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Journal Articles

RF design of the prototype spoke cavity for the JAEA-ADS linac

Tamura, Jun; Kondo, Yasuhiro; Yee-Rendon, B.; Meigo, Shinichiro; Maekawa, Fujio; Hasegawa, Kazuo; Kako, Eiji*; Umemori, Kensei*; Sakai, Hiroshi*; Konomi, Taro*

JPS Conference Proceedings (Internet), 33, p.011049_1 - 011049_6, 2021/03

JAEA Reports

Poro-elastic parameter acquisition test using siliceous mudstone (Wakkanai formation)

Aoki, Tomoyuki*; Tani, Takuya*; Sakai, Kazuo*; Koga, Yoshihisa*; Aoyagi, Kazuhei; Ishii, Eiichi

JAEA-Research 2020-002, 83 Pages, 2020/06


The Japan Atomic Energy Agency (JAEA) has conducted with the Horonobe Underground Research Project in Horonobe, Teshio-gun, Hokkaido for the purpose of research and development related to geological disposal technology for high-level radioactive wastes in sedimentary soft rocks. The geology around the Horonobe Underground Research Laboratory (HURL) is composed of the Koetoi diatomaceous mudstone layer and the Wakkanai siliceous layer, both of which contain a large amount of diatom fossils. Since these rocks exhibit relatively high porosity but low permeability, it is important to investigate the poro-elastic characteristics of the rock mass. For this objective, it is necessary to measure parameters based on the poro-elastic theory. However, there are few measurement results of the poro-elastic parameters for the geology around HURL, and the characteristics such as dependence on confining pressure are not clearly understood. One of the reasons is that the rocks show low permeability and the pressure control during testing is difficult. Therefore, a poro-elastic parameter measurement test was conducted on the siliceous mudstone of the Wakkanai formation to accumulate measurement results on the poro-elastic parameters and to examine the dependence of the parameters on confining pressure. As a result, some dependency of the poro-elastic parameters on confining pressure was observed. Among the measured or calculated poro-elastic parameters, the drained bulk modulus increased, while the Skempton's pressure coefficient, and the Biot-Wills coefficient in the elastic region decreased with the increase in confining pressure. The measurement results also inferred that the foliation observed in the rock specimens might impact a degree of dependency of those parameters on confining pressure.

Journal Articles

Electromagnetic design of the prototype spoke cavity for the JAEA-ADS linac

Tamura, Jun; Kondo, Yasuhiro; Yee-Rendon, B.; Meigo, Shinichiro; Maekawa, Fujio; Hasegawa, Kazuo; Kako, Eiji*; Umemori, Kensei*; Sakai, Hiroshi*; Konomi, Taro*

Proceedings of 19th International Conference on RF Superconductivity (SRF 2019) (Internet), p.399 - 402, 2019/11

Journal Articles

Gamma-ray glow preceding downward terrestrial gamma-ray flash

Wada, Yuki*; Enoto, Teruaki*; Nakamura, Yoshitaka*; Furuta, Yoshihiro; Yuasa, Takayuki*; Nakazawa, Kazuhiro*; Morimoto, Takeshi*; Sato, Mitsuteru*; Matsumoto, Takahiro*; Yonetoku, Daisuke*; et al.

Communications Physics (Internet), 2(1), p.67_1 - 67_9, 2019/06

 Times Cited Count:27 Percentile:91.38(Physics, Multidisciplinary)

Journal Articles

Development of proposed guideline of flow-induced vibration evaluation for hot-leg piping in a sodium-cooled fast reactor

Sakai, Takaaki; Yamano, Hidemasa; Tanaka, Masaaki; Ono, Ayako; Ohshima, Hiroyuki; Kaneko, Tetsuya*; Hirota, Kazuo*; Sago, Hiromi*; Xu, Y.*; Iwamoto, Yukiharu*; et al.

