab. The biodistribution of radioactivity after injection of [Re]CpTR-GK-Fab was compared with that of [Re]CpTR-Fab. [Re]CpTR-GK-Fab exhibited significantly lower renal radioactivity levels than did [Re]CpTR-Fab. The analysis of urine samples collected for 6 h postinjection of [Re]CpTR-GK-Fab showed that [Re]CpTR-Gly was the major radiometabolite. In tumor-bearing mice, [Re]CpTR-GK-Fab significantly reduced renal radioactivity levels without impairing the radioactivity levels in tumor. These findings indicate that the molecular design of radioparmaceuticals labeled with metallic radionuclides can be useful by using a radiometal chelate of high inertness and by designing a radiometabolite of high urinary excretion when released from antibody fragments following cleavage of a glycyl-lysine linkage. This study also indicates that a change in chemical structure of a radiolabel attached to a glycyl-lysine linkage significantly affected enzymes involved in the hydrolysis reaction.
Ikeura, Hiromi*; Sekiguchi, Tetsuhiro; Koike, Masaki*
Journal of Electron Spectroscopy and Related Phenomena, 144-147, p.453 - 455, 2005/06
Times Cited Count：15 Percentile：56.91(Spectroscopy)no abstracts in English
solutionsHaba, Hiromitsu; Tsukada, Kazuaki; Asai, Masato; Goto, Shinichi*; Toyoshima, Atsushi; Nishinaka, Ichiro; Akiyama, Kazuhiko; Hirata, Masaru; Ichikawa, Shinichi; Nagame, Yuichiro; et al.
Journal of Nuclear and Radiochemical Sciences, 3(1), p.143 - 146, 2002/06
We have investigated the sorption behavior of element 104 rutherfordium (Rf) on an anion exchange resin from HCl and HNO solutions. In the HCl experiments, the distribution coefficients of Rf increase with an increase of HCl concentration from 7.0 M to 11.5 M, indicating that anionic species such as [Rf(OH)Cl
]
or [RfCl
] are formed. This sorption behavior of Rf is typical of the group-4 elements Zr and Hf, and is quite different from that of the pseudo-homologue Th. It is also noted that the distribution coefficients decrease in the order Rf, Zr, Hf at 9.0 M HCl, which is consistent with the expected order of ionic radii. On the other hand, Rf appears to behave like Zr and Hf in 8 M HNO not like Pu and Th.
Sakurai, Hiroshi*; Tamura, Takuro*; Kurachi, Toshitaka*; Homma, Satoshi*; Oike, Hiromi*; Agui, Akane; Sakurai, Yoshiharu*; Ito, Masayoshi*; Adachi, Hiromichi*; Kawata, Hiroshi*
no journal, ,
no abstracts in English
Sugiyama, Akira; Kondo, Kiminori; Kiriyama, Hiromitsu; Ochi, Yoshihiro; Tanaka, Momoko; Nakai, Yoshiki; Sasao, Hajime; Tateno, Ryo; Okada, Hajime; Koike, Masato
no journal, ,
Our laser research and development group was newly founded in this April. The aim of our group is to build up powerful light sources promoting the high-peak optical field science such as laser particle acceleration and quantum beam generation, etc. To realize our mission, we will intend to develop the essential technology for the upgrade of J-KAREN and TOPAZ systems. These essential technologies that will be developed in two laser systems can be absolutely used for the advanced laser light source in near future.
Okada, Hajime; Kiriyama, Hiromitsu; Nakai, Yoshiki; Shimomura, Takuya*; Tanoue, Manabu*; Akutsu, Atsushi; Kondo, Shuji; Kanazawa, Shuhei; Sugiyama, Akira; Daido, Hiroyuki; et al.
no journal, ,
no abstracts in English
Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.
no journal, ,
We demonstrated laser peak intensity above 10W/cm and temporal contrast exceeding 10 at a 10 Hz repetition rate with a 60 TW, 30 fs laser (J-KAREN laser). Here we report the upgrade of the J-KAREN laser to the petawatt peak power level. This is accomplished by adding a Ti:sapphire booster amplifier downstream of the final amplifier chain of the 60 TW J-KAREN laser system. Stretched pulses of energy 3 J from the previous J-KAREN laser are up-collimated and introduced into the final booster amplifier. The booster amplifier consists of a large-aperture Ti:sapphire crystal pumped by a frequency-doubled Nd:silicate glass laser with pulse energy 60 J. Diffractive optical elements are used for pump beam homogenization to maintain a uniform spatial profile and reliable, damage-free operation. The system produces an uncompressed output pulse energy exceeding 30 J with a near homogeneous flat-top spatial distribution, indicating potential peak power of 500 TW.
Okuno, Hiroshi; Tonoike, Kotaro; Kawasaki, Hiromitsu*
no journal, ,
no abstracts in English
Kiriyama, Hiromitsu; Mori, Michiaki; Nakai, Yoshiki; Shimomura, Takuya; Tanoue, Manabu*; Okada, Hajime; Kondo, Shuji; Kanazawa, Shuhei; Sagisaka, Akito; Daito, Izuru; et al.
no journal, ,
We have demonstrated over 30 J broadband output energy based on optical parametric chirped-pulse amplification (OPCPA) and Ti:sapphire chirped-pulse amplification (CPA), indicating potential for peak power of 500 TW with extremely high temporal contrast.
