Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Fukunaga, Hisanori*; Matsuya, Yusuke; Tokuue, Koichi*; Omura, Motoko*
British Journal of Radiology, 93(1111), p.20200311_1 - 20200311_4, 2020/07
Times Cited Count：0 Percentile：100(Radiology, Nuclear Medicine & Medical Imaging)Boron neutron capture therapy (BNCT) has attracted attention as a selective treatment approach for cancer cells while sparing surrounding normal cells. The basic concept of BNCT was developed in the 1930s, but it has not yet been commonly popular in clinical practice, even though there is now a large number of experimental and translational studies demonstrating its marked therapeutic potential. With the development of neutron accelerators that can be installed in medical institutions, accelerator-based BNCT is expected to become available at several medical institutes around the world in the near future. In this commentary, from the point of view of microdosimetry, we discuss the biological effects of BNCT, especially the underlying mechanisms of cell responses. The recent development of new treatment methods that combine proton beam sources and BNCT technology is expected to contribute significantly improving the prognosis of cancer treatment in the near future. Therefore, radiobiologists in the field of BNCT and related techniques will have a significant role to play in creating synergy effects in clinical oncology.
Matsuya, Yusuke; Fukunaga, Hisanori*; Omura, Motoko*; Date, Hiroyuki*
cells, 9(5), p.1117_1 - 1117_16, 2020/05
Times Cited Count：0 Percentile：100(Cell Biology)When delivering a high absorbed dose to cancer cells following boron neutron capture therapy (BNCT), heterogeneous dose distribution, the time line of 
B concentrations and the long dose-delivery time must be considered. Changes in radiosensitivity during such a long dose-delivery time can reduce the probability of tumor control; however, such change has not yet been evaluated. Here, we developed a cell-killing model that accounts for changes in microdosimetric quantities and dose rates depending on the B concentration and investigated dose-rate effects (cell recovery during BNCT irradiation) of melanoma. The developed model shows good agreement with in-vitro experimental survival data for exposure to 
Co 
-rays, thermal neutrons, and BNCT. The model estimation suggests that the impact of cell recovery during BNCT irradiations with high linear energy transfer (LET) is reduced compared to Co -rays irradiation with low LET. The present model is expected to predict radio-sensitivity for BNCT irradiations.
Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura; Yokota, Yuichiro; Nakano, Takashi*; Kobayashi, Yasuhiko
Radiotherapy and Oncology, 89(2), p.231 - 236, 2008/11
Times Cited Count：22 Percentile：39.47(Oncology)Hamada, Nobuyuki*; Kataoka, Keiko*; Sora, Sakura*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Nakano, Takashi*; Kobayashi, Yasuhiko
Radiotherapy and Oncology, 89(2), p.227 - 230, 2008/11
Times Cited Count：7 Percentile：70.97(Oncology)Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Ni, M.*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko
Uchu Seibutsu Kagaku, 22(2), p.46 - 53, 2008/10
Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko
Cancer Letters, 268(1), p.76 - 81, 2008/09
Times Cited Count：10 Percentile：74.2(Oncology)Hara, Takamitsu*; Hamada, Nobuyuki*; Omura, Motoko*; Sakashita, Tetsuya; Wada, Seiichi*; Kakizaki, Takehiko; Fukamoto, Kana; Suzuki, Michiyo; Funayama, Tomoo; Kobayashi, Yasuhiko
no journal, ,
no abstracts in English
-rays and heavy charged particlesHara, Takamitsu*; Hamada, Nobuyuki*; Omura, Motoko*; Sakashita, Tetsuya; Wada, Seiichi*; Kobayashi, Yasuhiko
no journal, ,
no abstracts in English
Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Omura, Motoko*; et al.
no journal, ,
no abstracts in English
Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Omura, Motoko*; et al.
no journal, ,
no abstracts in English
Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Omura, Motoko*; Kobayashi, Yasuhiko
no journal, ,
no abstracts in English
Hamada, Nobuyuki*; Hara, Takamitsu*; Kataoka, Keiko*; Sora, Sakura*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Yokota, Yuichiro; Kobayashi, Yasuhiko
no journal, ,
no abstracts in English
Hamada, Nobuyuki*; Kataoka, Keiko*; Sora, Sakura*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Omura, Motoko*; Kobayashi, Yasuhiko
no journal, ,
no abstracts in English
Hamada, Nobuyuki*; Hara, Takamitsu*; Kataoka, Keiko*; Sora, Sakura*; Funayama, Tomoo; Sakashita, Tetsuya; Yokota, Yuichiro; Omura, Motoko*; Kobayashi, Yasuhiko
no journal, ,
no abstracts in English
