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Journal Articles

Improvement of the hybrid approach between Monte Carlo simulation and analytical function for calculating microdosimetric probability densities in macroscopic matter

Sato, Tatsuhiko; Matsuya, Yusuke*; Ogawa, Tatsuhiko; Kai, Takeshi; Hirata, Yuho; Tsuda, Shuichi; Parisi, A.*

Physics in Medicine & Biology, 68(15), p.155005_1 - 155005_15, 2023/07

 Times Cited Count:0 Percentile:86.76

In this study, we improved the microdosimetric function implemented in PHITS using the latest track-structure simulation codes. The improved function is capable of calculating the probability densities of not only the conventional microdosimetric quantities such as lineal energy but also the numbers of ionization events occurred in a target site, the so-called ionization cluster size distribution, for arbitrary site diameters from 3 nm to 1 um. As a new application of the improved function, we calculated the relative biological effectiveness of the single-strand break and double-strand break yields for proton irradiations using the updated PHITS coupled with the simplified DNA damage estimation model, and confirmed its equivalence in accuracy and its superiority in computational time compared to our previously proposed method based on the track-structure simulation.

Journal Articles

Application of a simple DNA damage model developed for electrons to proton irradiation

Matsuya, Yusuke; Kai, Takeshi; Parisi, A.*; Yoshii, Yuji*; Sato, Tatsuhiko

Physics in Medicine & Biology, 67(21), p.215017_1 - 215017_13, 2022/11

 Times Cited Count:3 Percentile:80.16(Engineering, Biomedical)

Proton beam therapy allows to irradiate tumor volumes with reduced side effects on normal tissues with respect to X-ray radiotherapy. Biological effects such as cell killing after proton beam irradiations depend on the proton kinetic energy, which is intrinsically related in the early DNA damage induction. As such, the estimation of DNA damage yields based on Monte Carlo simulations is a research topic of worldwide interest. In this study, we investigate the possibility of applying a simple model developed for electron to proton without any modification. The yields of single-strand breaks (SSB), double-strand breaks (DSB) and the complex DSB were assessed as a function of the proton kinetic energy. The PHITS-based estimation accurately reproduced the experimental and simulated yields of various DNA damage types induced by protons with linear energy transfer (LET) up to about 30 keV/$$mu$$m. These results suggest that current DNA damage model implemented in PHITS is sufficient for estimating DNA lesion yields induced after protons irradiation except for lower energies than MeV.

Journal Articles

Theoretical and experimental estimation of the relative optically stimulated luminescence efficiency of an optical-fiber-based BaFBr:Eu detector for swift ions

Hirata, Yuho; Sato, Tatsuhiko; Watanabe, Kenichi*; Ogawa, Tatsuhiko; Parisi, A.*; Uritani, Akira*

Journal of Nuclear Science and Technology, 59(7), p.915 - 924, 2022/07

 Times Cited Count:5 Percentile:92.56(Nuclear Science & Technology)

The reliability of dose assessment with radiation detectors is an important feature in various fields, such as radiotherapy, radiation protection, and high-energy physics. However, many detectors irradiated by high linear energy transfer (LET) radiations exhibit decreased efficiency called the quenching effect. This quenching effect depends not only on the particle LET but strongly on the ion species and its microscopic pattern of energy deposition. Recently, a computational method for estimating the relative efficiency of luminescence detectors was proposed following analysis of microdosimetric specific energy distributions simulated using the particle and heavy ion transport code system (PHITS). This study applied the model to estimate the relative optically stimulated luminescence (OSL) efficiency of BaFBr:Eu detectors. Additionally, we measured the luminescence intensity of BaFBr:Eu detectors exposed to $$^{4}$$He, $$^{12}$$C and $$^{20}$$Ne ions to verify the calculated data. The model reproduced the experimental data in the cases of adopting a microdosimetric target diameter of approximately 30-50 nm. The calculated relative efficiency exhibit ion-species dependence in addition to LET. This result shows that the microdosimetric calculation from specific energy is a successful method for accurately understanding the results of OSL measurements with BaFBr:Eu detectors irradiated by various particles.

