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Sato, Tetsuro*; Ando, Masaki; Sato, Masako*; Saito, Kimiaki
Journal of Environmental Radioactivity, 210, p.105973_1 - 105973_7, 2019/12
Times Cited Count:8 Percentile:39.2(Environmental Sciences)A method was devised for estimation of external doses of Fukushima residents expected to return to their homes after evacuation orders are lifted. 211 residents expected to return to six towns and villages were surveyed in FY 2014, FY 2015, and FY2016. Interviewing returning residents about their expected life patterns after returning, air dose rate were measured along the reported personal trails representing their patterns of movement in daily life. Excluding 15 residents from whose homes we were unable to take air dose rate measurements, the maximum external effective dose and the average external effective dose were estimated respectively as 4.9 mSv/y and 0.86 mSv/y. Although the mean values and dispersion of external effective doses differ depending on the evacuation level, for 93.3% of all residents, the estimated external effective doses were less than 2 mSv/y. The average exposure dose at home accounts for 66.8% of the annual exposure dose.
Minato, Futoshi; Tsukada, Kazuaki; Sato, Nozomi*; Watanabe, Satoshi*; Saeki, Hideya*; Kawabata, Masako*; Hashimoto, Shintaro; Nagai, Yasuki*
Journal of the Physical Society of Japan, 86(11), p.114803_1 - 114803_6, 2017/11
Times Cited Count:8 Percentile:56.38(Physics, Multidisciplinary)We have measured the yield of Mo, the mother nuclide of
Tc used in nuclear diagnostic procedure.
Mo was produced by
Mo(
,
)
Mo using neutrons with thermal energy up to about 40 MeV, provided by C(
,
). The
Mo yield agrees with an estimated yield with the use of the latest data of C(
,
) and the evaluated cross section given in the JENDL. Based on this, a new calculation was carried out to produce
Mo to seek for a good economical condition. Various conditions such as the
MoO
sample mass, the distance between the carbon target and the sample, the radius of the deuteron beam, and the neutron irradiation time were considered. The calculated
Mo yield indicates that about 30% of the
Mo demand in Japan can be fulfilled with a single accelerator. The elusion of
Tc from the
Mo twice per day would meet about 50% of the
Mo demand.
Sugo, Yumi*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Nagai, Yasuki*
Journal of the Physical Society of Japan, 86(2), p.023201_1 - 023201_3, 2017/02
Times Cited Count:13 Percentile:68.78(Physics, Multidisciplinary)Cu produced by the
Zn(
)
Cu reaction was used for the first time to determine the biodistribution of
CuCl
in colorectal tumor-bearing mice. High uptake of
Cu was observed in the tumor as well as in the liver and kidney which are the major organs for copper metabolism. The result showing
Cu accumulation in the tumor suggests that
CuCl
can be a potential radionuclide agent for cancer radiotherapy. It would also encourage further studies on the therapeutic effect in small animals using an increased dose of
Cu produced by the
Zn(
)
Cu reaction using intense neutrons available at present.
Hashimoto, Kazuyuki; Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji*; Ota, Masayuki; Konno, Chikara; Ochiai, Kentaro; et al.
Journal of the Physical Society of Japan, 84(4), p.043202_1 - 043202_4, 2015/04
Times Cited Count:7 Percentile:51.13(Physics, Multidisciplinary)Kawabata, Masako; Nagai, Yasuki; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*
Journal of the Physical Society of Japan, 84(2), p.023201_1 - 023201_4, 2015/02
Times Cited Count:6 Percentile:46.87(Physics, Multidisciplinary)Tc for medical use can be separated by thermochromatography from a molten
MoO
sample. Effect of moist oxygen gas on the
Tc release from molten
MoO
samples was investigated using a
Mo/
Tc generator.
Mo was produced with
Mo(n,2n)
Mo. A new phenomenon has been observed: release rate, separation- and recovery-efficiencies of
Tc were higher in the moist oxygen gas than those in the dry oxygen gas. The present result is a significant progress towards the stable production of a high quality
Tc from a molten MoO
sample with high separation efficiency. The result would also give us a new insight into the interaction between the moist oxygen gas and the molten MoO
.
