Li, W.*; Yamada, Shinya*; Hashimoto, Tadashi; Okumura, Takuma*; Hayakawa, Ryota*; Nitta, Kiyofumi*; Sekizawa, Oki*; Suga, Hiroki*; Uruga, Tomoya*; Ichinohe, Yuto*; et al.
Analytica Chimica Acta, 1240, p.340755_1 - 340755_9, 2023/02
no abstracts in English
Saga, Ryo*; Matsuya, Yusuke; Sato, Hikari*; Hasegawa, Kazuki*; Obara, Hideki*; Komai, Fumio*; Yoshino, Hironori*; Aoki, Masahiko*; Hosokawa, Yoichiro*
Radiotherapy and Oncology, p.109444_1 - 109444_9, 2023/00
When treating non-small cell lung cancer (NSCLC), stereotactic body radiotherapy (SBRT) with high-dose irradiation is often utilized. The fractionation schemes and curative effects can be evaluated by mathematical models for predicting cell survival curve. Such model parameters can be determined from in vitro experiment, but they are empirically determined based on experiences in clinics. As such, there is a large gap between in vitro and clinical study. As such background, translational study between in vitro cell survival and clinical curative effects is necessary. In this study, explicitly considering existence of cancer stem-like cells (CSCs), we developed an all-in-one model for predicting both in vitro cell survival and clinical curative effects (integrated microdosimetric-kinetic (IMK) model) and performed retrospective evaluation of clinical outcomes following SBRT for NSCLC in Hirosaki University Hospital. As a result, the IMK model successfully reproduced both in vitro cell survival and the tumor control probability with various fractionation schemes (i.e., 6-10 Gy per fraction). The developed model would contribute on precisely understanding the impact of CSCs on curative effects after SBRT for NSCLC with high precision.
Takayama, Yusuke; Sato, Daisuke*; Kikuchi, Hirohito*
Genshiryoku Bakkuendo Kenkyu (CD-ROM), 29(2), p.101 - 111, 2022/12
Swelling pressure tests have been conducted to understand the swelling properties of bentonite which is planned to be used as a buffer material in repositories for the geological disposal of radioactive waste. It has been reported that the swelling pressure obtained by swelling pressure test increases monotonically or temporarily decreases after increasing with the passage of the time depending on the initial water content. In this study, swelling pressure tests were conducted under several different initial water content conditions, and the change in wet density distribution inside the specimen during the swelling pressure tests was observed by X-ray CT measurement. It was confirmed that the presence or absence of collapse behavior and its magnitude affect the shape of the change in swelling pressure. When the collapse deformation was large, the amount of temporary decrease in swelling pressure was large. On the other hand, swelling pressure increased monotonically when there was no deformation due to collapse.
Matsuya, Yusuke; Kai, Takeshi; Parisi, A.*; Yoshii, Yuji*; Sato, Tatsuhiko
Physics in Medicine & Biology, 67(21), p.215017_1 - 215017_13, 2022/11
Proton beam therapy allows to irradiate tumor volumes with reduced side effects on normal tissues with respect to X-ray radiotherapy. Biological effects such as cell killing after proton beam irradiations depend on the proton kinetic energy, which is intrinsically related in the early DNA damage induction. As such, the estimation of DNA damage yields based on Monte Carlo simulations is a research topic of worldwide interest. In this study, we investigate the possibility of applying a simple model developed for electron to proton without any modification. The yields of single-strand breaks (SSB), double-strand breaks (DSB) and the complex DSB were assessed as a function of the proton kinetic energy. The PHITS-based estimation accurately reproduced the experimental and simulated yields of various DNA damage types induced by protons with linear energy transfer (LET) up to about 30 keV/m. These results suggest that current DNA damage model implemented in PHITS is sufficient for estimating DNA lesion yields induced after protons irradiation except for lower energies than MeV.
