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Tsuchida, Hidetsugu*; Tezuka, Tomoya*; Kai, Takeshi; Matsuya, Yusuke*; Majima, Takuya*; Saito, Manabu*
Journal of Chemical Physics, 161(10), p.104503_1 - 104503_8, 2024/09
Times Cited Count：0 Percentile：0.00(Chemistry, Physical)Although fast ion beams can damage DNA by chemical products such as secondary electrons produced by their interaction with water in living cells, the process of formation of these chemical products in the Bragg peak region used in particle therapy is not fully understood. To investigate this process, we performed experiments to evaluate the yields of radiolytic products produced when a liquid water jet in vacuum is irradiated with a MeV-energy carbon beam. In addition, ionization processes in water due to incident ions and secondary electrons were simulated using a radiation transport Monte Carlo code. The results indicated that the primary source of ionization in water is secondary electrons. Finally, we show that these elementary processes contribute to the development of radiation biophysics and biochemistry to study the formation mechanism of DNA damage.
Tsuchida, Hidetsugu*; Kai, Takeshi; Kitajima, Kensei*; Matsuya, Yusuke; Majima, Takuya*; Saito, Manabu*
European Physical Journal D, 74(10), p.212_1 - 212_7, 2020/10
Times Cited Count：5 Percentile：34.32(Optics)Fundamental study of interaction between biomolecules and heavy ions in water is very important to predict an initial stage of radiation biological effects. A heavy ion irradiation experiment into droplet target assumed as a biological system in a vacuum was performed to measure production yields of cations and anions for glycine, which was ejected from the droplet target to the vacuum. However, the production mechanisms have been unknown. The PHITS code adapting ion track structure mode was used to analyze the production mechanisms from the dose evaluation at the surface between the vacuum and the water. It is found that induction yields of ionization and excitation, and dissociative electron attachment involved in the secondary electrons were correlated with the production yields of cations and anions of the glycine. The results provide us newly scientific insights to predict an initial stage of radiation biological effects.
Fujimoto, Hirofumi*; Higuchi, Mariko; Koike, Manabu*; Ode, Hirotaka*; Pinak, M.; Kotulic Bunta, J.*; Nemoto, Toshiyuki*; Sakudo, Takashi*; Honda, Naoko*; Maekawa, Hideaki*; et al.
Journal of Computational Chemistry, 33(3), p.239 - 246, 2012/01
Times Cited Count：36 Percentile：66.58(Chemistry, Multidisciplinary)Lysine acetylation is one of the most common protein post transcriptional modifications. The acetylation effects of lysine residues on Ku protein were examined herein applying several computer simulation techniques. Acetylation of the lysine residues did not reduce the affinity between Ku and its substrate, DNA, in spite of the fact that the substitution of lysine with glutamine (KQ mutant) reduced the affinity of Ku for DNA, or the substitution of lysine with arginine (KR mutant) did not reduce it, as previously reported in experimental studies. These results suggest that the effects of in vivo acetylation may be overestimated when the KQ mutant is employed in mimicry of the acetylated protein.
collisions at 
= 200 and 62.4 GeVAdare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Armendariz, R.*; et al.
Physical Review C, 83(6), p.064903_1 - 064903_29, 2011/06
Times Cited Count：192 Percentile：99.41(Physics, Nuclear)Transverse momentum distributions and yields for 
, and 
in collisions at = 200 and 62.4 GeV at midrapidity are measured by the PHENIX experiment at the RHIC. We present the inverse slope parameter, mean transverse momentum, and yield per unit rapidity at each energy, and compare them to other measurements at different collisions. We also present the scaling properties such as 
and 
scaling and discuss the mechanism of the particle production in collisions. The measured spectra are compared to next-to-leading order perturbative QCD calculations.
and Au+Au collisions at 
= 200 GeVAdare, A.*; Afanasiev, S.*; Aidala, C.*; Ajitanand, N. N.*; Akiba, Yasuyuki*; Al-Bataineh, H.*; Alexander, J.*; Aoki, Kazuya*; Aphecetche, L.*; Aramaki, Y.*; et al.
Physical Review C, 83(4), p.044912_1 - 044912_16, 2011/04
Times Cited Count：10 Percentile：54.83(Physics, Nuclear)Measurements of electrons from the decay of open-heavy-flavor mesons have shown that the yields are suppressed in Au+Au collisions compared to expectations from binary-scaled collisions. Here we extend these studies to two particle correlations where one particle is an electron from the decay of a heavy flavor meson and the other is a charged hadron from either the decay of the heavy meson or from jet fragmentation. These measurements provide more detailed information about the interaction between heavy quarks and the quark-gluon matter. We find the away-side-jet shape and yield to be modified in Au+Au collisions compared to collisions.
Iwatsuki, Teruki; Sato, Haruo; Tanai, Kenji; Inagaki, Manabu; Sawada, Atsushi; Niinuma, Hiroaki; Ishii, Eiichi; Maekawa, Keisuke; Tomura, Goji; Sanada, Hiroyuki; et al.