Proceedings of 15th International Topical Meeting on Nuclear Reactor Thermal Hydraulics (NURETH-15) (USB Flash Drive), 13 Pages, 2013/05

The development of flow-induced vibration evaluation methodology has reached a milestone that separate-effect experimental data under a high Reynolds number regime including swirl and deflected inflow conditions are available for the validation of the methodology. On the other hand, technical standards are desirable to be documented for designers of sodium-cooled fast reactors. From such a background, the documentation of a flow-induced vibration design guideline has been made for the hot-leg piping of Japan sodium-cooled fast reactor. This paper describes the design guideline of the flow-induced vibration evaluation methodology, which has been informed from main separate-effect experiments, as well as supplemental interpretation for the guideline.

Journal Articles

Effect of swirl inflow on flow pattern and pressure fluctuation onto a single-elbow pipe in Japan Sodium-cooled Fast Reactor

Yamano, Hidemasa; Sago, Hiromi*; Hirota, Kazuo*; Hayakawa, Satoshi*; Xu, Y.*; Tanaka, Masaaki; Sakai, Takaaki

Journal of Fluid Science and Technology (Internet), 7(3), p.329 - 344, 2012/09

As part of the development of a flow-induced vibration evaluation methodology for the primary cooling piping in Japan Sodium-cooled Fast Reactor, important factors were discussed in evaluating the flow-induced vibration for the hot-leg piping. To investigate a complex flow near the inlet of the hot-leg piping, a reactor scale numerical analysis was carried out for the reactor upper plenum flow, which was simulated in a 1/10-scale reactor upper plenum experiment. Based on this analysis, experimental conditions on swirl inflow and deflected inflow that were identified as important factors were determined for flow-induced vibration experiments simulating only the hot-leg piping. In this study, the effect of the swirl inflow on flow pattern and pressure fluctuation onto the pipe wall was investigated in a 1/3-scale hot-leg pipe experiment. The experiment has indicated less significant for the pressure fluctuations, while the flow separation region was slightly influenced by the swirl flow. Computational fluid dynamics simulation results also appear in this paper, focusing on its applicability to the hot-leg piping experiments.

Journal Articles

Study on flow induced vibration evaluation for a large scale JSFR piping, 1; Current status of flow induced vibration evaluation for hot-leg piping

Yamano, Hidemasa; Sakai, Takaaki; Tanaka, Masaaki; Sago, Hiromi*; Hirota, Kazuo*; Xu, Y.*

Proceedings of 19th International Conference on Nuclear Engineering (ICONE-19) (CD-ROM), 8 Pages, 2011/10

Journal Articles

Quantitative analysis of cisplatin sensitivity of human esophageal squamous cancer cell lines using in-air micro-PIXE

Tanaka, Naritake*; Kimura, Hitoshi*; Faried, A.*; Sakai, Makoto*; Sano, Takaaki*; Inose, Takanori*; Soda, Makoto*; Okada, Koji*; Nakajima, Masanobu*; Miyazaki, Tatsuya*; et al.

Cancer Science, 101(6), p.1487 - 1492, 2010/06

 Times Cited Count:12 Percentile:33.54(Oncology)

We examined the intracellular localization of cisplatin, a key chemotherapeutic agent, in esophageal cancer cell lines and determined their sensitivity to cisplatin using in-air micro-PIXE. Two human esophageal squamous cell carcinoma (ESCC) cell lines, TE-2 and TE-13, were examined for their response to cisplatin using MTT assay, flow cytometry and DNA fragmentation assays. Real-time reverse transcription-polymerase chain reaction was also used to evaluate the mRNA expression of multidrug resistance protein 2 (MRP2) in both cell lines. Platinum localizations of intracellular and intranuclear were measured using in-air micro-PIXE. TE-2 cells were more sensitive to cisplatin than TE-13 cells. The results of this study suggest that in-air micro-PIXE could be a useful quantitative method for evaluating the cisplatin sensitivity of individual cells. Finally, we speculate that MRP2 in the cell membrane may play an important role in regulating cisplatin sensitivity of ESCC cells.