Sato, Nozomi; Tsukada, Kazuaki; Watanabe, Satoshi; Ishioka, Noriko; Kawabata, Masako; Saeki, Hideya; Nagai, Yasuki; Kin, Tadahiro*; Minato, Futoshi; Iwamoto, Nobuyuki; et al.
Journal of the Physical Society of Japan, 83(7), p.073201_1 - 073201_4, 2014/07
Times Cited Count:13 Percentile:63.56(Physics, Multidisciplinary)We have for the first time demonstrated that the therapeutic nuclide of Cu produced by
Zn(
,
)
Cu has highest radionuclide purity compared to previous ones. We measured a
-ray spectrum of the reaction product produced by bombarding an enriched
Zn sample with neutrons with a HPGe detector. The neutrons were obtained by
C(
,
) using 41 MeV deuterons provided from Takasaki Ion Accelerators for Advanced Radiation Application of Japan Atomic Energy Agency. Relative production yields of impurity radionuclides such as
Zn to
Cu are extremely low, which allow us to chemically separate
Cu from an irradiated
Zn sample with a few steps and to reuse high cost an enriched
Zn sample. The present result strongly suggest that the
Zn(
,
)
Cu reaction is the most promising route to produce high quality
Cu and could solve a longstanding problem of establishing an appropriate production method of
Cu.
Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*
Journal of the Physical Society of Japan, 83(8), p.083201_1 - 083201_4, 2014/07
Times Cited Count:10 Percentile:59.23(Physics, Multidisciplinary)Kawaguchi, Yuko*; Yang, Y.*; Kawashiri, Narutoshi*; Shiraishi, Keisuke*; Takasu, Masako*; Narumi, Issey*; Sato, Katsuya; Hashimoto, Hirofumi*; Nakagawa, Kazumichi*; Tanigawa, Yoshiaki*; et al.
Origins of Life and Evolution of Biospheres, 43(4-5), p.411 - 428, 2013/10
Times Cited Count:38 Percentile:79.99(Biology)Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Saeki, Hideya; Motoishi, Shoji; Sonoda, Nozomi; Kawabata, Masako; Harada, Hideo; Kin, Tadahiro*; Tsukada, Kazuaki; et al.
Journal of the Physical Society of Japan, 82(6), p.064201_1 - 064201_7, 2013/06
Times Cited Count:41 Percentile:85.53(Physics, Multidisciplinary)Yamasaki, Chisato*; Murakami, Katsuhiko*; Fujii, Yasuyuki*; Sato, Yoshiharu*; Harada, Erimi*; Takeda, Junichi*; Taniya, Takayuki*; Sakate, Ryuichi*; Kikugawa, Shingo*; Shimada, Makoto*; et al.
Nucleic Acids Research, 36(Database), p.D793 - D799, 2008/01
Times Cited Count:51 Percentile:72.31(Biochemistry & Molecular Biology)Here we report the new features and improvements in our latest release of the H-Invitational Database, a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of fulllength cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 protein-coding and 642 non-protein-coding loci; 858 transcribed loci overlapped with predicted pseudogenes.
Sakurai, Hideyuki*; Okamoto, Masahiko*; Shin, Masako*; Takeuchi, Aiko*; Hasegawa, Masatoshi*; Sato, Takahiro; Oikawa, Masakazu*; Kamiya, Tomihiro; Arakawa, Kazuo; Nakano, Takashi*
no journal, ,
no abstracts in English
Okamoto, Masahiko*; Sakurai, Hideyuki*; Shin, Masako*; Hasegawa, Masatoshi*; Oikawa, Masakazu*; Sato, Takahiro; Kamiya, Tomihiro; Arakawa, Kazuo; Nakano, Takashi*
no journal, ,
no abstracts in English
Tsukada, Kazuaki; Sato, Nozomi; Watanabe, Satoshi; Ishioka, Noriko; Hatsukawa, Yuichi; Hashimoto, Kazuyuki; Kin, Tadahiro*; Kawabata, Masako; Saeki, Hideya; Nagai, Yasuki
no journal, ,
no abstracts in English
Kawabata, Masako; Hashimoto, Kazuyuki; Saeki, Hideya; Sato, Nozomi*; Motoishi, Shoji*; Nagai, Yasuki
no journal, ,
no abstracts in English
Nagai, Yasuki; Kawabata, Masako; Sato, Nozomi*; Hashimoto, Kazuyuki; Saeki, Hideya; Motoishi, Shoji*; Hatsukawa, Yuichi; Ota, Akio; Shiina, Takayuki; Kawauchi, Yukimasa
no journal, ,
Tc, the daughter nuclide of
Mo, is widely used for medical diagnosis. In Japan, about 0.9 million diagnostic procedures are carried out using
Tc.