Hirata, Yuho; Kai, Takeshi; Ogawa, Tatsuhiko; Matsuya, Yusuke; Sato, Tatsuhiko
Japanese Journal of Applied Physics, 61(10), p.106004_1 - 106004_6, 2022/10
Some radiation effects such as pulse-height defects and soft errors can cause problems in silicon (Si) devices. Local energy deposition in microscopic scales is essential information to elucidate the mechanism of these radiation effects. We, therefore, developed an electron track-structure model, which can simulate local energy deposition down to nano-scales, dedicated to Si and implemented it into PHITS. Then, we verified the accuracy of our developed model by comparing the ranges and depth-dose distributions of electrons obtained from this study with the corresponding experimental values and other simulated results. As an application of the model, we calculated the mean energies required to create an electron-hole pair, the so-called epsilon value. We found that the threshold energy for generating secondary electrons reproducing the epsilon value is 2.75 eV, consistent with the corresponding data deduced from past theoretical and computational studies. Since the magnitudes of the radiation effects on Si devices largely depend on the epsilon value, the developed code is expected to contribute to precisely understanding the mechanisms of pulse-height defects and semiconductor soft errors.
Ishii, Yui*; Yamamoto, Arisa*; Sato, Naoki*; Nambu, Yusuke*; Kawamura, Seiko; Murai, Naoki; Ohara, Koji*; Kawaguchi, Shogo*; Mori, Takao*; Mori, Shigeo*
Physical Review B, 106(13), p.134111_1 - 134111_7, 2022/10
Sato, Tatsuhiko; Matsuya, Yusuke; Hamada, Nobuyuki*
International Journal of Radiation Oncology, Biology, Physics, 114(1), p.153 - 162, 2022/09
The microdosimetric kinetic model, which was originally developed for estimating cell surviving fractions for various radiations, was improved to be capable of estimating the mean and uncertainty of RBE for skin reactions. The parameter used in the model was independently determined from in vitro measurements of dermal cell survival and in vivo measurements of skin reactions taken from 8 and 23 papers, respectively. Our model quantitatively revealed that RBE for skin reactions tend to be higher than that for dermal cell survival. RBE of various mono-energetic radiations calculated from this model confirmed that the past evaluations made by ICRP and NCRP a few decades ago are still supported by recent experimental data. Conclusions: Our model can play important roles not only in medical physics for avoiding unnecessary skin reactions in particle therapy and BNCT but also in radiation protection for future decision making of the recommended RBE values.
Furuta, Takuya; Koba, Yusuke*; Hashimoto, Shintaro; Chang, W.*; Yonai, Shunsuke*; Matsumoto, Shinnosuke*; Ishikawa, Akihisa*; Sato, Tatsuhiko
Physics in Medicine & Biology, 67(14), p.145002_1 - 145002_15, 2022/07
Carbon ion radiotherapy has an advantage over conventional radiotherapy such that its superior dose concentration on the tumor helps to reduce unwanted dose to surrounding normal tissues. Nevertheless, a little dose to normal tissues, which is a potential risk of secondary cancer, is still unavoidable. The Monte Carlo simulation is a good candidate for the tool to assess secondary cancer risk, including the contributions of secondary particles produced by nuclear reactions. We therefore developed a new dose reconstruction system implementing PHITS as the engine. In this system, the PHITS input is automatically created from the DICOM data sets recorded in the treatment planning. The developed system was validated by comparing to experimental dose distribution in water and treatment plan on an anthropomorphic phantom. This system will be used for retrospective studies using the patient data in National Institute for Quantum and Science and Technology.
Murase, Kiyoka*; Kataoka, Ryuho*; Nishiyama, Takanori*; Nishimura, Koji*; Hashimoto, Taishi*; Tanaka, Yoshimasa*; Kadokura, Akira*; Tomikawa, Yoshihiro*; Tsutsumi, Masaki*; Ogawa, Yasunobu*; et al.