Journal Articles

Intracellular changes of metal elements by fucoidan extracted from brown seaweed; ${it Cladosiphon okamuranus}$

Nagamine, Takeaki*; Takada, Hisashi*; Kusakabe, Takahiko*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Kamiya, Tomihiro; Arakawa, Kazuo; Iha, Masahiko*

Biological Trace Element Research, 124(1), p.60 - 69, 2008/07

 Times Cited Count:2 Percentile:7.14(Biochemistry & Molecular Biology)

This study was undertaken to elucidate the intracellular changes of metal elements after the administration of fucoidan extracted from ${it Cladosiphon okamuranus}$. TRL1215 cells (normal rat liver cell line) were treated with 0, 0.1, or 1.0 mg/mL fucoidan. The cellular distribution of elements was analyzed using in-air micro-PIXE induced X-ray emission. In fucoidan-treated cells, the focal accumulation of Br (BrdU) was correlated spatially with phosphorous-rich region, suggesting that Br was localized within the nucleus. Al distribution provided a spatial association with Br map. These data suggest that fucoidan binding Al us postulated to be transferred into the nucleus.

Journal Articles

Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice

Nakazato, Kyomi*; Nagamine, Takeaki*; Suzuki, Keiji*; Kusakabe, Takahiko*; Moon, H. D.*; Oikawa, Masakazu*; Sakai, Takuro; Arakawa, Kazuo

Biometals, 21(1), p.83 - 91, 2008/02

 Times Cited Count:15 Percentile:31.09(Biochemistry & Molecular Biology)

To clarify the relation of essential metals to cadmium (Cd) toxicity, we evaluated metallothionein expression and analyzed the subcellular distribution of essential metals using in-air micro-PIXE. Four mice were dosed orally with 100 mg/L of Cd in drinking water for 1.5 or 2 years. Compared to the control, the Cd-exposed mice markedly accumulated zinc in the liver and renal cortex. Elemental maps showed that a large amount of Cd was spatially combined with zinc in the 1.5y-Cd mouse. The data suggest that zinc may contribute to protect against oral-administrated Cd toxicity.

Journal Articles

Design of pencil beam formation system for high-accuracy carbon-ion microsurgery

Arakawa, Kazuo; Oikawa, Masakazu*; Shimada, Hirofumi*; Kamiya, Tomihiro; Nakano, Takashi*; Yusa, Ken*; Kato, Hiroyuki*; Sato, Takahiro; Agematsu, Takashi; Kashiwagi, Hirotsugu; et al.

Proceedings of 4th Annual Meeting of Particle Accelerator Society of Japan and 32nd Linear Accelerator Meeting in Japan (CD-ROM), p.279 - 281, 2007/00

no abstracts in English

Journal Articles

Interferon$$beta$$-induced changes in metallothionein expression and subcellular distribution of zinc in HepG2 cells

Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; Nakazato, Kyomi*; Sakai, Takuro; Oikawa, Masakazu*; Sato, Takahiro; Arakawa, Kazuo

Cytokine, 34(5-6), p.312 - 319, 2006/06

 Times Cited Count:8 Percentile:17.22(Biochemistry & Molecular Biology)

no abstracts in English

Journal Articles

Research of disease onset mechanism by determining the distribution of intracellular trace elements using an in-air micro-PIXE analyzer system

Nakano, Takashi*; Arakawa, Kazuo; Sakurai, Hideyuki*; Hasegawa, Masatoshi*; Yuasa, Kazuhisa*; Saito, Etsuko*; Takagi, Hitoshi*; Nagamine, Takeaki*; Kusakabe, Takahiko*; Takada, Hisashi*; et al.

International Journal of PIXE, 16(1&2), p.69 - 76, 2006/00

A new program was started out to create a new medical scientific field, which is consisting of radiation oncology and nuclear medicine, utilizing the advanced accelerator and ion beam technology. An in-air micro-PIXE analyzer system, which is among the most important technical basis of the program, was upgraded to improve accuracy of elemental mapping for samples having thickness variation in a scope of microbeam scanning. In the program, on the other hand, in order to approach important bio-medical problems on cancer, intracellular dynamics of the trace elements according to mechanism of development of diseases were studied using this system. This paper outlines this program and shows the system upgraded, and results of preliminary studied about the problems.