Mo has been mostly produced using
U in research reactors. Because of recent shortages of
Mo, a variety of alternative production methods of
Mo or
Tc were proposed. We proposed to produce
Mo by
Mo(n,2n) using neutrons from an accelerator. The route is characterized to produce a large quantity of high-quality
Mo with a minimum level of radioactive wastes, since the cross section of the
Mo(n,2n)
Mo reaction at 11
En
18 MeV is large, and the cross sections of the (n,He), (n,n'p), and (n,p) reactions on
Mo are quite small. Intense neutrons are available because of recent progresses of accelerator and target technologies. In the talk, we show our recent experimental results to obtain
Tc with high-quality using
Mo produced by
Mo(n,2n).
Hashimoto, Kazuyuki; Kawabata, Masako; Saeki, Hideya; Tsukada, Kazuaki; Sato, Nozomi*; Motoishi, Shoji*; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko
no journal, ,
Copper-67 is an attractive radionuclide for cancer therapy, because of emissions of medium energy particle (a mean energy of 141 keV) and
rays (91, 93, 185 keV) suitable for imaging, and its appropriate half-life (62 hours). However, the use of
Cu for clinical researches has been limited due to the difficulty in obtaining sufficient quantities. In this study, we have investigated the production of
Cu by the
Zn(n,x)
Cu reaction (x = n'p, d) using fast neutrons from
C(d,n) reaction. The highly purified
Cu was obtained by the two columns separation method (chelate resin chelex-100 and anion exchange resin AG1-X8). Furthermore, the labelling of DOTA and TETA which are useful bifunctional ligands for the labelling monoclonal antibodies was succeeded in more than 97% yield.
Hashimoto, Kazuyuki; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Watanabe, Satoshi; Nagai, Yasuki
no journal, ,
no abstracts in English
Kawabata, Masako*; Nagai, Yasuki; Hashimoto, Kazuyuki; Hatsukawa, Yuichi; Motoishi, Shoji*; Saeki, Hideya*; Sato, Nozomi*; Ota, Akio*; Shiina, Takayuki*; Kawauchi, Yukimasa*; et al.
no journal, ,
no abstracts in English
Hashimoto, Kazuyuki; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Hatsukawa, Yuichi; Nagai, Yasuki; Watanabe, Satoshi; Ishioka, Noriko
no journal, ,
no abstracts in English
Tsukada, Kazuaki; Sato, Nozomi*; Watanabe, Satoshi; Ishioka, Noriko; Hatsukawa, Yuichi; Hashimoto, Kazuyuki; Kin, Tadahiro*; Takeda, Shinsaku*; Kawabata, Masako; Saeki, Hideya; et al.
no journal, ,
A new system has been proposed for the generation of radioisotopes with accelerator neutrons by deuterons, especially the production of Mo-99, Y-90, Cu-67, and Cu-64. Enriched Mo-100, Zr-90, Zn-68 and Zn-64 oxide samples were irradiated with neutrons, which were obtained by the C(d,n) and Be(d,n) using 40 MeV deuterons provided from the TIARA cyclotron. Mo-99, Y-90, Cu-67, and Cu-64 were successfully produced via the (n, x) reactions, and we clearly observed the
-rays. Particularly, yields of impurity radionuclides were much smaller than that of Mo-99 and Cu-67, and therefore radioactive waste produced during chemical processing would be reduced compared with other proposed reaction systems. The present results demonstrate that the radioisotopes, Mo-99, Y-90, Cu-67, and Cu-64, can be produced by using fast neutrons, and strongly suggest that the reaction system is one of the most promising routes to produce high quality medical radioisotope.