Journal of Space Weather and Space Climate (Internet), 12, p.18_1 - 18_16, 2022/06
We identified two energetic electron precipitation (EEP) events during the growth phase of moderate substorms and estimated the mesospheric ionization rate for an EEP event for which the most comprehensive dataset from ground-based and space-born instruments was available. The mesospheric ionization signature reached below 70 km altitude and continued for ~15 min until the substorm onset, as observed by the PANSY radar and imaging riometer at Syowa Station in the Antarctic region. We also used energetic electron flux observed by the Arase and POES 15 satellites as the input for the air-shower simulation code PHITS to quantitatively estimate the mesospheric ionization rate. Combining the cutting-edge observations and simulations, we shed new light on the space weather impact of the EEP events during geomagnetically quiet times, which is important to understand the possible link between the space environment and climate.
Mattan, K.*; Ono, Toshio*; Kawamura, Seiko; Nakajima, Kenji; Nambu, Yusuke*; Sato, Taku*
Physical Review B, 105(13), p.134403_1 - 134403_8, 2022/04
Spin dynamics of the spin-1/2 kagome-lattice antiferromagnet CsCuSnF was studied using high-resolution, time-of-flight inelastic neutron scattering. The flat mode, a characteristic of the frustrated kagome antiferromagnet, and the low-energy dispersive mode, which is dominated by magnons, can be well described by the linear spin-wave theory. However, the theory fails to describe three weakly dispersive modes between 9 and 14 meV. These modes could be attributed to two-spinon bound states, which decay into free spinons away from the zone center and at a high temperature, giving rise to continuum scattering.
Zhao, Y.*; Suzuki, T.*; Iimori, T.*; Kim, H.-W.*; Ahn, J. R.*; Horio, Masafumi*; Sato, Yusuke*; Fukaya, Yuki; Kanai, T.*; Okazaki, K.*; et al.
Physical Review B, 105(11), p.115304_1 - 115304_8, 2022/03
no abstracts in English
Matsuya, Yusuke; Hamada, Nobuyuki*; Yachi, Yoshie*; Satou, Yukihiko; Ishikawa, Masayori*; Date, Hiroyuki*; Sato, Tatsuhiko
Cancers (Internet), 14(4), p.1045_1 - 1045_15, 2022/02
An insoluble cesium-bearing microparticle (Cs-BMP) was discovered after the incident at the Fukushima nuclear power plant. Radiation risk by intake of internal exposure to radioactive cesium is conventionally estimated from organ dose, assuming that soluble cesium is uniformly distributed throughout human body. Meanwhile, such Cs-BMPs are assumed to adhere in the long term to normal tissue, leading to chronic non-uniform exposure. In this study, to clarify the normal tissue effects for Cs-BMP exposure, we investigated the relationship between the inflammatory responses and DNA damage induction. From experiments focusing on the inflammatory signaling pathways such as NF-B p65 and COX-2, compared to the uniform exposure to -rays, NF-B p65 tended to be more activated in the cells proximal to the Cs-BMP, while both NF-B p65 and COX-2 were significantly activated in the distal cells. Experiments with inhibitors for NF-B p65 and COX-2 suggested involvement of such inflammatory responses both in the reduced radiosensitivity of the cells proximal to Cs-BMP and the enhanced radiosensitivity of the cells distal from Cs-BMP. These results suggested that radiation effects for Cs-BMP exposure can differ from that estimated based on conventional uniform exposure to normal tissues.