Journal Articles

Project of the JAERI superconducting AVF cyclotron for applications in biotechnology and materials science

Miyawaki, Nobumasa; Kurashima, Satoshi; Okumura, Susumu; Chiba, Atsuya; Agematsu, Takashi; Kamiya, Tomihiro; Kaneko, Hirohisa; Nara, Takayuki; Saito, Yuichi; Ishii, Yasuyuki; et al.

Proceedings of 17th International Conference on Cyclotrons and Their Applications (CYCLOTRONS 2004), p.208 - 210, 2005/00

A project to expand at TIARA (Takasaki Ion Accelerators for Advanced Radiation Application) facilities of JAERI has been proposed to broaden applications in biotechnology and materials science. Heavy ions with energy more than 100 MeV/n are required for remarkable progress in breeding of plant and development of new materials. The magnet of a superconducting AVF cyclotron with a K number of 900 has been designed to cope with acceleration of both 150 MeV/n heavy ions and 300 MeV protons. The lower limit of energies has been investigated to overlap the energy region covered by the JAERI AVF cyclotron, required to increase beam time for present users. We have designed a beam transport system to satisfy requirements of the applications.

Journal Articles

Analysis of intracellular distribution of boron and gadolinium in 9L sarcoma cells using a single-ended accelerator (Micro PIXE)

Endo, Kiyoshi*; Shibata, Yasushi*; Yoshida, Fumiyo*; Nakai, Kei*; Yamamoto, Tetsuya*; Matsumura, Akira*; Ishii, Keizo*; Sakai, Takuro; Sato, Takahiro; Oikawa, Masakazu*; et al.

Proceedings of 11th World Congress on Neutron Capture Therapy (ISNCT-11) (CD-ROM), 2 Pages, 2004/10

Micro PIXE, which is installed in a single end accelerator in JAERI, was used for quantitative analysis of boron and gadolinium distribution in a cell level. The micro beam of 1 $$mu$$m diameter is possible to observe the distribution. In the adjustment procedure of the sample, first is a fix of mylar film by using a glass ring and a bite ring of 2cm diameter. Next the 9L cells were scattered on the washed film, and is cultivated on 37$$^{circ}$$C in medium until they form the mono-layer. After the Gd-BOPTA was added, it incubates for the 24-72 hour on 37$$^{circ}$$C. The film is washed in the THAM liquid, and is directly put on liquid nitrogen. A vacuum drying for 24 hours is conducted in order to fix a film on holder. It is important to uniformly fix the cell in distribution analysis in the cell using Micro PIXE. In recent result, it became possible that the distribution of P, S, Gd, etc. was analyzed. But we could not distinguish whether K and Gd exist in the cell or whether it exists around the cell. It was indicated that these elements was leaked by the reason of cell breaking or other on the cytoplasm.

Journal Articles

Feasilibity study of the K900 superconducting AVF cyclotron for materials science and biotechnology

Fukuda, Mitsuhiro; Okumura, Susumu; Kurashima, Satoshi; Miyawaki, Nobumasa; Ishii, Yasuyuki; Saito, Yuichi; Mizuhashi, Kiyoshi; Agematsu, Takashi; Chiba, Atsuya; Sakai, Takuro; et al.

Proceedings of 1st Annual Meeting of Particle Accelerator Society of Japan and 29th Linear Accelerator Meeting in Japan, p.643 - 645, 2004/08

A superconducting AVF cyclotron with a bending limit of 900 MeV and a focusing limit of 300 MeV is being designed to meet the requirements for the research in materials science and biotechnology at TIARA facility of JAERI. The spiral-sector shape of the cyclotron magnet has been optimized for acceleration of a 300 MeV proton to produce sufficient focusing forces in an extraction region. An energy range of the superconducting AVF cyclotron overlaps with that of the present K110 JAERI AVF cyclotron. Characteristics of a resonator for the superconducting AVF cyclotron have been investigated using the MAFIA code. An acceleration voltage in a frequency range of 24 to 64 MHz can be produced by the resonator with a $$lambda$$/2 excitation mode.

