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Matsuya, Yusuke; Yoshii, Yuji*; Kusumoto, Tamon*; Ogawa, Tatsuhiko; Onishi, Seiki*; Hirata, Yuho; Sato, Tatsuhiko; Kai, Takeshi
Physical Chemistry Chemical Physics, 27(14), p.6887 - 6898, 2025/04
Times Cited Count:1 Percentile:0.00(Chemistry, Physical)Radicals by water radiolysis play an important role in evaluating radiation-induced biological effects, such as DNA damage induction, chromosomal aberrations, and carcinogenesis. In the Particle and Heavy Ion Transport code System (PHITS), a track-structure simulation mode enabling the estimation of each atomic interactions in water and a chemical simulation code (PHITS-Chem) dedicated to electron beams that can simulate radical dynamics have been developed in our previous study. Here, we developed the PHITS-Chem code applicable to any ion species, considering a space partitioning method to detect radical reactions more efficiently and the 4D visualization function. The updated PHITS-Chem code was verified by comparing the simulated G values of proton beams, particle beams, and carbon ion beams to the corresponding values in the literature. We succeeded in intuitively evaluating the diffusion dynamics of radicals using the PHITS 3D drawing software, PHIG-3D. The time to calculate the G values was reduced (e.g., about 28 times faster) while maintaining its calculation accuracy. The developed PHITS-Chem code is expected to contribute to precise and intuitive understanding of the biological effects induced by radicals in ion-beam radiotherapy.
Sato, Yusuke*; Fukaya, Yuki; 14 of others*
Physical Review Materials (Internet), 9(1), p.014002_1 - 014002_11, 2025/01
Times Cited Count:0 Percentile:0.00(Materials Science, Multidisciplinary)no abstracts in English
Yamashita, Takuma*; Iwami, Satone*; Mitsuyasu, Yusuke*; Ono, Kenta*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Sekine, Tsutomu*; Shimizu, Yoshinaka*; Chiba, Mirei*; et al.
KEK Proceedings 2024-6, p.85 - 90, 2024/12
To clarify the radiation effects of the accident at the TEPCO's Fukushima Daiichi NPP on living organisms, it is important to accurately estimate the dose to each individual. We have developed a multi-component analysis program using random number optimization to extract only the components derived from carbonate radicals from the ESR spectra.
Iwami, Satone*; Yamashita, Takuma*; Mitsuyasu, Yusuke*; Ono, Kenta*; Oka, Toshitaka; Takahashi, Atsushi*; Kino, Yasushi*; Sekine, Tsutomu*; Shimizu, Yoshinaka*; Chiba, Mirei*; et al.
KEK Proceedings 2024-6, p.91 - 95, 2024/12
We aim to improve the detection limit of the ESR dosimetry method. In this study, the saturation behavior of each radical was investigated by varying the microwave power during ESR measurement. Based on the difference in spin relaxation time between carbonate radicals and native radicals, it is expected that the signal-to-noise ratio improves and the detection limit can be lowered when the microwave power is increased to 4.0 mW.
Ogawa, Tatsuhiko; Hirata, Yuho; Matsuya, Yusuke; Kai, Takeshi; Sato, Tatsuhiko; Iwamoto, Yosuke; Hashimoto, Shintaro; Furuta, Takuya; Abe, Shinichiro; Matsuda, Norihiro; et al.
EPJ Nuclear Sciences & Technologies (Internet), 10, p.13_1 - 13_8, 2024/11
The latest updates on PHITS, a versatile radiation transport code, focusing specifically on track-structure models are presented. Track structure calculations are methods used to simulate the movement of charged particles while explicitly considering each atomic reaction. Initially developed for radiation biology, these calculation methods aimed to analyze the radiation-induced damage to DNA and chromosomes. Several track-structure calculation models, including PHITS-ETS, PHITS-ETS for Si, PHITS-KURBUC, ETSART, and ITSART, have been developed and implemented to PHITS. These models allow users to study the behavior of various particles at the nano-scale across a wide range of materials. Furthermore, potential applications of track-structure calculations have also been proposed so far. This collection of track-structure calculation models, which encompasses diverse conditions, opens up new avenues for research in the field of radiation effects.
Takayama, Yusuke; Sato, Daisuke*; Sugita, Yutaka
Kansai Geo-Symposium 2024; Chikasui Jiban Kankyo, Bosai, Keisoku Gijutsu Ni Kansuru Shinpojiumu Rombunshu, p.115 - 119, 2024/11
During the initial phases after closure of a high-level radioactive waste repository, the temperature of the buffer material will increase. Therefore, fundamental properties regarding the temperature dependence of bentonite, which is the main material of the buffer material, have been tested. The number of tests for the temperature dependence of displacement behavior is less than the number of tests for the temperature dependence of swelling pressure and permeability. In this paper, two tests were conducted using a consolidation test device that can control temperature conditions. One is a cyclic loading and unloading test under temperature conditions from room temperature to 80 C. The second is a temperature rise and fall test from room temperature to 80
C under stable loading condition. It was clarified that large deformations occur in the specimen under high temperature conditions, that the deformation associated with temperature changes is affected by the past stress path, and that irreversible deformation occurs under normal consolidation conditions.
