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Kaira, Kyoichi*; Sunose, Yutaka*; Ohshima, Yasuhiro; Ishioka, Noriko; Arakawa, Kazuhisa*; Ogawa, Tetsushi*; Sunaga, Noriaki*; Shimizu, Kimihiro*; Tominaga, Hideyuki*; Oriuchi, Noboru*; et al.
BMC Cancer, 13, p.482_1 - 482_12, 2013/10
Times Cited Count：74 Percentile：88.89(Oncology)
resolutionShimizu, Noriko*; Sugiyama, Shigeru*; Maruyama, Mihoko*; Takahashi, Yoshinori*; Adachi, Motoyasu; Tamada, Taro; Hidaka, Koshi*; Hayashi, Yoshio*; Kimura, Toru*; Kiso, Yoshiaki*; et al.
Crystal Growth & Design, 10(7), p.2990 - 2994, 2010/06
Times Cited Count：11 Percentile：72.02(Chemistry, Multidisciplinary)We report crystal growth of human immunodeficiency virus 1 protease (HIV PR) in a complex with its inhibitor KNI-272 by six different methods. Comparative analysis indicates that top-seeded solution growth (TSSG) and TSSG combined with the floating and stirring technique (TSSG-FAST) are efficient strategies for rapidly obtaining large single crystals and effectively preventing polycrystallization of the seed crystal. Neutron diffraction analysis confirmed that the crystalobtained by TSSG is a high-quality single crystal. Furthermore, crystal shape was observed to be influenced by solution flow, suggesting that the degree of supersaturation significantly affects the crystal growth direction of HIV PR complex. This finding implies that the shape of the HIV PR complex crystal might be controlled by the solution flow rate.
Asanuma, Noriko*; Miyano, Riku*; Shimizu, Tomu*; Aihara, Haruka; Watanabe, So; Nomura, Kazunori
no journal, ,
no abstracts in English
Nakamura, Hironobu; Takeda, Seiichi; Shimizu, Yasuyuki; Takeda, Hideyuki; Aoki, Rie; Shirafuji, Masaya; Kitao, Takahiko; Miyaji, Noriko
no journal, ,
In the consultancy meeting "Safeguards Guidelines for post-accident facilities and associated waste management facilities" held in IAEA, decommissioning activities, and the relevant safeguards activities in TRP/PCDF are reported. In general, the facility after accident with access limitation, operator decides to conduct decommissioning. Therefore, our report regarding the decommissioning plan and the relevant safeguards activities are very helpful to be considered. The nuclear material remove and waste management (storage/treatment) are essential work in the normal accessible facility as well as post-accident facility. Otherwise, in the case of post accident facility, alternative safeguards measures is required according to the access situation because normal safeguards activities might not be taken appropriately. In this report, we would present that outline of decommissioning plan in the TRP/PCDF and the relevant safeguards and nuclear material accountancy.
