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Journal Articles

Epigenetic modifier as a potential radiosensitizer for heavy-ion therapy on malignancy, 2

Saito, Katsuyo*; Funayama, Tomoo; Kobayashi, Yasuhiko; Murakami, Takashi*

JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 83, 2015/03

Epigenetic modifiers, such as histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors, have emerged recently as promising anticancer agents and it has been expected that epigenetic modifiers may enhance the effect of other cancer therapeutics including radiotherapy. Therefore, we investigated whether the use of epigenetic modifiers could sensitize melanoma cells for the heavy-ion therapy. Murine B16F10 melanoma cells were treated with investigational or comparator epigenetic modifier, then exposed to carbon ions of JAEA-Takasaki. After irradiation, the viabilities of cells were evaluated by colony formation assay. Treatment of B16F10 melanoma cells with HDACi trichostatin A (TSA) in combination with heavy-ion radiation provided enhanced inhibition of colony formation. The data suggest that combination of an epigenetic modifier TSA together with heavy-ion therapy may provide improved therapeutic responses in melanoma patients.

Journal Articles

MFM observation of micrometer-sized magnetic patterns produced by heavy ion microbeam irradiation in FeRh films

Aiko, Kazuma*; Toki, Atsushi*; Matsui, Toshiyuki*; Iwase, Akihiro*; Sato, Takahiro; Takano, Katsuyoshi*; Koka, Masashi; Saito, Yuichi; Kamiya, Tomihiro

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 133, 2013/01

Journal Articles

Visualization of a single cluster particle track in polystyrene films

Asano, Atsushi*; Takano, Katsuyoshi*; Chiba, Atsuya; Saito, Yuichi; Marui, Hiromi*; Omichi, Masaaki*; Maeyoshi, Yuta*; Honsho, Yoshito*; Saeki, Akinori*; Yamada, Keisuke; et al.

JAEA-Review 2012-046, JAEA Takasaki Annual Report 2011, P. 163, 2013/01

Journal Articles

MFM and PEEM observation of micrometre-sized magnetic dot arrays fabricated by ion-microbeam irradiation in FeRh thin films

Aiko, Kazuma*; Toki, Atsushi*; Matsui, Toshiyuki*; Iwase, Akihiro*; Sato, Takahiro; Takano, Katsuyoshi*; Koka, Masashi; Saito, Yuichi; Kamiya, Tomihiro; Okochi, Takuo*; et al.

Journal of Synchrotron Radiation, 19(2), p.223 - 226, 2012/03

 Times Cited Count:6 Percentile:35.76(Instruments & Instrumentation)

Journal Articles

Micrometer-sized magnetic patterning of FeRh films using an energetic ion microbeam

Fujita, Naoki*; Matsui, Toshiyuki*; Kosugi, Shinya*; Sato, Takahiro; Saito, Yuichi; Takano, Katsuyoshi; Koka, Masashi; Kamiya, Tomihiro; Seki, Shu*; Iwase, Akihiro*

Japanese Journal of Applied Physics, 49(6), p.060211_1 - 060211_3, 2010/06

 Times Cited Count:11 Percentile:46.09(Physics, Applied)

Oral presentation

Evaluation of radioactivity inventory in the Fugen, 12; Development of activation activity evolution system (ORIGEN-2) for Fugen

Kitamura, Koichi; Tanji, Kazuhiro*; Morishita, Yoshitsugu; Hayashi, Hirokazu; Yamaguchi, Katsuyoshi*; Saito, Kuniyoshi*

no journal, , 

no abstracts in English

Oral presentation

A Study on residual stress measurement of forged Al alloy part with coarse grain by neutron diffraction

Saito, Toru; Terakado, Katsuyoshi*; Ishibashi, Toshihiro*; Katayanagi, Kazue*; Machiya, Shutaro; Tomota, Yo*

no journal, , 

no abstracts in English

Oral presentation

Production of micrometer-sized magnetic domain patterns in FeRh films by heavy ion micro-beam irradiation

Iwase, Akihiro*; Matsui, Toshiyuki*; Toki, Atsushi*; Aiko, Kazuma*; Sato, Takahiro; Takano, Katsuyoshi*; Koka, Masashi; Saito, Yuichi; Kamiya, Tomihiro

no journal, , 

no abstracts in English

Oral presentation

Epigenetic modification potentially sensitizes heavy-ion therapy for malignancy

Saito, Katsuyo*; Funayama, Tomoo; Kobayashi, Yasuhiko; Murakami, Takashi*

no journal, , 

Malignant melanoma is one of the most common cutaneous malignancies. Epigenetic modifiers, such as histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors, have emerged recently as promising anticancer agents and has been expected as a sensitizer for other cancer therapeutics including radiotherapy. In addition, the biological effects of the high linear energy transfer (LET) heavy-ion radiation are more pronounced than the low-LET radiation. These accumulating evidences allowed us to investigate whether the use of HDACi could sensitize melanoma cells for the heavy-ion therapy. Treatment of B16F10 melanoma cells with HDACi in combination with heavy-ion radiation provided enhanced anti-tumor effects. These data suggest that combination of HDACi together with heavy-ion therapy may provide improved therapeutic responses in melanoma patients.

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