Refine your search:     
Report No.
 - 
Search Results: Records 1-8 displayed on this page of 8
  • 1

Presentation/Publication Type

Initialising ...

Refine

Journal/Book Title

Initialising ...

Meeting title

Initialising ...

First Author

Initialising ...

Keyword

Initialising ...

Language

Initialising ...

Publication Year

Initialising ...

Held year of conference

Initialising ...

Save select records

Journal Articles

Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness

Ito, Takachika*; Suzuki, Shoichi*; Kanaji, Sachiko*; Shiraishi, Hiroshi*; Ota, Shoichiro*; Arima, Kazuhiko*; Tanaka, Go*; Tamada, Taro; Honjo, Eijiro*; Garcia, K. C.*; et al.

Journal of Biological Chemistry, 284(36), p.24289 - 24296, 2009/09

 Times Cited Count:23 Percentile:45.55(Biochemistry & Molecular Biology)

Both IL-4 and IL-13 can bind to the shared receptor composed of the IL-4 receptor $$alpha$$ chain and the IL-13 receptor $$alpha$$-1 chain (IL-13R$$alpha$$1); however, the assembly mechanisms of these ligands to the receptor is different, enabling the principal functions of these ligands to be different. We have previously shown that the N-terminal Ig-like domain in IL-13R$$alpha$$1, called the D1 domain, is the specific and critical binding unit for IL-13. However, it has still remained obscure which the amino acid has specific binding capacity to IL-13 and why the D1 domain acts as the binding site for IL-13, but not IL-4. To address these questions, in this study, we performed the mutational analyses for the D1 domain, combining the structural data to identify the amino acids critical for binding to IL-13. Mutations of Lys76, Lys77, or Ile78 in c' strand in which the crystal structure showed interact with IL-13 and those of Trp65 and Ala79 adjacent to the interacting site, resulted in significant impairment of IL-13 binding, demonstrating that these amino acids generate the binding site. Furthermore, mutations of Val35, Leu38, or Val42 at N-terminal $$beta$$-strand also resulted in loss of IL-13 binding, probably from decrease structural stability. None of the mutations employed here affected IL-4 binding. These results demonstrate that the hydrophobic patch composed of Lys76, Lys77, and Ile78 is the IL-13 recognition site and solidify our understanding that the differential requirements of the D1 domain in IL-13R$$alpha$$1 allows the shared receptor to respond differentially to IL-4 and IL-13.

Journal Articles

Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells

Sasano, Nakashi*; Enomoto, Atsushi*; Hosoi, Yoshio*; Katsumura, Yosuke; Matsumoto, Yoshihisa*; Shiraishi, Kenshiro*; Miyagawa, Kiyoshi*; Igaki, Hiroshi*; Nakagawa, Keiichi*

Journal of Radiation Research, 48(6), p.495 - 503, 2007/11

 Times Cited Count:20 Percentile:52.48(Biology)

Journal Articles

Comprehensive cost estimation method for decommissioning

Kudo, Kenji; Kawatsuma, Shinji; Rindo, Hiroshi; Watabe, Kozo; Tomii, Hiroyuki; Shiraishi, Kunio; Yagi, Naoto; Fukushima, Tadashi; Zaitsu, Tomohisa

Proceedings of 14th International Conference on Nuclear Engineering (ICONE-14) (CD-ROM), 8 Pages, 2006/07

Japan Atomic Energy Research Institute (JAERI) played a leading role in basic research in the field of atomic energy research and development, while Japan Nuclear Cycle Development Institute (JNC) did a major role in FBR cycle development and high level waste disposal. Following the Government's decision in December 2001, JAERI and JNC was merged as of October 1st, 2005. The new organization, Japan Atomic Energy Agency (JAEA), is an institute for comprehensive R&D for atomic energy, and is the largest research and development institute among Governmental R&D organizations. Its missions are basic research on atomic energy, R&D for nuclear fuel cycle, decommissioning of own facilities and disposal of waste, contribution to safety and non-proliferation, etc. The JAEA owns a number of nuclear facilities: research reactors such as JRR-2 and Joyo, prototype reactors such as ATR "Fugen" and FBR "Monju", fuel cycle plants such as Uranium Enrichment Demonstration Plant at Ningyo-Toge, MOX fuel plants at Tokai, Reprocessing Plant at Tokai, and Hot Laboratories such as JRTF and FMF. As a part of preparation of the mergence, JNC and JAERI have jointly developed a comprehensive cost estimation method for decommissioning, based on decommissioning and refurbishing experiences of JAERI and JNC. This method involves more estimation parameters from typical decommissioning activities than before, so as to make it more reliable. JAERI and JNC have estimated the total cost for decommissioning by using this method, and concluded that the cost would be 600 billion yen (approx. 5 billion USD).

