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Murmiliuk, A.*; Iwase, Hiroki*; Kang, J.-J.*; Mohanakumar, S.*; Appavou, M.-S.*; Wood, K.*; Almsy, L.*; Len, A.*; Schwrzer, K.*; Allgaier, J.*; et al.
Journal of Colloid and Interface Science, 665, p.801 - 813, 2024/07
Times Cited Count:3 Percentile:81.53(Chemistry, Physical)The complexity of protein structure limits our ability to predict and tune the properties of the formed nanoparticles. The goal of our research is to elucidate the key triggers of the morphological transition in protein/PE complexes, evaluate their encapsulation efficacy, and assess particle stability by the systematic study of complexes formed by block copolymers with proteins and ionic drugs. We demonstrated that copolymers consisting of PE and neutral hydrophilic block co-assemble with insulin at pH values close to the protein isoelectric point. The insulin arrangement within the particle is controlled by electrostatic forces between protein molecules, and the morphology of the formed particles can be tuned by varying pH and ionic strength.
Kaneko, Fumitoshi*; Radulescu, A.*; Nakagawa, Hiroshi
Journal of Applied Crystallography, 56(5), p.1522 - 1527, 2023/10
Times Cited Count:1 Percentile:37.25(Chemistry, Multidisciplinary)Small angle neutron scattering (SANS) is widely used as a powerful technique to study the higher-order structure of soft matter. To increase the reliability of SANS profile analysis for complex, multi-component systems, combining different types of structural information obtained by other methods is desirable. A simultaneous measurement system combining SANS and Fourier transform infrared (FTIR) spectroscopy meets this objective and is particularly useful for targets for which it is difficult to match the timing of structural changes between experiments, but there is a problem that samples suitable for SANS are too thick for typical transmission FTIR measurements. To overcome this problem, a new simultaneous measurement system that employs the attenuated total reflection sampling method for FTIR spectroscopy has been developed.
Kaneko, Fumitoshi*; Kawaguchi, Tatsuya*; Radulescu, A.*; Iwase, Hiroki*; Morikawa, Toshiaki*; Takata, Shinichi; Nishiura, Masayoshi*; Hou, Z.*
Review of Scientific Instruments, 90(9), p.093906_1 - 093906_6, 2019/09
Times Cited Count:5 Percentile:26.73(Instruments & Instrumentation)Kaneko, Fumitoshi*; Radulescu, A.*; Iwase, Hiroki*; Takata, Shinichi; Nishiura, Masayoshi*; Hou, Z.*
Macromolecular Symposia, 386(1), p.1900008_1 - 1900008_5, 2019/08
Times Cited Count:0 Percentile:0.00(Polymer Science)Michel-Sendis, F.*; Gauld, I.*; Martinez, J. S.*; Alejano, C.*; Bossant, M.*; Boulanger, D.*; Cabellos, O.*; Chrapciak, V.*; Conde, J.*; Fast, I.*; et al.
Annals of Nuclear Energy, 110, p.779 - 788, 2017/12
Times Cited Count:71 Percentile:99.17(Nuclear Science & Technology)Zhao, Y.; Yoshida, Miru*; Oshima, Tatsuya*; Koizumi, Satoshi*; Rikukawa, Masahiro*; Szekely, N.*; Radulescu, A.*; Richter, D.*
Polymer, 86, p.157 - 167, 2016/03
Times Cited Count:13 Percentile:42.48(Polymer Science)Zhao, Y.; Yoshimura, Kimio; Shishitani, Hideyuki*; Yamaguchi, Susumu*; Tanaka, Hirohisa*; Koizumi, Satoshi*; Szekely, N.*; Radulescu, A.*; Richter, D.*; Maekawa, Yasunari
Soft Matter, 12(5), p.1567 - 1578, 2016/02
Times Cited Count:29 Percentile:79.89(Chemistry, Physical)