Matsuya, Yusuke; Kai, Takeshi; Sato, Tatsuhiko
Shototsu, 21(3), p.R008_1 - R008_8, 2024/11
Particle and Heavy Ion Transport code System PHITS is a Monte Carlo code that enables the simulation of the behavior of radiation using a computer. Since 2018, a track-structure mode has been developed that allows the simulation of each atomic interaction in liquid water, which is a main component of living organisms. This development has made it possible to perform high-spatial resolution radiation track-structure analysis on the DNA scale. Meanwhile, based on the spatial information of atomic interactions calculated in the track-structure mode, we have also succeeded in developing an analysis code that enables the estimate of the various types of DNA damage yields efficiently and with high accuracy. In this review, we introduce an overview of the track-structure mode and DNA damage estimation model implemented in the latest version of PHITS, and show examples of applications of PHITS in the field of life sciences.
Nagano, Takuya*; Matsuya, Yusuke; Kaida, Atsushi*; Nojima, Hitomi*; Furuta, Takuya; Sato, Kaoru; Yoshimura, Ryoichi*; Miura, Masahiko*
Journal of Radiation Research (Internet), 65(5), p.628 - 639, 2024/09
Times Cited Count:0 Percentile:0.00(Biology)In X-ray therapy, radiation regimen is planned to eliminate tumors while minimizing side effects on normal tissue. When irradiating the oral cavity, which includes dental metallic crowns, intense mucositis can occasionally be induced. However, the mechanism underlying the radiosensitization remains unclear. In this study, we investigated the radiosensitization mechanism using cell experiments and computational simulations. As a result, the enhancement ratio observed in the cell experiments was 1.2-1.4, which was found to be predominately attributed to local dose increase near metal. On the other hand, as a result of dose evaluation based on CT images as a preclinical test, it was found that the dose increase was underestimated due to the complex anatomical structure of the human body, and microscopic dose evaluation was necessary. This outcome contributes to the precise understanding of side effects on normal cells around metals.
Sato, Tatsuhiko; Matsuya, Yusuke; Hamada, Nobuyuki*
Journal of Radiation Research (Internet), 65(4), p.500 - 506, 2024/07
Times Cited Count:3 Percentile:82.15(Biology)We therefore evaluated the mean and uncertainty of relative biological effectiveness (RBE) for diseases of the circulatory system (DCS) by applying a microdosimetric kinetic model specialized for RBE estimation of tissue reactions. For this purpose, we analyzed several RBE data for DCS determined by past animal experiments and evaluated the radius of the subnuclear domain best fit to each experiment as a single free parameter included in the model. Our analysis suggested that RBE for DCS tends to be lower than that for skin reactions, and their difference was borderline significant due to large variances of the evaluated parameters. These findings will help determine RBE by ICRP for preventing tissue reactions.
Matsuya, Yusuke; Sato, Tatsuhiko; Kusumoto, Tamon*; Yachi, Yoshie*; Seino, Ryosuke*; Miwa, Misako*; Ishikawa, Masayori*; Matsuyama, Shigeo*; Fukunaga, Hisanori*
Scientific Reports (Internet), 14, p.16696_1 - 16696_14, 2024/07
Times Cited Count:3 Percentile:82.15(Multidisciplinary Sciences)Boron neutron capture therapy (BNCT) is a unique radiotherapy to selectively eradicate tumor cells using boron compounds (e.g., 4-borono-L-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. However, the impacts of tempo-spatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector, cell cycle analysis, and biophysical simulations, we demonstrated the cell cycle-dependent heterogenicity of BPA uptake and following biological impacts of B(n,
)
Li reactions in HeLa cells expressing Fluorescent Ubiquitination-based Cell Cycle Indicators (FUCCI), as well as its modification effects of polyvinyl alcohol (PVA). As a result, we revealed that the intracellular BPA concentration in the S/G2/M phase was higher than that in the G1/S phase and that PVA modified the cell cycle dependence. Further, these findings lead to the development of the first BPA-PVA-based model for predicting BNCT treatment effects. These outcomes may contribute to more precision of therapeutic efficacy, when BNCT is combined with PVA and/or cell cycle-specific anticancer agents.
