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Journal Articles

Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability

Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.

Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01

 Times Cited Count:6 Percentile:92.29(Multidisciplinary Sciences)

Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.

JAEA Reports

Internal dose coefficients for various gastrointestinal absorption fractions (Contract research)

Hirouchi, Jun; Tokashiki, Yuji*; Takahara, Shogo; Manabe, Kentaro

JAEA-Research 2021-001, 284 Pages, 2021/03

JAEA-Research-2021-001.pdf:4.23MB

Doses to the public are calculated with internal dose coefficients based on the publications of the International Commission on Radiological Protection (ICRP) in OSCAAR, which is a level 3 Probabilistic Risk Assessment code developed by Japan Atomic Energy Agency (JAEA). The gastrointestinal absorption fraction, $$f_{1}$$, which is one of parameters of internal dose coefficient, is given the recommended value. However, although it has been reported that $$f_{1}$$ has uncertainty, the uncertainty analysis of $$f_{1}$$ has been performed on few radionuclides. In this report, to evaluate the influence of uncertainty of $$f_{1}$$ on the internal dose, we calculated the internal dose coefficient with various $$f_{1}$$, and derive the relationship between the coefficient and $$f_{1}$$. As a result, we indicate that the relationships are expressed by a linear function for radionuclides with a half-life of more than 0.5 days and are expressed by a cubic function for radionuclides with a half-life of less than 0.5 days.

Journal Articles

Tacticity, molecular weight, and molecular-weight-distribution relationships in stereoregular polyacrilonitrile prepared by electron beam irradiation canal polymerization

Minagawa, Masatomo*; Okada, Yasushi*; Nouchi, Kentaro*; Sato, Yasuhiko*; Yoshii, Fumio

Colloid and Polymer Science, 278(8), p.757 - 763, 2000/08

no abstracts in English

JAEA Reports

Safety Operation of Tokai Reprocessing Plant

Yamamura, Osamu; Yamanouchi, Takamichi; Takahashi, Keizo; Sugiyama, Toshihide; Kuno, Yusuke; Nakai, Toshiro; Kobayashi, Kentaro

PNC TN8100 92-004, 79 Pages, 1992/01

PNC-TN8100-92-004.pdf:9.53MB

None

Oral presentation

Present status of J-PARC high-pressure neutron diffractometer PLANET and application to the structure analysis of disordered materials

Hattori, Takanori; Sano, Asami; Suzuya, Kentaro; Funakoshi, Kenichi*; Abe, Jun*; Machida, Shinichi*; Ouchi, Keiichi*; Okazaki, Nobuo*; Kameda, Yasuo*; Otomo, Toshiya*

no journal, , 

PLANET is the beamline dedicated for the high-pressure experiments. The operation has been started at JFY 2013, and now many users are coming to use. In this talk, we introduce the current state of the PLANET and the example of the structure analysis of disordered materials. PLANET adopted the double staged compression system of the multi anvil 6-6, and enables the data collation at 10 GPa and 2000 K. To extend accessible PT range, we newly introduce another compression system of multi-anvil 6-8, and succeeded in generating 16 GPa and 1273 K. In addition, the PLANET is designed so that we can analyze the structure of liquid under pressure. In the analysis, the program for liquid analysis developed at BL21 NOVA is used. Here, we briefly introduce the reliability of the results and the pressure evolution of the silica glass.

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