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Journal Articles

External dose evaluation based on detailed air dose rate measurements in living environments

Sato, Tetsuro*; Ando, Masaki; Sato, Masako*; Saito, Kimiaki

Journal of Environmental Radioactivity, 210, p.105973_1 - 105973_7, 2019/12

https://doi.org/10.1016/j.jenvrad.2019.05.005
 Times Cited Count：9 Percentile：36.49(Environmental Sciences)

A method was devised for estimation of external doses of Fukushima residents expected to return to their homes after evacuation orders are lifted. 211 residents expected to return to six towns and villages were surveyed in FY 2014, FY 2015, and FY2016. Interviewing returning residents about their expected life patterns after returning, air dose rate were measured along the reported personal trails representing their patterns of movement in daily life. Excluding 15 residents from whose homes we were unable to take air dose rate measurements, the maximum external effective dose and the average external effective dose were estimated respectively as 4.9 mSv/y and 0.86 mSv/y. Although the mean values and dispersion of external effective doses differ depending on the evacuation level, for 93.3% of all residents, the estimated external effective doses were less than 2 mSv/y. The average exposure dose at home accounts for 66.8% of the annual exposure dose.

Journal Articles

Measurement and estimation of the $$^{99}$$Mo production yield by $$^{100}$$Mo($$n,2n$$)$$^{99}$$Mo

Minato, Futoshi; Tsukada, Kazuaki; Sato, Nozomi*; Watanabe, Satoshi*; Saeki, Hideya*; Kawabata, Masako*; Hashimoto, Shintaro; Nagai, Yasuki*

Journal of the Physical Society of Japan, 86(11), p.114803_1 - 114803_6, 2017/11

https://doi.org/10.7566/JPSJ.86.114803
 Times Cited Count：9 Percentile：56.98(Physics, Multidisciplinary)

We have measured the yield of $$^{99}$$Mo, the mother nuclide of $$^{99m}$$Tc used in nuclear diagnostic procedure. $$^{99}$$Mo was produced by $$^{100}$$Mo($$n$$,$$2n$$)$$^{99}$$Mo using neutrons with thermal energy up to about 40 MeV, provided by C($$d$$,$$n$$). The $$^{99}$$Mo yield agrees with an estimated yield with the use of the latest data of C($$d$$,$$n$$) and the evaluated cross section given in the JENDL. Based on this, a new calculation was carried out to produce $$^{99}$$Mo to seek for a good economical condition. Various conditions such as the $$^{100}$$MoO$$_{3}$$ sample mass, the distance between the carbon target and the sample, the radius of the deuteron beam, and the neutron irradiation time were considered. The calculated $$^{99}$$Mo yield indicates that about 30% of the $$^{99}$$Mo demand in Japan can be fulfilled with a single accelerator. The elusion of $$^{99m}$$Tc from the $$^{99}$$Mo twice per day would meet about 50% of the $$^{99}$$Mo demand.

Journal Articles

Application of $$^{67}$$Cu produced by $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu to biodistribution study in tumor-bearing mice

Sugo, Yumi*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Nagai, Yasuki*

Journal of the Physical Society of Japan, 86(2), p.023201_1 - 023201_3, 2017/02

https://doi.org/10.7566/JPSJ.86.023201
 Times Cited Count：14 Percentile：68.14(Physics, Multidisciplinary)

$$^{67}$$Cu produced by the $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu reaction was used for the first time to determine the biodistribution of $$^{67}$$CuCl$$_{2}$$ in colorectal tumor-bearing mice. High uptake of $$^{67}$$Cu was observed in the tumor as well as in the liver and kidney which are the major organs for copper metabolism. The result showing $$^{67}$$Cu accumulation in the tumor suggests that $$^{67}$$CuCl$$_{2}$$ can be a potential radionuclide agent for cancer radiotherapy. It would also encourage further studies on the therapeutic effect in small animals using an increased dose of $$^{67}$$Cu produced by the $$^{68}$$Zn($$n,n'p+d$$)$$^{67}$$Cu reaction using intense neutrons available at present.

Journal Articles

SPECT imaging of mice with $$^{99m}$$Tc-radiopharmaceuticals obtained from $$^{99}$$Mo produced by $$^{100}$$Mo(n,2n)$$^{99}$$Mo and fission of $$^{235}$$U

Hashimoto, Kazuyuki; Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji*; Ota, Masayuki; Konno, Chikara; Ochiai, Kentaro; et al.

