Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Initialising ...
Hirai, Yuta*; Koba, Yusuke*; Furuta, Takuya; Matsumura, Akihiko*; Shinsho, Kiyomitsu*
no journal, ,
In radiation therapy, irradiation of normal tissues is unavoidable, posing a long-term risk of radiation-induced secondary cancers. Therefore, assessment of doses to normal tissues in both vicinity of treatment site and out-of-field is important. However, conventional treatment planning systems (TPS) for carbon radiotherapy (CIRT) limit dose calculation to the treatment region, leaving out-of-field doses to normal tissues largely unexplored. In this study, we applied RT-PHITS for CIRT, a Monte Carlo-based system that reconstructs treatment beam geometry from TPS data and enables detailed, whole-body dose evaluation. Five prostate cancer treatment plans were created using the TPS with whole-body CT data from The Cancer Imaging Archive (TCIA). RT-PHITS for CIRT reproduced TPS dose distributions near the target and further quantified distant doses down to 0.01% of the isocenter dose. These results demonstrate the capability of RT-PHITS for CIRT to perform particle-resolved, wide-field dose evaluations, providing a foundation for future studies on secondary cancer risk assessment in CIRT patients.
Hirai, Yuta*; Koba, Yusuke*; Yonai, Shunsuke*; Chang, W.*; Ishikawa, Akihisa; Shinsho, Kiyomitsu*
no journal, ,
no abstracts in English
Hirai, Yuta*; Koba, Yusuke*; Furuta, Takuya; Chang, W.*; Shinsho, Kiyomitsu*
no journal, ,
Irradiation of normal tissues cannot be completely avoided in radiotherapy, and there is a known risk of secondary cancer development due to radiation exposure in the prognosis. Although it has been reported that the incidence of secondary cancer is predominantly lower in carbon-ion radiotherapy for localized prostate cancer than in photon therapy, dose assessment only around the treatment site by conventional treatment planning systems is not sufficient to better understand the relationship between secondary cancer incidence and radiation dose. Therefore, the Japan Atomic Energy Agency and the Quantum Science and Technology Agency have developed RT-PHITS for CIRT, a system that can calculate and evaluate a wide range of dose distribution during carbon-ion radiotherapy for patients using the Monte Carlo method. In this study, using the developed system and whole-patient CT data provided by The Cancer Imaging Archive, we created treatment plans to treat the prostate cancer on the patient and performed detailed dose evaluation for low-dose areas far from the treatment site. We confirmed the usefulness of this system for retrospective dose analysis of carbon-ion radiotherapy.