Ishikawa, Akihisa; Koba, Yusuke*; Furuta, Takuya; Chang, W.*; Yonai, Shunsuke*; Matsumoto, Shinnosuke*; Hashimoto, Shintaro; Hirai, Yuta*; Sato, Tatsuhiko
Radiological Physics and Technology, 17(2), p.553 - 560, 2024/06
Matsuya, Yusuke; Sato, Tatsuhiko; Yachi, Yoshie*; Date, Hiroyuki*; Hamada, Nobuyuki*
Scientific Reports (Internet), 14, p.12160_1 - 12160_14, 2024/05
Times Cited Count:2 Percentile:70.65(Multidisciplinary Sciences)Understand mechanisms of radiation cataracts that are of concern in the field of radiation protection and radiation therapy. However, biological effects in HLEC following protracted exposure have not yet fully been explored. Here, we investigated the temporal kinetics of DNA double-strand breaks (DSBs) and cell survival of HLEC after exposure to photon beams at various dose rates, compared to those of human lung fibroblasts (WI-38). In parallel, we quantified the recovery for DSB and cell survival using a biophysical model. The study revealed that HLEC cells have a lower repair rate than WI-38 cells. There is no significant impact of dose rate on cell survival in both cell lines in the dose-rate range of 0.033-1.82 Gy/min. On the other hand, the experimental residual DSBs showed inverse dose rate effects (IDREs) compared to the model prediction, highlighting the importance of the IDREs in evaluating radiation effects on the ocular lens.
Sekikawa, Takuya; Matsuya, Yusuke; Hwang, B.*; Ishizaka, Masato*; Kawai, Hiroyuki*; Ono, Yoshiaki*; Sato, Tatsuhiko; Kai, Takeshi
Nuclear Instruments and Methods in Physics Research B, 548, p.165231_1 - 165231_6, 2024/03
Times Cited Count:1 Percentile:52.60(Instruments & Instrumentation)One of the main causes of radiation effects on the human body is thought to be damage to DNA, which carries genetic information. However, it is not fully understood what kind of molecular structural changes DNA undergoes upon radiation damage. Since it has been reported that various types of DNA damage are formed when DNA is irradiated, our group has investigated the relationship between DNA damage and various patterns of radiation-induced ionization induced by radiation. Although we have so far analyzed DNA damage in a simple system using a rigid body model of DNA, more detailed calculations are required to analyze the molecular structural changes in DNA, which are considered to be important in considering the effects on the human body. In this study, we attempted to clarify the molecular conformational changes of DNA using OpenMX, a first-principles calculation software that can discuss electronic states based on molecular structures. Specifically, we calculated the most stable structure, band dispersion, and wave function of DNA under the assumption that one and two electrons are ionized by various radiation. In the presentation, we will discuss the relationship between the energy dependence of each incident radiation type and the molecular conformational change of DNA. In addition, the radiation-induced changes in the basic physical properties of DNA (corresponding to the initial stage of DNA damage) will be discussed from the viewpoints of both radiation physics and solid state physics.
Saito, Yuki*; Ishiwata, Tobimaru*; Horiuchi, Misato*; Nishiki, Yuto*; Kikuchi, Ryosuke*; Otake, Tsubasa*; Kawakita, Ryohei; Takayama, Yusuke; Mitsui, Seiichiro; Sato, Tsutomu*
Shigen, Sozai Koenshu (Internet), 11(1), 7 Pages, 2024/03
no abstracts in English
Hirata, Yuho; Kai, Takeshi; Ogawa, Tatsuhiko; Matsuya, Yusuke; Sato, Tatsuhiko
Nuclear Instruments and Methods in Physics Research B, 547, p.165183_1 - 165183_7, 2024/02
Times Cited Count:0 Percentile:0.00(Instruments & Instrumentation)The luminescence efficiency of the phosphors for swift ions is known to decrease because of the quenching effects. To obtain the precise dose distributions using phosphor detectors, understanding the mechanisms of quenching effects is mandatory. Here, we developed a new model for estimating the luminescence intensity of phosphors based on the track-structure modes for arbitrary materials implemented in PHITS. The developed model enabled the simulation of the quenching effects of the BaFBr detector and was verified by comparing the results to the corresponding measured data. The present model is expected to contribute to developing phosphor detectors worldwide.
