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Journal Articles

Impact of microdosimetric modeling on computation of relative biological effectiveness for carbon ion radiotherapy

Hartzell, S.*; Furutani, K. M.*; Parisi, A.*; Sato, Tatsuhiko; Kase, Yuki*; Deglow, C.*; Friedrich, T.*; Beltran, C. J.*

Radiation (Internet), 5(2), p.21_1 - 21_24, 2025/06

Journal Articles

Extending TOPAS with an analytical microdosimetric function; Application and benchmarking with nBio track structure simulations

Hartzell, S.*; Parisi, A.*; Sato, Tatsuhiko; Beltran, C. J.*; Furutani, K. M.*

Physics in Medicine & Biology, 70(10), p.105010_1 - 105010_19, 2025/05

 Times Cited Count:0 Percentile:0.00(Engineering, Biomedical)

Journal Articles

LET-based approximation of the microdosimetric kinetic model for proton radiotherapy

Parisi, A.*; Furutani, K. M.*; Sato, Tatsuhiko; Beltran, C. J.*

Medical Physics, 51(10), p.7589 - 7605, 2024/10

 Times Cited Count:2 Percentile:70.65(Radiology, Nuclear Medicine & Medical Imaging)

In this study, we have developed an approximate MKM (microdosimetric kinetic model) based on LET (dose-averaged linear energy transfer) to address the challenges of biological relative effectiveness (RBE) models for proton therapy. This is an attempt to apply the mechanism-based approach used in carbon ion therapy to proton beams. This LET-based MKM establishes a correlation between dose-averaged LET and microbiological indices and successfully models survival rates for multiple cell lines. This has resulted in a mathematical description of RBE based on physical quantities that can be readily used in proton therapy planning systems.

Journal Articles

Comparative evaluation of two analytical functions for the microdosimetry of ions from $$^{1}$$H to $$^{238}$$U

Parisi, A.*; Furutani, K. M.*; Sato, Tatsuhiko; Beltran, C. J.*

Quantum Beam Science (Internet), 8(3), p.18_1 - 18_16, 2024/09

Journal Articles

Development of a new microdosimetric biological weighting function for the RBE$$_{10}$$ assessment in case of the V79 cell line exposed to ions from $$^{1}$$H to $$^{238}$$U

Parisi, A.*; Sato, Tatsuhiko; Matsuya, Yusuke; Kase, Yuki*; Magrin, G.*; Verona, C.*; Tran, L.*; Rosenfeld, A.*; Bianchi, A.*; Olko, P.*; et al.

Physics in Medicine & Biology, 65(23), p.235010_1 - 235010_20, 2020/12

 Times Cited Count:34 Percentile:88.18(Engineering, Biomedical)

A new biological weighting function (IBWF) is proposed to phenomenologically relate microdosimetric lineal energy probability density distributions with the relative biological effectiveness (RBE) for the in vitro clonogenic cell survival (survival fraction = 10%) of the most commonly used mammalian cell line, i.e. the Chinese hamster lung fibroblasts (V79). The RBE values assessed by the IBWF were found to be consistent and in good agreement with the ones calculated in combination with computer-simulated microdosimetric spectra, with an average relative deviation of 0.8% and 5.7% for H and C ions respectively.

Journal Articles

Evaluation of large 3600 MWth sodium-cooled fast reactor OECD neutronic benchmarks

Buiron, L.*; Rimpault, G*; Fontaine, B.*; Kim, T. K.*; Stauff, N. E.*; Taiwo, T. A.*; Yamaji, Akifumi*; Gulliford, J.*; Fridmann, E.*; Pataki, I.*; et al.

Proceedings of International Conference on the Physics of Reactors; The Role of Reactor Physics toward a Sustainable Future (PHYSOR 2014) (CD-ROM), 16 Pages, 2014/09

Within the activities of the Working Party on Scientific Issues of Reactor Systems (WPRS) of the OECD, an international collaboration is ongoing on the neutronic analyses of several Generation-IV Sodium-cooled Fast Reactor (SFR) concepts. This paper summarizes the results obtained by participants from institutions of different countries (ANL, CEA, ENEA, HZDR, JAEA, CER, KIT, UIUC) for the large core numerical benchmarks. These results have been obtained using different calculation methods and analysis tools to estimate the core reactivity and isotopic composition evolution, neutronic feedbacks and power distribution. For the different core concepts analyzed, a satisfactory agreement was obtained between participants despite the different calculation schemes used. A good agreement was generally obtained when comparing compositions after burnup, the delayed neutron fraction, the Doppler coefficient, and the sodium void worth. However, some noticeable discrepancies between the k-effective values were observed and are explained in this paper. These are mostly due to the different neutronic libraries employed (JEFF3.1, ENDFB7.0 or JENDL-4.0) and to a lesser extent the calculations methods.

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