Sato, Yusuke*; Fukaya, Yuki; Cameau, M.*; Kundu, A. K.*; Shiga, Daisuke*; Yukawa, Ryu*; Horiba, Koji*; Chen, C.-H.*; Huang, A.*; Jeng, H.-T.*; et al.
Physical Review Materials (Internet), 4(6), p.064005_1 - 064005_6, 2020/06
no abstracts in English
Matsuya, Yusuke; Sato, Tatsuhiko; Nakamura, Rui*; Naijo, Shingo*; Date, Hiroyuki*
Physics in Medicine and Biology, 65(9), p.095006_1 - 095006_12, 2020/05
Radio-resistance induced under low oxygen pressure plays an important role in malignant progression in fractionated radiotherapy. For the general approach to predict cell killing under hypoxia, cell-killing models (e.g., the Linear-Quadratic model) have to be fitted to experimental survival data for both normoxia and hypoxia to obtain the oxygen enhancement ratio (OER). However, model parameters for every oxygen condition needs to be considered by model-fitting approaches. This is inefficient for fractionated irradiation planning. Here, we present an efficient model for fractionated radiotherapy the integrated microdosimetric-kinetic model including cell-cycle distribution and the OER at DNA double-strand break endpoint. The cell survival curves described by this model can reproduce the experimental survival data for both acute and chronic low oxygen concentrations. The OER used for calculating cell survival agrees well with experimental DSB ratio of normoxia to hypoxia. This work provides biological effective dose (BED) under various oxygen conditions including its uncertainty, which can contribute to creating fractionated regimens for multi-fractionated radiotherapy. If the oxygen concentration in a tumor can be quantified by medical imaging, the present model will make it possible to estimate the cell-killing and BED under hypoxia in more realistic intravital situations.
Matsuya, Yusuke; Nakano, Toshiaki*; Kai, Takeshi; Shikazono, Naoya*; Akamatsu, Ken*; Yoshii, Yuji*; Sato, Tatsuhiko
International Journal of Molecular Sciences (Internet), 21(5), p.1701_1 - 1701_13, 2020/03
Among various DNA damage induced after irradiation, clustered damage composed of at least two vicinal lesions within from 10 to 20 base pairs is recognized as fatal damage to human tissue. Such clustered damage yields have been evaluated by means of computational approaches; however, the simulation validity has not been sufficiently made yet. Meanwhile, the experimental technique to detect clustered DNA damage has been evolved in the recent decades, so both approaches with simulation and experiment get used to be available for investigating clustered damage recently. In this study, we have developed a simple model for estimating clustered damage yield based on the spatial density of ionization and electronic excitation events obtained by the PHITS code, and compared the computational results to the experimental clustered damage coupled with base damage (BD) measured by gel electrophoresis and atomic force microscopy. The computational results agreed well with experimental fractions of clustered damage of strand breaks (SB) and BD, when the yield ratio of BD/SSB is assumed to be 1.3. From the comparison of complex DNA double-strand break coupled with BDs between simulation and experimental data, it was suggested that aggregation degree of the events along electron track reflects the complexity of DNA damage. The resent simulation enables to quantify the type of clustered damage which cannot be measured in in vitro experiment, which succeeded in interpreting the experimental detection efficiency for clustered BD.
Matsuya, Yusuke; Kai, Takeshi; Yoshii, Yuji*; Yachi, Yoshie*; Naijo, Shingo*; Date, Hiroyuki*; Sato, Tatsuhiko
Journal of Applied Physics, 126(12), p.124701_1 - 124701_8, 2019/09
Biological effects after ionizing radiation exposure arise from initial DNA strand breaks. DNA damage can be estimated from the simulation with both track structure analysis and diffusion of free radicals; however, the simulation is a time-consuming process. In this study, we present a simple model for estimating yields of strand breaks based only on spatial patterns of inelastic interactions (i.e., ionization and electronic excitation) generated by electrons, which are evaluated by PHITS code without considering the production and diffusion of free radicals. In this model, the number of events per track and that of the two events pair within 3.4 nm (corresponding to 10 base pair) were stochastically sampled for calculating SSB and DSB yields, respectively. The calculated results agreed well with other simulations and experimental data on DSB yield and yield ratio of DSB/SSB for the exposure to mono-energetic electrons. The present model also can demonstrate the relative biological effectiveness at the DSB endpoint for various photon exposures. This study indicated that the spatial pattern of inelastic events composed of ionization and electronic excitation is sufficient to obtain the impact of electrons on initial induction to DNA strand break.
Yamashiki, Yosuke*; Maehara, Hiroyuki*; Airapetian, V.*; Notsu, Yuta*; Sato, Tatsuhiko; Notsu, Shota*; Kuroki, Ryusuke*; Murashima, Keiya*; Sato, Hiroaki*; Namekata, Kosuke*; et al.