Matsuya, Yusuke; Yoshii, Yuji*; Kusumoto, Tamon*; Akamatsu, Ken*; Hirata, Yuho; Sato, Tatsuhiko; Kai, Takeshi
Physics in Medicine & Biology, 69(3), p.035005_1 - 035005_12, 2024/02
Times Cited Count:4 Percentile:88.58(Engineering, Biomedical)Time-dependent yields of chemical products resulted in water radiolysis play a great role in evaluating DNA damage response after exposure to ionizing radiation. Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo simulation code for radiation transport, which allows to determine several atomic interactions such as ionizations and electronic excitations as physical stage. However, a chemical code for simulating products of water radiolysis does not exist in the PHITS package. Here, we developed a chemical simulation code dedicated for the PHITS code, hereafter called PHITS-Chem code, which enables calculating G values of water radiolysis species (OH radical, e, H
, H
O
etc) by electron beams. The estimated G values during 1
s are in agreement with the experimental ones and other simulations. This PHITS-Chem code enables simulating the dynamics in the presence of OH radical scavenger, and is useful for evaluating contributions of direct and indirect effects on DNA damage induction. This code will be included and be available in the future version of PHITS.
Sato, Tatsuhiko; Iwamoto, Yosuke; Hashimoto, Shintaro; Ogawa, Tatsuhiko; Furuta, Takuya; Abe, Shinichiro; Kai, Takeshi; Matsuya, Yusuke; Matsuda, Norihiro; Hirata, Yuho; et al.
Journal of Nuclear Science and Technology, 61(1), p.127 - 135, 2024/01
Times Cited Count:144 Percentile:99.97(Nuclear Science & Technology)The Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo radiation transport code that can simulate the behavior of most particle species with energies up to 1 TeV (per nucleon for ions). Its new version, PHITS3.31, was recently developed and released to the public. In the new version, the compatibility with high-energy nuclear data libraries and the algorithm of the track-structure modes have been improved. In this paper, we summarize the upgraded features of PHITS3.31 with respect to the physics models, utility functions, and application software introduced since the release of PHITS3.02 in 2017.
Hirata, Yuho; Kai, Takeshi; Ogawa, Tatsuhiko; Matsuya, Yusuke*; Sato, Tatsuhiko
Japanese Journal of Applied Physics, 62(10), p.106001_1 - 106001_6, 2023/10
Times Cited Count:4 Percentile:47.87(Physics, Applied)Optimization of semiconductor detector design requires theoretical analysis of the process of radiation conversion to carriers (excited electrons) in semiconductor materials. We, therefore, developed an electron track-structure code that can trace an incident electron trajectory down to a few eV and simulate many excited electron productions in semiconductors, named ETSART, and implemented it into PHITS. The accuracy of ETSART was validated by comparing calculated electron ranges in semiconductor materials with the corresponding data recommended in ICRU Report 37 and obtained from another simulation code. The average energy required to produce a single excited electron (epsilon value) is an important value that describes the characteristics of semiconductor detectors. Using ETSART, we computed the epsilon values in various semiconductors and found that the calculated epsilon values cannot be fitted well with a linear model of the band-gap energy. ETSART is expected to be useful for initial and mechanistic evaluations of electron-hole generation in undiscovered materials.
Tsuchikawa, Yusuke; Kai, Tetsuya; Abe, Yuta; Oikawa, Kenichi; Parker, J. D.*; Shinohara, Takenao; Sato, Ikken
Journal of Physics; Conference Series, 2605, p.012022_1 - 012022_6, 2023/10
We developed a method to obtain the areal density distribution of boron, which has a large neutron cross section, by means of an energy resolved neutron imaging. Commonly in a measurement of elements with very high neutron sensitivity, the quantitative measurement becomes more difficult with the amount of element due to the neutron self-shielding effect. To avoid this effect, an energy-resolved method using known cross section data was attempted, and a quantitative imaging of such elements was demonstrated at the MLF of J-PARC. This presentation introduces a measurement of melted simulated-fuel assemblies obtained in the research of the Fukushima Daiichi Nuclear Power Plant after the severe accident. Energy-dependent neutron transmission rates of the samples were measured by a neutron imaging detector, and were analyzed to obtained the areal density of boron at each position.
Sato, Hisashi*; Takayama, Yusuke; Suzuki, Hideaki*; Sato, Daisuke*
JAEA-Data/Code 2023-010, 47 Pages, 2023/09
When a high-level radioactive waste repository is constructed in a coastal area, it is necessary to fully evaluate the impact of seawater-based groundwater on engineered barriers, including buffer materials. In this report, one-dimensional saltwater infiltration tests were conducted to obtain data to understand the impact of seawater-based groundwater on the migration phenomena of water and solutes in the buffer material during the transient period. As a result, it was confirmed that the infiltration rate increased as the NaCl concentration in the infiltration solution increased. And it was confirmed that the water content ratio distribution changed as the NaCl concentration in the infiltration solution increased. As a result of analysis of the chloride ion concentration of the post-test specimens confirmed that chloride ion enrichment was occurred with infiltration. As a result of verifying the mechanism by which chloride ion enrichment occurs, it was confirmed that the phenomenon of chloride ion enrichment due to infiltration depends on the initial water content ratio.