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Journal Articles

Implications of radiation microdosimetry for accelerator-based boron neutron capture therapy; A Radiobiological perspective

Fukunaga, Hisanori*; Matsuya, Yusuke; Tokuue, Koichi*; Omura, Motoko*

British Journal of Radiology, 93(1111), p.20200311_1 - 20200311_4, 2020/07

 Times Cited Count:0 Percentile:100(Radiology, Nuclear Medicine & Medical Imaging)

Boron neutron capture therapy (BNCT) has attracted attention as a selective treatment approach for cancer cells while sparing surrounding normal cells. The basic concept of BNCT was developed in the 1930s, but it has not yet been commonly popular in clinical practice, even though there is now a large number of experimental and translational studies demonstrating its marked therapeutic potential. With the development of neutron accelerators that can be installed in medical institutions, accelerator-based BNCT is expected to become available at several medical institutes around the world in the near future. In this commentary, from the point of view of microdosimetry, we discuss the biological effects of BNCT, especially the underlying mechanisms of cell responses. The recent development of new treatment methods that combine proton beam sources and BNCT technology is expected to contribute significantly improving the prognosis of cancer treatment in the near future. Therefore, radiobiologists in the field of BNCT and related techniques will have a significant role to play in creating synergy effects in clinical oncology.

Journal Articles

A Model for estimating dose-rate effects on cell-killing of human melanoma after boron neutron capture therapy

Matsuya, Yusuke; Fukunaga, Hisanori*; Omura, Motoko*; Date, Hiroyuki*

cells, 9(5), p.1117_1 - 1117_16, 2020/05

 Times Cited Count:0 Percentile:100(Cell Biology)

When delivering a high absorbed dose to cancer cells following boron neutron capture therapy (BNCT), heterogeneous dose distribution, the time line of $$^{10}$$B concentrations and the long dose-delivery time must be considered. Changes in radiosensitivity during such a long dose-delivery time can reduce the probability of tumor control; however, such change has not yet been evaluated. Here, we developed a cell-killing model that accounts for changes in microdosimetric quantities and dose rates depending on the $$^{10}$$B concentration and investigated dose-rate effects (cell recovery during BNCT irradiation) of melanoma. The developed model shows good agreement with in-vitro experimental survival data for exposure to $$^{60}$$Co $$gamma$$-rays, thermal neutrons, and BNCT. The model estimation suggests that the impact of cell recovery during BNCT irradiations with high linear energy transfer (LET) is reduced compared to $$^{60}$$Co $$gamma$$-rays irradiation with low LET. The present model is expected to predict radio-sensitivity for BNCT irradiations.

Journal Articles

Energetic heavy ions overcome tumor radioresistance caused by overexpression of Bcl-2

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura; Yokota, Yuichiro; Nakano, Takashi*; Kobayashi, Yasuhiko

Radiotherapy and Oncology, 89(2), p.231 - 236, 2008/11

 Times Cited Count:22 Percentile:39.47(Oncology)

Journal Articles

The Small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation

Hamada, Nobuyuki*; Kataoka, Keiko*; Sora, Sakura*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Nakano, Takashi*; Kobayashi, Yasuhiko

Radiotherapy and Oncology, 89(2), p.227 - 230, 2008/11

 Times Cited Count:7 Percentile:70.97(Oncology)

Journal Articles

Heavy-ion microbeam irradiation induces bystander killing of human cells

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Ni, M.*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko

Uchu Seibutsu Kagaku, 22(2), p.46 - 53, 2008/10

Journal Articles

The Survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny

Hamada, Nobuyuki*; Hara, Takamitsu*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Sora, Sakura*; Nakano, Takashi*; Kobayashi, Yasuhiko

Cancer Letters, 268(1), p.76 - 81, 2008/09

 Times Cited Count:10 Percentile:74.2(Oncology)

Oral presentation

Alterations in radiosensitivity of malignant cells by Bcl-2 overexpression

Hara, Takamitsu*; Hamada, Nobuyuki*; Omura, Motoko*; Sakashita, Tetsuya; Wada, Seiichi*; Kakizaki, Takehiko; Fukamoto, Kana; Suzuki, Michiyo; Funayama, Tomoo; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Killing of Bcl-2 overexpressing tumor cells by $$gamma$$-rays and heavy charged particles

Hara, Takamitsu*; Hamada, Nobuyuki*; Omura, Motoko*; Sakashita, Tetsuya; Wada, Seiichi*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Heavy-ion irradiation overcomes the radioresistance of tumor cells overexpressing Bcl-2

Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Omura, Motoko*; et al.

no journal, , 

no abstracts in English

Oral presentation

Overcoming the radioresistance of Bcl-2 overexpressing tumor cells with heavy-ion irradiation

Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Suzuki, Michiyo; Fukamoto, Kana; Yokota, Yuichiro; Omura, Motoko*; et al.

no journal, , 

no abstracts in English

Oral presentation

Overcoming the radioresistance of Bcl-2 overexpressing tumor cells with heavy-ion irradiation

Hamada, Nobuyuki*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Kataoka, Keiko*; Sora, Sakura; Omura, Motoko*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

Bcl-2 as a potential target for heavy-ion therapy

Hamada, Nobuyuki*; Hara, Takamitsu*; Kataoka, Keiko*; Sora, Sakura*; Omura, Motoko*; Funayama, Tomoo; Sakashita, Tetsuya; Yokota, Yuichiro; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

HA14-1, an inhibitor of Bcl-2, may sensitize tumor cells to heavy ions

Hamada, Nobuyuki*; Kataoka, Keiko*; Sora, Sakura*; Hara, Takamitsu*; Funayama, Tomoo; Sakashita, Tetsuya; Omura, Motoko*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

Oral presentation

The Bcl-2 as an attractive target to improve the efficiency of heavy-ion therapy

Hamada, Nobuyuki*; Hara, Takamitsu*; Kataoka, Keiko*; Sora, Sakura*; Funayama, Tomoo; Sakashita, Tetsuya; Yokota, Yuichiro; Omura, Motoko*; Kobayashi, Yasuhiko

no journal, , 

no abstracts in English

14 (Records 1-14 displayed on this page)
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