Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol

Matsuya, Yusuke; Sato, Tatsuhiko; Kusumoto, Tamon*; Yachi, Yoshie*; Seino, Ryosuke*; Miwa, Misako*; Ishikawa, Masayori*; Matsuyama, Shigeo*; Fukunaga, Hisanori*

Scientific Reports (Internet), 14, p.16696_1 - 16696_14, 2024/07

https://doi.org/10.1038/s41598-024-67041-6

Boron neutron capture therapy (BNCT) is a unique radiotherapy to selectively eradicate tumor cells using boron compounds (e.g., 4-borono-L-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. However, the impacts of tempo-spatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector, cell cycle analysis, and biophysical simulations, we demonstrated the cell cycle-dependent heterogenicity of BPA uptake and following biological impacts of B(n, )Li reactions in HeLa cells expressing Fluorescent Ubiquitination-based Cell Cycle Indicators (FUCCI), as well as its modification effects of polyvinyl alcohol (PVA). As a result, we revealed that the intracellular BPA concentration in the S/G2/M phase was higher than that in the G1/S phase and that PVA modified the cell cycle dependence. Further, these findings lead to the development of the first BPA-PVA-based model for predicting BNCT treatment effects. These outcomes may contribute to more precision of therapeutic efficacy, when BNCT is combined with PVA and/or cell cycle-specific anticancer agents.

Analysis work report on removal of spent fuel sheared powder for decommissioning of main plant

Aoya, Juri; Mori, Amami; Sato, Hinata; Kono, Soma; Morokado, Shiori; Horigome, Kazushi; Goto, Yuichi; Yamamoto, Masahiko; Taguchi, Shigeo

JAEA-Technology 2023-008, 34 Pages, 2023/06

JAEA-Technology-2023-008.pdf:1.92MB

Flush-out, by which nuclear materials in the Tokai Reprocessing Plant process are recovered, has been started in June 2022 as the first step of decommissioning. Flush-out consists of removal of spent fuel sheared powder, plutonium solution, uranium solution, and the other nuclear materials. Removal of spent fuel sheared powder has been completed in September 2022. During removal of spent fuel sheared powder, uranium concentration, plutonium concentration, acid concentration, radioactivity concentration, and solution density have been analyzed for process control. For nuclear material accountancy, uranium concentration, plutonium concentration, isotope ratio, and solution density have been analyzed. Analysis work including sample pretreatment before transportation to IAEA analytical facility for safeguards, and the other operations related to Flush-out such as calibration of analytical instruments, education, and training of operators are reported.

Modeling the transport and deposition of Be produced by the strongest solar proton event during the holocene

Spiegl, T. C.*; Yoden, Shigeo*; Langematz, U.*; Sato, Tatsuhiko; Chhin, R.*; Noda, Satoshi*; Miyake, Fusa*; Kusano, Kanya*; Schaar, K.*; Kunze, M.*

Journal of Geophysical Research; Atmospheres, 127(13), p.e2021JD035658_1 - e2021JD035658_21, 2022/07

https://doi.org/10.1029/2021JD035658

The abundance of cosmogenic isotopes in natural archives carries important information about the complex pathways from their source in the upper atmosphere to their deposition via atmospheric transport processes. Here, we use a new modelling framework to (a) estimate the Be production yield for the 774 CE/775 event, (b) evaluate the performance of our model framework by comparing the model results to four ice core records and (c) investigate the atmospheric pathways with a state-of-the-art climate model in detail. The results give new constraints regarding the seasonal timing of the event, underpin the role of the background conditions in the stratosphere, and highlight regional variations in the cosmogenic surface flux.

Space weather benchmarks on Japanese society

Ishii, Mamoru*; Shiota, Daiko*; Tao, Chihiro*; Ebihara, Yusuke*; Fujiwara, Hitoshi*; Ishii, Takako*; Ichimoto, Kiyoshi*; Kataoka, Ryuho*; Koga, Kiyokazu*; Kubo, Yuki*; et al.