Journal Articles

Cost estimation method for decommissioning of nuclear facilities

Tomii, Hiroyuki; Matsuo, Kiyoshi*; Shiraishi, Kunio; Watabe, Kozo; Saiki, Hideo*; Kawatsuma, Shinji*; Rindo, Hiroshi*; Zaitsu, Tomohisa*

Dekomisshoningu Giho, (31), p.11 - 20, 2005/03

no abstracts in English

Journal Articles

Cost estimation method for decommissioning of nuclear facilities

Tomii, Hiroyuki*; Matsuo, Kiyoshi*; Shiraishi, Kunio*; Watabe, Kozo*; Saiki, Hideo; Kawatsuma, Shinji; Rindo, Hiroshi; Zaitsu, Tomohisa

Dekomisshoningu Giho, (31), p.11 - 20, 2005/03

Japanese Government decided that Japan Atomic Energy Research Institute ( JAERI ) and Japan Nuclear Cycle Development Institute ( JNC ) shall be consolidated to a New rganization as of October 2005, which organization would be an Institute for comprehensive research and development for atomic.Through the preparation for unification, JAERI and JNC have been developing the Decommissioning program for own facilities, estimating decommissioning cost and the amount of waste from the decommissioning, and developing Management Program. Planning the Decommissioning program, it is important to estimate decommissioning cost effectively, because JAERI and JNC retain about 230 nuclear facilities which are reactors, fuel cycle facilities and research facilities. Then the decommissioning cost estimation method has developed based on several dismantling and replacement experiences. This method has adopted more estimation fomulae for decommissioning various works than ever, so as to be more reliable. And decommissioning cost for the facilities has estimated under the common condition. This method would be improved, reflecting future nuclear facilities dismantling and replacement events.This paper shows the cost estimation method for nuclear facilities and cost evaluation result for about 230 facilities of both JAERI and JNC.

Journal Articles

Electron irradiation effects on Y$$_{1}$$Ba$$_{2}$$CCu$$_{3}$$O$$_{y}$$ superconductors

Watanabe, Mitsuo; Kato, Teruo; Naramoto, Hiroshi; Maeta, Hiroshi; Shiraishi, Kensuke; ; Iwase, Akihiro; Iwata, Tadao

Advances in Superconductivity, p.469 - 474, 1989/00

no abstracts in English

Oral presentation

In-situ dismantling of the liquid waste storage tank LV-1 in JRTF, 1; An Outline of the dismantling program

Nakashio, Nobuyuki; Mimura, Ryuji; Muraguchi, Yoshinori; Nemoto, Koichi; Shiraishi, Kunio; Tachibana, Mitsuo; Kubota, Shintaro; Kawagoshi, Hiroshi

no journal, , 

For the purpose of the development of technology for dismantling and decontamination at the high dose area, ${it in-situ}$ dismantling method is applied for the liquid waste storage tank (LV-1) which is in the concrete cell at the JRTF. This report describes the outline of the program for ${it in-situ}$ dismantling of the LV-1.

Oral presentation

In-situ dismantling of the liquid waste storage tank LV-1 in JRTF, 3; Evaluation of the radioactivity inventory of LV-1

Kubota, Shintaro; Kawagoshi, Hiroshi; Tachibana, Mitsuo; Muraguchi, Yoshinori; Mimura, Ryuji; Nakashio, Nobuyuki; Nemoto, Koichi; Shiraishi, Kunio

no journal, , 

no abstracts in English

8 (Records 1-8 displayed on this page)
  • 1