Matsuya, Yusuke; Kai, Takeshi; Sato, Tatsuhiko; Ogawa, Tatsuhiko; Hirata, Yuho; Yoshii, Yuji*; Parisi, A.*; Liamsuwan, T.*
International Journal of Radiation Biology, 98(2), p.148 - 157, 2022/02
When investigating radiation-induced biological effects, it is essential to perform detailed track-structure simulations explicitly by considering each atomic interaction in liquid water (which is equivalent to human tissues) at sub-cellular and DNA scales. The Particle and Heavy Ion Transport code System (PHITS) is a Monte Carlo code which can be used for track structure calculations by employing an original electron track-structure mode (etsmode) and the world-famous KURBUC algorithms (PHITS-KURBUC mode) for protons and carbon ions. In this study, the physical features (i.e., range, radial dose and microdosimetry) of these modes have been verified by comparing to the available experimental data and Monte Carlo simulation results reported in literature. In addition, applying the etsmode to radiobiological study, we estimated the yields of single-strand breaks (SSBs), double-strand breaks (DSBs) and complex DSBs, and evaluated the dependencies of DNA damage yields on incident electron energy. As a result, the simulations suggested that DNA damage types are intrinsically related with the spatial patterns of ionization and electronic excitations and that approximately 500 eV electron can cause much complex DSBs. In this paper, we show the development status of the PHITS track-structure modes and its application to radiobiological research, which would be expected to identify the underlying mechanisms of radiation effects based on physics.
Fukui, Roman*; Saga, Ryo*; Matsuya, Yusuke; Tomita, Kazuo*; Kuwahara, Yoshikazu*; Ouchi, Kentaro*; Sato, Tomoaki*; Okumura, Kazuhiko*; Date, Hiroyuki*; Fukumoto, Manabu*; et al.
Scientific Reports (Internet), 12(1), p.1056_1 - 1056_12, 2022/01
Alive cancer cells after fractionated irradiations with 2 Gy X-rays per day for more than 30 days show clinically relevant radioresistant. Such radioresistance is experimentally interpreted to attributed to the increment of stem-like cell content. However, only an experimental approach cannot clarify the cell responses (DNA damage and cell death induction) of cancer stem cells, so the radioresistant mechanisms remain uncertain. In addition to the conventional cell experiments using radio-resistant cell lines established after fractionated irradiations, in this study we developed a mathematical model (so called integrated microdosimetric-kinetic (IMK) model) explicitly considering cancer stem-like cell content and DNA damage responses and investigated radioresistant mechanisms acquired after fractionated irradiations. The IMK model analysis suggested that the changes of stem-like cell fraction and DNA repair efficiency play important roles of radioresisitance acquired after irradiations. Considering these into the IMK model, we successfully reproduced the experimental survival of various cell lines and various irradiation conditions. This work would contribute to not only the precise understanding of the radioresistant mechanisms induced after irradiation but also predicting curative effects with high precision.
Ishii, Mamoru*; Shiota, Daiko*; Tao, Chihiro*; Ebihara, Yusuke*; Fujiwara, Hitoshi*; Ishii, Takako*; Ichimoto, Kiyoshi*; Kataoka, Ryuho*; Koga, Kiyokazu*; Kubo, Yuki*; et al.
Earth, Planets and Space (Internet), 73(1), p.108_1 - 108_20, 2021/12
We surveyed the relationship between the scale of space weather events and their occurrence rate in Japan and we discussed the social impact of these phenomena during the Project for Solar-Terrestrial Environment Prediction (PSTEP). The information was compiled for domestic users of space weather forecasts for appropriate preparedness against space weather disasters. This paper gives a comprehensive summary of the survey, focusing on the fields of electricity, satellite operations, communication and broadcasting, satellite positioning usage, aviation, human space activity, and daily life on the Earth's surface, using the cutting-edge knowledge of space weather. Quantitative estimations of the economic impact of space weather events on electricity and aviation are also given.