Journal Articles

Track-structure modes in Particle and Heavy Ion Transport code System (PHITS); Application to radiobiological research

Matsuya, Yusuke; Kai, Takeshi; Sato, Tatsuhiko; Ogawa, Tatsuhiko; Hirata, Yuho; Yoshii, Yuji*; Parisi, A.*; Liamsuwan, T.*

International Journal of Radiation Biology, 98(2), p.148 - 157, 2022/02

 Times Cited Count:10 Percentile:81.47(Biology)

When investigating radiation-induced biological effects, it is essential to perform detailed track-structure simulations explicitly by considering each atomic interaction in liquid water (which is equivalent to human tissues) at sub-cellular and DNA scales. The Particle and Heavy Ion Transport code System (PHITS) is a Monte Carlo code which can be used for track structure calculations by employing an original electron track-structure mode (etsmode) and the world-famous KURBUC algorithms (PHITS-KURBUC mode) for protons and carbon ions. In this study, the physical features (i.e., range, radial dose and microdosimetry) of these modes have been verified by comparing to the available experimental data and Monte Carlo simulation results reported in literature. In addition, applying the etsmode to radiobiological study, we estimated the yields of single-strand breaks (SSBs), double-strand breaks (DSBs) and complex DSBs, and evaluated the dependencies of DNA damage yields on incident electron energy. As a result, the simulations suggested that DNA damage types are intrinsically related with the spatial patterns of ionization and electronic excitations and that approximately 500 eV electron can cause much complex DSBs. In this paper, we show the development status of the PHITS track-structure modes and its application to radiobiological research, which would be expected to identify the underlying mechanisms of radiation effects based on physics.

Journal Articles

Development of a new microdosimetric biological weighting function for the RBE$$_{10}$$ assessment in case of the V79 cell line exposed to ions from $$^{1}$$H to $$^{238}$$U

Parisi, A.*; Sato, Tatsuhiko; Matsuya, Yusuke; Kase, Yuki*; Magrin, G.*; Verona, C.*; Tran, L.*; Rosenfeld, A.*; Bianchi, A.*; Olko, P.*; et al.

Physics in Medicine & Biology, 65(23), p.235010_1 - 235010_20, 2020/12

 Times Cited Count:20 Percentile:88.2(Engineering, Biomedical)

A new biological weighting function (IBWF) is proposed to phenomenologically relate microdosimetric lineal energy probability density distributions with the relative biological effectiveness (RBE) for the in vitro clonogenic cell survival (survival fraction = 10%) of the most commonly used mammalian cell line, i.e. the Chinese hamster lung fibroblasts (V79). The RBE values assessed by the IBWF were found to be consistent and in good agreement with the ones calculated in combination with computer-simulated microdosimetric spectra, with an average relative deviation of 0.8% and 5.7% for H and C ions respectively.

Journal Articles

Evaluation of large 3600 MWth sodium-cooled fast reactor OECD neutronic benchmarks

Buiron, L.*; Rimpault, G*; Fontaine, B.*; Kim, T. K.*; Stauff, N. E.*; Taiwo, T. A.*; Yamaji, Akifumi*; Gulliford, J.*; Fridmann, E.*; Pataki, I.*; et al.

Proceedings of International Conference on the Physics of Reactors; The Role of Reactor Physics toward a Sustainable Future (PHYSOR 2014) (CD-ROM), 16 Pages, 2014/09

Within the activities of the Working Party on Scientific Issues of Reactor Systems (WPRS) of the OECD, an international collaboration is ongoing on the neutronic analyses of several Generation-IV Sodium-cooled Fast Reactor (SFR) concepts. This paper summarizes the results obtained by participants from institutions of different countries (ANL, CEA, ENEA, HZDR, JAEA, CER, KIT, UIUC) for the large core numerical benchmarks. These results have been obtained using different calculation methods and analysis tools to estimate the core reactivity and isotopic composition evolution, neutronic feedbacks and power distribution. For the different core concepts analyzed, a satisfactory agreement was obtained between participants despite the different calculation schemes used. A good agreement was generally obtained when comparing compositions after burnup, the delayed neutron fraction, the Doppler coefficient, and the sodium void worth. However, some noticeable discrepancies between the k-effective values were observed and are explained in this paper. These are mostly due to the different neutronic libraries employed (JEFF3.1, ENDFB7.0 or JENDL-4.0) and to a lesser extent the calculations methods.

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