Astrophysical Journal, 881(2), p.114_1 - 114_24, 2019/08
The impact of Stellar flares on extrasolar planetary systems has been discussed and argued, especially whether there is a potential impact on their life systems. Here, we propose a comprehensive evaluation system for stellar flares, focusing on Stellar Proton Events (SPE) on selected extrasolar planets with hypothetical atmospheres and oceans. This is done by cross-linking KIC flare-observed and flare-estimated stars by their start pots that are directly linked with the Monte Carlo simulation system PHITS through the exoplanetary database system ExoKyoto. The estimated dose at ground level for each planetary surface did not exceed the critical dose for complex animals.
Matsuya, Yusuke; McMahon, S. J.*; Ghita, M.*; Yoshii, Yuji*; Sato, Tatsuhiko; Date, Hiroyuki*; Prise, K. M.*
Scientific Reports (Internet), 9(1), p.9483_1 - 9483_12, 2019/07
In radiotherapy, intensity modulated radiation fields and complex dose-delivery are used to prescribe doses to tumors. Here, we analyzed the impact of modulated field on radio-sensitivity and cell recovery during irradiation time. The dose was delivered to either 50% of the area of the flask containing cells (half-field) or 100% of the flask (uniform-field). We also modelled cell-killing considering dose-rate effects and intercellular signals. It is found that (i) in-field cell survival under half-field exposure is higher than uniform-field exposure even with the same dose; (ii) the importance of sub-lethal damage repair in normal human skin fibroblast cells under the half-field is reduced; (iii) the increase of cell survival under half-field is predominantly attributed to not rescue effects (increased repair) but protective effects (reduced initial DNA lesion yield). These findings provide new understanding of radio-sensitivity for hit and non-hit cells under non-uniform exposure.
Matsuya, Yusuke; Satou, Yukihiko; Hamada, Nobuyuki*; Date, Hiroyuki*; Ishikawa, Masayori*; Sato, Tatsuhiko
Scientific Reports (Internet), 9(1), p.10365_1 - 10365_9, 2019/07
Insoluble radioactive microparticles (so called Cs-bearing particles) have been assumed to adhere in the long term to trachea after aspirated into respiratory system, leading to heterogeneous dose distribution within healthy tissue around the particles. The biological effects posed by such a particle remain unclear. Here, we show cumulative DNA damage in cultured cells proximal and distal to the particle under localized chronic exposure in comparison with uniform exposure. We placed the particle-contained microcapillary onto a glass-base dish containing normal human lung cells in vitro, and observed a significant change in nuclear -H2AX foci after 24 h or 48 h exposure to the particle. The dose calculation by a Monte Carlo simulation and the comparison with nuclear foci under uniform exposure suggested that the localized exposure to a Cs-bearing particle leads to not only signal-induced DNA damage to distal cells but also the reduction of DNA damage induction yield to proximal cells (protective effects). Considering the small organ dose, the conventional radiation risk assessment is adequate. This study is the first to quantify the spatial distribution of cumulative DNA lesions under heterogeneous exposure by insoluble Cs-bearing particles.
Takeda, Yusuke; Iida, Kiyoshi*; Sato, Shinji*; Matsuo, Tadatoshi*; Nagashima, Yasuyuki*; Okubo, Nariaki; Kondo, Keietsu; Hirade, Tetsuya
JPS Conference Proceedings (Internet), 25, p.011023_1 - 011023_3, 2019/03
In this study, we prepared samples under two different conditions, (1) 810C, for 600 min, and (2) 850C, for 720 min. A depth-profile analysis of the surfaces of the samples is conducted through Doppler broadening (DB) measurements of positron annihilation rays using a slow positron beam. It was indicated that many of positrons annihilated in defects near the surface. According to the TEM image, there are nano-crystal grains near the surface and then positrons can diffuse in the grains and annihilate in defects at the grain boundaries. Furthermore, DB measurements indicated that there is a depth dependence on the chemical composition where positrons annihilate. EDS spectroscopy measurements also indicated that there is a depth dependence of impurities such as Vanadium. These results indicated change of the chemical composition at the grain boundaries.
Shimomura, Yusuke; Sato, Takuya; Fukui, Yasutaka; Kudo, Kenji; Yoshioka, Tatsuji
JAEA-Review 2018-023, 220 Pages, 2019/01
On September 11, 2015, leaky traces of bituminized wastes were confirmed from four drums filled with bituminization in waste packages storage yard (II) of waste management facility in Oarai Research and Development Center. Moreover, even after the subsequent investigation, a leakage trace was found from one bituminous drum on November 10, 2015. Furthermore, on December 2, 2015, there was no a leakage trace in one bituminous drum, however the upper lid was found to be intensely corroded. To investigate the causes and the countermeasures for leakages of bituminized wastes from the drums, we have set up a Work Group to investigate the causes and the countermeasures to leakage traces from the drums. This report is based on "Report on Cause Investigation and Countermeasure of Leakage Trace from the Drum" summarized by this working group, the report was reconstructed including the contents clarified in the subsequent document investigation.