Matsuya, Yusuke; Kai, Takeshi; Ogawa, Tatsuhiko; Hirata, Yuho; Sato, Tatsuhiko
Hoshasen Kagaku (Internet), (112), p.15 - 20, 2021/11
Particle and Heavy Ion Transport code System (PHITS) is a general-purpose Monte Carlo code enabling radiation kinetics, which is often used in diverse research fields, such as atomic energy, engineering, medicine and science. After released in 2010, the PHITS code has been developed to expand its functions and to improve its convenience. In the few years, track-structure mode has been introduced in PHITS that can simulate each atomic interaction by electrons, positions, protons and carbon ions in liquid water. Thanks to the development of track-structure mode, the latest PHITS code enables microscopic dose calculations by decomposing it to the scale of DNA. Aiming at realizing the track-structure mode with high precision, the further developments of electron and ion track-structure mode for arbitrary materials are recently ongoing. This review shows the development history and future prospect of PHITS track-structure mode, which can expect to be further applied to the research fields of atomic physics, radiation chemistry, and quantum life science.
Chang, W.*; Koba, Yusuke*; Furuta, Takuya; Yonai, Shunsuke*; Hashimoto, Shintaro; Matsumoto, Shinnosuke*; Sato, Tatsuhiko
Journal of Radiation Research (Internet), 62(5), p.846 - 855, 2021/09
With the aim of developing a revaluation tool of treatment plan in carbon-ion radiotherapy using Monte Carlo (MC) simulation, we propose two methods; one is dedicated to identify realistic-tissue materials from a CT image with satisfying the well-calibrated relationship between CT numbers and stopping power ratio (SPR) provided by TPS, and the other is to estimate dose to water considering the particle- and energy-dependent SPR between realistic tissue materials and water. We validated these proposed methods by computing depth dose distribution in homogeneous and heterogeneous phantoms composed of human tissue materials and water irradiated by a 400 MeV/u carbon beam with 8 cm SOBP using a MC simulation code PHITS and comparing with results of conventional treatment planning system (TPS). Our result suggested that use of water as a surrogate of real tissue materials, which is adopted in conventional TPS, is inadequate for dose estimation from secondary particles because their production rates cannot be scaled by SPR of the primary particle in water. We therefore concluded that the proposed methods can play important roles in the reevaluation of the treatment plans in carbon-ion radiotherapy.
Chen, Y.*; Sato, Masahiro*; Tang, Y.*; Shiomi, Yuki*; Oyanagi, Koichi*; Masuda, Takatsugu*; Nambu, Yusuke*; Fujita, Masaki*; Saito, Eiji
Nature Communications (Internet), 12, p.5199_1 - 5199_7, 2021/08
Matsuya, Yusuke; McMahon, S. J.*; Butterworth, K. T.*; Naijo, Shingo*; Nara, Isshi*; Yachi, Yoshie*; Saga, Ryo*; Ishikawa, Masayori*; Sato, Tatsuhiko; Date, Hiroyuki*; et al.
Physics in Medicine & Biology, 66(7), p.075014_1 - 075014_11, 2021/04
Hypoxic cancer cells within solid tumours show radio-resistance, leading to malignant progression in fractionated radiotherapy. When prescribing dose to tumours under heterogeneous oxygen pressure with intensity-modulated radiation fields, intercellular signalling could have an impact on radiosensitivity between in-field and out-of-field cells. However, the impact of hypoxia on radio-sensitivity under modulated radiation intensity remains uncertain. In this study, we investigate the impact of hypoxia on in-field and out-of-field radio-sensitivities using two types of cancer cells. These in vitro measurements indicate that hypoxia apparently impacts out-of-field cells, although the OER values in out-of-field cells were smaller compared to those for in-field and uniformly irradiated cells. These decreased radio-sensitivities of out-of-field cells were shown as a consistent tendency for both DSB and cell death endpoints, suggesting that radiation-induced intercellular communication is of importance in treatment planning with intensity-modulated radiotherapy.
Abe, Yuta; Tsuchikawa, Yusuke; Kai, Tetsuya; Matsumoto, Yoshihiro*; Parker, J. D.*; Shinohara, Takenao; Oishi, Yuji*; Kamiyama, Takashi*; Nagae, Yuji; Sato, Ikken
JPS Conference Proceedings (Internet), 33, p.011075_1 - 011075_6, 2021/03