Earth, Planets and Space (Internet), 73(1), p.108_1 - 108_20, 2021/12

https://doi.org/10.1186/s40623-021-01420-5

We surveyed the relationship between the scale of space weather events and their occurrence rate in Japan and we discussed the social impact of these phenomena during the Project for Solar-Terrestrial Environment Prediction (PSTEP). The information was compiled for domestic users of space weather forecasts for appropriate preparedness against space weather disasters. This paper gives a comprehensive summary of the survey, focusing on the fields of electricity, satellite operations, communication and broadcasting, satellite positioning usage, aviation, human space activity, and daily life on the Earth's surface, using the cutting-edge knowledge of space weather. Quantitative estimations of the economic impact of space weather events on electricity and aviation are also given.

Quantifying the dislocation structures of additively manufactured Ti-6Al-4V alloys using X-ray diffraction line profile analysis

Yamanaka, Kenta*; Kuroda, Asumi*; Ito, Miyu*; Mori, Manami*; Bian, H.*; Shobu, Takahisa; Sato, Shigeo*; Chiba, Akihiko*

Additive Manufacturing, 37, p.101678_1 - 101678_12, 2021/01

https://doi.org/10.1016/j.addma.2020.101678

Tuning strain-induced -to- martensitic transformation of biomedical Co-Cr-Mo alloys by introducing parent phase lattice defects

Mori, Manami*; Yamanaka, Kenta*; Sato, Shigeo*; Tsubaki, Shinki*; Sato, Kozue*; Kumagai, Masayoshi*; Imafuku, Muneyuki*; Shobu, Takahisa; Chiba, Akihiko*

Journal of the Mechanical Behavior of Biomedical Materials, 90, p.523 - 529, 2019/02

https://doi.org/10.1016/j.jmbbm.2018.10.038

observation of dislocation evolution in ferritic and austenitic stainless steels under tensile deformation by using neutron diffraction

Sato, Shigeo*; Kuroda, Asumi*; Sato, Kozue*; Kumagai, Masayoshi*; Harjo, S.; Tomota, Yo*; Saito, Yoichi*; Todoroki, Hidekazu*; Onuki, Yusuke*; Suzuki, Shigeru*

Tetsu To Hagane, 104(4), p.201 - 207, 2018/00

https://doi.org/10.2355/tetsutohagane.TETSU-2017-082

Recent progress of line-profile analyses for neutron or X-ray diffraction

Tomota, Yo*; Sato, Shigeo*; Harjo, S.

Tetsu To Hagane, 103(2), p.73 - 85, 2017/01

https://doi.org/10.2355/tetsutohagane.TETSU-2016-085

Microstructure analysis in steel using quantum beam diffraction method

Sato, Shigeo*; Onuki, Yusuke*; Shobu, Takahisa; Shiro, Ayumi*; Tashiro, Hitoshi*; Todoroki, Hidekazu*; Suzuki, Shigeru*

Kinzoku, 86(8), p.654 - 660, 2016/08

http://ci.nii.ac.jp/naid/40020920777

no abstracts in English

Study on the behavior of radiolytically produced hydrogen in a high-level liquid waste tank of a reprocessing plant; Comparison between actual and simulated solutions

Kinuhata, Hiroshi*; Yamamoto, Masahiko; Taguchi, Shigeo; Surugaya, Naoki; Sato, Soichi; Kodama, Takashi*; Tamauchi, Yoshikazu*; Shibata, Yuki*; Anzai, Kiyoshi*; Matsuoka, Shingo*

Nuclear Technology, 192(2), p.155 - 159, 2015/11

https://doi.org/10.13182/NT15-15

Experiments using a small-scale apparatus with 30 ml actual high-level liquid waste from the Tokai Reprocessing Plant were carried out to show that the hydrogen concentration in the gas phase reaches a steady-state value of much less than 4% (lower explosive limit) in the absence of sweeping-air. The H concentration reached a steady-state value as was expected and it was compared with a value predicted from an equation with parameters which had been obtained using the simulated solution. Satisfactory agreement showed that the Pd-ion catalytic H consumption reaction previously found in the simulated solution proceeded equally well in the actual solution.