Kataoka, Ryuho*; Nishiyama, Takanori*; Tanaka, Yoshimasa*; Kadokura, Akira*; Uchida, Herbert Akihito*; Ebihara, Yusuke*; Ejiri, Mitsumu*; Tomikawa, Yoshihiro*; Tsutsumi, Masaki*; Sato, Kaoru*; et al.
Earth, Planets and Space (Internet), 71, p.9_1 - 9_10, 2019/01
Transient ionization of the mesosphere was detected at around 65 km altitude during the isolated auroral expansion occurred at 2221-2226 UT on June 30, 2017. A general-purpose Monte Carlo particle transport code PHITS suggested that significant ionization is possible in the middle atmosphere due to auroral X-rays from the auroral electrons of 10 keV.
Sato, Tetsuya; Asai, Masato; Borschevsky, A.*; Beerwerth, R.*; Kaneya, Yusuke*; Makii, Hiroyuki; Mitsukai, Akina*; Nagame, Yuichiro; Osa, Akihiko; Toyoshima, Atsushi; et al.
Journal of the American Chemical Society, 140(44), p.14609 - 14613, 2018/11
The first ionization potential (IP) yields information on valence electronic structure of an atom. IP values of heavy actinides beyond einsteinium (Es, Z = 99), however, have not been determined experimentally so far due to the difficulty in obtaining these elements on scales of more than one atom at a time. Recently, we successfully measured IP of lawrencium (Lr, Z = 103) using a surface ionization method. The result suggests that Lr has a loosely-bound electron in the outermost orbital. In contrast to Lr, nobelium (No, Z = 102) is expected to have the highest IP among the actinide elements owing to its full-filled 5f and the 7s orbitals. In the present study, we have successfully determined IP values of No as well as fermium (Fm, Z = 100) and mendelevium (Md, Z = 101) using the surface ionization method. The obtained results indicate that the IP value of heavy actinoids would increase monotonically with filling electrons up in the 5f orbital like heavy lanthanoids.
Ozaki, Yusuke; Ishibashi, Masayuki; Matsushita, Tomoaki*; Masumoto, Kazuhiko*; Imasato, Takehiko*
Proceedings of 13th SEGJ International Symposium (USB Flash Drive), 4 Pages, 2018/11
In the Mizunami Underground Research Laboratory, Groundwater REcoverty Experiment in Tunnel (GREET) is performed to understanding the recovery process of geological environment after the closure of drift. In this experiment, we performed 2D electrical resistivity surveys three times. First survey was performed before the closure of test drift. Second and third surveys were performed after the closure test. The first survey detected two layers conformation that consists of conductive and resistive zones at shallower and deeper part from the drift surface, respectively. These layers correspond to the shotcrete and host rock, respectively. Second and third measurements show that the conductive zone expanded to deeper resistive part while the shallower conductive part did not change. We concluded that we captured the saturation process of dried fractures near the drift wall by closure of drift as an electrical resistivity response.
Sato, Shigeo*; Kuroda, Asumi*; Sato, Kozue*; Kumagai, Masayoshi*; Harjo, S.; Tomota, Yo*; Saito, Yoichi*; Todoroki, Hidekazu*; Onuki, Yusuke*; Suzuki, Shigeru*
Tetsu To Hagane, 104(4), p.201 - 207, 2018/00
Takayasu, Kentaro; Onuki, Kenji*; Kawamoto, Koji*; Takayama, Yusuke; Mikake, Shinichiro; Sato, Toshinori; Onoe, Hironori; Takeuchi, Ryuji
JAEA-Technology 2017-011, 61 Pages, 2017/06
The Groundwater REcovery Experiment in Tunnel (GREET) was put into effect as development of drift backfilling technologies. This test was conducted by making the Closure Test Drift (CTD) recovered with water after carrying out a plug around 40m distance from northern edge face of horizontal tunnel of depth 500m, for the purpose of investigation of recovering process of rock mass and groundwater under the influence of excavation of tunnel. This report presents the efforts of backfilling investigation using bentonite composite soil and execution of backfilling into borehole pits excavated in the CTD which were carried out in fiscal 2014 as a part of GREET, and succeeding observation results inside pits from September 2014 to March 2016.