Journal of the Physical Society of Japan, 84(4), p.043202_1 - 043202_4, 2015/04

https://doi.org/10.7566/JPSJ.84.043202
 Times Cited Count：8 Percentile：53(Physics, Multidisciplinary)

Journal Articles

New phenomenon observed in thermal release of $$^{99m}$$Tc from molten $$^{100}$$MoO$$_{3}$$

Kawabata, Masako; Nagai, Yasuki; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*

Journal of the Physical Society of Japan, 84(2), p.023201_1 - 023201_4, 2015/02

https://doi.org/10.7566/JPSJ.84.023201
 Times Cited Count：6 Percentile：45.25(Physics, Multidisciplinary)

$$^{99m}$$Tc for medical use can be separated by thermochromatography from a molten $$^{99}$$MoO$$_{3}$$ sample. Effect of moist oxygen gas on the $$^{99m}$$Tc release from molten $$^{99}$$MoO$$_{3}$$ samples was investigated using a $$^{99}$$Mo/$$^{99m}$$Tc generator. $$^{99}$$Mo was produced with $$^{100}$$Mo(n,2n)$$^{99}$$Mo. A new phenomenon has been observed: release rate, separation- and recovery-efficiencies of $$^{99m}$$Tc were higher in the moist oxygen gas than those in the dry oxygen gas. The present result is a significant progress towards the stable production of a high quality $$^{99m}$$Tc from a molten MoO$$_{3}$$ sample with high separation efficiency. The result would also give us a new insight into the interaction between the moist oxygen gas and the molten MoO$$_{3}$$.

Journal Articles

First measurement of the radionuclide purity of the therapeutic isotope $$^{67}$$Cu produced by $$^{68}$$Z($$n$$,$$x$$) reaction using $$^{rm nat}$$C($$d$$,$$n$$) neutrons

Sato, Nozomi; Tsukada, Kazuaki; Watanabe, Satoshi; Ishioka, Noriko; Kawabata, Masako; Saeki, Hideya; Nagai, Yasuki; Kin, Tadahiro*; Minato, Futoshi; Iwamoto, Nobuyuki; et al.

Journal of the Physical Society of Japan, 83(7), p.073201_1 - 073201_4, 2014/07

https://doi.org/10.7566/JPSJ.83.073201
 Times Cited Count：13 Percentile：64.07(Physics, Multidisciplinary)

We have for the first time demonstrated that the therapeutic nuclide of $$^{67}$$Cu produced by $$^{68}$$Zn($$n$$,$$x$$)$$^{67}$$Cu has highest radionuclide purity compared to previous ones. We measured a $$gamma$$-ray spectrum of the reaction product produced by bombarding an enriched $$^{68}$$Zn sample with neutrons with a HPGe detector. The neutrons were obtained by $$^{rm nat}$$C($$d$$,$$n$$) using 41 MeV deuterons provided from Takasaki Ion Accelerators for Advanced Radiation Application of Japan Atomic Energy Agency. Relative production yields of impurity radionuclides such as $$^{65}$$Zn to $$^{67}$$Cu are extremely low, which allow us to chemically separate $$^{67}$$Cu from an irradiated $$^{68}$$Zn sample with a few steps and to reuse high cost an enriched $$^{68}$$Zn sample. The present result strongly suggest that the $$^{68}$$Zn($$n$$,$$x$$)$$^{67}$$Cu reaction is the most promising route to produce high quality $$^{67}$$Cu and could solve a longstanding problem of establishing an appropriate production method of $$^{67}$$Cu.

Journal Articles

High thermo-separation efficiency of $$^{99m}$$Tc from molten $$^{100}$$MoO$$_{3}$$ samples by repeated milking tests

Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*

Journal of the Physical Society of Japan, 83(8), p.083201_1 - 083201_4, 2014/07

https://doi.org/10.7566/JPSJ.83.083201
 Times Cited Count：10 Percentile：57.84(Physics, Multidisciplinary)

Journal Articles

The Possible interplanetary transfer of microbes; Assessing the viability of ${it Deinococcus}$ spp. under the ISS environmental conditions for performing exposure experiments of microbes in the Tanpopo mission

Kawaguchi, Yuko*; Yang, Y.*; Kawashiri, Narutoshi*; Shiraishi, Keisuke*; Takasu, Masako*; Narumi, Issey*; Sato, Katsuya; Hashimoto, Hirofumi*; Nakagawa, Kazumichi*; Tanigawa, Yoshiaki*; et al.