Journal Articles

Replication of individual snow crystals for their subsequent chemical analysis using micro-PIXE

Kasahara, Mikio*; Ma, C.-J.*; Okumura, Motonori*; Kojima, Takuji; Hakoda, Teruyuki; Sakai, Takuro; Arakawa, Kazuo

JAERI-Review 2003-033, TIARA Annual Report 2002, p.270 - 272, 2003/11

A snow crystal scavenges earozol particles and trasfer various elements in atomosphere through heterogenious nucleation. The snow has many complicated crystal shapes which results in difficulty in comparison of its environmental purification function directly with that of raindrops. The replica of individual snow crystal grain was prepared by their immobilization on the collodion film. The replica samples were analized by micro-PIXE at JAERI and PIXE st Kyoto university. The following results are obtained: (1) Size(circumscribed diameter) of individual snow crystal are in the range of 0.12-2.5mm, (2)snow crystal grows from hexagnal plate to dendritic sectored plate, (3) major elements captured by a snow crystal are Si,S,K,Ca,Fe,S, (4)there is relation between snow crystal size and captured-element masses. The result leads us to presume the chemical inner-structure and the elemental mixing state in/on single snow crystal.

Journal Articles

A Project of the K900 JAERI superconducting AVF cyclotron at JAERI

Fukuda, Mitsuhiro; Okumura, Susumu; Ishii, Yasuyuki; Saito, Yuichi; Miyawaki, Nobumasa; Mizuhashi, Kiyoshi; Agematsu, Takashi; Kurashima, Satoshi; Chiba, Atsuya; Sakai, Takuro; et al.

Dai-14-Kai Kasokuki Kagaku Kenkyu Happyokai Hokokushu, p.302 - 304, 2003/00

no abstracts in English

Journal Articles

The Kinetics of Fe and Ca for the development of radiation-induced apoptosis by micro-PIXE imaging

Harada, Satoshi*; Tamakawa, Yoshiharu*; Ishii, Keizo*; Tanaka, Akira*; Sato, Takahiro; Matsuyama, Shigeo*; Yamazaki, Hiromichi*; Kamiya, Tomihiro; Sakai, Takuro; Arakawa, Kazuo; et al.

Nuclear Instruments and Methods in Physics Research B, 189(1-4), p.437 - 442, 2002/04

 Times Cited Count:1 Percentile:12.77(Instruments & Instrumentation)

To study the interactions between the induction of radiation-induced apoptosis and trace elements kinetics, human leukemia cells were irradiated in vitro by $$^{60}$$Co $$gamma$$ rays, after which the cells were evaluated for the detection of apoptosis and trace element imaging was carried out. The frequency of apoptosis was obtained by microscopic assay using TUNEL staining. The trace element distribution in the cell was determined by micro-PIXE. In the early phase of apoptosis, the maximum level of Fe accumulation was observed in the cell stroma. In the mid to end phase, Fe accumulation was diminished, and instead, Ca accumulation increased and Zn decreased in the nucleus. There appear to be two steps for the development of apoptosis: (1) the signaling from cell stroma to nucleus by Fe or an Fe-containing enzyme; and (2) the degeneration of the nucleus by Ca-dependent enzyme, and release of Zn from digested nucleus. Those strong accumulations may be new markers for apoptosis.

Journal Articles

LT-STM/STS observations on an electrical field etched surfaces of YBa$$_{2}$$Cu$$_{3}$$O$$_{7-delta}$$ single crystal

Murakami, Hironaru*; Asaoka, Hidehito; Sakai, Kazuo*; Ito, Toshimichi*; Tonouchi, Masayoshi*

Applied Surface Science, 175-176, p.306 - 311, 2001/05

 Times Cited Count:7 Percentile:41.95(Chemistry, Physical)

no abstracts in English

42 (Records 1-20 displayed on this page)