Ono, Masato; Fujiwara, Yusuke; Honda, Yuki; Sato, Hiroyuki; Shimazaki, Yosuke; Tochio, Daisuke; Homma, Fumitaka; Sawahata, Hiroaki; Iigaki, Kazuhiko; Takada, Shoji
Proceedings of 2017 International Congress on Advances in Nuclear Power Plants (ICAPP 2017) (CD-ROM), 5 Pages, 2017/04
Japan Atomic Energy Agency (JAEA) has carried out research and developments towards nuclear heat utilization of High Temperature Gas-cooled Reactor (HTGR) using High Temperature Engineering Test Reactor (HTTR). The nuclear heat utilization systems connected to HTGR will be designed on the basis of non-nuclear-grade standards in terms of easier entry for the chemical plant companies and the construction economics of the systems. Therefore, it is necessary that the reactor operations continue even if abnormal events occur in the systems. Heat application system abnormal simulating test with HTTR was carried out in non-nuclear heating operation to focus on the thermal effect in order to obtain data of the transient temperature behavior of the metallic components in the Intermediate Heat Exchanger (IHX). The IHX is the key components to connect the HTTR with the heat application system. In the test, the coolant helium gas temperature was heated up to 120C by the compression heat of the gas circulators in the HTTR under the ideal condition to focus on the heat transfer. The tests were conducted by decreasing the helium gas temperature stepwise by increasing the mass flow rate to the air cooler. The temperature responses of the IHX were investigated. For the components such as the heat transfer tubes and heat transfer enhancement plates of IHX, the temperature response was slower in the lower position in comparison with the higher position. The reason is considered that thermal load fluctuation is imposed in the secondary helium gas which flows from the top to the bottom in the heat transfer tubes of the IHX. The test data are useful to verify the numerical model of the safety evaluation code.
Takeda, Yusuke; Iida, Kiyoshi*; Sato, Shinji*; Matsuo, Tadatoshi*; Nagashima, Yasuyuki*; Okubo, Nariaki; Kondo, Keietsu; Hirade, Tetsuya
Journal of Physics; Conference Series, 791(1), p.012022_1 - 012022_4, 2017/02
Titanium alloy is widely used for applications such as golf club heads and structural materials for aircrafts. The surface can be exceedingly hardened by nitriding treatment that initiates defects, but there are some difficulties on use of titanium nitride because the layer can be exfoliated by stress. Therefore, we prepared samples in two different treatment conditions, (1) 810C 600 min and (2) 850C 720 min and performed depth profile analysis of Doppler broadening of positron annihilation -rays (DB) for these samples. According to a calculation of nitrogen diffusion depth, the nitride layer should be only about 0.05-0.1m. However, the depth profile analysis of the DB measurement indicated that the defects introduced by nitriding treatment extended to a depth of 0.5m.
Sato, Tetsuya; Asai, Masato; Borschevsky, A.*; Stora, T.*; Sato, Nozomi*; Kaneya, Yusuke; Tsukada, Kazuaki; Dllmann, C. E.*; Eberhardt, K.*; Eliav, E.*; et al.
EPJ Web of Conferences (Internet), 131, p.05001_1 - 05001_6, 2016/12
Ionization efficiency in a surface ionization process depends on the first ionization potential of the atom. Based on the dependence, the ionization potential of the atom can be determined. We measured ionization efficiencies of fermium, einsteinium, mendelevium, and lawrencium by using a newly developed gas-jet coupled surface ion-source. The ionization potential of the elements have not been determined so far due to their low production rates and/or their short half-lives. Based on a relationship between the ionization efficiency and the ionization potential obtained via measurements of short-lived lanthanide isotopes, the ionization potentials of these actinide elements have been successfully determined.
Eichler, R.*; Asai, Masato; Brand, H.*; Chiera, N. M.*; Di Nitto, A.*; Dressler, R.*; Dllmann, Ch. E.*; Even, J.*; Fangli, F.*; Goetz, M.*; et al.
EPJ Web of Conferences (Internet), 131, p.07005_1 - 07005_7, 2016/12
In recent years gas-phase chemical studies assisted by physical pre-separation allowed for the productions and investigations of fragile single molecular species of superheavy elements. The latest highlight is the formation of very volatile hexacarbonyl compound of element 106, Sg(CO). Following this success, second-generation experiments were performed to measure the first bond dissociation energy between the central metal atom and the surrounding ligand. The method using a tubular decomposition reactor was developed and successfully applied to short-lived Mo(CO), W(CO), and Sg(CO).
Onuki, Yusuke*; Hoshikawa, Akinori*; Sato, Shigeo*; Xu, P. G.; Ishigaki, Toru*; Saito, Yoichi*; Todoroki, Hidekazu*; Hayashi, Makoto*
Journal of Applied Crystallography, 49(5), p.1579 - 1584, 2016/10
Sato, Shigeo*; Onuki, Yusuke*; Shobu, Takahisa; Shiro, Ayumi*; Tashiro, Hitoshi*; Todoroki, Hidekazu*; Suzuki, Shigeru*
Kinzoku, 86(8), p.654 - 660, 2016/08
no abstracts in English