Origins of Life and Evolution of Biospheres, 43(4-5), p.411 - 428, 2013/10

https://doi.org/10.1007/s11084-013-9346-1
 Times Cited Count：41 Percentile：80.34(Biology)

Journal Articles

Generation of radioisotopes with accelerator neutrons by deuterons

Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji; Sonoda, Nozomi; Kawabata, Masako; Harada, Hideo; Kin, Tadahiro*; Tsukada, Kazuaki; et al.

Journal of the Physical Society of Japan, 82(6), p.064201_1 - 064201_7, 2013/06

https://doi.org/10.7566/JPSJ.82.064201
 Times Cited Count：43 Percentile：85.02(Physics, Multidisciplinary)

Journal Articles

The H-Invitational Database (H-InvDB); A Comprehensive annotation resource for human genes and transcripts

Yamasaki, Chisato*; Murakami, Katsuhiko*; Fujii, Yasuyuki*; Sato, Yoshiharu*; Harada, Erimi*; Takeda, Junichi*; Taniya, Takayuki*; Sakate, Ryuichi*; Kikugawa, Shingo*; Shimada, Makoto*; et al.

Nucleic Acids Research, 36(Database), p.D793 - D799, 2008/01

https://doi.org/10.1093/nar/gkm999
 Times Cited Count：51 Percentile：71.25(Biochemistry & Molecular Biology)

Here we report the new features and improvements in our latest release of the H-Invitational Database, a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of fulllength cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 protein-coding and 642 non-protein-coding loci; 858 transcribed loci overlapped with predicted pseudogenes.

Oral presentation

Attempt at visualization and quantification of cisplatin in human lung cancer cell using in-air micro-PIXE

Sakurai, Hideyuki*; Okamoto, Masahiko*; Shin, Masako*; Takeuchi, Aiko*; Hasegawa, Masatoshi*; Sato, Takahiro; Oikawa, Masakazu*; Kamiya, Tomihiro; Arakawa, Kazuo; Nakano, Takashi*

no journal, , 

no abstracts in English

Oral presentation

Analysis of trace elements in lung by in-air micro-PIXE

Okamoto, Masahiko*; Sakurai, Hideyuki*; Shin, Masako*; Hasegawa, Masatoshi*; Oikawa, Masakazu*; Sato, Takahiro; Kamiya, Tomihiro; Arakawa, Kazuo; Nakano, Takashi*

no journal, , 

no abstracts in English

Oral presentation

Medical radioisotope production with accelerator neutrons by 40 MeV deuterons

Tsukada, Kazuaki; Sato, Nozomi; Watanabe, Satoshi; Ishioka, Noriko; Hatsukawa, Yuichi; Hashimoto, Kazuyuki; Kin, Tadahiro*; Kawabata, Masako; Saeki, Hideya; Nagai, Yasuki

no journal, , 

no abstracts in English

Oral presentation

Production of $$^{67}$$Cu and $$^{64}$$Cu using zinc target irradiated with accelerator neutrons

Kawabata, Masako; Hashimoto, Kazuyuki; Saeki, Hideya; Sato, Nozomi*; Motoishi, Shoji*; Nagai, Yasuki

no journal, , 

no abstracts in English

Oral presentation

High quality $$^{99m}$$Tc obtained from $$^{99}$$Mo produced by $$^{100}$$Mo(n,2n) using accelerator neutrons

Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Hatsukawa, Yuichi; Ota, Akio; Shiina, Takayuki; Kawauchi, Yukimasa

no journal, , 

$$^{99m}$$Tc, the daughter nuclide of $$^{99}$$Mo, is widely used for medical diagnosis. In Japan, about 0.9 million diagnostic procedures are carried out using $$^{99m}$$Tc. $$^{99}$$Mo has been mostly produced using $$^{235}$$U in research reactors. Because of recent shortages of $$^{99}$$Mo, a variety of alternative production methods of $$^{99}$$Mo or $$^{99m}$$Tc were proposed. We proposed to produce $$^{99}$$Mo by $$^{100}$$Mo(n,2n) using neutrons from an accelerator. The route is characterized to produce a large quantity of high-quality $$^{99}$$Mo with a minimum level of radioactive wastes, since the cross section of the $$^{100}$$Mo(n,2n)$$^{99}$$Mo reaction at 11 $$<$$ En $$<$$ 18 MeV is large, and the cross sections of the (n,He), (n,n'p), and (n,p) reactions on $$^{100}$$Mo are quite small. Intense neutrons are available because of recent progresses of accelerator and target technologies. In the talk, we show our recent experimental results to obtain $$^{99m}$$Tc with high-quality using $$^{99}$$Mo produced by $$^{100}$$Mo(n,2n).

Oral presentation

Production of $$^{67}$$Cu for cancer therapy using fast neutrons from $$^{nat}$$C(d,n) reaction

Hashimoto, Kazuyuki; Kawabata, Masako; Saeki, Hideya; Tsukada, Kazuaki; Sato, Nozomi*; Motoishi, Shoji*; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko

no journal, , 

Copper-67 is an attractive radionuclide for cancer therapy, because of emissions of medium energy $$beta$$ particle (a mean energy of 141 keV) and $$gamma$$ rays (91, 93, 185 keV) suitable for imaging, and its appropriate half-life (62 hours). However, the use of $$^{67}$$Cu for clinical researches has been limited due to the difficulty in obtaining sufficient quantities. In this study, we have investigated the production of $$^{67}$$Cu by the $$^{68}$$Zn(n,x)$$^{67}$$Cu reaction (x = n'p, d) using fast neutrons from $$^{nat}$$C(d,n) reaction. The highly purified $$^{67}$$Cu was obtained by the two columns separation method (chelate resin chelex-100 and anion exchange resin AG1-X8). Furthermore, the labelling of DOTA and TETA which are useful bifunctional ligands for the labelling monoclonal antibodies was succeeded in more than 97% yield.

Oral presentation

Production of $$^{67}$$Cu for cancer therapy using accelerator neutrons

Hashimoto, Kazuyuki; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Watanabe, Satoshi; Nagai, Yasuki

no journal, , 

no abstracts in English

Oral presentation

Production of $$^{99}$$Mo using accelerator neutrons and thermochromatographic separation of $$^{99m}$$Tc

Kawabata, Masako*; Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Motoishi, Shoji*; Saeki, Hideya*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*; et al.

no journal, , 

no abstracts in English

Oral presentation

Production of $$^{67}$$Cu for cancer therapy with accelerator neutrons by deuterons

Hashimoto, Kazuyuki; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Hatsukawa, Yuichi; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko

no journal, , 

no abstracts in English

Oral presentation

Medical radioisotope production with accelerator neutrons by deuterons

Tsukada, Kazuaki; Sato, Nozomi*; Watanabe, Satoshi; Ishioka, Noriko; Hatsukawa, Yuichi; Hashimoto, Kazuyuki; Kin, Tadahiro*; Takeda, Shinsaku*; Kawabata, Masako; Saeki, Hideya; et al.

no journal, , 

A new system has been proposed for the generation of radioisotopes with accelerator neutrons by deuterons, especially the production of Mo-99, Y-90, Cu-67, and Cu-64. Enriched Mo-100, Zr-90, Zn-68 and Zn-64 oxide samples were irradiated with neutrons, which were obtained by the $$^{nat}$$C(d,n) and Be(d,n) using 40 MeV deuterons provided from the TIARA cyclotron. Mo-99, Y-90, Cu-67, and Cu-64 were successfully produced via the (n, x) reactions, and we clearly observed the $$gamma$$-rays. Particularly, yields of impurity radionuclides were much smaller than that of Mo-99 and Cu-67, and therefore radioactive waste produced during chemical processing would be reduced compared with other proposed reaction systems. The present results demonstrate that the radioisotopes, Mo-99, Y-90, Cu-67, and Cu-64, can be produced by using fast neutrons, and strongly suggest that the reaction system is one of the most promising routes to produce high quality medical radioisotope.

23 (Records 1-20 displayed on this page)