JAEA-Research 2009-002, 156 Pages, 2009/05
JAEA-Research-2009-002.pdf:12.86MB
The research and development plan for geological investigation, engineering technology and safety assessment during the drilling of a shaft down to intermediate depth are summarized according to the Midterm Plan till 2009 Fiscal year of JAEA. This report describes subject, current status and programme in the "Phase 2: Construction phase" (investigations during construction of the underground facilities). Furthermore regarding R&D plan in next Midterm Plan of JAEA, preliminary ideas are summarized.
Imai, Makoto*; Shirai, Toshizo*; Saito, Manabu*; Haruyama, Yoichi*; Ito, Akio*; Imanishi, Nobutsugu*; Fukuzawa, Fumio*; Kubo, Hirotaka
Journal of Plasma and Fusion Research SERIES, Vol.7, p.323 - 326, 2006/00
no abstracts in English
emission spectroscopy of layered manganate La
Sr
Mn
O
Agui, Akane; K
mbre, T.*; S
the, C.*; Nordgren, J.*; Usuda, Manabu; Saito, Tomohiko*; Moritomo, Yutaka*
Journal of Electron Spectroscopy and Related Phenomena, 144-147, p.589 - 592, 2005/06
Times Cited Count：1 Percentile：5.61(Spectroscopy)Current research in the perovskite and layered perovskite-type manganese oxides has expanded to include the study of electronic and magnetic properties such as the colossal magnetoresistance (CMR), orbital ordering and charge ordering. The O K soft X-ray emission and absorption spectra (XES and XAS) of LaSrMnO were measured at selected excitation energies in order to investigate the electronic structure. The measurements were carried out by using a soft X-ray emission spectrometer at beamline BW3 at HASYLAB, Germany. The dependence of O K XES on excitation-energy was observed. It is attributed the different site of oxygen ions.
,CH
,CH
,C
H
and CO moleculesIto, Akio*; Imanishi, Nobutsugu*; ; Hamamoto, Nariaki*; ; Tanaka, Takashi*; ; Saito, Manabu*; Haruyama, Yoichi*; Shirai, Toshizo
Journal of the Physical Society of Japan, 64(9), p.3255 - 3264, 1995/09
Times Cited Count：20 Percentile：70.36(Physics, Multidisciplinary)no abstracts in English
Hamamoto, Nariaki*; Tanaka, Takashi*; Ito, Akio*; Imanishi, Nobutsugu*; Saito, Manabu*; Haruyama, Yoichi*; Shirai, Toshizo
JAERI-M 93-202, 45 Pages, 1993/10
no abstracts in English
Matoba, Shiro; Narumi, Kazumasa; Saito, Yuichi; Chiba, Atsuya; Yamada, Keisuke; Kamiya, Tomihiro; Koizumi, Tetsuo*; Takahashi, Karin*; Ishikawa, Manabu*; Moriya, Sosuke*; et al.
no journal, ,
no abstracts in English
Matoba, Shiro; Narumi, Kazumasa; Saito, Yuichi; Yamada, Keisuke; Chiba, Atsuya; Koizumi, Tetsuo*; Takahashi, Karin*; Ishikawa, Manabu*; Shiromaru, Haruo*; Kato, Ryoya*; et al.
no journal, ,
no abstracts in English
Konishi, Suzuka*; Minagawa, Hideaki*; Majima, Takuya*; Imai, Makoto*; Saito, Manabu*; Hirade, Tetsuya; Tsuchida, Hidetsugu*
no journal, ,
To clarify the damage behavior under ion irradiation in quartz glass, Age-Momentum Correlation measurement that is a coincidence measurement of positron annihilation lifetime and annihilation gamma ray Doppler broadening was performed under 2 MeV proton irradiation. From the change in momentum distribution of electrons involved in positron annihilation in voids of the quartz glass, flux dependence of damage behavior could be detected.
Yamaguchi, Kohei; Honda, Akira; Inagaki, Manabu; Yui, Mikazu; Saito, Hironori*
no journal, ,
The bench mark analysis concerning the change in the material transportation characteristic according to the chemical reaction were done by using pass experiment result (Mader et al., 2006) of the high pH solution to the natural crack core in granite as part of international collaboration LCS (Long-term Cement Study). We were able to reproduce the observed blockage tendency as a result experimentally the material transportation model characteristic according to the chemical reaction.
Saito, Shigeru; Wakui, Takashi; Tsukada, Manabu*; Yamashita, Naoki; Sano, Naruto; Dai, Y.*; Futakawa, Masatoshi
no journal, ,
Post irradiation examination (PIE) of the MEGAPIE (MEGAwatt Pilot Experiment) project has been performed on the samples allotted to JAEA. In the experiments, specimens for tensile test are prepared by taking from the component of the MEGAPIE target such as the beam window (BW) of T91. The irradiation temperatures were about 250 
C and the displacement-damage levels ranged between 0.75 and 1.74 dpa. After the tensile tests, SP specimens are prepared from the grip part of the tested tensile specimens. Testing temperatures for SP tests ranged from -150C to 250C. From the area of the load-displacement curves (LDC) of the SP tests, ductile-brittle transition temperature (DBTT) was evaluated. Comparison of these data with previous STIP data showed similar values. In addition, the yield stress and ultimate tensile strength were calculated from the SP tests results by applying the conversion equation. These were compared with the results of the tensile tests and found to be in good agreement.
